Expression of catecholaminergic genes in the midbrain and prepulse inhibition in rats with a genetic catatonia by M. A. Ryazanova, O. I. Prokudina, V. S.  Plekanchuk, T. A. Alekhina

“…For the first time, a decrease of PPI in GC rats compared with WAG rats was shown, both with a prepulse power of 75 dB and at 85 dB, which may indicate a violation of filtration of sensorimotor information into the central nervous system in GC rats. Real-time PCR showed a decrease in mRNA level of Adra1A in intact rats with genetic catatonia when compared to control WAG rats. …”
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A comprehensive review of remimazolam for sedation by Nazir Noor, Rhorer Legendre, Alexandra Cloutet, Ahish Chitneni, Giustino Varrassi, Alan D. Kaye

“…This is provided by the benzodiazepine molecule binding and causing a conformational change to the chloride ion channel to cause hyperpolarization and thus inhibition of the central nervous system. Each type of benzodiazepine has a preferred role within the realm of medicine. …”
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Methods to address functional unblinding of raters in CNS trials by Steven D. Targum, William P. Horan, Vicki G. Davis, Alan Breier, Stephen K. Brannan

“…Abstract Treatment-emergent adverse events (TEAEs) associated with the unique properties of a pharmaceutical product may functionally unblind clinician ratings, obscure true medication effects, and affect confidence about clinical trial results. Central nervous system studies are particularly susceptible to functional unblinding because they rely on relatively subjective symptom assessments. …”
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Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity by Chiara Macchi, Andrea Giachi, Isabella Fichtner, Silvia Pedretti, Piercarlo Sarzi-Puttini, Nico Mitro, Alberto Corsini, Massimiliano Ruscica, Roberta Gualtierotti

“…Additionally, we found a mild correlation between the widespread pain index and the BHI, possibly indicating that the altered mitochondrial function, in these patients, narrows musculoskeletal rather than central nervous system involvement.…”
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Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase by Lies De Groef, Manuel Salinas-Navarro, Griet Van Imschoot, Claude Libert, Roosmarijn E. Vandenbroucke, Lieve Moons

“…Matrix metalloproteinases (MMPs) have been designated as both friend and foe in the central nervous system (CNS): while being involved in many neurodegenerative and neuroinflammatory diseases, their actions appear to be indispensable to a healthy CNS. …”
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Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo by Chien-Wei Feng, Nan-Fu Chen, Te-Fu Chan, Wu-Fu Chen

“…However, few studies have investigated the role of PTP1B in the central nervous system. Our study showed that suramin, an inhibitor of PTP1B, could improve neuronal damage. …”
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A Case Report of Acute Esotropia in a Young Woman following Heroin Withdrawal by Bethel Shiferaw, Ebisa Bekele, Sara Syed, Lu Fan, Nirav Patel, Samia Qazi, Nicolas Biro

“…Acute onset esotropia is rare and must be investigated right away to exclude central nervous system pathologies, where no opiates use is reported. …”
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Coexisting Congenital Mesoblastic Nephroma and Lissencephaly: Unique Case Report with Pathological Analysis and Its Clinical Significance by Hristina Zakić, Olivera Kontić Vučinić, Jelena Stamenković, Jovan Jevtić, Milena Perišić Mitrović, Maja Životić

“…Conclusions: Outlining the prenatal progression of CMN and the outcome of pregnancies involving fetal CMN and lissencephaly, this case underscores the importance of comprehensive ultrasound examinations, including central nervous system evaluation, to identify potential coexisting anomalies and refine prenatal diagnostic practices.…”
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Development of Postural Control in Healthy Children: A Functional Approach by Christine Assaiante, Sophie Mallau, Sébastien Viel, Marianne Jover, Christina Schmitz

“…When studying the emergence of postural strategies, it is essential to distinguish between results that can be explained by biomechanical reasons strictly and those reflecting the maturation of the central nervous system (CNS). To address this problem, we have studied our young subjects in situations requiring various types of adaptation. …”
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The Relationship between Heart Rate Variability and Adiposity Differs for Central and Overall Adiposity by B. Gwen Windham, Stefano Fumagalli, Alessandro Ble, John J. Sollers, Julian F. Thayer, Samar S. Najjar, Michael E. Griswold, Luigi Ferrucci

“…While frank obesity is associated with reduced HRV, indicative of poorer autonomic nervous system (ANS) function, the association between body mass index (BMI) and HRV is less clear. …”
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Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications by Asmae Hbika, Ayoub Farihi, Mohammed Benali, Fatima-Zahrae Ed-darraz, Abdelhamid Bouyanzer, Mohammed F. Hawwal, Ramzi A. Mothana, Elkhadir Gharibi

“…ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system.…”
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Neuroborreliosis with encephalitis: a broad spectrum of clinical manifestations by Dominica Hudasch, Franz Felix Konen, Nora Möhn, Lea Grote-Levi, Ulrich Wurster, Gabriel Welte, Josef Conzen, Nima Mahmoudi, Thomas Skripuletz, Philipp Schwenkenbecher

“…In addition to central nervous system involvement, all patients exhibited characteristic features of neuroborreliosis like painful meningoradiculitis or peripheral facial palsy. …”
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Focused ultrasound for treatment of peripheral brain tumors by Phillip Mitchell Johansen, Payton Yerke Hansen, Ali A. Mohamed, Sarah J. Girshfeld, Marc Feldmann, Brandon Lucke-Wold

“…Malignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemotherapy. …”
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Age-Related Changes in Gut Health and Behavioral Biomarkers in a Beagle Dog Population by Anna Fernández-Pinteño, Rachel Pilla, Jan Suchodolski, Emmanuelle Apper, Celina Torre, Anna Salas-Mani, Xavier Manteca

“…The gut and the gut microbiome communicate with the nervous system through the gut–brain axis via neuroimmune and neuroendocrine mechanisms. …”
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The Economic and Humanistic Burden of Pediatric-Onset Multiple Sclerosis by Nupur Greene, Lita Araujo, Cynthia Campos, Hannah Dalglish, Sarah Gibbs, Irina Yermilov

“…**Background:** Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. Pediatric-onset MS (POMS), defined as onset of MS before 18 years of age, is estimated to account for 2% to 5% of the MS population worldwide. …”
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Sexual dysfunction and quality of life across age groups in multiple sclerosis patients: a prospective cross-sectional analysis by Reza Dehghaniathar, Ali Faegh, Fahimeh Hajiakhoundi, Behnam Shakiba, Zeynab Najjar

“…Abstract Introduction As the most frequent chronic neurological disorder in young adults, Multiple sclerosis (MS) significantly affects neurological function, particularly the autonomic nervous system. While the physical symptoms are visible, MS also causes hidden effects like sexual dysfunction. …”
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Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons by Anne-Emilie Allain, Hervé Le Corronc, Alain Delpy, William Cazenave, Pierre Meyrand, Pascal Legendre, Pascal Branchereau

“…γ-aminobutyric acid (GABA) acting on Cl−-permeable ionotropic type A (GABAA) receptors (GABAAR) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates. In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontaneous activities that are instructive for the construction of neural networks but GABA also acts as a potent trophic factor. …”
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Coordinated human-exoskeleton locomotion emerges from regulating virtual energy. by Rezvan Nasiri, Hannah Dinovitzer, Nirosh Manohara, Arash Arami

“…These findings may have implications for understanding how the central nervous system controls our locomotion.…”
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Extracellular Vesicles as Tools for Crossing the Blood–Brain Barrier to Treat Lysosomal Storage Diseases by Giovanni Lerussi, Verónica Villagrasa-Araya, Marc Moltó-Abad, Mireia del Toro, Guillem Pintos-Morell, Joaquin Seras-Franzoso, Ibane Abasolo

“…Extracellular vesicles (EVs) are nanosized, membrane-bound structures that have emerged as promising tools for drug delivery, especially in the treatment of lysosomal storage disorders (LSDs) with central nervous system (CNS) involvement. This review highlights the unique properties of EVs, such as their biocompatibility, capacity to cross the blood–brain barrier (BBB), and potential for therapeutic cargo loading, including that of enzymes and genetic material. …”
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Predictors of recurrent febrile seizure in children aged from 6 months to 5 years: A cross-sectional study by Anand Muttath, Thomas Antony, Rati Santhakumar, Rose Xavier, Jassal Mathew

“…Clinical evaluations ruled out central nervous system infections and fever causes were diagnosed per ICD-10 at discharge. …”
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