Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

“…Here, we investigate the role of apoptosis and the protein pirin in CCG-257081-mediated suppression of drug resistance.MethodsUsing naïve and resistant mouse YUMMER melanoma cells, we studied the effect of the BRAF inhibitor Vem with or without CCG-257081 on real-time growth and apoptosis (activation of caspase, Propidium iodide (PI) staining, and PARP cleavage). …”
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Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil by Joao Leandro Paula Ferreira, Rosangela Rodrigues, Andre Minhoto Lança, Valeria Correia de Almeida, Simone Queiroz Rocha, Taisa Grotta Ragazzo, Denise Lotufo Estevam, Luis Fernando de Macedo Brigido

“…We assessed 225 HIV-1 infected, antiretroviral naïve individuals, from HIV Reference Centers at two major metropolitan areas of Sao Paulo (Sao Paulo and Campinas), the state that concentrates most of the Brazilian Aids cases. …”
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Impact of major duodenal papilla morphology on the outcomes of primary needle-knife fistulotomy for deep biliary cannulation by Amir Sadeghi, Erfan Arabpour, Reyhaneh Rastegar, Samareh Omidvari, Mehdi Azizmohammad Looha, Masoumeh Keshavarzian, Mohammad Reza Zali

“…A review of medical records between 2022 and 2024 revealed 200 patients with naïve MDP who underwent pNKF at Taleghani Hospital. …”
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Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production by Lucas Faustino, Daniel Mucida, Alexandre Castro Keller, Jocelyne Demengeot, Karina Bortoluci, Luiz Roberto Sardinha, Maisa Carla Takenaka, Alexandre Salgado Basso, Ana Maria Caetano Faria, Momtchilo Russo

“…Lung regulatory T cells expressed an effector/memory phenotype (CCR4highCD62LlowCD44highCD54highCD69+) that distinguished them from naive regulatory T cells (CCR4intCD62LhighCD44intCD54intCD69−). …”
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Peripheral Nerve Blocks Are Associated With Decreased Early Medical Complications, Dislocations, and Opioid Consumption Following Total Hip Arthroplasty by Brian P. McCormick, MD, Sean B. Sequeira, MD, Mark D. Hasenauer, MD, Robert P. McKinstry, MD, Frank R. Ebert, MD, Henry R. Boucher, MD

“…The purpose of this study was to evaluate the association between PNBs and postoperative complication rates, healthcare utilization, and opioid consumption following elective THA. Methods: Opioid-naive patients who received PNBs on the same day as undergoing THA for degenerative etiologies were identified from a large national database and matched 1:5 to a control cohort using propensity scoring. …”
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Innovator ranibizumab ComparEd to Biosimilar ranibizumab in combination with Expansile gas in submaculaR HemorrhaGe: the ICEBERG study by Debdulal Chakraborty, Tushar Kanti Sinha, Soumen Mondal, Subhendu Boral, Arnab Das, Saptorshi Majumbar, Angshuman Mukherjee, Ranabir Bhattacharya, Sumit Randhir Singh

“…Abstract Purpose To compare the anatomical and visual outcomes in eyes with submacular hemorrhage (SMH) treated with a combination of ranibizumab (RBZ) either innovator or biosimilar (Razumab) and intravitreal perfluoropropane gas (C3F8). Methods Treatment naïve neovascular age related macular degeneration (n-AMD) patients with SMH were retrospectively analyzed. …”
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AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab – protocol for a multicentre, open-label, pha... by Seitaro Yoshida, Masashi Taki, Hideyuki Takedani, Midori Shima, Keiji Nogami, Azusa Nagao, Haruko Yamaguchi-Suita, Yui Kyogoku, Akira Ishiguro, Kaoru Kitsukawa

“…Currently, 30 participants have been enrolled, including 20 emicizumab-naïve participants and 10 who transferred from HOHOEMI, a previous study in paediatric PwHA.Ethics and dissemination The AOZORA study was approved by the Institutional Review Boards of Nara Medical University and the St Marianna University Group. …”
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Prognostics optical coherence tomography biomarker in macular oedema secondary to retinal vein occlusion by Andrea R. Silitonga, Hanna T.H. Silitonga, Rova Virgana, Iwan Sovani, Arief Kartasasmita, Erwin Iskandar, Grimaldi Ihsan, Made Indra

“…Methods: Retrospective study of 36 treatment-naïve eyes with RVO-MO (22 eyes with central retinal vein occlusion and 14 eyes with branch retinal vein occlusion). …”
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Frailty Status, Not Just Age, is Associated With Postoperative Opioid Consumption: A Retrospective, Population-based Analysis by Kyle R. Latack, MD, Ryan Howard, MD, Mark C. Bicket, MD, PhD, Samantha Cooley, MSW, Vidhya Gunaseelan, MBA, MS, MHA, Michael Englesbe, MD, Jennifer Waljee, MD, MPH, MS

“…We conducted a retrospective analysis of opioid-naïve adult patients undergoing common general, vascular, and gynecologic procedures across a statewide quality improvement program from November 6, 2017 to February 28, 2021. …”
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Voice pathology detection using machine learning algorithms based on different voice databases by Nurul Mu'azzah Abdul Latiff, Fahad Taha Al-Dhief, Nurul Fariesya Suhaila Md Sazihan, Marina Mat Baki, Nik Noordini Nik Abd. Malik, Musatafa Abbas Abbood Albadr, Ali Hashim Abbas

“…Several algorithms, including Online Sequential Extreme Learning Machine (OSELM), Support Vector Machine (SVM), Decision Tree (DT), and Naïve Bayes (NB), were evaluated using two databases: the Saarbrucken Voice Database (SVD) and the Malaysian Voice Pathology Database (MVPD). …”
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Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis by Francisco Rodríguez, Daniel Samacá-Samacá, Claudia Hernández-Castillo, Laura Prieto-Pinto, Carolina Sardi, Hugo Ocampo, Joshua Kock, Fabián Hernández

“…Network meta-analyses (NMA) were performed, including sensitivity and subgroup analyses for naïve population. Outcomes included changes in visual acuity (Early Treatment of Diabetic Retinopathy Study [ETDRS] letters), anatomical changes, frequency of injections and adverse events. …”
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Emotion dysregulation in adolescents is normalized by ADHD pharmacological treatment by Krisztina Kondi, Mária Takács, Evelyn Kovács-Posta, Claudia Szajli, Tünde Sebők-Welker, János M. Réthelyi, Nóra Bunford

“…Methods Examined, in N = 297 adolescents (M age=15.77 years, SD = 1.06; 39.06% girls; n = 86 classified as with ADHD), whether accounting for depression and oppositional symptoms, concurrent and 18-month prospective measures of parent- and self-reported ED (1) differ across adolescents without ADHD, medication-naïve adolescents with ADHD, and ever-medicated (currently or previously) adolescents with ADHD. …”
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Long-term mindfulness meditation increases occurrence of sensory and attention brain states by Daniel Yochai Panitz, Daniel Yochai Panitz, Daniel Yochai Panitz, Avi Mendelsohn, Avi Mendelsohn, Avi Mendelsohn, Joana Cabral, Joana Cabral, Joana Cabral, Aviva Berkovich-Ohana, Aviva Berkovich-Ohana

“…Here, intrinsic functional network dynamics were compared between experienced meditators and meditation-naïve participants during rest. Our analysis revealed that meditators tend to spend more time in two brain states that involve synchrony among cortical regions associated with sensory perception. …”
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Three-Year Outcomes of Patients with Neovascular Age-Related Macular Degeneration Treated with Aflibercept under the National Health Insurance Program in Taiwan by Kang-Jung Lo, Jin-Yu Chang, Hsin-Yi Chang, Shih-Hwa Chiou, De-Kuang Hwang, Shih-Jen Chen

“…This retrospective observational study was conducted at Taipei Veterans General Hospital. Patients with naive nAMD who were treated with aflibercept and followed for more than 3 years were reviewed. …”
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Immune Checkpoint Inhibitors +/− Chemotherapy for Patients With NSCLC and Brain Metastases: A Systematic Review and Network Meta‐Analysis by Lauren Julia Brown, Nicholas Yeo, Harriet Gee, Benjamin Y. Kong, Eric Hau, Inês Pires daSilva, Adnan Nagrial

“…Methods A systematic review and network meta‐analysis were performed to evaluate ICI efficacy and the influence of additional chemotherapy on survival outcomes in treatment‐naïve metastatic NSCLC with BM. Randomized phase II/III studies with at least one treatment arm with an ICI were eligible. …”
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Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury by Ke Xie, Yu-sen Chai, Shi-hui Lin, Fang Xu, Chuan-jiang Wang

“…Luteolin-induced Treg differentiation from naïve CD4+ T cells may be a potential mechanism for regulating IL-10 production.…”
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Carboplatin in combination with etoposide for advanced small cell lung cancer complicated with idiopathic interstitial pneumonia: a single-arm phase II study by Masaru Matsumoto, Yuji Minegishi, Katsuyuki Higa, Aya Fukuizumi, Naomi Onda, Susumu Takeuchi, Akihiko Miyanaga, Akihiko Gemma, Masahiro Seike

“…We conducted a single-arm phase II study to evaluate the safety and efficacy of carboplatin plus etoposide for the treatment of patients with SCLC complicated with IIP. Methods Chemotherapy-naïve patients with advanced SCLC complicated with IIP were enrolled. …”
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Pour une théorie de la réception du discours grammatical by Jean-Rémi Lapaire

“…Finally, the study shows that seemingly “naïve” remarks on language functioning do not necessarily reflect deficient conceptions of language. …”
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Solitary Nitric Oxide Signaling Mediates Mild Stress-Induced Anxiety and Norepinephrine Release in the Bed Nucleus of the Stria Terminalis during Protracted Ethanol Withdrawal by Zhenglin Zhao, Sang Chan Kim, Yu Jiao, Yefu Wang, Bong Hyo Lee, Hee Young Kim, Chul Won Lee, Chae Ha Yang, Rongjie Zhao

“…In elevated plus maze tests, EtOHW rats but not EtOH-naive rats exhibited anxiety-like behavior when challenged with 7-minute mild restraint stress, which was, respectively, mitigated by prior intra-NTS infusion of the nitric oxide scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), nonselective NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), or selective neuronal NOS (nNOS) inhibitor 7-nitroindazole (7-NI). …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Additionally, the proportion of naive B cells decreased as disease severity progressed.Conclusion: Synovial fibroblasts in OA have been shown to promote the differentiation and activation of B cells, indicating that B cells play a significant role in the pathogenesis of synovium inflammation in OA.Keywords: osteoarthritis, B cells, inflammation, immune, transcriptome sequencing, synovium…”
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