Toll-Like Receptor Homolog CD180 Expression Is Diminished on Natural Autoantibody-Producing B Cells of Patients with Autoimmune CNS Disorders by Zsófia Hayden, Szabina Erdő-Bonyár, Beáta Bóné, Noémi Balázs, Kornélia Bodó, Zsolt Illes, Timea Berki, Diána Simon

“…Results. We found decreased naïve and increased memory B cells in NMOSD compared to MS. …”
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Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–co... by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…Cases were matched to controls on age, sex and OAC naïve status. Using logistic regression, adjusted ORs with 95% CIs were calculated for the outcomes comparing apixaban/rivaroxaban use (appropriate or inappropriate dosing based on the product label criteria) and warfarin.Results For IS/SE, ORs (95% CIs) for apixaban versus warfarin were 1.19 (0.92–1.52) for appropriate dose and 1.01 (0.67–1.51) for inappropriate dose; for rivaroxaban versus warfarin, estimates were 1.07 (0.83–1.37) for appropriate dose and 1.21 (0.78–1.88) for inappropriate dose. …”
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NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness by Tehila Mizrachi, Livnat Brill, Malcolm Rabie, Yoram Nevo, Yakov Fellig, Mayan Zur, Dimitrios Karussis, Oded Abramsky, Talma Brenner, Adi Vaknin-Dembinsky

“…Injection of either AQP4 peptide or NMO-Ig to EAMG or to naive mice caused increased fatigability and aggravation of EAMG symptoms as expressed by augmented muscle weakness (but not paralysis), decremental response to repetitive nerve stimulation, increased neuromuscular jitter, and aberration of immune responses. …”
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Treat-to-target strategy with secukinumab as a first-line biological disease modifying anti-rheumatic drug compared to standard-of-care treatment in patients with active axial spon... by Xenofon Baraliakos, Denis Poddubnyy, Ludwig Hammel, Marvin Heyne, Justyna Veit, Claudia Jentzsch

“…This study aims to evaluate the efficacy of a T2T strategy in patients with axSpA, with secukinumab as a first-line bDMARD, compared with standard-of-care (SOC) treatment.Methods and analyses This is a randomised, parallel-group, open-label, multicentre ongoing study in patients with axSpA who are naïve to bDMARD and who have had an inadequate response to NSAIDs. …”
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Machine learning assisted radiomics in predicting postoperative occurrence of deep venous thrombosis in patients with gastric cancer by Yuan Zeng, Yuhao Chen, Dandan Zhu, Jun Xu, Xiangting Zhang, Huiya Ying, Xian Song, Ruoru Zhou, Yixiao Wang, Fujun Yu

“…Four machine learning algorithms, known as random forest (RF), extreme gradient boosting (XGBoost), support vector machine (SVM) and naive Bayes (NB), were used to develop models for predicting the risk of lower extremity DVT occurrence in GC patients. …”
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Interleukin-12p70 Expression by Dendritic Cells of HIV-1-Infected Patients Fails to Stimulate gag-Specific Immune Responses by Ellen Van Gulck, Nathalie Cools, Derek Atkinson, Lotte Bracke, Katleen Vereecken, Marc Vekemans, Viggo F. I. Van Tendeloo, Zwi N. Berneman, Guido Vanham

“…Since dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique capability to stimulate naïve T cells into effector T cells, their use for the induction of HIV-specific immune responses has been studied intensively. …”
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Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder by Jinkun Zeng, Qinghua Luo, Lian Du, Wei Liao, Yongmei Li, Haixia Liu, Dan Liu, Yixiao Fu, Haitang Qiu, Xirong Li, Tian Qiu, Huaqing Meng

“…We collected longitudinal diffusion tensor imaging in the first-episode, drug-naïve major depressive disorder (MDD) patients n=24 before and after a predefined time window ECT treatment. …”
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Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90% of HIV-Infected Individual... by Prossie Merab Ingabire, Fred Semitala, Moses R. Kamya, Damalie Nakanjako

“…Up to 75% of hospitalized HIV-infected, cART-naïve, cART-eligible patients did not initiate cART and had a 33% pre-ART mortality rate within two weeks of eligibility for cART. …”
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Vasoreactivity and inhaled treprostinil response in interstitial lung disease pulmonary hypertension by Eileen M. Harder, Farbod N. Rahaghi, Jane A. Leopold, David M. Systrom, George R. Washko, Aaron B. Waxman

“…Materials and methods In this retrospective cohort analysis, we identified treatment-naive PH-ILD patients with vasoreactivity testing using O2 and O2+iNO. 6-month iTre outcome was assessed. …”
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Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB’WHU Chronically Infected Chinese Rhesus Macaque by Gao-Hong Zhang, Run-Dong Wu, Hong-Yi Zheng, Xiao-Liang Zhang, Ming-Xu Zhang, Ren-Rong Tian, Guang-Ming Liu, Wei Pang, Yong-Tang Zheng

“…LPS induced upregulation of CD8+ naïve T cells and downregulated the number of CD4+ and CD8+ T effector memory cells. …”
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Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury by JiaQi Hu, WenYong Fan, Yue Xu, XiaoFei Li, HaoYang Zhang, Shun Li, Lei Xue

“…High-dose extracellular administration of AEA increased the excitability of naive DRG neurons, leading to the transition from a rapidly accommodating (RA) hypoexcitable state to a highly excitable non-accommodating (NA) state. …”
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Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically by Mingming Zhao, Dragana Jankovic, Verena M. Link, Camila Oliveira Silva Souza, Katherine M. Hornick, Oyebola Oyesola, Yasmine Belkaid, Justin Lack, Png Loke

“…Additionally, IL-4-activated C57BL/6 TRMs demonstrate an augmented synergistic response upon in vitro lipopolysaccharide (LPS) exposure, despite naïve BALB/c TRMs displaying a more robust transcriptional response to LPS. …”
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Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

“…To address this unmet need, global metabolomic profiling was performed on tumor tissue and paired serum samples from patients with treatment‐naïve (TN; n = 18) and neoadjuvant leucovorin calcium (folinic acid), fluorouracil, irinotecan hydrochloride and oxaliplatin (FOLFIRINOX)‐treated (NAT; n = 17) PDAC using liquid chromatography mass spectrometry. …”
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Predictive model of acute kidney injury in critically ill patients with acute pancreatitis: a machine learning approach using the MIMIC-IV database by Shengwei Lin, Wenbin Lu, Ting Wang, Ying Wang, Xueqian Leng, Lidan Chi, Peipei Jin, Jinjun Bian

“…Model construction involved an ensemble of ML, including random forest (RF), support vector machine (SVM), k-nearest neighbors (KNN), naive Bayes (NB), neural network (NNET), generalized linear model (GLM), and gradient boosting machine (GBM). …”
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Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors by Christopher K. Nyirenda, Edmond K. Kabagambe, John R. Koethe, James N. Kiage, Benjamin H. Chi, Patrick Musonda, Meridith Blevins, Claire N. Bosire, Michael Y. Tsai, Douglas C. Heimburger

“…In a cross-sectional study among 210 antiretroviral therapy-naïve HIV-infected adults from Lusaka, Zambia, we collected data on medical history and dietary intake using 24 hr DR. …”
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The pilot study of the features of HIV-1 resistant variants spread using molecular clusters by Alina A. Kirichenko, Dmitry E. Kireev, Yulia N. Sidorina, Natalia D. Abashina, Elena E. Brusentseva, Vasily G. Akimkin

“…Molecular clusters were more often formed by HIV-1 nucleotide sequences from ART-naïve patients. HIV-1 DR variants were less likely to fall into molecular clusters. …”
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NIEKO NĖRA, ARBA BŪTIES PROBLEMA SOFISTŲ MĄSTYME by Skirmantas Jankauskas

“…It is inferred that Gorgias in this way complicated "naive" or unproblematic thinking of the Greek philosophers, and concurrently identified, though only in a negative aspect, the fundamental premise of the Sophistic movement - the significance of individual opinion. …”
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The Protective Effect of Teprenone on Aspirin-Related Gastric Mucosal Injuries by Jing Zhao, Yihong Fan, Wu Ye, Wen Feng, Yue Hu, Lijun Cai, Bin Lu

“…Methods. 280 patients with coronary diseases, naïve to aspirin medication, were admitted between 2011 and 2013 at the First Affiliated Hospital of Zhejiang Chinese Medical University and randomized into two groups (n=140). …”
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Unveiling shadows: A data-driven insight on depression among Bangladeshi university students by Sanjib Kumar Sen, Md. Shifatul Ahsan Apurba, Anika Priodorshinee Mrittika, Md. Tawhid Anwar, A.B.M. Alim Al Islam, Jannatun Noor

“…Seven machine learning models, including Support Virtual Machine (SVM), K-Nearest Neighbor (K-NN), Gaussian Naive Bayes (GNB), Decision Tree (DT), Random Forest Classifier (RFC), Artificial Neural Network (ANN), and Gradient Boosting (GB), were trained and tested using the collected data (n = 750) to identify the most effective method for predicting depression. …”
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Glucocorticoid Functional Reserve in Full-Spectrum Intensity of Primary Hypothyroidism by René Rodríguez-Gutiérrez, Camilo González-Velázquez, Gerardo González-Saldívar, Jesús Zacarías Villarreal-Pérez, José Gerardo González-González

“…Consequently a prospective, longitudinal, controlled study of sixty adult patients with primary hypothyroidism was carried out. Patients naïve to L-T4 treatment were compared with control participants. …”
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