Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity by Emiliano Santarnecchi, Chiara Del Bianco, Isabella Sicilia, Davide Momi, Giorgio Di Lorenzo, Salvatore Ferrone, Giulia Sprugnoli, Simone Rossi, Alessandro Rossi

“…We investigated changes of voxel-wise connectivity patterns in a sample of 17 drug-naïve PI patients and 17 age-gender matched healthy controls, as well as the relationship between brain connectivity and age of onset, illness duration, and severity. …”
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The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

“…Methods: The ESTO1 trial randomized 158 statin-naïve PCa patients to receive high-dose atorvastatin (80 mg daily) or placebo before prostatectomy. …”
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Geospatial Data and Deep Learning Expose ESG Risks to Critical Raw Materials Supply: The Case of Lithium by Christopher J. M. Lawley, Marcus Haynes, Bijal Chudasama, Kathryn Goodenough, Toni Eerola, Artem Golev, Steven E. Zhang, Junhyeok Park, Eleonore Lèbre

“…., disputes, protests, violence) that can negatively impact CRM supply chains: (1) a knowledge-driven fuzzy logic model that yields an area under the curve (AUC) for the receiver operating characteristics plot of 0.72 for the entire model; (2) a naïve Bayes model that yields an AUC of 0.81 for the test set; and (3) a deep learning model comprising stacked autoencoders and a feed-forward artificial neural network that yields an AUC of 0.91 for the test set. …”
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Development and validation of a risk prediction model related to inflammatory and nutritional indexes for postoperative pulmonary infection after radical colorectal cancer surgery by He Huang, Yanli Wang, Chengfei Liu, Jingxiang Han, Tian Yao, Linna Gao, Huiyang Gao, Yuhao Chen, Yinglei Cao, Fubin Qiu, Kai Jia

“…Predictive models were constructed using LR, random forest, support vector machine, K-nearest neighbours, naive Bayes and XGBoost. The LR model was used to generate a nomogram for POI prediction. …”
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Renaissance Man, Man of his Times: Norman Mailer’s "The White Negro" and Literary Manhood in 1950s America by Matthew Kriz

“…Au lieu de cela, ces critiques ont vu dans cet essai un signe historique des préoccupations des années 50, époque souvent marquée par la croyance naïve en un individu transcendant et par une vision de la notion de race simpliste et essentialiste. …”
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The efficacy and safety of Vonoprazan and Tegoprazan in eradication: a comprehensive systematic review and meta-analysis of randomized controlled trials by Ting Jin, Wei Wu, Lei Zhang, Han Xuan, Haixiang Zhang, Li Zhong

“…Subgroup analysis demonstrated higher eradication rates with P-CAB-based therapy in treatment-naïve participants, VPZ recipients, and those receiving 7- or 14-day regimens (dual, triple, or quadruple therapy). …”
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Effect of potent nucleos(t)ide analog on alpha fetoprotein changes and occurrence of hepatocellular carcinoma in patients with chronic hepatitis B by Qianqian Ma, Junzhao Ye, Ling Luo, Yanhong Sun, Wei Wang, Shiting Feng, Bing Liao, Bihui Zhong

“…Methods We prospectively enrolled treatment-naive CHB adults who commenced treatment with ETV or TDF. …”
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Increased serum ferritin is associated with severity of orbital disease in COVID-19–associated rhino-orbito-cerebral mucormycosis: A quantitative analysis by Shashi Tanwar, Nibha Mishra, Prachi Sharma, Apjit Kaur

“…Methods: Hundred (n) out of 155 treatment-naive patients of COVID-19 infection presenting with the signs and symptoms of rhino-orbito-cerebral mucormycosis were enrolled in study. …”
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Protective Efficacy of Decreasing Antigen Doses of a <i>Chlamydia abortus</i> Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model by Morag Livingstone, Kevin Aitchison, Javier Palarea-Albaladejo, Francesco Ciampi, Clare Underwood, Antonia Paladino, Francesca Chianini, Gary Entrican, Sean Ranjan Wattegedera, David Longbottom

“…A similar reduction in bacterial shedding of infectious organisms following parturition was observed in the vaccinated groups compared to the challenge control group, which is important in terms of reducing potential transmission to naive animals. Conclusions: The results show that a dose of 10 µg antigen in the vaccine will be optimal in terms of maximising efficacy, reducing shedding at parturition, and ensuring it is cost-effective to produce for commercial manufacture.…”
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Neuroprotective Potential of <i>Origanum majorana</i> L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model by Ion Brinza, Razvan Stefan Boiangiu, Iasmina Honceriu, Ahmed M. Abd-Alkhalek, Samir M. Osman, Omayma A. Eldahshan, Elena Todirascu-Ciornea, Gabriela Dumitru, Lucian Hritcu

“…In this research, we focused on the effects of <i>O. majorana</i> essential oil (OmEO, at concentrations of 25, 150, and 300 μL/L), evaluating chemical structure as well as its impact on cognitive performance and oxidative stress, in both naive zebrafish (<i>Danio rerio</i>), as well as in a scopolamine-induced amnesic model (SCOP, 100 μM). …”
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Time to antiretroviral therapy initiation in HIV-positive patients with opportunistic infections/AIDS-defining illness in Southern Thailand: a prospective cohort study by Chanadda Wuttikul, Nattasiri Thanawuth, Malee Rojpibulsatit, Sutthiporn Pattharachayakul

“…Material and methods A prospective cohort study was performed among ART-naïve HIV patients with OIs/ADI. Time to ART initiation was defined as the time from being diagnosed with OIs/ADI to ART initiation. …”
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A Circulating Subpopulation of Monocytic Myeloid-Derived Suppressor Cells as an Independent Prognostic/Predictive Factor in Untreated Non-Small Lung Cancer Patients by Eleni-Kyriaki Vetsika, Filippos Koinis, Marianthi Gioulbasani, Despoina Aggouraki, Anna Koutoulaki, Eirini Skalidaki, Dimitris Mavroudis, Vassilis Georgoulias, Athanasios Kotsakis

“…The percentages and correlation between MDSCs and distinct immune cells in the peripheral blood of 110 chemotherapy-naive patients before treatment and healthy controls were investigated using flow cytometry. …”
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An Intelligent System for Classifying Patient Complaints Using Machine Learning and Natural Language Processing: Development and Validation Study by Xiadong Li, Qiang Shu, Canhong Kong, Jinhu Wang, Gang Li, Xin Fang, Xiaomin Lou, Gang Yu

“…A total of 3 ML algorithms (Multifactor Logistic Regression, Multinomial Naive Bayes, and Support Vector Machines [SVM]) were used for model training and validation. …”
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Preliminary evidence of immune infiltration and neutrophil degranulation in peripheral blood of non-obese OSA patients related to cognitive decline by Qingqing Liu, Yanru Ou, Ting Liu, Yuming He, Xiangming Quan, Ruoyun Ouyang, Zhihui Shi

“…Cohorts of healthy control (n = 20) and non-obese, treatment-naïve OSA patients (n = 20) were recruited. We collected their peripheral blood mononuclear cells and neutrophils, and their cognitive performances were evaluated by the Montreal Cognitive Assessment (MoCA). …”
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High-dose dual therapy for Helicobacter pylori eradication inducing less impact on the gut microbiota by Jia-Lun Guan, Ting-Ting Xu, Ya Lin, Yan-Shuai Mo, Bi-Yu He, Ying-Ying Han, Ji-Yan Li, Su-Hong Xia, Ya-Ni Zhou, Jia-Zhi Liao, Pei-Yuan Li

“…Pylori-infected treatment-naive patients were recruited and screened from September 2023 to April 2024 and randomly assigned to the HDDT group (esomeprazole 20 mg, amoxicillin 750 mg, qid, 14 days) or BQT group (esomeprazole 20 mg, amoxicillin 1000 mg, clarithromycin 500 mg, and bismuth potassium citrate 600 mg, bid, 14 days). …”
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Predicting home delivery and identifying its determinants among women aged 15–49 years in sub-Saharan African countries using a Demographic and Health Surveys 2016–2023: a machine... by Adem Tsegaw Zegeye, Binyam Chaklu Tilahun, Makida Fekadie, Eliyas Addisu, Birhan Wassie, Berihun Alelign, Mequannet Sharew, Nebebe Demis Baykemagn, Abdulaziz Kebede, Tirualem Zeleke Yehuala

“…Machine learning models such as Random Forest, Decision Tree, K-Nearest Neighbor, Logistic Regression, Extreme Gradient Boosting, AdaBoost, Artificial Neural Network, and Naive Bayes were used. The predictive model was evaluated by area under the curve, accuracy, precision, recall, and F-measure. …”
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Alternative approaches for monitoring and evaluation of lymphatic filariasis following mass drug treatment with ivermectin, diethylcarbamazine and albendazole in East New Britain P... by Krufinta Bun, Benedict Mode, Melinda Susapu, Joyceline Salo, Catherine Bjerum, Michael Payne, Daniel Tisch, Makoto Sekihara, Emanuele Giorgi, Gary J Weil, Peter U Fischer, Leanne Robinson, Moses Laman, Christopher L King

“…<h4>Background</h4>WHO recommends two annual rounds of mass drug administration (MDA) with ivermectin, diethylcarbamazine, and albendazole (IDA) for lymphatic filariasis (LF) elimination in treatment naïve areas that are not co-endemic for onchocerciasis such as Papua New Guinea (PNG). …”
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CD-1 mice females recognize male reproductive success via volatile organic compounds in urine by A. S. Khotskina, E. L. Zavjalov, E. P. Shnayder, L. A. Gerlinskaya, S. O. Maslennikova, D. V. Petrovskii, M. N. Baldin, A. L. Makas, V. M. Gruznov, M. L. Troshkov, M. P. Moshkin

“…The reproductive success of the male was assessed by the presence or absence of pregnant females. At the same time, naive females, who did not participate in reproduction, assessed the urine of the successful males as more attractive, which was expressed in shorter Latency time of sniffs in the Olfactory test. …”
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The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltration by Chiara Cencioni, Silvia Malatesta, Virginia Vigiano Benedetti, Valerio Licursi, Livia Perfetto, Federica Conte, Danilo Ranieri, Armando Bartolazzi, Martina Kunkl, Loretta Tuosto, Alberto Larghi, Geny Piro, Antonio Agostini, Giampaolo Tortora, Vincenzo Corbo, Carmine Carbone, Francesco Spallotta

“…Methods PDAC development upon dysmetabolic conditions was investigated in: 1) high fat diet fed wild type immunocompetent syngeneic mice by orthotopic transplantation of pancreatic intraepithelial neoplasia (PanIN) organoids; and 2) primary pancreatic CAFs isolated from chemotherapy naïve PDAC patients with/without an history of metabolic syndrome. …”
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Dynamin-1 is a potential mediator in cancer-related cognitive impairment by Ding Quan Ng, Casey Hudson, Tracy Nguyen, Sukesh Kumar Gupta, Yong Qin Koh, Munjal M. Acharya, Alexandre Chan

“…The human study recruited newly diagnosed, chemotherapy-naïve adolescent and young adult cancer and non-cancer controls to complete a cognitive instrument (FACT-Cog) and blood draws for up to three time points. …”
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