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241
Impact of Time Delay in Perceptual Decision-Making: Neuronal Population Modeling Approach
Published 2017-01-01“…Impairments in decision-making are frequently observed in neurodegenerative diseases, but the mechanisms underlying such pathologies remain elusive. …”
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242
A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation
Published 2024-09-01“…Pathological activation of transposable elements is a likely cause of neurodegenerative diseases with memory impairment. Analysis of the scientific literature allowed us to identify changes in the expression of 40 microRNAs derived from transposons in Alzheimer’s disease. …”
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243
Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation
Published 2024-12-01“…Microtubule-associated protein tau is inextricably linked to a group of clinically diverse neurodegenerative diseases termed tauopathies. The ratio balance of the major tau splicing isoform groups (3 R- and 4 R-tau) is critical in maintaining healthy neurons. …”
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244
MRI-guided focused ultrasound for treating Parkinson’s disease with human mesenchymal stem cells
Published 2025-01-01“…Mesenchymal stem cell therapy may be a viable treatment option for neurodegenerative diseases such as Parkinson’s. Transcranial MRgFUS serves as an efficacious and safe method for targeted and minimally invasive stem cell homing.…”
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245
Dental Mesenchymal Stem/Stromal Cells and Their Exosomes
Published 2018-01-01“…The therapeutic applicability of these cells and exosomes in dental practice, neurodegenerative diseases, and many other difficultly treatable diseases, like myocardial infarction, focal cerebral ischemia, acute lung or brain injury, acute respiratory distress syndrome, acute inflammation, and several others is concisely covered. …”
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246
Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review
Published 2024-12-01“…Emerging research suggests that NP2 is implicated in the pathogenesis of various neurological disorders, including neurodegenerative diseases, neuropsychiatric disorders, and neuropathies. …”
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247
The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease
Published 2011-01-01“…Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases as strict regulation of integrated mitochondrial functions is essential for neuronal signaling, plasticity, and transmitter release. …”
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248
The Efficiency of Direct Maturation: the Comparison of Two hiPSC Differentiation Approaches into Motor Neurons
Published 2022-01-01“…Motor neurons (MNs) derived from human-induced pluripotent stem cells (hiPSC) hold great potential for the treatment of various motor neurodegenerative diseases as transplantations with a low-risk of rejection are made possible. …”
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249
Identifying natural inhibitors against FUS protein in dementia through machine learning, molecular docking, and dynamics simulation
Published 2025-02-01“…Dementia, a complex and debilitating spectrum of neurodegenerative diseases, presents a profound challenge in the quest for effective treatments. …”
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250
Acute β-N-Methylamino-L-alanine Toxicity in a Mouse Model
Published 2015-01-01“…Long-term exposure to L-BMAA is believed to lead to neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases and amyotrophic lateral sclerosis (Lou Gehrig’s disease). …”
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251
Possible impact of use of a ketogenic diet in pregnancy on the fetus: Review of animal and human studies
Published 2025-03-01“…It is an effective form of treatment for many diseases including epilepsy, obesity, neurodegenerative diseases and some metabolic disorders.In women with Polycystic Ovary Syndrome ketogenic diet has a positive effect on fertility by reducing weight, insulin resistance and hormonal regulation [4–7]. …”
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252
Genomic exploration of pediatric neurological disorders: a case series
Published 2025-01-01“…Abstract Background Pediatric neurological disorders include neurodegenerative diseases causing cognitive impairment and vision loss. …”
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253
Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model
Published 2020-01-01“…Pathophysiological changes leading to the death of nerve cells present in the brain and spinal cord are referred to as neurodegenerative diseases. Presently, treatment of these diseases is not effective and encounters many challenges due to the cost of drug and side effects. …”
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254
Unveiling the biological effects of radio-frequency and extremely-low frequency electromagnetic fields on the central nervous system performance
Published 2024-07-01“…ELF-EMF exposure has been associated with the enhancement of CNS performance, marked by improved memory retention, enhanced learning ability, and potential mitigation of neurodegenerative diseases. Nevertheless, it is essential to acknowledge that ELF-EMF exposure has also been linked to the induction of anxiety states, oxidative stress, and alterations in hormonal regulation. …”
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255
Impact of Aluminium Chloride (AlCl₃) on Brain Function: A Review of Neurotoxic Mechanisms and Implications for Alzheimer's Disease
Published 2024-12-01“…This review emphasizes the need for further research into AlCl3's neurotoxic mechanisms to clarify its role in AD and other neurodegenerative diseases. Enhanced understanding may help develop preventive measures and regulations to mitigate the health risks posed by aluminium exposure in daily life.…”
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256
Mechanism of Inflammation in Age-Related Macular Degeneration
Published 2012-01-01“…In the aging retina, free radicals and oxidized lipoproteins are considered to be major causes of tissue stress resulting in local triggers for parainflammation, a chronic status which contributes to initiation and/or progression of many human neurodegenerative diseases such as AMD. Experimental and clinical evidences strongly indicate the pathogenetic role of immunologic processes in AMD occurrence, consisting of production of inflammatory related molecules, recruitment of macrophages, complement activation, microglial activation and accumulation within those structures that compose an essential area of the retina known as macula lutea. …”
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257
QSPR Analysis of Some Alzheimer’s Compounds via Topological Indices and Regression Models
Published 2024-01-01“…Neurodegenerative diseases (NDDs) have received considerable interest from scientists for a long time due to their multifactorial nature. …”
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258
Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review
Published 2023-05-01“…Regarding the urgent need for the development of novel treatments for neurodegenerative diseases, researchers have recently perused the function of natural phytobioactive combinations, such as resveratrol (RES), in vivo and in vitro (animal models of AD). …”
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259
The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection
Published 2025-01-01“…In neurological manifestations, IAA can lead to neurotransmitter disorders, neurodevelopment dysfunction, and even neurodegenerative diseases. Taken together, our review provides insights into the mechanisms of IAA neurotoxicity that will contribute to future studies of IAA neurotoxicity and its protective strategies.…”
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260
The roles of pleiotrophin in brain injuries: a narrative review of the literature
Published 2025-12-01“…Considering this, this review focuses on the roles and related regulatory pathways of PTN in brain injuries, what is known to date.Methods PubMed and Embase databases have been searched, and related studies are compiled and summarized.Results Our review has found PTN participates in the repairment of brain injuries, including hypoxic-ischemic brain injury, preterm white matter injury, traumatic brain injury, and neurodegenerative diseases, mainly based on animal data and small sample size studies. …”
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