Exploration of Degradation Mechanism of Chlorogenic Acids in Stevia Based on UPLC-QTOF MS/MS by Juan-juan WU, Zi-xuan WANG, Yun-he LIAN, Li-juan HOU, Zhi-ping NIU, Wen-chang WANG, Di WU

“…Therefore, high-performance liquid chromatography (HPLC) was employed to assess the content variation of seven chlorogenic acid derivatives, namely 3-caffeoylquinic acid (3-CQA), 4-caffeoylquinic acid (4-CQA), 5-caffeoylquinic acid (5-CQA), caffeic acid, 3,4-di-caffeoylquinic acid (3,4-diCQA), 3,5-di-caffeoylquinic acid (3,5-diCQA) and 4,5-di-caffeoylquinic acid (4,5-diCQA) in the stevia chlorogenic acid samples subjected to environmental stimuli. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Methods Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs). …”
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Fabrication of tin nanoparticles with functionalized platinum nanodendrites on ITO electrode for simultaneous detection of Cd2+, Pb2+, and Cu2+ ions by Nurul Hidayah Ramli, Noorhashimah Mohamad Nor, Zainovia Lockman, Khairunisak Abdul Razak

“…The optimized electrode, namely, Nafion/7 µL PtND-CA-SnNP/ITO, demonstrated high sensitivity and selectivity and successfully detected Cd(II), Pb(II), and Cu(II) ions during simultaneous detection with linear ranges of 1–5 ppb for low concentration and 10–100 ppb for high concentration. …”
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Role of cognitive impairment in predicting the long-term risk of all-cause mortality: a 20-year prospective cohort study in China by Shuang Zhao, Han Yang, Haijuan Zhao, Miao Miao, Qingqing Wang, Yaru Wang, Yuying Yin, Xin Wang

“…Impairment in the subdomain of naming foods (AHR = 1.12, 95% CI 1.04–1.21), registration (AHR = 1.18, 95% CI 1.11–1.26), attention and calculation (AHR = 1.13, 95% CI 1.07–1.21), copy figure (AHR = 1.13, 95% CI 1.06–1.20), delayed recall (AHR = 1.14, 95% CI 1.07–1.20) and language (AHR = 1.14, 95% CI 1.05–1.24) were independently associated with increased mortality risk among participants. …”
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Cancer mortality trends after implementation of the national programme for dispensarization of certain groups of the adult population: a population-based study from arkhangelsk, no... by L. E. Valkova, M. L. Levit, V. M. Merabishvili, A. Yu. Pankrateva, M. V. Krupina, D. M. Dubovichenko, A. V. Agaeva, A. Yu. Ryzhov, E. F. Potekhina, M. Yu. Valkov

“…Purpose of the study.To conduct a comparative analysis of the mortality from malignant neoplasms (MNs) detected during the implementation of the oncological component of National Prevention Programme named Dispensarization of certain groups of the adult population (DCGAP) according to the data of the Arkhangelsk Regional Cancer Registry (ARCR) for the period from 2006 to 2019.Materials and methods. …”
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A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNA by Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li, Robert Chunhua Zhao

“…Results Human-specific lncRNA, we named it MEK6-AS1, was the most up-regulated transcript during adipogenic differentiation of MSCs. …”
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Haemoglobin for Fall Risk Screening in Gynaecological and Obstetric Wards: Retrospective Survey and Delphi Validation by Bijun Mao, Yan Chen, Chunsheng Wang, Yihan Ma, Huifeng Gu, Ya Shen, Luping Liu, Peihong Zhou, Huiping Jiang

“…Reporting Method This study has adhered to relevant EQUATOR guidelines and named the reporting method. No Patient or Public Contribution.…”
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Systemic risk factors for developing of primary open-angle glaucoma by E.A. Egorov, V.P. Erichev, S.Yu. Petrov, A.V. Kuroyedov, A.A. Antonov, A.A. Vitkov

“…Vitkov⁵<br> ¹Pirogov Russian National Research Medical University, Moscow, Russian Federation<br> ² Scientific Research Institute of Eye Diseases, Moscow, Russian Federation<br> ³ Novokuznetsk State Institute of Postgraduate Medicine — branch of Russian Medical<br> &nbsp;Academy of Continuous Professional Education, Russian Federation<br> ⁴ Central Military Clinical Hospital named after P. V. Mandryka, Moscow, Russian Federation<br> ⁵ Sechenov University, Moscow, Russian Federation<br> <br> <b>Abstract</b><br> Primary open-angle glaucoma (POAG) is a disease that manifests itself in the late stages and leads to irreversible vision loss. …”
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Genotype by environment interactions and phenotypic traits stability of the EUCLEG faba bean collection by Dejan Sokolović, Snežana Babić, Mirjana Petrović, Ignacio Solís, Mathias Cougnon, Natalia Gutierrez, Pertti Pärssinen, Dirk Reheul, Jasmina Radović, Ana M. Torres

“…The “which-won-where” analyses identified two mega-environment namely South European mega environment (SE-ME) and North European mega environment (NE-ME), while the best performing and most stable genotypes according to the nine traits were identified using “means vs stability” analyses. …”
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Quantifying the potential of using Soil Moisture Active Passive (SMAP) soil moisture variability to predict subsurface water dynamics by A. K. Nayak, X. Xu, X. Xu, S. K. Frey, S. K. Frey, O. Khader, O. Khader, A. R. Erler, D. R. Lapen, H. A. J. Russell, E. A. Sudicky, E. A. Sudicky

“…This study compares the SSM variability captured by the Soil Moisture Active and Passive (SMAP) satellite and the Soil Water Index (SWI) derived from SMAP SSM with subsurface SM and groundwater (GW) dynamics simulated by a high-resolution fully integrated surface water–groundwater model over an agriculturally dominated watershed in eastern Canada across two spatial scales, namely SMAP product grid (9 km) and watershed (<span class="inline-formula">∼4000</span> km<span class="inline-formula">²</span>). …”
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Toward accurate prediction of carbon dioxide (CO2) compressibility factor using tree-based intelligent schemes (XGBoost and LightGBM) and equations of state by Behnam Amiri-Ramsheh, Aydin Larestani, Saeid Atashrouz, Elnaz Nasirzadeh, Meriem Essakhraoui, Ali Abedi, Mehdi Ostadhassan, Ahmad Mohaddespour, Abdolhossein Hemmati-Sarapardeh

“…In this study, two powerful and robust tree-based machine learning (ML) algorithms, namely light gradient boosted machine (LightGBM) and extreme gradient boosting (XGBoost) were utilized to precisely estimate CO2 Z-factor. …”
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Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications by Miriam E. L. Gakpey, Shadrack A. Aidoo, Toheeb A. Jumah, George Hanson, Siyabonga Msipa, Florence N. Mbaoji, Omonijo Bukola, Palesa C. Tjale, Mamadou Sangare, Hedia Tebourbi, Olaitan I. Awe

“…Subsequently, in silico analyses such as protein-ligand interaction, physicochemical and pharmacokinetic profiling (ADMET), and molecular dynamics simulation coupled with binding free energy calculations were performed to identify lead compounds with high binding affinity and low toxicity.ResultsFive natural compounds, namely, (+)-pipoxide, Zinc000095485961, Naamidine A, (−)-pipoxide, and 1,6-di-o-p-hydroxybenzoyl-beta-d-glucopyranoside, were identified as potential inhibitors of aldose reductase. …”
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Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers by Mei Zhang, Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons

“…This has created a major challenge in understanding how CD11b converts the differences in the receptor-ligand binding into subsequent signaling responses and using this information for therapeutic development.Methods This study aimed to investigate the antitumor effect of a carbohydrate ligand, named BG34-200, which modulates the CD11b+ cells. …”
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Antistaphylococcal Triazole-Based Molecular Hybrids: Design, Synthesis and Activity by Kostiantyn Shabelnyk, Alina Fominichenko, Oleksii Antypenko, Olexandr Gaponov, Svitlana Koptieva, Svitlana Shyshkina, Oleksii Voskoboinik, Sergiy Okovytyy, Serhii Kovalenko, Valentyn Oksenych, Oleksandr Kamyshnyi

“…In this regard, we developed and successfully implemented a strategy for the search for new hybrid molecules, namely, the not broadly known [2-(3-R-1<i>H</i>-[1,2,4]-triazol-5-yl)phenyl]amines. …”
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Sustainability assessment of animal feed production from by-products of Sago palm smallholder industry by Allaily ., A.D. Santoso, M.N. Rofiq, N.A. Sasongko, H. Daulay, E.I. Wiloso, E. Widjaja, B.N. Utomo, A.I. Yanuar, S. Suryani, Y.P. Erlambang, U.N. Thiyas, D. Iskandar, A. Anhar, M. Rahmawati, T. Simamora, Y. Yusriani, G. Maghfirah, M. Ammar

“…Therefore, this study aimed to assess sustainability of Sago palm smallholder industry in Simeulue Regency and identify the values of each attribute in the four impacting dimensions.METHODS: This study was carried out through the direct interview method, using a questionnaire containing 35 attributes related to 4 dimensions, namely 8 attributes of economy, 12 environmental, 10 social, and 5 technological. …”
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A long-term drought reconstruction based on oxygen isotope tree ring data for central and eastern parts of Europe (Romania) by V. Nagavciuc, V. Nagavciuc, G. Helle, M. Rădoane, C.-C. Roibu, M.-G. Cotos, M. Ionita, M. Ionita

“…Moreover, extreme values of <span class="inline-formula"><i>δ</i>¹⁸</span>O are also associated with the prevalence of a hemispheric teleconnection pattern, namely wave number 4. This <span class="inline-formula"><i>δ</i>¹⁸</span>O chronology and the corresponding August SPEI9 reconstruction offer valuable tools for understanding past climate variability and its relationship with large-scale atmospheric and oceanic circulation patterns.…”
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Anaemia prevalence in children newly registered at UNRWA schools: a cross-sectional study by Yassir Turki, Wafaa Zeidan, Akihiro Seita, Majed Hababeh, Nada AbuKishk, Suha Saleh, Shatha Albaik, Zoheir el-Khatib, Nimer Kassim, Hasan Arab, Khawalah Abu-Diab

“…Our study aimed to assess anaemia prevalence and undernutrition indicators among new entrant school children during their preschool medical examination.Settings In 2017, we conducted a cross-sectional study in 59 UNRWA HCs, targeting children entering first grade at UNRWA schools in four of UNRWA’s countries of operation (known as fields), namely Gaza, West Bank, Syria and Lebanon.Participants 2419 completed the study. …”
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Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma by Minh-Khang Le, Masataka Kawai, Kenta Masui, Takashi Komori, Takakazu Kawamata, Yoshihiro Muragaki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Tetsuo Kondo

“…Using the concept of multiple-instance learning, we developed an AI framework named GLioma Image-level and Slide-level gene Predictor (GLISP) to predict nine genetic abnormalities in hematoxylin and eosin sections: <i>IDH1/2</i>, <i>ATRX</i>, <i>TP53</i> mutations, <i>TERT</i> promoter mutations, <i>CDKN2A/B</i> homozygous deletion (CHD), <i>EGFR</i> amplification (<i>EGFR</i>amp), 7 gain/10 loss (7+/10−), 1p/19q co-deletion, and <i>MGMT</i> promoter methylation. …”
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Types of electronic nicotine delivery systems (ENDS) used by people of different age and smoking status groups: results from a US nationally representative survey by Lucy Popova, Robert T Fairman, David L Ashley, Zachary B Massey, Bai Cham, Ruiyan Luo, Mohammed Alqahtani, Scott Weaver

“…., several times a week or more) of ENDS device types, namely cigalikes, disposables, refillable tank/box mods, closed pods, refillable pods and drippers. …”
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Ethanolamine-induced assembly of microcompartments is required for Fusobacterium nucleatum virulence by Dana S. Franklin, Yi-Wei Chen, Yimin Chen, Manuel Wittchen, Angela Agnew, Alexis Luu, Julian P. Whitelegge, Z. Hong Zhou, Andreas Tauch, Asis Das, Hung Ton-That

“…ABSTRACT Many bacteria metabolize ethanolamine as a nutrient source through cytoplasmic organelles named bacterial microcompartments (BMCs). Here we investigated the molecular assembly, regulation, and function of BMCs in Fusobacterium nucleatum—a Gram-negative oral pathobiont that is associated with adverse pregnancy outcomes. …”
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