Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Furthermore, the therapeutic potential of emerging approaches, such as the use of microRNAs to regulate key cellular processes and nanotherapy, which enables precise drug delivery to the central nervous system, is analyzed. Despite promising advances in these strategies, the incidence of Alzheimer’s disease continues to rise. …”
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Neurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology by Takamasa Mizoguchi, Ayumi Maki, Yuno Nakase, Mayu Okita, Yuina Minami, Misa Fukunaga, Motoyuki Itoh

“…Ischemic stroke (IS) is a pathological condition characterized by the cessation of blood flow due to factors such as thrombosis, inflicting severe damage to the cranial nervous system and resulting in numerous disabilities including memory impairments and hemiplegia. …”
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Optimization of In Vivo Studies by Combining Planar Dynamic and Tomographic Imaging: Workflow Evaluation on a Superparamagnetic Nanoparticles System by Maritina Rouchota, Alessio Adamiano, Michele Iafisco, Eirini Fragogeorgi, Irineos Pilatis, Gilles Doumont, Sébastien Boutry, Daniele Catalucci, Argyro Zacharioudaki, George C. Kagadis

“…Molecular imaging holds great promise in the noninvasive monitoring of several diseases with nanoparticles (NPs) being considered an efficient imaging tool for cancer, central nervous system, and heart- or bone-related diseases and for disorders of the mononuclear phagocytic system (MPS). …”
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Remote Epilepsy Monitoring: Signal Quality and Reliability Comparative Analysis by Theeban Raj Shivaraja, Rabani Remli, Wan Asyraf Wan Zaidi, Kalaivani Chellappan

“…Epilepsy, a neurological condition affecting approximately 50 million individuals globally, is among the most common nervous system disorders. Electroencephalography (EEG) is vital for evaluating epilepsy, yet its intricate nature often restricts its application to specialized clinical environments. …”
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Comparison of mNGS with conventional methods for diagnosis of cryptococcal meningitis: a retrospective study by Zai-Jie Jiang, Jian-Chen Hong, Bi-Wei Lin, Wei-Qing Zhang, Qi-Chao Fan, Bi-Hui Yang, Xiang-Ping Yao

“…Initial cerebrospinal fluid (CSF) samples were collected from 65 patients with suspected central nervous system (CNS) infection and tested using conventional tests and/or mNGS. mNGS offers a culture-independent approach, facilitating a rapid and unbiased detection of a broad spectrum of pathogens. …”
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6‐Nitrodopamine potentiates catecholamine‐induced contractions of human isolated vas deferens by Antonio Tiago Lima, Sami Jabbour, José Britto‐Júnior, Demétrio Martinho Ramos deCarvalho, Adriano Fregonesi, Fernanda V. Mariano, Valéria Barbosa deSouza, Andre Almeida Schenka, Edson Antunes, Gilberto De Nucci

“…Abstract 6‐Nitrodopamine (6‐ND) is the main catecholamine released from human isolated vas deferens and the adrenergic nervous system is known to play a major role in the contractions of the epididymal portion of the vas deferens. …”
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Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations by Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb

“…<b>Background:</b> Dopamine receptors (DRs) are G-protein-coupled receptors (GPCRs) found in the central nervous system (CNS). DRs are essential for mediating various downstream signaling cascades and play a critical role in regulating the dopaminergic nigrostriatal pathway, which is involved in motor control. …”
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Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…Still, they face substantial hurdles when applied to the central nervous system (CNS), such as the blood–brain barrier (BBB) and unwanted systemic effects. …”
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tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats by Alireza Majdi, Liyi Chen, Lars E. Larsen, Robrecht Raedt, Myles Mc Laughlin

“…The TN projects to key brainstem nuclei that regulate neurotransmitter release throughout the central nervous system, but the specific pathways involved are not yet well understood. …”
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A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy by Annik Prat, Maik Behrendt, Edwige Marcinkiewicz, Sebastien Boridy, Ram M. Sairam, Nabil G. Seidah, Dusica Maysinger

“…The concordance of results from APPsw/PS1Δ9 mice with or without FSH-R deletion and those with letrozole treatment in vitro (with and without Aβ treatment) of primary cortical/hippocampal cultures suggests the usefulness of these models to explore molecular mechanisms involved in microglia and astrocyte activation in hypoestrogenic states in the central nervous system.…”
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Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice by John D. Morrey, Venkatraman Siddharthan, Hong Wang, Alexandre L. R. Oliveira, Keiichiro Susuki, Rakesh Kaundal, Sara M. Freeman, Aaron J. Thomas, Naveen Duhan, Nathan G. Corry

“…Abstract Zika virus (ZIKV) causes a variety of peripheral and central nervous system complications leading to neurological symptoms such as limb weakness. …”
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Triiodothyronine treatment in mice improves stroke outcome and reduces blood–brain barrier damage by Daniel Ullrich, Dagmar Führer, Heike Heuer, Steffen Mayerl, Steffen Haupeltshofer, Linda-Isabell Schmitt, Markus Leo, Rebecca D Szepanowski, Tim Hagenacker, Markus Schwaninger, Christoph Kleinschnitz, Friederike Langhauser

“…Objective: Thyroid hormones control a variety of processes in the central nervous system and influence its response to different stimuli, such as ischemic stroke. …”
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Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered by Michael Griessmair, Michael Griessmair, Claire Delbridge, Claus Zimmer, Eva Mayr, Arthur Wagner, Julian Canisius, Marie-Christin Metz, Benedikt Wiestler, Benedikt Wiestler

“…Molecular neuropathology revealed the diagnosis of diffuse midline glioma with a H3K27M mutation WHO (World Health Organization) CNS (central nervous system) grade 4. Interestingly, MR imaging conducted for migraine diagnosis 6 years ago in retrospect already showed a small, nodular T2w hyperintense lesion in the right thalamus.ConclusionDespite a more precise, molecularly driven classification of pediatric HGG (high-grade glioma) in the 5th edition of the WHO classification of CNS tumors, many genetic factors influencing the biological tumor development as well as the precise molecular evolution of tumors remain unclear. …”
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pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…Experimental autoimmune encephalomyelitis (EAE) is a demyelinating pathology of the central nervous system (CNS) used as a model to study multiple sclerosis immunopathology. …”
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Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury by Xin Li, Yan Qian, Wanling Shen, Shiying Zhang, Hui Han, Yu Zhang, Shuangmei Liu, Shaokun Lv, Xiuying Zhang

“…Spinal cord injury (SCI) is a common injury of the central nervous system (CNS), and astrocytes are relatively abundant glial cells in the CNS that impairs the recovery of motor function after SCI. …”
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy by Dandan Zhu, Peng Wang, Xiyue Chen, Kaituo Wang, Yunsong Wu, Min Zhang, Jianhua Qin

“…The astrocyte–microglia crosstalk in the central nervous system (CNS) plays important roles in various neurological diseases. …”
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Sex-Specific Differences in the Pathophysiology of Hypertension by Hannah Zhang, Pawan K. Singal, Amir Ravandi, Inna Rabinovich-Nikitin

“…As a result, its pathophysiological mechanisms have been studied extensively and are focused around pressure natriuresis, the renin–angiotensin system (RAS), the sympathetic nervous system, oxidative stress, and endothelial dysfunction. …”
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Peripheral signaling pathways contributing to non-histaminergic itch in humans by Andrea Fiebig, Victoria Leibl, David Oostendorf, Saskia Lukaschek, Jens Frömbgen, Maral Masoudi, Andreas E. Kremer, Marion Strupf, Peter Reeh, Miriam Düll, Barbara Namer

“…It is unclear how the peripheral nervous system differentiates the signaling of non-histaminergic itch and pain. …”
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The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury by Farnaz Mahdavi, Sima Fallah-Arzpeima, Zoheir Reihanian, Khatereh Asadi, Nooshin Zaresharifi, Roghaye Zare, Mohammad Ali Yazdanipour, Masoud Shabani Chobe

“…COVID-19 can impact the central nervous system (CNS) and hematologic system and appears to affect clinical outcomes and the average cerebral hemorrhage volume (ACHV) in patients with TBI. …”
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Optimizations of Placenta Extracellular Matrix‐Loaded Silk Fibroin/Alginate 3D‐Printed Scaffolds Structurally and Functionally for Bone Tissue Engineering by Zahra Bashiri, Zahra Khosrowpour, Ali Moghaddaszadeh, Davod Jafari, Sanaz Alizadeh, Hajar Nasiri, Houman Parsaei, Zahra Keshtkaran, Meghdad Abdollahpour‐Alitappeh, Farshad Bargrizaneh, Behzad Rezaei, Sara Simorgh, Mazaher Gholipourmalekabadi

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