Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer by Luca Mastracci, Patrizio Castagnola, Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

“…Since tumor immune escape mechanisms do not impact pre-existing and consolidated immune responses, we tested the hypothesis of redirecting a pregenerated immunity to cancer: to recall a non-tumor antigen response against the tumor, silk fibroin nanoparticles (SFNs) have been selected as ‘Trojan-horse’ carriers, promoting the antigen uptake by the tumor cells.Methods SFNs have been loaded with either ovalbumin (OVA) or CpG oligonucleotide (CpG) as antigen or adjuvant, respectively. …”
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Ultrasound‐Activated Precise Sono‐Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis by Xiang Li, Gao He, Hui Jin, Xinyu Xiang, Dong Li, Renmiao Peng, Jing Tao, Xinping Li, Kaiyang Wang, Yu Luo, Xiaoan Liu

“…Therefore, to improve the response rate of immunotherapy and reduce pulmonary fibrosis, this study designed and prepared an intelligent nanodrug based on dendritic mesoporous silica nanoparticles (DMSNs) loaded with a sono‐sensitive agent protoporphyrin IX (PpIX). …”
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Multi-channel microelectrode arrays for detection of single-cell level neural information in the hippocampus CA1 under general anesthesia induced by low-dose isoflurane by Ruilin Hu, Penghui Fan, Yiding Wang, Jin Shan, Luyi Jing, Wei Xu, Fan Mo, Mixia Wang, Yan Luo, Ying Wang, Xinxia Cai, Jinping Luo

“…In this research, four-shank 32-channel implantable microelectrode arrays (MEAs) were developed for the real-time recording of single-cell level neural information in rat hippocampal CA1. Platinum nanoparticles were modified onto the microelectrodes to substantially enhance the electrical properties of the microelectrode arrays. …”
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NIR-triggered programmable nanomotor with H2S and NO generation for cascading oncotherapy by three-pronged reinforcing ICD by Jinlong Zhang, Quan Jing, Longlong Yuan, Xianhui Zhou, Duolong Di, Jinyao Li, Dong Pei, Zhongxiong Fan, Jun Hai

“…In brief, a gas signal molecule donor NOSH with H2S and NO capable of on-demand H2S and NO release was synthesized and then loaded into hollow mesoporous copper sulfide nanoparticles (termed as HCuSNPs) with an inherent NIR absorption and surface modification activity to obtain the programmable nanomotor (termed as NOSH@PEG-HCuSNPs). …”
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Dual‐Enhanced SERS Satellite Immuno‐Nanocomplex for Multiple PSA‐Mediated PHI Assay Toward Clinical Prostate Cancer Screening by Dong Chen, Yilin Ma, Annan Yang, Liping Hu, Hanlin Zhou, Jun Xu, Shanze Chen, Dingmeng Nie, Weifeng Feng, Huaihong Cai, Yanguang Cong, Jiang Pi, Lang Rao, Xueqin Huang, Pinghua Sun, Haibo Zhou

“…Herein, this study reports a double‐SERS satellite immunoassay, made of an Au–Ag dealloyed intra‐nanogap nanoflower (Au–Ag DINF) with strong SERS signals and Au magnetic nanoparticles (AuMNPs) with magnetic capture and SERS amplification, for sensing multiple PSA (free PSA (fPSA), complexed PSA (cPSA) and [‐2]proPSA (p2PSA)) toward potential PCa screening. …”
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Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs by Siyuan Deng, Han Shao, Hongtao Shang, Lingjin Pang, Xiaomeng Chen, Jingyi Cao, Yi Wang, Zhao Zhao

“…<b>Background/Objectives:</b> The endosomal escape of lipid nanoparticles (LNPs) is crucial for efficient mRNA-based therapeutics. …”
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Numerical simulation of Stephan blowing impacts on thermally laminated 3D flow of MHD trihybrid nanofluid with Soret and Dufour effects by Noureddine Elboughdiri, Munawar Abbas, Hamdi Ayed, Abir Mouldi, Nahid Fatima, Dilsora Abduvalieva, Mohamed Said, Ibrahim Mahariq, Ahmed S. Hendy, Ahmed M. Galal

“…The heat transfer rate is increased by 21.87 % for the ternary hybrid nanofluid, 16.56 % for the hybrid nanofluid, and 11.25 % for the mono nanofluid when the nanoparticles volume fraction is increased from 0.01 to 0.04.…”
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Aggregation‐induced circularly polarized luminescence and delayed fluorescence enabled by activating high‐level reverse intersystem crossing by Ke Wang, Xinwen Ou, Xiaofei Niu, Zhenghao Wang, Fengyan Song, Xiaobin Dong, Wu‐jie Guo, Hui‐Qing Peng, Zujin Zhao, Jacky W. Y. Lam, Jianwei Sun, Hongkai Wu, Shu‐Yan Yu, Fei Li, Ben Zhong Tang

“…In addition, CPL “on–off” switching is further achieved in nanoparticles by acid–base stimulus, showing its potential as an acid–base responsive material.…”
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A multistage drug delivery approach for colorectal primary tumors and lymph node metastases by Yihang Yuan, Quanjun Lin, Hai-Yi Feng, Yunpeng Zhang, Xing Lai, Mao-Hua Zhu, Jue Wang, Jiangpei Shi, Yanhu Huang, Lele Zhang, Qin Lu, Zeli Yuan, Jonathan F. Lovell, Hong-Zhuan Chen, Peng Sun, Chao Fang

“…Here, we develop an enzyme-responsive formulation of small-sized doxorubicin-loaded mesoporous silica nanoparticles (DMSN, 40 nm) encapsulated in nanoliposomes (DMSN@Pla-Lipo, 160 nm). …”
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Identification of robust and abundant reference transcripts for EV mRNA cargo normalization by Antje M. Zickler, Radosław Grochowski, André Görgens, Erik Bäcklin, Maximilian Kordes, J.-Matthias Löhr, Joel Z. Nordin, Samir EL Andaloussi, Daniel W. Hagey

“…Extracellular vesicles (EVs) have been investigated intensively because of their potential as biomarkers of disease and their versatility as bioengineered therapeutic nanoparticles. EVs carry diverse biomolecular cargo, but absolute quantification has been challenging due to a lack of established molecular standards. …”
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Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

“…The photothermal effect, induced by the surface plasmon resonance (SPR) from the Au-Pt shell under near infrared-II (NIR-II) laser irradiation, not only directly causes tumor cell death through photothermal therapy (PTT), but also significantly enhances the catalase-like activity between Pt nanoparticles and endogenous H2O2. This, subsequently, results in a heightened yield of O2, which further facilitates the release of DOX. …”
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A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model by Fengyu Chi, Fengyu Chi, Xu Zhang, Xu Zhang, Dong Zhang, Dong Zhang, Airu Zhu, Zhen Zhuang, Zhaoyong Zhang, Zhenjie Zhang, Chuansong Quan, Kaixiao Nie, Juan Li, Chunhong Yin, Jie Tong, Yuming Li, Yuming Li, Yuming Li

“…This study investigates the potential of an mRNA vaccine targeting the EV-A71 VP1 protein.MethodsA nucleoside-modified mRNA vaccine encoding the VP1 protein of EV-A71, encapsulated in lipid nanoparticles (LNPs), was developed. Immunogenicity and protective efficacy were evaluated in BALB/c and neonatal A129 mice, respectively. …”
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FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

“…Methods Liver-targeted lipid nanoparticles (LNP)-mRNA formulations encoding FGF21, APOA1, and a chimeric APOA1-FGF21, were first tested for protein expression and bioavailability in vitro and in mice fed a high-fat diet. …”
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…Introduction: Gut microbiome–derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest as promising tools for studying the link between the gut microbiome and human health. …”
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Flow and Heat Transfer of Cu-Water Nanofluid between a Stretching Sheet and a Porous Surface in a Rotating System by M. Sheikholeslami, H. R. Ashorynejad, G. Domairry, I. Hashim

“…The lower plate is a stretching sheet and the upper one is a solid porous plate. Copper (Cu) as nanoparticle and water as its base fluid have been considered. …”
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Evolutionary Optimization of Electronic Circuitry Cooling Using Nanofluid by Manu Mital

“…For a given value of pumping power, the benefit of nanoparticle addition is evaluated by independently optimizing the heat sink, first with nanofluid and then with water. …”
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Low-Cost Printed Flexible Antenna by Using an Office Printer for Conformal Applications by Kashif Nisar Paracha, Sharul Kamal Abdul Rahim, Hassan Tariq Chattha, Saqer Saleh Aljaafreh, Sabih ur Rehman, Yew Chiong Lo

“…An office inkjet printer is used to have desired patterns of silver nanoparticle ink on the PET substrate without any postprocessing. …”
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Mixed Convection over an Inclined Wavy Surface in a Nanofluid Saturated Non-Darcy Porous Medium with Radiation Effect by Darbhasayanam Srinivasacharya, Poshala Vijay Kumar

“…The effect of pertinent parameters on the nondimensional velocity, temperature, nanoparticle volume fraction, heat, and nanoparticle mass transfer rates is studied and presented graphically.…”
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Highly effective treatment of bacterial infection-accompanied wounds by fat extract-embedded phototherapeutic hydrogel by Haonan Wang, Yingnan Xiao, Deli Zhuge, Genghe Shi, Chengping Liu, Hui Liang, Jing Wu, Yunxuan Huang, Yilin Xie, Chunnan Hu, Jiafeng Xie, Xinyi Wang, Yao Yao, Fang Wang, Xufei Zhang, Chengke Huang, Yingzheng Zhao, Weiyang Meng, Yijie Chen, Mengchun Chen

“…To address these issues, we have developed a nanoparticle-hydrogel superstructure comprising phototherapeutic liposomal nanobubbles (NB) and fat extract (FE) encapsulated by F-127 hydrogel. …”
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Effect of Tunable Dielectric Core on Optical Bistability in Cylindrical Core–Shell Nanocomposites by Shewa Getachew

“…In this paper, the effect of a tunable dielectric core on local field enhancement, induced optical bistability, and the optical bistability domain in cylindrical core–shell nanoparticle composites are studied. The local field enhancement factor increases significantly at two resonant frequencies. …”
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