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701
Validity of serum autotaxin and Doppler ultrasound as noninvasive markers of esophageal varices in patients with liver cirrhosis
Published 2025-01-01“…Results In our prospective study, 100 newly diagnosed naïve patients with liver cirrhosis and with no past history of upper gastrointestinal bleeding were enrolled. …”
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702
Differential T cell accumulation within intracranial and subcutaneous melanomas is associated with differences in intratumoral myeloid cells
Published 2024-11-01“…Transferred activated or naïve CD8 T cells accumulated in similar numbers in both tumors, suggesting that the vasculature does not differentially impair T cell presence. …”
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703
Prediction of Liver Steatosis and Fibrosis Based on Clinical Variables Using a Large National Survey Database
Published 2023-01-01“…We used adaptive lasso regression, gradient-boosted model, and decision trees to determine clinical variables strongly related to these outcomes. A Naïve Byes classifier and decision trees were used to calculate the predicted probabilities of liver steatosis and fibrosis. …”
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704
Late Onset of Antiretroviral Therapy in Adults Living with HIV in an Urban Area in Brazil: Prevalence and Risk Factors
Published 2019-01-01“…This study aimed to analyze characteristics and factors associated with late initiation of ART among HIV-infected treatment-naïve patients. Methods. This cross-sectional study included PLHIV older than 17 years who initiated ART at two public health facilities from 2009 to 2012, in a city located in Midwestern Brazil. …”
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705
Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications
Published 2008-01-01“…To clarify the role of CD8+ effector T cells for infectious complications, 92 recipients were classified according to the hierarchical clustering of preoperative CD8+CD45 isoforms: Group I was naive, Group II was effector memory, and Group III was effector (E) T cell-dominant. …”
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706
Which clinical trial designs and statistical approaches have been used in assessments of orphan maintenance by the European Medicines Agency between 2012 and 2022? A cross-sectiona...
Published 2024-12-01“…Among the indirect comparisons, naive side-by-side comparisons are most often used (71%, 129/182), whereas inferential approaches that adjust for population differences and quantify the uncertainty of the comparison are used less often (29%, 53/182). …”
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707
Impact of Age and Sex on Viral Load in Hepatitis C Virus Infection
Published 2024-12-01“…<i>n</i> = 922 patients (males <i>n</i> = 497, median age 62 years), all naïve to direct antiviral agents, were studied. Females were older (median age 68 vs. 57, <i>p</i> < 0.001) and had a higher prevalence of genotype 2 (33% vs. 20%, <i>p</i> < 0.001) than males; there was no difference between sexes regarding the METAVIR stage. …”
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708
Enhanced quantitative precipitation estimation through the opportunistic use of Ku TV-SAT links via a dual-channel procedure
Published 2025-01-01“…It is shown that this technique when compared to rain gauge measurements gives far better results than a naive single-channel approach neglecting the natural radiation of atmosphere but that significant errors remain in rainfall assessment, leading to a persistent underestimation of rain accumulation. …”
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709
Development of a Novel Sensor System Based on Magnetic Microspheres to Detect Cardiac Troponin T
Published 2020-01-01“…The present study is aimed at exploring a novel sensing system with high specificity and precision based on magnetic microspheres developed to detect cardiac troponin T (cTnT), which is the most specific diagnostic marker for AMI in cardiovascular diseases. Naive human cTnT protein in serum samples and antigens on functional magnetic microspheres will competitively bind with limited specific antibodies. …”
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710
Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization
Published 2014-01-01“…First, our in vitro studies reveal that recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 in vitro, and rHMGB1-activated DCs prime naïve lymphocytes to produce the Th17 cytokine IL-17A. …”
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711
Hypomania, Depression, Euthymia: New Evidence in Parkinson’s Disease
Published 2020-01-01“…We enrolled 93 PD outpatients (three groups: drug naive—DN; not exhibiting motor fluctuations—n-MF; and exhibiting motor fluctuations—MF) and 50 healthy controls. …”
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712
Prognosis modelling of adverse events for post-PCI treated AMI patients based on inflammation and nutrition indexes
Published 2025-01-01“…These nine factors were employed to establish stepwise regression (SR), random forest (RF), naïve Bayes (NB), decision trees (DT), and artificial neutron network (ANN), whose performances were evaluated in terms of accuracy, kappa, F1, receiver operating characteristic, precision recall curve, etc. …”
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713
Dissolved Gas Analysis for Fault Prediction in Power Transformers Using Machine Learning Techniques
Published 2024-12-01“…The MLMs used for transformer fault diagnosis were random forest (RF), backpropagation neural network (BPNN), K-nearest neighbors (KNN), support vector machine (SVM), decision tree (DT), and Naive Bayes (NB). The MLMs were implemented by using 628 dataset samples, which were obtained from laboratories, other studies, and electricity stations in Iraq. …”
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714
Adjuvanted subunit intranasal vaccine reduces SARS-CoV-2 onward transmission in hamsters
Published 2025-02-01“…As a subunit intranasal COVID-19 vaccine reduced nasopharyngeal virus more than did an intramuscular (IM) vaccine, we hypothesized that this vaccine might reduce onward transmission to others.MethodsWe vaccinated hamsters with either the IM-administrated licensed mRNA vaccine twice or one dose of mRNA IM followed by adjuvanted subunit intranasal vaccine. 24 hours after SARS-CoV-2 challenge, these animals were housed with naïve recipients in a contactless chamber that allows airborne transmission.ResultsOnward airborne transmission was profoundly blocked: the donor and recipients of the intranasal vaccine-boosted group had lower oral and lung viral loads (VL), which correlated with mucosal ACE2 inhibition activity. …”
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715
Learning “How to Learn”: Super Declarative Motor Learning Is Impaired in Parkinson’s Disease
Published 2017-01-01“…The aim of this study is to investigate the retention and anterograde interference using a declarative sequence learning task in drug-naive patients in the disease’s early stages. Eleven patients with PD and eleven age-matched controls learned a visuomotor sequence, SEQ1, during Day1; the following day, retention of SEQ1 was assessed and, immediately after, a new sequence of comparable complexity, SEQ2, was learned. …”
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716
Mast Cell-Derived Exosomes Promote Th2 Cell Differentiation via OX40L-OX40 Ligation
Published 2016-01-01“…BMMC-exosomes significantly enhanced the differentiation of naive CD4+ T cells to Th2 cells in a surface contact method, and this ability was partly inhibited by the addition of anti-OX40L Ab. …”
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717
Automatic three-dimensional reconstruction of the oesophagus in achalasia patients undergoing POEM: an innovative approach for evaluating treatment outcomes
Published 2024-05-01“…In addition, these values were compared with normal value indices of non-achalasia patients.Results 50 treatment-naive achalasia patients were enrolled prospectively. …”
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718
Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3
Published 2011-01-01“…The assessment of CCR7 and CD45RA expression on the expanded CD4+CD127lowFOXP3+ Treg cells revealed an increase of both naïve as well as central and effector memory Treg cells in peripheral blood. …”
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719
Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression
Published 2025-02-01“…Both inhibitors show potent anti‐proliferative effects in enzalutamide‐treated or ‐naive PC models. Thus, targeting aberrant alternative splicing at the 3′UTR of ARV7 by disturbing the CLK2/SRSF9 axis might be a valuable therapeutic approach in late stage, ARSI‐resistant PC.…”
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720
Leptonic dipole operator with $$\Gamma _2$$ Γ 2 modular invariance in light of Muon $$(g-2)_\mu $$ ( g - 2 ) μ
Published 2024-12-01“…We found that the NP contributions to $$\Delta a_{e(\mu )}$$ Δ a e ( μ ) are proportional to the lepton masses squared likewise the naive scaling $$\Delta a_\ell \propto m^2_\ell $$ Δ a ℓ ∝ m ℓ 2 . …”
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