Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice by Elle EM Scheijen, Naomi Veeningen, Sam Duwé, Anna Ivanova, Jana Van Broeckhoven, Sven Hendrix, David M Wilson

“…Results: Our analysis revealed that increased DNA damage foci were present from 1 hpi to 3 dpi in SCI mice relative to controls (sham surgery and naive), with the damage signal spreading over time longitudinally from the affected area to more rostral and caudal regions. …”
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Healthcare resource utilization and costs in immunodeficient patients receiving subcutaneous Ig: Real-world evidence from France. by Guillaume Lefèvre, Isabelle Borget, Cinira Lefèvre, Chahrazed Maherzi, Arnaud Nucit, Mouna Hennaoui, Aurélie Schmidt, Hannah Lennon, Benjamin Grenier, Florent Daydé, Nizar Mahlaoui

“…<h4>Methods</h4>This retrospective study of Ig-naïve patients with PID or SID newly receiving a SCIg between 2016 and 2018, extracted from the French National Healthcare reimbursement database (SNDS), analyzed the SCIg-related HCRU and reimbursed costs generated from in-hospital (hospitalizations and SCIg doses) or at-home (nurse visits [NV] and pump provider visits [PPV], drug doses) SCIg administration.…”
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A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies by Tarana Parvez Kaovasia, Sarah Duclos, Dinank Gupta, Kourosh Kalayeh, Mario Fabiilli, Douglas C. Noll, Jonathan Sukovich, Aditya Pandey, Zhen Xu, Timothy L. Hall

“…To validate the design of the system, histotripsy, BBBO, and hyperthermia were performed in naïve brains of two mice for each modality. Histotripsy and BBBO were performed using MRI-based stereotactic co-registration. …”
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The volatilome – investigation of volatile organic metabolites (VOM) as potential tumor markers in patients with head and neck squamous cell carcinoma (HNSCC) by Philipp Opitz, Olf Herbarth

“…Methods In this retrospective case-control study urinary VOM of 53 therapy-naive patients with head and neck squamous cell carcinoma (HNSCC) and 82 healthy controls were semi-quantified by headspace solid-phase micro extraction (SPME) gas chromatography (GC) mass spectrometry (MS). …”
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Use of pattern recognition in photoacoustic imaging to identify neuronal ensembles in the prefrontal cortex of rats undergoing conditioned fear learning by Shane A. Perrine, Mohammad Beirami, James I. Matchynski, Rayyan Manwar, Srinivasu Kallakuri, Alana C. Conti, Kamran Avanaki

“…Our results show that a qualitatively-unique pattern in signal intensity exists only for the fear-conditioned group compared to sham-conditioned, behaviourally-naïve, or fear-conditioned vehicle control groups. …”
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Neuraminidase-mediated enhancement of Streptococcus pneumoniae colonization is associated with altered mucus characteristics and distribution by Matthew T. Montgomery, Mila Ortigoza, Cynthia Loomis, Jeffrey N. Weiser

“…Mucus exposed to NA showed increased localization within goblet cells and lining the glycocalyx. By contrast, NA-naïve mucus was more likely to be observed sloughing away from the epithelial surface. …”
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Molecular Mechanisms of Immunomodulation Properties of Mesenchymal Stromal Cells: A New Insight into the Role of ICAM-1 by Yury Rubtsov, Кirill Goryunov, Аndrey Romanov, Yulia Suzdaltseva, George Sharonov, Vsevolod Tkachuk

“…Immunomodulation by MSC ranging from support of naive T cell survival to immunosuppression of activated T cells may affect the tissue microenvironment protecting from aberrant regeneration.…”
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Exposure of Mycobacteriodes abscessus clones to mucin affects bacterial phenotype by Amy Leestemaker-Palmer, Tiffany Ong, Luiz E Bermudez

“…Mucin exposed clones had less of this decrease between day 7 and day 14 compared to clones naïve to mucin. The number of bacteria in the biofilms were similar in all 6 months in 7H9 medium and 7H9 with mucin. …”
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Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy by Shay Tzaban, Ori Stern, Elad Zisman, Galit Eisenberg, Galit Eisenberg, Shiri Klein, Shiri Klein, Shoshana Frankenburg, Michal Lotem, Michal Lotem, Michal Lotem

“…This process makes splicing isoforms defining features of cell states, exemplified by CD45 splice isoforms, which characterize the transition from naïve to memory states. Two developments have accelerated the use of AS dynamics for therapeutic interventions: advancements in long-read RNA sequencing and progress in nucleic acid chemical modifications. …”
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Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART by Suman Karmakar, Surendra K. Sharma, Richa Vashishtha, Abhishek Sharma, Sanjay Ranjan, Deepak Gupta, Vishnubhatla Sreenivas, Sanjeev Sinha, Ashutosh Biswas, Vinay Gulati

“…A prospective analysis of ART-naïve adults started on HAART from November, 2008 to May, 2010 was done in a tertiary care hospital in north India. …”
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Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer’s disease: insights from machine learning analyses and WGCNA by Sanying Mao, Xiyao Zhao, Lei Wang, Yilong Man, Kaiyuan Li

“…Immune cell infiltration analysis revealed significant associations between ZDHHC22 expression and the infiltration of several immune cell types, including naïve B cells, CD8 + T cells, and M1 macrophages. …”
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Modeling suction of unsaturated granular soil treated with biochar in plant microbial fuel cell bioelectricity system by K. C. Onyelowe, Ahmed M. Ebid, Rosa Belén Ramos Jiménez, Viroon Kamchoom, M. Vishnupriyan, Krishna Prakash Arunachalam

“…Additionally, different machine learning models such as the “Gradient Boosting (GB)”, “CN2 Rule Induction (CN2)”, “Naive Bayes (NB)”, “Support vector machine (SVM), “Stochastic Gradient Descent (SGD)”, “K-Nearest Neighbors (KNN)”, “Tree Decision (Tree)”, “Random Forest (RF)”, and “Response Surface Methodology” (RSM), have been developed to predict SWCC based on soil suction, electric current, electrical potential, volumetric water content, temperature, and bulk density. …”
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Six-Year Real-World Outcomes of Antivascular Endothelial Growth Factor Monotherapy and Combination Therapy for Various Subtypes of Polypoidal Choroidal Vasculopathy by Jingyuan Yang, Mingzhen Yuan, Song Xia, Youxin Chen

“…Forty-eight treatment-naive PCV eyes of 46 patients were reviewed retrospectively, which underwent anti-VEGF monotherapy or initial combination therapy. …”
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Advances in bioinformatics and multi-omics integration: transforming viral infectious disease research in veterinary medicine by Alyaa Elrashedy, Walid Mousa, Mohamed Nayel, Akram Salama, Ahmed Zaghawa, Ahmed Elsify, Mohamed E. Hasan

“…Numerous pathogens have established themselves in naïve populations, harming reproduction, productivity, and health. …”
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Non-target effects of ten essential oils on the egg parasitoid Trichogramma evanescens by van Oudenhove, Louise, Cazier, Aurélie, Fillaud, Marine, Lavoir, Anne-Violette, Fatnassi, Hicham, Perez, Guy, Calcagno, Vincent

“…Most EOs also affect parasitoid behavior: (i) Basil, Coriander, Oregano, Peppermint, Mugwort and Thyme EOs are highly repellent for naive female parasitoids; (ii) Anise and Fennel EOs can have repellent or attractive effects depending on strains; and (iii) Sweet orange, Oregano and Rosemary EOs have no detectable impact on orientation behavior. …”
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Probing the Pitfalls: Understanding SVD’s Shortcomings in Language Model Compression by Сергей Александрович Плетенев

“…We compared the changes in the model's internal representations with its ability to solve natural language inference (NLI) tasks and the compression rate achieved through factorization. Results: Naive uniform factorization often led to significant accuracy drops, even at small compression rates, reflecting a noticeable degradation in the model's ability to understand textual entailments. …”
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Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology by Grigorios Panagiotou, Sofia Triantafyllidou, Basil C. Tarlatzis, Eleni Papakonstantinou

“…Disease-free individuals (N = 56) and patients with histologically proven benign (N = 61) or malignant tumor (N = 96; subdivided into recently diagnosed/treatment-naïve (N = 72) and chemotherapy-treated (N = 24) subgroups) were enrolled in this study. …”
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Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 by Letícia Penna Braga, Cássia Cristina Pinto Mendicino, Edna Afonso Reis, Ricardo Andrade Carmo, Cristiane Menezes de Pádua

“…Inclusion criteria were as follows: having been treatment-naive patient ≥18 years old who initiated ART between 2001 and 2005 in these three referral centers. …”
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Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4+ T Helper Cell Responses by Irem Ozel, Ilgin Akkaya, Ece Oylumlu, Goksu Uzel, Ceren Ciraci

“…Furthermore, cocultures of NLRP11-expressing Burkitt’s lymphoma cells and naïve human peripheral CD4+ T lymphocytes had reduced IFN-γ and IL-17A production, whereas IL-13 and IL-10 cytokines did not change. …”
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Correlation between Imaging Morphological Findings and Laboratory Biomarkers in Patients with Diabetic Macular Edema by Eleni Dimitriou, Theodoros N. Sergentanis, Vaia Lambadiari, George Theodossiadis, Panagiotis Theodossiadis, Irini Chatziralli

“…Participants in this cross-sectional study were 36 consecutive patients (36 eyes) with treatment-naïve DME, who underwent spectral domain-optical coherence tomography (SD-OCT), fundus photography, and fundus fluorescein angiography (FFA). …”
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