A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…FindingsIn this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine.MeaningEnvironmental exposures such as drugs are relevant players in the pathogenesis of autoimmune diseases and clinicians who treat patients with autoimmune blistering diseases such as pemphigus should consider performing a detailed medication history leveraging this information regarding deleterious drug-disease interactions at initial evaluation as well as longitudinal monitoring of patients to better inform clinical care decisions.ImportancePemphigus vulgaris (PV) is a rare, potentially fatal autoimmune disease with pathogenic contributions from both genetic as well as environmental factors, notably drug exposures. …”
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Immune responses and resistance of white shrimp (Litopenaeus vannamei) fed Probiotic Bacillus sp NP5 and prebiotic honey against White Spot Syndrome Virus infection by Widanarni Widanarni, Dewi Rahmi, Muhamad Gustilatov, Sukenda Sukenda, Diah Ayu Satyari Utami

“…This study consisted of five treatments and three replications, namely positive control (feeding without probiotics, prebiotics, and synbiotics then challenged with WSSV), negative control (feeding without probiotics, prebiotics, synbiotics, then injected with PBS), pro (feeding with the addition of Bacillus sp. …”
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Development and validation of a machine learning-based model to predict survival in patients with cirrhosis after transjugular intrahepatic portosystemic shuntResearch in context by Binlin Da, Huan Chen, Wei Wu, Wuhua Guo, Anru Zhou, Qin Yin, Jun Gao, Junhui Chen, Jiangqiang Xiao, Lei Wang, Ming Zhang, Yuzheng Zhuge, Feng Zhang

“…These parameters were included in a new score named the RF model. The accuracy, precision, recall, and F1 Score of the RF model were 0.84 (95% CI: 0.76, 0.91), 0.84 (95% CI: 0.77, 0.91), 0.99 (95% CI: 0.95, 1.00), 0.91 (95% CI: 0.81, 0.10) in the testing set, and 0.88 (95% CI: 0.84, 0.91), 0.89 (95% CI: 0.85, 0.92), 0.99 (95% CI: 0.97, 1.00), 0.93 (95% CI: 0.85, 0.97) in the validation cohort, respectively. …”
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Associations between milk infrared-predicted plasma biomarkers of stress resilience and fertility in dairy cattle: Insights for enhancing breeding programs and herd management by Alessio Cecchinato, Hugo Toledo-Alvarado, Lucio Flavio Macedo Mota, Vittoria Bisutti, Erminio Trevisi, Riccardo Negrini, Sara Pegolo, Stefano Schiavon, Luigi Gallo, Giovanni Bittante, Diana Giannuzzi

“…Our study aimed to infer the associations between milk infrared-predicted blood biomarkers of stress resilience and fertility traits, namely the interval from calving to first service (iCF), days open (DO), and the pregnancy rate at first service (PRF) in a multibreed population of 89,097 dairy cows. …”
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Production of giant gourami Osphronemus goramy Lac. juvenile with different rate of water exchange by Tatag Budiardi, Rona Albrettico Nemanita Ginting, Yani Hadiroseyani

“…Water exchange was performed twice a day at a level depending on the treatment, namely 75% (50% at morning and 25% at evening), 100% (50% at morning and evening) and 125% (75% at morning and 50% at evening) of total water volume. …”
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Association of rs3755319 and rs4148325 of the <i>UGT1A1</i> gene, rs2328136 of the <i>NUP153-AS</i> gene, and rs16928809 of the <i>SLC22A18</i> gene with benign unconjugated hyperb... by Anastasiya A. Ivanova, Natalia E. Apartseva, Anastasiia P. Kashirina, Elena G. Nemcova, Julija V. Ivanova, Margarita V. Kruchinina, Svetlana A. Kurilovich, Vladimir N. Maksimov

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Evaluation of Dynamic Visual Perception of Riverside Interface in Mountainous Cities from the Perspective of Boating by Dan LUO, Ruhong WEI

“…By sorting out the space types, it is found that among the five types of visual units, namely the multi-level unit, characteristic unit, concave unit, filling unit and natural unit, the filling unit gets a lower score in the evaluation of interface perception, which is mainly affected by the less change of building level. …”
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Segmentasi Citra X-Ray Dada Menggunakan Metode Modifikasi Deeplabv3+ by Rima Tri Wahyuningrum, Maughfirotul Jannah, Budi Dwi Satoto, Amillia Kartika Sari, Anggraini Dwi Sensusiati

“…There are 4 test scenarios in this study, namely with a learning rate of 0,01 without CLAHE, a learning rate of 0,01 and using CLAHE, a learning rate of 0,0001 without CLAHE, and a learning rate of 0,0001 using CLAHE. …”
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TRACE Model: Predicting Treatment Response to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma by Wang W, Zhang Q, Cui Y, Zhang S, Li B, Xia T, Song Y, Zhou S, Ye F, Xiao W, Cao K, Chi Y, Qu J, Zhou G, Chen Z, Zhang T, Chen X, Ju S, Wang YC

“…A combined model was further constructed by incorporating one-month treatment response, selected clinical and radiological factors and radiomics signature.Results: Among all the clinical and radiological features, only corona enhancement and one-month treatment response were selected. The combined model, named TRACE model (Treatment response at 1 month, RAdiomics and Corona Enhancement), with AUCs of 0.91 (training cohort) and 0.84 (test cohort). …”
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Bilateral Virtual Water Trade Balance and Sustainable Development using the Gravity Model An Explanation by sepideh ameri golestan, sadegh bakhtiari, Sara Ghobadi

“…Due to the centrality of the severe lack of water resources in the world, the first major United Nations conference on water was held in 2023, and in general, the decade from 2018 to 2028 was named as the "International Decade of Water for Sustainable Development". …”
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Diagnostic markers of severe diabetic macular edema in patients with type 2 diabetes by S.A. Suk, S.Yu. Mogilevskyy

“…There was a reliable relationship between UСVA and MCVA in DME 3 in patients with type 2 diabetes and OCT indicators, namely area thickness, min in fovea, central sector, NFL + GCL + IPL average, NFL + GCL + IPL min, GCL and NFL (p < 0.01). …”
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High prevalence of resistance to macrolides and fluoroquinolones in Mycoplasma genitalium isolated from patients in two Russian megalopolises – Moscow and St. Petersburg in 2021– 2... by Edelstein I.A., Gushchin A.E., Gladin D.P., Romanov A.V., Negasheva E.S., Frigo N.V., Kozlov R.S., Potekaev N.N., Kozlova N.S., Borukhovich D.G.

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Climate model downscaling in central Asia: a dynamical and a neural network approach by B. Fallah, B. Fallah, M. Rostami, M. Rostami, E. Russo, P. Harder, C. Menz, P. Hoffmann, I. Didovets, F. F. Hattermann, F. F. Hattermann

“…The CCLM, at 0.22° horizontal resolution, is driven by the MPI-ESM1-2-HR GCM (at 1° spatial resolution) for the historical period of 1985–2014 and the projection period of 2019–2100 under three Shared Socioeconomic Pathways (SSPs), namely the SSP1-2.6, SSP3-7.0, and SSP5-8.5 scenarios. …”
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The sense of safety theoretical framework: a trauma-informed and healing-oriented approach for whole person care by Johanna M. Lynch, Kurt C. Stange, Christopher Dowrick, Linn Getz, Pamela J. Meredith, Mieke L. Van Driel, Meredith G. Harris, Meredith G. Harris, Kate Tillack, Caley Tapp, Caley Tapp

“…Five practitioner skills and attitudes that facilitate sense of safety were named: Valuing the Whole Picture; Holding Story Safely; Being with You; Learning Together; and Validating Dignity (Sense of Safety Practitioner Skills).ConclusionThe Sense of Safety Theoretical Framework developed in this study focusses on an experience that is a fundamental prerequisite of health. …”
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Dietary supplementation of Bacillus sp. NP5 and dayak onion simplicia powder Eleutherine bulbosa (Mill.) Urb. for the prevention of Aeromonas hydrophila in catfish Clarias sp. by R Herman Sudrajat, Munti Yuhana, Widanarni Widanarni, Julie Ekasari, Usamah Afiff

“…In the in vivo test, the study used a completely randomized design with five treatments, namely simplicia (DOSP 20 g/kg), probiotic (PRO, Bacillus sp. …”
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Fatty Acids of Erythrocyte Membranes and Blood Serum as Possible Predictors of Exacerbation in Patients with Inflammatory Bowel Diseases by M. V. Kruchinina, M. F. Osipenko, A. I. Valuyskikh, E. Yu. Valuiskikh, I. O. Svetlova

“…In the acute stage, patients with IBD have a higher total content of saturated fatty acids (SFAs) in erythrocyte membranes compared to the control group (p = 0.006), and, on the contrary, lower levels of unsaturated fatty acids (UFAs) (p = 0.005), mainly due to polyunsaturated FAs (PUFAs) (p = 0.026), namely omega-6 PUFAs (p = 0.011).Remission of IBD is associated with an increase in the level of a number of SFAs in the blood serum — margaric C17:0 (p = 0.024), arachidic acid (C20:0) — in erythrocyte membranes and serum (p = 0.0001 and p = 0.019, respectively), with a decrease in the total content of monounsaturated FAs in erythrocyte membranes (p = 0.022), an increase in the total concentration of PUFAs due to both omega-3 PUFAs (p = 0.0008) and omega-6 PUFAs (p = 0.033) in erythrocyte membranes compared with a group of healthy individuals.The exacerbation stage in patients with IBD examined over time is associated with higher levels of stearic FA C18:0 (p = 0.005), SFA/UFA (p = 0.034) and SFA/PUFA (p = 0.039) ratios in erythrocyte membranes, serum level of arachidic FA C20:0 (p = 0.008), and, on the contrary, lower content of UFAs in erythrocyte membranes — eicosapentaenoic C20:5n-3 (p = 0.0023), eicosadienoic C20:2n-6 (p = 0.0027), hexadecadienoic C16:2n-6 (p = 0.006), docosatetraenoic C22:4n-6 (p = 0.008) and alpha-linolenic C18:3n-3 (p = 0.039).A combined “panel” of fatty acids, including the levels of C20:2n-6, C18:0 in erythrocyte membranes and the content of C20:0 in blood serum, provided an AUC of 0.683 (95 % CI: 0.500–0.844), sensitivity 91.4 %, specificity 68.3 %.Levels of C20:5n-3, C20:2n-6, C18:0, C16:2n-6, C22:4n-6, C18:3n-3 fatty acids, SFA/UFA and SFA/PUFA ratios in erythrocyte membranes and content C20:0 in blood serum, used as biomarkers — predictors of the development of exacerbation in patients with IBD who were in remission, predicted the development of exacerbation of IBD after 2–4 months in the case of maximally changed levels of FAs, after 6–8 months — with moderately changed levels FAs, maintaining remission for 12 months — with minimally changed FAs levels.Conclusion. …”
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MOKSLO VERTYBINIO NEUTRALUMO PROBLEMA XX A. FILOSOFIJOJE (M. WEBERIS, ANALITINĖ MOKSLO FILOSOFIJA IR METAETIKA, KRITINĖ TEORIJA) by Zenonas Norkus

“…Against the prevailing interpretations of Weber as noncognitivist of emotivist (MacIntyre) or prescriptivist (Runciman) kind suggestion is made that Weber's views can be considered as cognitivist (namely, as cognitivist antinaturalist scepticism or agnosticism). …”
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Identification of positive selection signatures associated with milk and composition traits in Murciano-Granadina and Barki by Hossein Mohammadi, amir hossien khaltabadi farahani, Mohammad Hossein Moradi

“…Results of gene ontology analysis identified two biological pathways namely skeletal system development and calcium channel complex with two important KEGG pathways including glucagon signaling pathway and AMPK signaling pathway which play an important role in glucose metabolism and homeostasis and skeletal system development. …”
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The Edge Odd Graceful Labeling of Water Wheel Graphs by Mohammed Aljohani, Salama Nagy Daoud

“…The main objective of this manuscript is to introduce new classes of planar graphs, namely water wheel graphs, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>W</mi><msub><mi>W</mi><mi>n</mi></msub></mrow></semantics></math></inline-formula>; triangulated water wheel graphs, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>T</mi><msub><mi>W</mi><mi>n</mi></msub></mrow></semantics></math></inline-formula>; closed water wheel graphs, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>C</mi><msub><mi>W</mi><mi>n</mi></msub></mrow></semantics></math></inline-formula>; and closed triangulated water wheel graphs, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>C</mi><msub><mi>T</mi><mi>n</mi></msub></mrow></semantics></math></inline-formula>. …”
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POPULATION STRUCTURE OF LEAF PATHOGENS OF COMMON SPRING WHEAT IN THE WEST ASIAN REGIONS OF RUSSIA AND NORTH KAZAKHSTAN IN 2017 by E. I. Gultyaeva, N. M. Kovalenko, V. P. Shamanin, V. A. Tyunin, E. R. Shreyder, E. L. Shaydayuk, А. I. Morgunov

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