MICRO RNA: A PROSPECTIVE DIAGNOSTICBIOMARKER IN ALZHEIMER’S DISEASE by Syeda Uroosa Hashmi, Ameer Haider Ali

“…This research explores the mechanisms and roles of miRNAs in gene regulation related to AD and highlights their potential as therapeutic agents for neurodegenerative diseases. …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

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Peripheral Expression of IL-6, TNF-α and TGF-β1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

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Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice by Maiko Ono, Rena Kono, Kosei Hirata, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado

“…Abnormalities and alterations in the glycolytic pathway in the pathology of neurodegenerative diseases and brain aging have received much attention, as clinical applications of proton-based magnetic resonance spectroscopy (MRS) have recently illuminated the elevation of lactate concentrations in the brains of patients with neurodegenerative diseases, including Alzheimer’s disease. …”
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Wide field imaging biomarkers: A different perspective by Sakshi Shiromani, Niveditha Pattathil, Elham Sadeghi, Netan Choudhry, Jay Chhablani

“…We discuss quantitative biomarkers, including ischemic index, nonperfusion area and more, and their application in diabetic retinopathy, central retinal vein occlusion, neurodegenerative diseases, and more. In addition, we outline qualitative biomarkers such as choroidal venous hyperpermeability and intervortex anastomoses. …”
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Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications by Marta Szekalska, Agata Puciłowska, Emilia Szymańska, Patrycja Ciosek, Katarzyna Winnicka

“…The recent technological advancements with using alginates, issues related to alginates suitability as matrix for three-dimensional tissue cultures, adjuvants of antibiotics, and antiviral agents in cell transplantation in diabetes or neurodegenerative diseases treatment, and an update on the antimicrobial and antiviral therapy of the alginate based drugs are also highlighted.…”
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Directional entropy based model for diffusivity-driven tumor growth by Marcelo E. de Oliveira, Luiz M. G. Neto

“…In our formulation, the tumor aggressiveness and morphological behavior is tissue-type dependent, i.e. alterations in white and gray matter regions (which can e.g. be induced by normal aging in healthy individuals or neurodegenerative diseases) affect both tumor growth rates and their morphology.The feasibility of this new conceptual approach is supported by previous observations that the fractal dimension, which correlates with the Shannon entropy we calculate, is a quantitative parameter that characterizes the variability of brain tissue, thus, justifying the further evaluation of this new conceptual approach.…”
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The structure, functions and clinical significance of the glymphatic system by Tansu Kuşat, Emrah Sur

“…Since the concept of the glymphatic system is a relatively new concept, we will evaluate its clinical significance in this review by looking at its basic structural elements, functions, and relationship with some certain neurodegenerative diseases. We will give information about some research showing that various diseases causing the functional impairment of the glymphatic system and also which diseases the functional impairment of the glymphatic system may cause.…”
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Parkinson's Disease: Is It a Toxic Syndrome? by Seham A. Gad ELhak, Abdel Aziz A. Ghanem, Hassan AbdelGhaffar, Sahar El Dakroury, Mohamed M. Salama

“…Parkinson's disease (PD) is one of the neurodegenerative diseases which we can by certainty identify its pathology, however, this confidence disappeares when talking about the cause. …”
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DNA methylation, histone acetylation in the regulation of memory and its modulation during aging by Padmanabh Singh, Vijay Paramanik

“…Dysregulation of synaptic plasticity gene expression affects memory during aging and neurodegenerative diseases. Covalent modifications such as methylation on DNA and acetylation on histones regulate the transcription of synaptic plasticity genes. …”
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Chemokines and Neurodegeneration in the Early Stage of Experimental Ischemic Stroke by Pawel Wolinski, Andrzej Glabinski

“…Recently inflammation has been implicated in pathogenesis of neurodegeneration and neurodegenerative diseases. The aim of this study was analysis of expression of several inflammatory markers and its correlation with development of neurodegeneration during the early stage of experimental stroke. …”
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Change of Accent as an Atypical Onset of non Fluent Primary Progressive Aphasia by Susy Paolini, Lucia Paciaroni, Antonio Manca, Roberto Rossi, Daniela Fornarelli, Stefano F. Cappa, Angela M. Abbatecola, Osvaldo Scarpino

“…Language disorders can be the first symptom of many neurodegenerative diseases, including Alzheimer's disease (AD) and primary progressive aphasia (PPA). …”
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Author Correction: Sex differences in the association between repetitive negative thinking and neurofilament light by Yolanda Lau, Amit Bansal, Cassandre Palix, Harriet Demnitz-King, Miranka Wirth, Olga Klimecki, Gael Chetelat, Géraldine Poisnel, Natalie L. Marchant, The Medit-Ageing Research Group

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A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders by Birra Taha, Robert McGovern, Cornelius Lam, Cornelius Lam

“…Finally, we discuss the implications of flow dysregulation in the context of neurodegenerative diseases and discuss the rising role of perivascular drainage pathways including glymphatics.…”
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TSE Diagnostics: Recent Advances in Immunoassaying Prions by Anja Lukan, Tanja Vranac, Vladka Čurin Šerbec

“…Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of rare fatal neurodegenerative diseases, affecting humans and animals. They are believed to be the consequence of the conversion of the cellular prion protein to its aggregation-prone, β-sheet-rich isoform, named prion. …”
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Patient-derived induced pluripotent stem cell organoids for amyotrophic lateral sclerosis drug discovery by Wenyan Li, Jingqi Liu, Wenting Li, Lina Sun, Hao Zhang, Lei Gao, Chong Gao

“…However, challenges remain in utilizing organoids for ALS drug testing and other neurodegenerative diseases. In this review we summarize the current progress in ALS model development, encompassing both in vitro and in vivo non-human models, as well as iPSC-derived human models. …”
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MRI Findings in Neuroferritinopathy by Emiko Ohta, Yoshihisa Takiyama

“…Neuroferritinopathy is a neurodegenerative disease which demonstrates brain iron accumulation caused by the mutations in the ferritin light chain gene. …”
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Recent Advances in Peptide-Loaded PLGA Nanocarriers for Drug Delivery and Regenerative Medicine by Hossein Omidian, Renae L. Wilson, Ana M. Castejon

“…The versatility of PLGA nanocarriers extends across therapeutic domains, including cancer therapy, neurodegenerative diseases, vaccine development, and regenerative medicine. …”
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Canonical and noncanonical autophagy: involvement in Parkinson’s disease by Maria Sakurai, Tomoki Kuwahara

“…There have been many reports on the involvement of these autophagy-related mechanisms in neurodegenerative diseases, with Parkinson’s disease (PD) receiving particular attention because of the important roles of several causative and risk genes, including LRRK2. …”
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Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches by Antonio L. Teixeira, Mitzi M. Gonzales, Leonardo Cruz de Souza, Sara L. Weisenbach

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