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Neuropsychiatric symptoms in Alzheimer’s disease
Published 2024-02-01“…Alzheimer’s disease is one of the most common neurodegenerative diseases among older people that manifests as deterioration of cognitive functions, impaired daily activities, and progressive degeneration of cerebral cortex neurons. …”
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322
Extracellular vesicles contribute to the beneficial effects of exercise training in APP/PS1 mice
Published 2025-02-01“…In addition, eEVs mediate some of these effects, implicating EVs in the treatment of age-related neurodegenerative diseases.…”
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323
The Relationship between Removable Dental Prostheses and Brain Activity in Elderly Individuals: Systematic Review
Published 2025-01-01“…Conclusion: Removable dental prostheses play a crucial role in enhancing neurological health and preventing cognitive decline, making them an important consideration in the management of neurodegenerative diseases.…”
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324
Psychosocial Adjustment of In-Home Caregivers of Family Members with Dementia and Parkinson’s Disease: A Comparative Study
Published 2020-01-01“…Neurodegenerative diseases such as Parkinson’s and dementia are highly prevalent worldwide. …”
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325
Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
Published 2014-01-01“…Conversely, their reexpression in reactive astrocytes may also lead to detrimental effects and promote the progression of neurodegenerative diseases.…”
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326
Astaxanthin relieves HT22 cells from LPS-induced inflammation and apoptosis by inhibiting oxygen species and regulating the TLR4/MyD88/NFκB signaling pathway
Published 2025-02-01“…Astaxanthin exhibits promising anti-inflammatory effects in the treatment of neurodegenerative diseases. Our aim was to explore the mechanisms by which astaxanthin mitigates inflammation associated with these conditions. …”
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327
Brown rice: a missing nutrient-rich health food
Published 2023-09-01“…In this review, we systemically summarized the efficacy of BR on cardiovascular diseases (CVDs), hyperlipidemia, hypertension, diabetes, obesity, osteoporosis, neurodegenerative diseases, cancer, immune disorders, inflammation, anxiety, liver and stomach damage, etc. …”
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328
Canonical and noncanonical autophagy: involvement in Parkinson’s disease
Published 2025-01-01“…There have been many reports on the involvement of these autophagy-related mechanisms in neurodegenerative diseases, with Parkinson’s disease (PD) receiving particular attention because of the important roles of several causative and risk genes, including LRRK2. …”
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329
Revisiting Apathy in Alzheimer’s Disease: From Conceptualization to Therapeutic Approaches
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330
Neuroprotection Caused by Hyperoxia Preconditioning in Animal Stroke Models
Published 2011-01-01“…Ischemic tolerance induced by hyperoxia (HO) can protect against brain injury and neurodegenerative diseases. Although multiple studies demonstrate neuroprotection by HO, the exact mechanism(s) of HO neuroprotection has not been elucidated. …”
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331
Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells
Published 2016-01-01“…Motor neurons (MNs) represent a diverse pool of neuronal subtypes exhibiting differential vulnerability in different human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). …”
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332
A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study
Published 2025-01-01“… BackgroundThe prompt and accurate identification of mild cognitive impairment (MCI) is crucial for preventing its progression into more severe neurodegenerative diseases. However, current diagnostic solutions, such as biomarkers and cognitive screening tests, prove costly, time-consuming, and invasive, hindering patient compliance and the accessibility of these tests. …”
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333
Assessment of clinical prognosis in autoimmune encephalitis: Girona score
Published 2025-01-01Get full text
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334
Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model
Published 2020-01-01“…Pathophysiological changes leading to the death of nerve cells present in the brain and spinal cord are referred to as neurodegenerative diseases. Presently, treatment of these diseases is not effective and encounters many challenges due to the cost of drug and side effects. …”
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335
Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review
Published 2023-05-01“…Regarding the urgent need for the development of novel treatments for neurodegenerative diseases, researchers have recently perused the function of natural phytobioactive combinations, such as resveratrol (RES), in vivo and in vitro (animal models of AD). …”
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336
Insulin in Central Nervous System: More than Just a Peripheral Hormone
Published 2012-01-01“…Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. …”
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337
NET formation-mediated in situ protein delivery to the inflamed central nervous system
Published 2024-12-01“…Although this study focuses on IFNβ and autoimmune encephalomyelitis, the concept of hitchhiking neutrophils for CNS delivery and employing NET formation for inflamed site-specific nanoparticle release can be further applied for delivery of other protein drugs in the treatment of neurodegenerative diseases.…”
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338
The Role of Air Pollution and Olfactory Dysfunction in Alzheimer’s Disease Pathogenesis
Published 2025-01-01“…The focus of recent research has shifted towards understanding its potential association with neurodegenerative diseases, specifically Alzheimer’s disease (AD). …”
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339
Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders
Published 2025-01-01“… RNA-based therapeutics have emerged as one of the most potent therapeutic options used for the modulation of gene/protein expression and gene editing with the potential to treat neurodegenerative diseases. However, the delivery of nucleic acids to the central nervous system (CNS) by the systemic route, remains a major hurdle. …”
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340
Genome-wide association study unravels mechanisms of brain glymphatic activity
Published 2025-01-01“…Abstract Brain glymphatic activity, as indicated by diffusion-tensor imaging analysis along the perivascular space (ALPS) index, is involved in developmental neuropsychiatric and neurodegenerative diseases, but its genetic architecture is poorly understood. …”
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