Direct Effect of Two Naphthalene-Sulfonyl-Indole Compounds on Toxoplasma gondii Tachyzoite by Qasem Asgari, Hossein Keshavarz, Mostafa Rezaeian, Mohammad Hossein Motazedian, Saeedeh Shojaee, Mehdi Mohebali, Ramin Miri

“…To evaluate the infectivity, 2×106 tachyzoites exposed to the concentrations mentioned above were intraperitoneally inoculated into five mice from each group. Also, naïve parasites and parasites exposed to DMSO (control) were inoculated in both groups of mice. …”
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Predicting the infecting dengue serotype from antibody titre data using machine learning. by Bethan Cracknell Daniels, Darunee Buddhari, Taweewun Hunsawong, Sopon Iamsirithaworn, Aaron R Farmer, Derek A T Cummings, Kathryn B Anderson, Ilaria Dorigatti

“…However, in 53.4% (109/204) of the subjects, the highest titre change did not correspond to the infecting serotype, including in 34.3% (11/35) of dengue-naïve individuals (although 8/11 of these seronegative individuals were seropositive to Japanese encephalitis virus prior to their infection). …”
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Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex by Jason S. Hauptman, Joseph Antonios, Gary W. Mathern, Michael S. Levine, Carlos Cepeda

“…CPNs from normal mice chronically treated with rapamycin, compared with CPNs from naïve mice, showed reduced capacitance and time constant, increased input resistance, and changes in inhibitory synaptic inputs, consistent with increased pre-synaptic GABA release. …”
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Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia by Mian Li, Yue Wu, Yan Xu, Xin Huang, Kerun Gao, Nannan Hu, Shuangyue Zhu, Chengpeng Wang, Sugai Liang

“…This study included 38 drug-naive patients with FES and 43 healthy controls (HCs). …”
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Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis by Lina Mattson, Antonio Lentini, Danuta R. Gawel, Tejaswi V. S. Badam, Mikael Benson, Torbjorn Ledin, Colm E. Nestor, Mika Gustafsson, Jordi Serra-Musach, Janne Bjorkander, Zou Xiang, Huan Zhang

“…Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive T cells into Th1 cells. As SIT is thought to cause a shift towards Th1 dominance, we hypothesized that SIT would alter interferon type I signaling. …”
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Mood Detection from Physical and Neurophysical Data Using Deep Learning Models by Zeynep Hilal Kilimci, Aykut Güven, Mitat Uysal, Selim Akyokus

“…For this purpose, Feedforward Neural Network (FFNN), Convolutional Neural Network (CNN), Recurrent Neural Network (RNN), and Long Short-Term Memory (LSTM) neural network are employed as deep learning methodologies. Multinomial Naïve Bayes (MNB), Support Vector Regression (SVR), Decision Tree (DT), Random Forest (RF), and Decision Integration Strategy (DIS) are evaluated as conventional machine learning algorithms. …”
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Immunological Alterations due to Hemodialysis Might Interfere with Early Complications in Renal Transplantation by Kristin Mai, Andreas Boldt, Hans-Michael Hau, Michael Kirschfink, Stephan Schiekofer, Frieder Keller, Joachim Beige, Athanassios Giannis, Ulrich Sack, Franz Maximilian Rasche

“…Before HD, the median proportion of CD8+ effector cells, CD8+ CCR5+ effector cells, and HLA-DR+ regulatory T cells as well as the median concentration of soluble CD30 increased and naive CD8+ T cells decreased. During HD, there was a significant decrease in CD4- CD8- T cells (p<0.001) and an increase in CD25+ T cells (p=0.026), sCD30 (p<0.001), HLA-DR+ regulatory T cells (p=0.005), and regulatory T cells (p=0.003). …”
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Electricity Theft Detection Using Machine Learning in Traditional Meter Postpaid Residential Customers: A Case Study on State Electricity Company (PLN) Indonesia by Alief Pascal Taruna, Galih Arisona, Dwi Irwanto, Arif Bijak Bestari, Wildan Juniawan

“…Various classification models, including Decision Tree, Naive Bayes, Random Forest, K-Nearest Neighbors, Logistic Regression, and Deep Neural Network, were evaluated, with Random Forest achieving the best performance across simulations. …”
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Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality by Noor A. M. Bakker, Hannah Garner, Ewald van Dyk, Elisa Champanhet, Chris Klaver, Maxime Duijst, Leonie Voorwerk, Iris Nederlof, Rosie Voorthuis, Marte C. Liefaard, Marja Nieuwland, Iris de Rink, Onno B. Bleijerveld, Hendrika M. Oosterkamp, Lodewyk F. A. Wessels, Marleen Kok, Karin E. de Visser

“…Vδ1 γδ T cells from mTNBC patients produced more IL17 than those from HDs. Chemotherapy-naïve mTNBC patients showed increased classical monocytes and neutrophils. …”
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Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects by Sang Eon Park, Hyeong Seop Kim, Soo Jin Kwon, Min-Jeong Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Duk L. Na, Jong Wook Chang

“…We demonstrated that mouse groups treated with naïve MSCs and primed MSCs showed significant reductions in cell death, ubiquitin conjugate levels, and Aβ levels, but the effects were greater in primed MSCs. …”
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Resveratrol Supplementation in Wet AMD: Association With Fewer Intravitreal Injections and Reduced Macular Fibrosis by Datseris I, Rouvas A, Tzanidaki ME, Kardara M, Geros V, Gouliopoulos N

“…Ioannis Datseris,1 Alexandros Rouvas,2 Malvina-Efthymia Tzanidaki,1 Marina Kardara,1 Vasileios Geros,2 Nikolaos Gouliopoulos2 1Ophthalmology Department, Ophthalmological Institute “OMMA”, Athens, Greece; 2 2nd Department of Ophthalmology, Medical School of University of Athens, “attikon” University Hospital, Athens, GreeceCorrespondence: Ioannis Datseris, Ophthalmological Institute OMMA, Katehaki 74, Athens, 11525, Greece, Tel +302106755850, Fax +302106755851, Email jodats13@me.comPurpose: To evaluate the 2-year outcomes of resveratrol oral supplement given as an adjunctive treatment in patients with wet age-related macular degeneration (AMD) that were treated with intravitreal injections of aflibercept.Patients and Methods: In our retrospective study, 50 treatment-naïve patients suffering from wet-AMD were included. …”
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Factors Associated with Poor Eye Drop Administration Technique and the Role of Patient Education among Hong Kong Elderly Population by Bonnie Nga Kwan Choy, Ming Ming Zhu, Jason Chun Sum Pang, Jonathan Cheuk Hung Chan, Alex Lap Ki Ng, Michelle Ching Yim Fan, Lawrence Pui Leung Iu, Joseph Shiu Kwong Kwan, Jimmy Shiu Ming Lai, Patrick Ka Chun Chiu

“…To identify the risk factors for poor eye drop application technique in treatment-naïve subjects and to assess if patient education can benefit these subjects. …”
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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…Trial US (NCT02408913) enrolled 140 participants, including 26 EVD vaccine-naïve and 114 cAd3-Ebola-experienced participants (April-November 2015). …”
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Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma by Qianru Li, Qianru Li, Heli Li

“…Immune cell infiltration analysis demonstrated enrichment of CD4+ naïve and memory T cells, macrophages (M0 and M2), and CD8+ T cells in melanoma, all of which were associated with the expression of the four feature genes. …”
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NIEKO NĖRA, ARBA BŪTIES PROBLEMA SOFISTŲ MĄSTYME by Skirmantas Jankauskas

“…It is inferred that Gorgias in this way complicated "naive" or unproblematic thinking of the Greek philosophers, and concurrently identified, though only in a negative aspect, the fundamental premise of the Sophistic movement - the significance of individual opinion. …”
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Advancing privacy-aware machine learning on sensitive data via edge-based continual µ-training for personalized large models by Zhaojing Huang, Leping Yu, Luis Fernando Herbozo Contreras, Kamran Eshraghian, Nhan Duy Truong, Armin Nikpour, Omid Kavehei

“…The research acknowledges limitations such as the limited exploration of loss functions in multi-label models and constraints in architectural design, suggesting potential avenues for future investigation. While the proposed Naive Continual Fine-tuning Process is in its early stages, we highlight this paper’s potential model personalization on long-term data. …”
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Ranibizumab for Visual Impairment due to Diabetic Macular Edema: Real-World Evidence in the Italian Population (PRIDE Study) by Ugo Menchini, Francesco Bandello, Vincenzo De Angelis, Federico Ricci, Luigi Bonavia, Francesco Viola, Elisa Muscianisi, Massimo Nicolò

“…Majority of patients were not treatment-naïve before enrollment. Patients received ranibizumab as per the EU label (2011). …”
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Protection of the Peritoneal Membrane by Peritoneal Dialysis Effluent-Derived Mesenchymal Stromal Cells in a Rat Model of Chronic Peritoneal Dialysis by Lan Zhou, Ming Zong, Qiunong Guan, Gerald da Roza, Hao Wang, Hualin Qi, Caigan Du

“…Here, we showed that as compared to naive control, daily IP injection of the Dianeal PD solution for 6 weeks without pMSC treatment significantly reduced UF, which was associated with an increase in both PM thickness and blood vessel, while pMSC treatment prevented the UF loss and reduced PM injury and blood vessels. …”
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Radiation-induced rescue effect on human breast carcinoma cells is regulated by macrophages by Spoorthy Pathikonda, Li Tian, Clement Manohar Arava, Shuk Han Cheng, Yun Wah Lam

“…Conditioned medium from naïve by stander cells, i.e., cells not exposed to irradiated cells, could mitigate UV-induced DNA damages in human breast carcinoma MCF7 cells, as judged by phospho-H2AX and 53BP1 immunostaining. …”
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Systematic assessment of COVID-19 host genetics using whole genome sequencing data. by Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, DeCOI host genetics group, T Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V Schmidt, Philipp Schommers, Christoph D Spinner, Maria J G T Vehreschild, Thirumalaisamy P Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J Brent Richards, DeCOI, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L Schultze, Peter Nürnberg, Markus M Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C Schulte, Kerstin U Ludwig

“…Here, we present the results of whole genome sequencing in 1,220 mainly vaccine-naïve individuals with confirmed SARS-CoV-2 infection, including 827 hospitalized COVID-19 cases. …”
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