Coupling of mitochondrial state with active zone plasticity in early brain aging by Lu Fei, Yongtian Liang, Ulrich Kintscher, Stephan J. Sigrist

“…Neurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. …”
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Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications by Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis

“…Oxidative stress has been associated with a variety of pathologic conditions, including diabetes mellitus (DM), cancer, atherosclerosis, neurodegenerative diseases, rheumatoid arthritis, ischemia/reperfusion injury, obstructive sleep apnea, and accelerated aging. …”
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Biocomposite’s Multiple Uses for a New Approach in the Diagnosis of Parkinson’s Disease Using a Machine Learning Algorithm by Abdallah Al-Husban, Mustafa Mahdi Abdulridha, A. A. Hamad Mohamad, Abdelrahman Mohamed Ibrahim

“…Neurodegenerative diseases drastically affect human beings without distinction; it does not matter if they are male or female. …”
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The Relationship between Removable Dental Prostheses and Brain Activity in Elderly Individuals: Systematic Review by Arpit Sikri, Jyotsana Sikri, Rinshul Saroch, Charanjeet Singh Gill, Rimple Gupta, Chetan Pathak

“…Conclusion: Removable dental prostheses play a crucial role in enhancing neurological health and preventing cognitive decline, making them an important consideration in the management of neurodegenerative diseases.…”
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APOE4 and infectious diseases jointly contribute to brain glucose hypometabolism, a biomarker of Alzheimer's pathology: New findings from the ADNI. by Aravind Lathika Rajendrakumar, Konstantin G Arbeev, Olivia Bagley, Matt Duan, Anatoliy I Yashin, Svetlana Ukraintseva, Alzheimer’s Disease Neuroimaging Initiative

“…<h4>Background</h4>Impaired brain glucose metabolism is a preclinical feature of neurodegenerative diseases such as Alzheimer's disease (AD). …”
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Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction by Changhui Zhu, Xue Dong, Xiwei Wang, Yingying Zheng, Juanjuan Qiu, Yanling Peng, Jiajun Xu, Zhengbin Chai, Chunyan Liu

“…Therefore, SIRT2 can be involved in metabolic disorder-related inflammation and oxidative stress, thereby triggering the occurrence of metabolic disorder-related diseases, such as neurodegenerative diseases, tumours, diabetes, and cardiovascular diseases. …”
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Mast Cell Deficiency Protects Mice from Surgery-Induced Neuroinflammation by Xiang Zhang, Hongquan Dong, Fei Wang, Jun Zhang

“…Neuroinflammation plays a key role in the occurrence and development of neurodegenerative diseases. Microglia, the resident immune cells in the brain, have been recognized to contribute to neuroinflammation. …”
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Epidemiology and Risk Factors for Orthostatic Hypotension and Its Severity in Residents Aged > 60 years: A Cross-Sectional Study by Mingni Yang, Ruiqiang Peng, Zetuo Wang, Miaoduan Li, Yehua Song, Jianping Niu, Yong Ji

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Targeting the epigenome with advanced delivery strategies for epigenetic modulators by Sonia Guha, Yogeswaran Jagadeesan, Murali Monohar Pandey, Anupama Mittal, Deepak Chitkara

“…Epigenetic drugs exhibit promising therapeutic efficacy against several epigenetically originated diseases including several cancers, neurodegenerative diseases, metabolic disorders, cardiovascular disorders, and so forth. …”
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The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease by Xudong Sha, Jiayuan Lin, Kexin Wu, Jia Lu, Zhihua Yu

“…Abstract Microglia are progressively activated by inflammation and exhibit phagocytic dysfunction in the pathogenesis of neurodegenerative diseases. Lipid-droplet-accumulating microglia were identified in the aging mouse and human brain; however, little is known about the formation and role of lipid droplets in microglial neuroinflammation of Alzheimer’s disease (AD). …”
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From data to diagnosis: leveraging deep learning in IoT-based healthcare by Miracle A. Atianashie, Chukwuma Chinaza Adaobi

“…Furthermore, the implementation of deep learning technologies in healthcare IoT has proven effective in the early detection of critical health conditions, including cancer and neurodegenerative diseases, through sophisticated analysis of medical images and physiological data. …”
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Astaxanthin relieves HT22 cells from LPS-induced inflammation and apoptosis by inhibiting oxygen species and regulating the TLR4/MyD88/NFκB signaling pathway by Tan Wang, Rongrong Li, Ping Niu, Zhen Wei, Donge Xie, Huorong Huang, Jiayao Pan, Chunshu Rong

“…Astaxanthin exhibits promising anti-inflammatory effects in the treatment of neurodegenerative diseases. Our aim was to explore the mechanisms by which astaxanthin mitigates inflammation associated with these conditions. …”
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Carvacrol Essential Oil as a Neuroprotective Agent: A Review of the Study Designs and Recent Advances by Fahad Khan Tareen, Laura Catenacci, Sara Perteghella, Milena Sorrenti, Maria Cristina Bonferoni

“…Neurodegenerative diseases were mostly perceived as diseases of ageing populations, but now-a-days, these diseases pose a threat to populations of all age groups despite significant improvements in quality of life. …”
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Effect of Lipopolysaccharide and TNFα on Neuronal Ascorbic Acid Uptake by Veedamali S. Subramanian, Trevor Teafatiller, Anshu Agrawal, Masashi Kitazawa, Jonathan S. Marchant

“…Elevated levels of LPS and TNFα have been associated with neurodegenerative diseases together with reduced levels of AA. …”
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Genetic approaches to the investigation of serotonergic neuron functions in animals by U. S. Drozd, E. V. Shaburova, N. N. Dygalo

“…The understanding of its mechanisms will help scientists create new therapeutic approaches to the treatment of mental and neurodegenerative diseases and find out how this neurotransmitter system interacts with other parts of the brain and regulates their activity. …”
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The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response by E. V. Sukhareva

“…Disturbances of the CRH system regulation are directly related to such disorders: mental pathologies (depression, anxiety, addictions), deviations of neuroendocrinological functions, inflammation, as well as the onset and development of neurodegenerative diseases such as Alzheimer’s disease. In addition, the role of CRH as a regulator of the neurons structure in the areas of the developing and mature brain has been established. …”
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RIPK1 in necroptosis and recent progress in related pharmaceutics by Kunhou Yao, Zhihao Shi, Fengya Zhao, Cong Tan, Yixin Zhang, Hao Fan, Yingzhe Wang, Xingwang Li, Jun Kong, Qun Wang, Dingxi Li

“…RIPK1-mediated necroptosis further promotes cell death and inflammation in the pathogenesis of liver injury, skin diseases, and neurodegenerative diseases. The N-terminal kinase domain of RIPK1 is significant in the induction of cell death and can be used as a vital drug target for inhibitors. …”
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Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease by Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta

“…These findings suggest that securinine may be a potential candidate for the treatment of neurodegenerative diseases related to neuroinflammation.…”
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Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation by Doaa Abou El-ezz, Waleed Aldahmash, Tuba Esatbeyoglu, Sherif M. Afifi, Marawan Abd Elbaset

“…Cilostazol may hold promise as a therapeutic agent for neuroinflammatory conditions associated with neurodegenerative diseases.…”
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Structural Brain Changes Associated with Overweight and Obesity by Erick Gómez-Apo, Alejandra Mondragón-Maya, Martina Ferrari-Díaz, Juan Silva-Pereyra

“…Neuroinflammation in neurodegenerative diseases (such as Alzheimer’s and Parkinson’s diseases) may be similar to that in metabolic diseases induced by malnutrition. …”
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