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Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model
Published 2015-01-01“…Long-term exposure to L-BMAA is believed to lead to neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases and amyotrophic lateral sclerosis (Lou Gehrig’s disease). …”
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322
Possible impact of use of a ketogenic diet in pregnancy on the fetus: Review of animal and human studies
Published 2025-03-01“…It is an effective form of treatment for many diseases including epilepsy, obesity, neurodegenerative diseases and some metabolic disorders.In women with Polycystic Ovary Syndrome ketogenic diet has a positive effect on fertility by reducing weight, insulin resistance and hormonal regulation [4–7]. …”
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323
Genomic exploration of pediatric neurological disorders: a case series
Published 2025-01-01“…Abstract Background Pediatric neurological disorders include neurodegenerative diseases causing cognitive impairment and vision loss. …”
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324
Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model
Published 2020-01-01“…Pathophysiological changes leading to the death of nerve cells present in the brain and spinal cord are referred to as neurodegenerative diseases. Presently, treatment of these diseases is not effective and encounters many challenges due to the cost of drug and side effects. …”
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325
Unveiling the biological effects of radio-frequency and extremely-low frequency electromagnetic fields on the central nervous system performance
Published 2024-07-01“…ELF-EMF exposure has been associated with the enhancement of CNS performance, marked by improved memory retention, enhanced learning ability, and potential mitigation of neurodegenerative diseases. Nevertheless, it is essential to acknowledge that ELF-EMF exposure has also been linked to the induction of anxiety states, oxidative stress, and alterations in hormonal regulation. …”
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326
Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease
Published 2024-12-01“…This review emphasizes the need for further research into AlCl3's neurotoxic mechanisms to clarify its role in AD and other neurodegenerative diseases. Enhanced understanding may help develop preventive measures and regulations to mitigate the health risks posed by aluminium exposure in daily life.…”
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327
The Role of Physical Activity in Reducing Inflammation: Implications for Preventive Medicine
Published 2025-01-01“…Physical inactivity is associated with the development of various chronic diseases including cancer, cardiovascular, metabolic and neurodegenerative diseases [1]. All countries should adopt policies focused on encouraging people to move at all stages of life. …”
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328
Mechanism of Inflammation in Age-Related Macular Degeneration
Published 2012-01-01“…In the aging retina, free radicals and oxidized lipoproteins are considered to be major causes of tissue stress resulting in local triggers for parainflammation, a chronic status which contributes to initiation and/or progression of many human neurodegenerative diseases such as AMD. Experimental and clinical evidences strongly indicate the pathogenetic role of immunologic processes in AMD occurrence, consisting of production of inflammatory related molecules, recruitment of macrophages, complement activation, microglial activation and accumulation within those structures that compose an essential area of the retina known as macula lutea. …”
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329
QSPR Analysis of Some Alzheimer’s Compounds via Topological Indices and Regression Models
Published 2024-01-01“…Neurodegenerative diseases (NDDs) have received considerable interest from scientists for a long time due to their multifactorial nature. …”
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330
Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review
Published 2023-05-01“…Regarding the urgent need for the development of novel treatments for neurodegenerative diseases, researchers have recently perused the function of natural phytobioactive combinations, such as resveratrol (RES), in vivo and in vitro (animal models of AD). …”
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331
The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection
Published 2025-01-01“…In neurological manifestations, IAA can lead to neurotransmitter disorders, neurodevelopment dysfunction, and even neurodegenerative diseases. Taken together, our review provides insights into the mechanisms of IAA neurotoxicity that will contribute to future studies of IAA neurotoxicity and its protective strategies.…”
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332
The roles of pleiotrophin in brain injuries: a narrative review of the literature
Published 2025-12-01“…Considering this, this review focuses on the roles and related regulatory pathways of PTN in brain injuries, what is known to date.Methods PubMed and Embase databases have been searched, and related studies are compiled and summarized.Results Our review has found PTN participates in the repairment of brain injuries, including hypoxic-ischemic brain injury, preterm white matter injury, traumatic brain injury, and neurodegenerative diseases, mainly based on animal data and small sample size studies. …”
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333
Association of cognitive reserve with stroke outcome: a protocol for a systematic review
Published 2022-07-01“…Introduction The concept of cognitive reserve (CR) was introduced to account for individual differences in the clinical manifestation of neurodegenerative diseases. Though several mechanisms and risk factors are shared between neurodegeneration and stroke, the effect of CR on poststroke functional outcome has been poorly addressed. …”
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334
NET formation-mediated in situ protein delivery to the inflamed central nervous system
Published 2024-12-01“…Although this study focuses on IFNβ and autoimmune encephalomyelitis, the concept of hitchhiking neutrophils for CNS delivery and employing NET formation for inflamed site-specific nanoparticle release can be further applied for delivery of other protein drugs in the treatment of neurodegenerative diseases.…”
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335
Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity
Published 2016-01-01“…Lipopolysaccharide- (LPS-) mediated systemic inflammation plays a critical role in neurodegenerative diseases. The present study was conducted to evaluate the protective effects of epigallocatechin gallate (EGCG), the major component in green tea, on LPS-mediated inflammation and neurotoxicity. …”
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336
Mutations in human prion-like domains: pathogenic but not always amyloidogenic
Published 2024-12-01“…To date, over 60 mutations targeting the LCDs of hnRNPs have been identified and associated with a spectrum of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). …”
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337
Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment
Published 2019-01-01“…All studies demonstrated that dental stem cell-derived factors promote neurotrophic effects that can mechanistically stimulate nerve regeneration in neurodegenerative diseases and nerve injury. This data collection will enable researchers to gather information to create a precise formulation for future prescribed treatments.…”
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338
Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions
Published 2019-01-01“…Neuroinflammation is increasingly recognized as an important pathophysiological feature of neurodegenerative diseases such as Parkinson’s disease (PD). …”
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339
Statistical Complexity Analysis of Sleep Stages
Published 2025-01-01“…Studying sleep stages is crucial for understanding sleep architecture, which can help identify various health conditions, including insomnia, sleep apnea, and neurodegenerative diseases, allowing for better diagnosis and treatment interventions. …”
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340
Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro
Published 2020-08-01“…It has long been known that defects in the structure of the mitochondrial genome can cause various neuromuscular and neurodegenerative diseases. Nevertheless, at present there is no effective method for treating mitochondrial diseases. …”
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