Assessing national exposure to and impact of glacial lake outburst floods considering uncertainty under data sparsity by H. Chen, Q. Liang, J. Zhao, S. B. Maharjan

“…<p>Glacial lake outburst floods (GLOFs) are widely recognised as one of the most devastating natural hazards in the Himalayas, with catastrophic consequences, including substantial loss of life. …”
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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…Streptococcus zooepidemicus, a prominent HA industrial producer, naturally synthetizes HA with high MW. Currently, few effective approaches exist for the direct and precise regulation of HA MW through a one-step fermentation process, and S. zooepidemicus lacks metabolic regulatory elements with varying intensities. …”
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Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report by Lei Cai, Qing Lv, Ronghua Ma, Wei Liu, Yalun Guan, Zhongqiang Huang, Qingyu Liu, Yunfeng Li, Shuhua Liu, Ge Li, Yu Zhang

“…To delve into the pathological and physiological traits of spontaneous non-human primate spondyloarthritis, this study meticulously examined the disease features of this natural disease model through an array of techniques including X-ray imaging, MRI imaging, blood biochemistry, markers of bone metabolism, transcriptomics, proteomics, and metabolomics. …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Importantly, ADCC-prone Nb-Fc specifically depleted ti-Tregs in a natural killer (NK) cell-dependent fashion without affecting peripheral Tregs.Conclusions Collectively, our findings highlight the efficacy and safety of targeting CCR8 for the depletion of tumor-promoting ti-Tregs in combination with anti-PD-1 therapy.…”
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Organizaciones sociales en el barrio de La Boca: cambios y permanencias en un contexto de crisis by Hilda Herzer, Carla Rodríguez, Adriana Redondo, Mercedes Di Virgilio, Fernando Ostuni

“…En este contexto el barrio aparece como un espacio natural de acción y organización; se convierte en el lugar de interacción de distintos actores y organizaciones de base donde la militancia social territorial se reviste de nuevas características. …”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…Findings: Septic patients exhibited decreased proportions of natural killer (NK) cells and plasmacytoid dendritic cells (pDCs) in CD45+ leukocytes compared with non-septic ICU patients and healthy controls. …”
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Impact of Nutritional Support for Tuberculosis on Intermediate and Terminal Undernutrition and Treatment Outcomes (INSTITUT) study: a protocol for a quasi-experimental study to ass... by Dissou Affolabi, Chelsie Cintron, Madolyn Dauphinais, Attannon Arnauld Fiogbe, Mohammed Fall Dogo, Safiou Ate, Christine Adjonou, Kokou Agossou, Susie Jiaxing Pan, Marius Esse, Benjamin Ade, Komi Séraphin Adjoh, Pranay Sinha, Kobto G Koura

“…However, there is potential to understand the impact of macronutrient nutritional support through a natural experiment. Benin and Togo are neighbouring countries in West Africa. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…However, the responsive mechanism of <i>P. sinensis</i> to natural cold stress is unclear, especially in terms of metabolic pattern and molecular pathways. …”
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REPRODUCTIVE POTENTIAL OF POTATO ACCESSIONS FROM THE VIR COLLECTION IN MURMANSK PROVINCE by S. N. Travina, Т. Е. Zhigadlo

“…These conditions were formed under the sum of active air temperatures from 1170 to 1300°С (for June, July, and August), combined with insufficient provision of precipitation. Under the natural conditions in the north, the lack of moisture stimulates plants to enter the stages of flowering and fruit setting quicker and more intensively.Conclusion: The study made it possible to identify the optimal conditions for the fruit to be set by a potato plant in the north and also to acquire more data on the reproduction characteristics of potato cultivars.…”
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A gut-derived Streptococcus salivarius produces the novel nisin variant designated nisin G and inhibits Fusobacterium nucleatum in a model of the human distal colon microbiome by Garreth W. Lawrence, Enriqueta Garcia-Gutierrez, A. Kate O’Mahony, Calum J. Walsh, Paula M. O'Connor, Máire Begley, Caitriona M. Guinane, Paul D. Cotter

“…The structural nisin G peptide differs from the prototypical nisin A with respect to seven amino acids (Ile4Tyr, Ala15Val, Gly18Ala, Asn20His, Met21Leu, His27Asn, and His31Ile), including differences that have not previously been associated with a natural nisin variant. The nisin G gene cluster consists of nsgGEFABTCPRK with transposases encoded between the nisin G structural gene (nsgA) and nsgF, notably lacking an equivalent to the nisI immunity determinant. …”
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Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation by Chaowang Zhou, Ruqian Zhong, Lei Zhang, Renyi Yang, Yuxin Luo, Huijun Lei, Liang Li, Jianzhong Cao, Zhiying Yuan, Xiaoning Tan, Mengzhou Xie, Haoyu Qu, Zuomei He

“…Abstract Objective Rosmarinic acid (RosA) is a natural polyphenol compound that has been shown to be effective in the treatment of inflammatory disease and a variety of malignant tumors. …”
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Esophagoplasty Using a Jejunum Segment on a Vascular Pedicle by D. V. Ruchkin, V. A. Kozlov, M. M. Khamidov, D. E. Okonskaya, N. B. Kovalerova

“…The segment of the jejunum on the vascular pedicle, used for esophagoplasty, in the condition of a shortage of plastic material, allows not only to complete the reconstruction at once, but also to restore the natural passage of food and prevent bile reflux.…”
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Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics... by Chaoyan Yue, Qi Zhang, Fenyong Sun, Qiuhui Pan

“…Funding: This study was supported by National Natural Science Foundation of China (No. 82293662, No 82172357 and No 81930066), Key project of Shanghai ''Science and Technology Innovation Action Plan (22JC1402304) and Research fund of Shanghai Municipal Health Bureau (No. 2019cxjq03).…”
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Investigating a Suitable Ratio of Iron Ore Tailings and Quarry Dust in Concrete Production. by Kasozi, Mark

“…Concrete is a homogeneous mixture of cement, coarse and fine aggregates, and water which consolidates into hard mass due to the chemical reaction between the cement and water, but its production has significant environmental consequences, including high carbon emissions and natural resource depletion. As a result, there is an increasing interest in the development of sustainable concrete technologies that reduce concrete's environmental footprint while maintaining its performance and durability. …”
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Assessing the Suitability of Snail-Shell Powder as a Partial Replacement of Cement in Concrete Production. by Mukundane, Ivan

“…Physical properties of snail shells, fine aggregates, and coarse aggregates were also done and found to be fineness modulus of sand 2.56, water absorption of sand 2.3%, specific gravity of sand 1.23, natural moisture content of sand 1.47%, water absorption and specific gravity of coarse aggregates as 0.5% and 2.68 respectively, bulk density of coarse aggregates of 1555.56kg/m3 specific gravity and water absorption of the snail-shell sample as 2.95 and 2.02% respectively and fineness of SSP as 92.8%. …”
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Investigating the Effect of Heavy Metals in Water Used for Concrete Production: A Case Study of Kabale. by Bwengye, Felix

“…OPC was used in the production of concrete cube specimens. Natural sand and clean crushed aggregates with a maximum size of 20mm were used as fine and coarse aggregates respectively. …”
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Efecto de cuatro cultivares de brassica oleracea var. italica sobre la biología y la demografía de brevicoryne brassicae (l.) (hemiptera…….. by F.R La Rossa, A. Vasicek, A. Paglioni, M. López

“…La más alta tasa de reproducción (R0) correspondió a las cohortes criadas sobre Centenario y Prime (22,25 y 22,38 hembras/hembra/generación) mientras que la más baja se registró en Shogun (10,22 hembras/hembra/generación, en el que también se encontró la menor tasa intrínseca de crecimiento natural (rm) que fue de 0,147 hembras/hembra/ día. …”
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جداسازی و شناسایی گونه‌های فیتوفتورا از خیار گلخانه‌ای در جنوب استان کهگیلویه و بویراحمد و تعیین واکنش ارقام مختلف این گونه از خیارها به عامل بیماری یاد شده به آن‌ها...

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Challenges and opportunities for data integration to improve estimation of migratory connectivity by Jeffrey A. Hostetler, Emily B. Cohen, Christen M. Bossu, Amy L. Scarpignato, Kristen Ruegg, Andrea Contina, Clark S. Rushing, Michael T. Hallworth

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First report of non-marine ostracods (Crustacea, Ostracoda) from the Dahlak Archipelago (Eritrea), with the description of two new species by Giampaolo Rossetti, Ilaria Mazzini, Giorgio Chiozzi, Luca Vecchioni, Federico Marrone

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