Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions by Miranda Movahed, Ruy A. Louzada, Manuel Blandino-Rosano

“…Objective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells. …”
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The Role of Silymarin in Mitigating Inflammation and Cognitive Impairment Induced by Ovariectomy in Wistar Rats by Razieh Moalefshahri, Hossein Javid, Fatemeh Gheybi, Somaye Fallahnezhad, Seyed Isaac Hashemy

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Biomaterial Applications in Cell-Based Therapy in Experimental Stroke by Ligia S. B. Boisserand, Tomonobu Kodama, Jérémie Papassin, Rachel Auzely, Anaïck Moisan, Claire Rome, Olivier Detante

“…Tissue engineering has recently aroused a major interesting development of biomaterials for use into the central nervous system. Many biomaterials have been engineered based on natural compounds, synthetic compounds, or a mix of both with the aim of providing polymers with specific properties. …”
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Disseminated Cerebrospinal Embryonal Tumor in the Adult by Alessandro Caporlingua, Daniele Armocida, Federico Caporlingua, Gennaro Lapadula, Grazia Maria Elefante, Manila Antonelli, Maurizio Salvati

“…According to the 2016 World Health Organization classification of Tumors of the Central Nervous System, the term Primitive Neuroectodermal Tumor has been replaced by the term Embryonal Tumor (ET). …”
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A Challenging Case of Oral Ulcers and Gastrointestinal Bleeding: Crohn’s or Behçet’s Disease by Marina A. S. Dantas, Ana Luiza Graneiro, Rodrigo Cavalcante, Lina Maria Felipez

“…Given endoscopic findings and the worsening of an auto-inflammatory reaction in the central nervous system after COVID-19 in a patient with controlled GI symptoms, the most likely diagnosis is BD.…”
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Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats by Minna Tang, Jialu Hu, Wenshu Li, Ningzhi Zhang, Sisi Ning, Yan Yan, Zhaoqiang Cui

“…Evidence suggests ouabain contributes to hypertension mainly through activation of the sympathetic nervous system (SNS). Renal nerves play a vital role in the regulation of SNS activity, so we hypothesize that renal denervation may attenuate the development of ouabain-induced hypertension. …”
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Intrinsic and Extrinsic Neuronal Mechanisms in Temporal Coding: A Further Look at Neuronal Oscillations by Rémy Lestienne

“…Many studies in recent years have been devoted to the detection of fast oscillations in the Central Nervous System (CNS), interpreting them as synchronizing devices. …”
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Constipation at endocrine diseases by Yu. O. Shulpekova, A. G. Komova

“…Constipation is one of broad spectrum of gastro-intestinal hyperthyroidism manifestations, probably, related to change in expression of the genes regulating motility, decrease of autonomous nervous system excitability and dehydration. Decrease of enterochromaffin cells number and change of intestinal nervous ganglia structure is typical for hereditary endocrine syndromes (APECED, MEN-2). …”
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Assessment of Quality of Life in Patients with Parkinson's Disease by Freddy Fernando Jumbo Salazar, Carlos Alejandro Troya Altamirano, Daniela Abigail Cobo Álvarez

“…<strong>Foundation:</strong> parkinson's disease is a chronic progressive disorder of the nervous system that mainly affects motor coordination and movement control. …”
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Prospects for the use of <i>Bacillus anthracis</i> toxin in cancer therapy by A. P. Rodionov, S. V. Ivanova, E. A. Artemeva, L. A. Melnikova

“…The analysis of literature demonstrated good prospects for the potential use of the lethal factor to combat such types of cancer as liver, lung, colon, breast, pancreatic, ovarian, prostate, stomach and nervous system cancers. However, despite the impressive results, further in-depth research is needed in this area concerning selection of optimum doses of the lethal factor, determination of sensitivity of different types of cancer to it, investigation of its effects on other body tissues and interaction with the immune system during therapy.…”
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Direct Spinal Ventral Root Repair following Avulsion: Effectiveness of a New Heterologous Fibrin Sealant on Motoneuron Survival and Regeneration by Mateus Vidigal de Castro, Roberta Barbizan, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues de Oliveira

“…Axonal injuries at the interface between central and peripheral nervous system, such as ventral root avulsion (VRA), induce important degenerative processes, mostly resulting in neuronal and motor function loss. …”
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Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish by Ilse Bollaerts, Jessie Van houcke, An Beckers, Kim Lemmens, Sophie Vanhunsel, Lies De Groef, Lieve Moons

“…As adult mammals lack the capacity to replace or repair damaged neurons, degeneration and trauma (and subsequent dysfunction) of the central nervous system (CNS) seriously constrains the patient’s life quality. …”
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Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness by Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty

“…Persistent cognitive impairment is a primary central nervous system-related symptom in veterans afflicted with chronic Gulf War Illness (GWI). …”
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Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism by L. Di Cesare Mannelli, G. D'Agostino, A. Pacini, R. Russo, M. Zanardelli, C. Ghelardini, A. Calignano

“…Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic with a neurorestorative effect. …”
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Elevated Blood Ammonia Level Is a Potential Biological Risk Factor of Behavioral Disorders in Prisoners by Yunfeng Duan, Xiaoli Wu, Shan Liang, Feng Jin

“…Hydrothion (H2S) and ammonia (NH3) can be toxic for the human central nervous system and cause psychological disturbances and behavioral disorders. …”
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Surviving prematurity: retrospective longitudinal study of multisystem consequences in preterm-born individuals from infancy to adolescence by Ruta Morkuniene, Ruta Levuliene, Vilmantas Gegzna, Egle Marija Jakimaviciene, Janina Tutkuviene

“…Results Most diagnoses occurred by age 7, with eye diseases, congenital malformations, and infections most prevalent, but the greatest disparities with the general population were in blood, nervous system, mental, and neoplastic diseases. Lower BW significantly correlated with higher mean disease counts and greater diversity of health conditions across various ICD-10 chapters, while GA showed less pronounced associations. …”
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Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? by Stefania Gonfloni, Emiliano Maiani, Claudia Di Bartolomeo, Marc Diederich, Gianni Cesareni

“…Studies in mouse models have shown that the kinases of the c-Abl family play a role in the development of the central nervous system. Recent reports show that aberrant c-Abl activation causes neuroinflammation and neuronal loss in the forebrain of transgenic adult mice. …”
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Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…The disorder primarily affects the nervous system, leading to a range of neurological issues, including cerebellar ataxia. …”
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Movement in the Shadow of Sadness: How Physical Activity Supports the Fight Against Depression by Agata Ossolińska, Patrycja Marta, Filip Huzarski, Gabriela Ferfecka, Klaudia Pawełek, Lucyna Stolarska, Magdalena Rosa-Bończak, Natalia Morawiecka, Olivier Carlton, Weronika Kłosowicz

“…Regular moderate exercise is an effective method to prevent central fatigue and enhance the adaptability of the central nervous system. This paper explores the complex impact of physical activity on mental health and cognitive function, emphasizing its vital role in supporting the therapy of neurological and psychiatric disorders. …”
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A Rare Case of Fatal Hemorrhagic Stroke in a Young Female with Early Mixed Connective Tissue Disease by James R. Agapoff IV

“…Mixed connective tissue disease (MCTD) often presents as a slow progressive illness with low morbidity and mortality. Serious central nervous system disease is uncommon, and fatal outcomes are rarely seen. …”
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