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281
Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease
Published 2017-01-01“…These findings suggest that securinine may be a potential candidate for the treatment of neurodegenerative diseases related to neuroinflammation.…”
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282
Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation
Published 2024-01-01“…Cilostazol may hold promise as a therapeutic agent for neuroinflammatory conditions associated with neurodegenerative diseases.…”
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283
Drosophila Mutant Model of Parkinson’s Disease Revealed an Unexpected Olfactory Performance: Morphofunctional Evidences
Published 2016-01-01“…Parkinson’s disease (PD) is one of the most common neurodegenerative diseases characterized by the clinical triad: tremor, akinesia, and rigidity. …”
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284
Impact of Implementing Structured Compensatory Methods on Knowledge and Awareness of Cognitive Dysfunction Management Among Neurological Disorder Patients in Vijayapur Hospitals
Published 2025-01-01“…It can result from neurotoxicity ischemia or neurodegenerative diseases like Alzheimerrsquos and Parkinsonrsquos.Objectives The study aimed to assess knowledge about cognitive impairment evaluate the effectiveness of structured compensatory techniques and analyze the relationship between knowledge scores and sociodemographic variables.Methodology The study assessed the effectiveness of structured compensatory techniques in improving knowledge about cognitive impairment among neurological patients in Vijayapura hospitals. …”
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285
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286
Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance.
Published 2025-01-01“…During periodontitis pathobionts such as Pg can enter the bloodstream and growing evidence correlates periodontitis with increased risk of cardiovascular and neurodegenerative diseases. However, the mechanism by which immune cells respond to Pg challenge in vivo remains elusive. …”
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287
Maximizing the neuroprotection from Citrus aurantium leaves: Optimization of a blended extract from a sequential extraction process with compressed fluids and NADES
Published 2025-02-01“…Due to the different nature and bioactivity of the obtained extracts, the mixture of the three fractions was optimized to enhance its overall preventive potential against neurodegenerative diseases. Finally, its scalability to a semi-pilot scale was evaluated, giving rise to increased bioactive values of the blended extract.…”
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288
PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development
Published 2025-01-01“…As a result of this present review, the application of PROTACs will be discussed in oncology, leukemia, and neurodegenerative diseases. However, there are considerable difficulties regarding the bioavailability of PROTACs; one of which is selecting the appropriate degron. …”
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289
Multipotent Effect of Clozapine on Lipopolysaccharide-Induced Acetylcholinesterase, Cyclooxygenase-2,5-Lipoxygenase, and Caspase-3: In Vivo and Molecular Modeling Studies
Published 2025-01-01“…Dual inhibition of cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) is a recognized strategy for enhanced anti-inflammatory effects in small molecules, offering potential therapeutic benefits for individuals at risk of dementia, particularly those with neurodegenerative diseases, common cancers, and diabetes type. …”
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290
Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models
Published 2025-01-01“…These models offer essential insights into the development of therapeutic strategies for neurodegenerative diseases characterized by tau aggregation.…”
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291
Characterization of novel human endogenous retrovirus structures on chromosomes 6 and 7
Published 2025-01-01“…We examined a cohort of 222 individuals for HML-2 proviruses 6q14.1 and 7p22.1a, two loci that are capable of producing full-length viral proteins and have been previously implicated in several cancers, autoimmune disorders and neurodegenerative diseases, using long-read DNA sequencing. …”
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292
Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders
Published 2025-01-01“…Pharmacological modulation of these enzymes offers potential to enhance cognitive function and mitigate pathological mechanisms underlying brain injuries, neurodegenerative diseases, and psychiatric disorders. Further research into the regulation of PDE4 and PDE5 will advance therapeutic strategies for these conditions.…”
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293
Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein
Published 2016-01-01“…The search for the inhibitors that would block the interactions of FA DD with the other core proteins of the DISC is essential for the studies of the structure and function of this complex, investigation of the apoptosis mechanisms and development of new treatments for neurodegenerative diseases. In the course of this work, the screening for small inhibitors in silico that selectively interact with DED has been performed. …”
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294
Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial.
Published 2021-01-01“…<h4>Background</h4>Neurodegenerative diseases are sporadic hereditary conditions characterized by progressive dysfunction of the nervous system. …”
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295
Fucoxanthin Inhibits the NMDA and AMPA Receptors Through Regulating the Calcium Response on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice
Published 2025-01-01“…Glutamate excitotoxicity is considered as the etiology of stroke and neurodegenerative diseases, namely, Parkinson’s disease (PD), Alzheimer’s disease (AD), and others. …”
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296
Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i>
Published 2025-01-01“…The findings from <i>Caenorhabditis elegans</i> studies offer valuable insights into these complex processes and highlight potential avenues for developing targeted therapies to mitigate neurodegenerative disease progression.…”
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297
Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID
Published 2025-02-01“…Neurodegenerative diseases (NDs) and Long COVID represent critical and growing global health challenges, characterized by complex pathophysiological mechanisms including neuronal deterioration, protein misfolding, and persistent neuroinflammation. …”
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298
Effects of Intravenous Administration of Human Umbilical Cord Blood Stem Cells in 3-Acetylpyridine-Lesioned Rats
Published 2012-01-01“…Cell replacement strategies using human umbilical cord blood mononuclear cells (HuUCBMCs) have emerged as a promising approach for restoration of function in neurodegenerative diseases. The aim of this work was to investigate the potential therapeutic activity of HuUCBMCs in the 3-acetylpyridine (3-AP) rat model of cerebellar ataxia. …”
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299
Efficacy of Functional Re-Education as a Treatment for Infantile Flexible Flatfoot: Systematic Review
Published 2024-12-01Get full text
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300
Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats
Published 2025-01-01Get full text
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