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    L’aqueduc du Gier : nouvelles données sur le pont-siphon de Beaunant à Sainte-Foy-lès-Lyon (Métropole de Lyon) by David Baldassari, François Blondel, Stéphane Gaillot

    Published 2023-12-01
    “…The presence of this masonry structure suggests that in Antiquity the main channels of the river probably passed between the piers at the bottom of the eastern slope of the valley.Beyond this indication of the old route of the river, the geoarchaeological approach also provides matter for discussion on the possible causes of the collapse of the bridge, which probably involved one or more consecutive or associated factors: weaknesses in the subsoil, the influence of meteorological factors or natural disasters.The data acquired during this excavation contribute significantly to ideas about the techniques and architectural choices that governed the construction of the bridge, together with more general thinking about the dating of a hydraulic structure as important as the Gier aqueduct, which is of not insignificant impact for the analysis of the urban development of the Roman colony of Lugdunum.…”
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    Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis by Chuanxin Liu, Xiaobin Huang, Jiao Kong, Xuejiao Li, Yuming Wang, Fangfang Zhang, Jiajia Duan

    Published 2025-01-01
    “…This approach transforms fragmented toxicity indicators into systematic evidence of toxicity, presenting a hierarchical progression of toxicity evidence and avoiding data accumulation in natural drug toxicology. Our findings represent a significant breakthrough in the elucidation of the mechanisms of hepatotoxicity induced by podophyllotoxin.…”
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  19. 40779

    Global, regional, and national burdens of heart failure in adolescents and young adults aged 10–24 years from 1990 to 2021: an analysis of data from the Global Burden of Disease St... by Chengzhi Yang, Yuhe Jia, Changlin Zhang, Zening Jin, Yue Ma, Xuanye Bi, Aiju Tian

    Published 2025-01-01
    “…According to different underlying causes of HF, both high-income countries and low- and middle-income countries need to better prevent HF in adolescents and young adults. Funding: National Natural Science Foundation of China (grant 81900452) and Training Fund for Open Projects at Clinical Institutes and Departments of Capital Medical University (grant CCMU2022ZKYXY003).…”
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