Anti-amoebic effects of selected herbal extracts against Acanthamoeba species isolated from different borehole water samples from Budiriro District in Harare, Zimbabwe by Kudzai Fambisai, Petros Muchesa, Farisai Chidzwondo, Rumbidzai Mangoyi

“… Acanthamoeba species are the major cause of Acanthamoeba Keratitis (AK) of eyes, Acanthamoeba meningoencephalitis of the central nervous system, and fatal Granulomatous Amoebic Encephalitis (GAE) of the brain in humans. …”
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Functional Diversity of Fibroblast Growth Factors in Bone Formation by Yuichiro Takei, Tomoko Minamizaki, Yuji Yoshiko

“…Currently, intracellular FGFs appear to be primarily involved in the nervous system. Canonical FGFs such as FGF2 play significant roles in bone formation, and precise spatiotemporal control of FGFs and FGFRs at the transcriptional and posttranscriptional levels may allow for the functional diversity of FGFs during bone formation. …”
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The emerging role of 12/15-lipoxygenase in ischemic stroke by Xuening Wang, Qiuji Shao, Yuan Gao

“…The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. Ischemic stroke is a devastating disease in which the occlusion of cerebral arteries leads to a series of pathophysiological changes in brain tissue, triggering an inflammatory cascade within the brain that results in neuroinflammation. …”
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Cold induces brain region-selective cell activity-dependent lipid metabolism by Hyeonyoung Min, Yale Y Yang, Yunlei Yang

“…It has been well documented that cold is an enhancer of lipid metabolism in peripheral tissues, yet its effect on central nervous system lipid dynamics is underexplored. It is well recognized that cold acclimations enhance adipocyte functions, including white adipose tissue lipid lipolysis and beiging, and brown adipose tissue thermogenesis in mammals. …”
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Comprehensive Update on Rabies: A Neglected Zoonotic Disease of Public Health Concern by Kavitha Guladahalli Manjunatha, Chethana Chandrahasa, Sadanand Dangari Akshay, Akhila Dharnappa Sannejal, Rajeshwari Vittal, Govindaiah Kavitha, Khang Wen Goh, Shrikrishna Isloor, Devananda Devegowda

“…The virus targets the central nervous system of warm-blooded animals and claims the lives of over 60,000 individuals annually. …”
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Anesthetic-Induced Oxidative Stress and Potential Protection by Cheng Wang, Xuan Zhang, Fang Liu, Merle G. Paule, William Slikker, Jr.

“…Stimulation of immature neurons by NMDA antagonists or GABA agonists is thought to increase overall nervous system excitability and may contribute to abnormal neuronal cell death during development. …”
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Early Polytherapy for Probably Benzodiazepine Refractory Naïve Status Epilepticus (Stage 1 Plus) by Giuseppe Magro

“…These cases include not only prolonged SE as previously proposed by the author (SE lasting > 10 min) but also other cases notoriously associated with BDZ refractoriness such as the absence of prominent motor phenomena and acute etiology (especially primary central nervous system etiology). Interestingly, the absence of prominent motor phenomena as is the case of non convulsive SE might implicitly fall in the category of prolonged SE due to the delay in recognition and treatment. …”
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Finite volume modeling of neural communication: Exploring electrical signaling in biological systems by Muzammal Saleem, Muhammad Saqib, Badar Saad Alshammari, Shahid Hasnain, Amjad Ayesha

“…Action potentials electrical signals generated by neurons are crucial for communication within the nervous system. The Hodgkin–Huxley model offers an analytically representation of how neurons produce and propagate these action potentials by accounting for key factors, including membrane potential variations influenced by ion channel conductances. …”
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Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation by Adam Aguirre, Carola J. Maturana, Paloma A. Harcha, Juan C. Sáez

“…In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. …”
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Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages by Shaoming Jin, Xiao Ning, Jin Cao, Yaonan Wang

“…γ-Hydroxybutyrate (GHB) is a neurotransmitter, which exhibits a strong central nervous system depressant effect. The abuse of GHB or its precursor substances (γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD)) may cause serious problems. …”
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Parkinson’s disease and exosomes: from pathogenesis to diagnosis and treatment by A. Mišeikaitė, P. Vaitkienė

“…Due to their ability to cross the blood-brain barrier, exosomes may be promising for drug or molecular transportation and help in the development of more effective treatments for PD and other diseases of the nervous system. The article reviews the biogenesis of exosomes and their potential roles in the diagnosis, treatment, and long-term outcome of Parkinson’s disease. …”
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Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis by Shyi-Jou Chen, Yen-Ling Wang, Hueng-Chuen Fan, Wen-Tsung Lo, Chih-Chien Wang, Huey-Kang Sytwu

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, and CD4+ T cells form the core immunopathogenic cascade leading to chronic inflammation. …”
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Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature by Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino

“…Pilocytic astrocytoma is a low-grade glial neoplasm of the central nervous system (CNS) that tends to occur in the pediatric population and less commonly presents in adults. …”
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Research Progress on Biomaterials for Spinal Cord Repair by Liao Z, Bao Q, Saijilahu, Chimedtseren C, Tumurbaatar K, Saijilafu

“…Zhenglie Liao,1,* Qianyi Bao,1,* Saijilahu,2 Chimedragchaa Chimedtseren,3 Khaliunaa Tumurbaatar,3 Saijilafu1 1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, People’s Republic of China; 2Tongliao Centers for Disease Control and Prevention, Tongliao, Inner Mongolia, People’s Republic of China; 3Institute of Traditional Medicine and Technology of Mongolia, Ulaanbaatar city, Mongolia*These authors contributed equally to this workCorrespondence: Saijilafu, Email saijlf@hzcu.edu.cnAbstract: Spinal cord injury (SCI) is a very destructive disease of the central nervous system that often causes irreversible nerve damage. …”
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SOMATIC AND PSYCHIATRIC MORBIDITY OF ELDERLY DRIVERS KILLED IN MOTOR VEHICLE ACCIDENTS IN FINLAND DURING 22-YEAR FOLLOW-UP by JENNY TYNI, PIRKKO RIIPINEN, HELINÄ HAKKO, NIINA SIHVOLA, LIISA KANTOJÄRVI

“…The diseases of the nervous system and driving under the influence of alcohol were most common among the younger group. …”
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Adult ADHD Medications and Their Cardiovascular Implications by A. Sinha, O. Lewis, R. Kumar, S. L. H. Yeruva, B. H. Curry

“…Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobiological disorder exhibited by difficulty maintaining attention, as well as hyperactivity and impulsive behavior. Central nervous system (CNS) stimulants are the first line of treatment for ADHD. …”
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Nocardia thailandica Brain Abscess in an Immunocompromised Patient by Muhammad Effendi, Samad Tirmizi, Dayna McManus, Anita J. Huttner, David R. Peaper, Jeffrey E. Topal

“…To the best of our knowledge, N. thailandica has not yet been described in the medical literature to cause central nervous system (CNS) infection from brain abscess. We report the case of an immunocompromised patient who underwent successful treatment to treat his brain abscess caused by N. thailandica. …”
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Acute Toxicity and Neuroprotective Effect of “RJ6601”, a Newly Formulated Instant Soup, in Geriatric Rats by Rujikarn Chaisanam, Jintanaporn Wattanathorn

“…Given its antioxidant effects and central nervous system benefits, we hypothesized that RJ6601 should improve neurodegeneration in the hippocampus, a region critical for cognition and the maintenance of quality of life (QoL). …”
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Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins. by Jessica R Thomas, Jinglang Sun, Juan De la Rosa Vazquez, Amy Lee

“…Our results highlight the complexity whereby Cav2.2 channels integrate G-protein signaling pathways, which may enrich the information encoding potential of chemical synapses in the nervous system.…”
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A Rare Case of Eosinophilic Granulomatosis with Polyangiitis Associated with Cryoglobulinemia Presenting with a Bullous Skin Eruption of the Lower Limbs by D. D. K. Abeyaratne, C. Liyanapathirana, C. L. Fonseka, P. W. M. C. S. B. Wijekoon

“…It is characterized with asthma, eosinophilia, and renal and peripheral nervous system involvement. However, EGPA presenting with bullous skin eruption is an uncommon dermatological manifestation. …”
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