Mass Cytometry Reveals the Imbalanced Immune State in the Peripheral Blood of Patients with Essential Hypertension by Rui Yang, Yuhong He, Honggang Zhang, Qiuju Zhang, Bingwei Li, Changming Xiong, Yubao Zou, Bingyang Liu

“…Compared with the health control (HC) group, the percentage of total dendritic cells, two kinds of myeloid dendritic cell subsets, one intermediate/nonclassical monocyte subset and one CD4+ central memory T cell subset in the EH group, was significantly higher; the percentage of low-density neutrophils, four kinds of classical monocyte subsets, one CD14lowCD16- monocyte subset, one naive CD4+ and one naive CD8+ T cell subsets, one CD4+ effector and one CD4+ central memory T cell subsets, one CD8+ effector memory T cell subset, and one terminally differentiated γδ T cell subset, decreased significantly in EH. …”
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Effectiveness of Distant/Remote Blessing Treatment on Cognitive-motor Function: A Randomized Double-blind Placebo-controlled Trial by Alice Branton, Mahendra Kumar Trivedi, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana

“… # Results In the blessing treatment group, language function score (*p* \<0.01), working memory (*p* \<0.0001), and episodic memory (*p* \<0.0001) scores exhibited statistically significant differences compared to both the naïve control and sham control groups. Moreover, in the blessing intervention group, a substantial improvement was observed in locomotion (*p* \<0.0001), standing balance (*p* \<0.01), dexterity (*p* \<0.01), grip strength (*p* \<0.05), and muscle endurance (*p* \<0.05) compared to the naïve control and sham control groups. …”
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DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response by Esther Granot, Einat Jakobovich, Ruth Rabinowitz, Paloma Levy, Michael Schlesinger

“…CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group. …”
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Breast Cancer Detection Using Ensemble Classifiers for Accuracy Improvement by Mahboubeh Shamsi, Mohadaseh Karimian, Marziyeh Karimian

“…Our proposed model in the WBC database (reducing features by cfs+ optimizing samples using Resample+ ensemble classifier using data mining algorithms (kstar + random forest + Naïve Bayes and Bayes network)) has the best detection accuracy ( 100%), implementation time (0 seconds) and without any errors and on the WDBC database (reducing features by cfs+ optimizing samples using Resample+ ensemble classifier using data mining algorithms (IBK algorithm+ Naïve Bayes, Bayes network and kstar)) has an accuracy of 99/29, the implementation time is 0 seconds, and the mean absolute error is 0/007. …”
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Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis by Yutong Li, Xingyu Song, Yuyang Huang, Sifan Zhou, Linkun Zhong

“…Two-sample MRshowed that CD25 on naive-mature B cell, CD8 + NKT cell, and thymol sulfate level were found to have causal relationships with HD (P < 0.008). …”
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Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…Finally, we observe that luminal acinar tumor cells in treatment-naïve prostate cancer display heterogeneous androgen receptor (AR) signaling activity, including a split between AR-positive and AR-low profiles with similarity to PrU-like states. …”
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Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost by Bo Zhang, Youyi Fong, Lauren Dang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Daniel S. Graciaa, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Chenchen Yu, Craig A. Magaret, Cindy Molitor, Bhavesh Borate, Sydney Busch, David Benkeser, Antonia Netzl, Derek J. Smith, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martín Bäcker, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Seema U. Nayak, Paul C. Roberts, Peter B. Gilbert, Dean Follmann, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

“…Neutralizing antibody titer was a strong inverse correlate of Omicron COVID-19 in non-naïve individuals and a weaker correlate in naïve individuals, posing questions about how prior infection alters the neutralization correlate.…”
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Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins by Pradeep Kumar Yadalam, Deepavalli Arumuganainar, Prabhu Manickam Natarajan, Carlos M. Ardila

“…Hub proteins were identified using Cytoscape and Cytohubba, and machine learning algorithms including naïve Bayes, neural networks, gradient boosting, and random forest were used to predict hub genes. …”
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Première observation d’un comportement de Leaf Swallowing chez des chimpanzés vivant en captivité à la Réserve Africaine de Sigean, France by Nathan Cazelles-Durand, Ulrich Maloueki, Lyna Rachid, Marielle Beltrame, Fanny Juillard, Désiré Musuyu-Muganza

“…All these individuals were presumed naive to LS because this behaviour had never been observed in this population before the study. …”
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A decision support system based on classification algorithms for the diagnosis of periodontal disease by Abdulrahman Alshehri, Mohammed Dahman, Mousa Assiri, Abdulkarim Alshehri, Sharifah Alqahtani, Mohammed Shaiban, Bashyer Alqahtani, Sabah Althbyani, Hatem Alhefdi, Khalid Hakami, Abdulbari Ali, Abdullah Saeed

“…Results showed little effectiveness for the Naïve Bayes on grading periodontal disease. Discussion and Conclusion: DSS models show promise in enhancing periodontal disease diagnostics, particularly RF and ANN models. …”
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Wogonin Attenuates Ovalbumin Antigen-Induced Neutrophilic Airway Inflammation by Inhibiting Th17 Differentiation by Rie Takagi, Masaaki Kawano, Kazuyuki Nakagome, Kumiko Hashimoto, Takehiro Higashi, Katsuya Ohbuchi, Atsushi Kaneko, Sho Matsushita

“…Wogonin suppressed the differentiation of naïve T cells to Th17 cells, while showing no effects on activated Th17 cells.…”
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Adjunct Intravitreous Triamcinolone Acetonide in the Treatment of Diabetic Macular Edema with Anti-VEGF Agents by Robert B. Garoon, Robert E. Coffee, Lai Jiang, Christina Y. Weng, Petros E. Carvounis

“…To compare visual and anatomic outcomes of adjunct intravitreous (IVT) triamcinolone acetonide to antivascular endothelial growth factor (VEGF) injections to IVT anti-VEGF injections alone for center-involving diabetic macular edema (DME) in treatment-naïve eyes. Methods. Retrospective study of treatment-naïve eyes with center-involving DME. …”
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Effect of Efavirenz on Endogenous Progesterone Concentrations and Contraceptive Outcomes among Ugandan HIV Infected Women Coadministering Ethinylestradiol/Levonorgestrel by Grant Munkwase, Kuteesa R. Bisaso, Othman Kakaire, Sarah Nanzigu

“…A higher proportion of HIV positive women on efavirenz based HAART (26.5%) was at risk of contraceptive failure than their HIV infected HAART naïve counterparts (20%) though it was not statistically significant (p=0.63). …”
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A study of lipid profile peculiarities and atherogenic index of plasma in patients younger than fifty years of age with newly diagnosed rheumatoid arthritis by Varsha R. Bhatt, Kavita K. Krishna, Vishal Asrani, Rajat Chauhan

“…Aims: Evaluation of lipid profile and atherogenic index of plasma (AIP) in newly diagnosed DMARD naïve patients of RA younger than 50 years of age, and its comparison with age- and sex-matched healthy controls. …”
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Rapid Acting Insulin Use and Persistence among Elderly Type 2 Diabetes Patients Adding RAI to Oral Antidiabetes Drug Regimens by Usha Sambamoorthi, Arijita Deb, Steve Zhou, Rahul Garg, Tao Fan, Anders Boss

“…Real-world persistence of RAI in insulin-naïve elderly patients with type 2 diabetes was very poor when RAI was added to an OAD regimen.…”
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Immune Dysfunction in HIV: A Possible Role for Pro- and Anti-Inflammatory Cytokines in HIV Staging by Iorhen Ephraim Akase, Bolanle O. P. Musa, Reginald Onyedumarakwe Obiako, Abdurrahman Ahmad Elfulatiy, Abdullahi Asara Mohammed

“…The serum IL-6 and IL-10 concentrations were significantly higher among the AR-naïve participants compared to the ART-experienced group. …”
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Optimal timing for discontinuation of ERCP in cases of difficult selective biliary cannulation by Han Taek Jeong, Jimin Han

“…Patients and methods: Patients with naïve papilla who underwent ERCP between January 2021 and December 2021 were analyzed. …”
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CTLA-4 Engagement Inhibits Th2 but not Th1 Cell Polarisation by Vanessa Ubaldi, Lucia Gatta, Luigia Pace, Gino Doria, Claudio Pioli

“…Results show that CTLA-4 engagement during differentiation inhibits polarisation of naïve CD4+ cells to the Th2 but not the Th1 cell subset. …”
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Differentiations in Illness Duration, Thyroid-Stimulating Hormone, Glucose and P300 Latency Between Drug-Na&iuml;ve Unipolar and Bipolar Depression: A Comparative Cross-Sectional S... by Li C, Yang L, Zhang Q, Zhang Y, Li R, Jia F, Wang L, Ma X, Yao K, Tian H, Liu Z, Zhuo C

“…Chao Li,1,2 Lei Yang,1,2 Qiuyu Zhang,1,2 Ying Zhang,1,2 Ranli Li,1,2 Feng Jia,1,2 Lina Wang,1,2 Xiaoyan Ma,1,2 Kaifang Yao,1,2 Hongjun Tian,3,&ast; Zengxun Liu,4,&ast; Chuanjun Zhuo1,2,&ast; 1Computational Biology and Animal Imaging Center (CBAC), Tianjin Anding Hospital, Nankai University Affiliated Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Mental Health Center, Tianjin, 300222, People’s Republic of China; 2Laboratory of Psychiatric-Neuroimaging-Genetic and Co-morbidity (PNGC_Lab), Tianjin Anding Hospital, Tianjin Mental Health Center of Tianjin Medical University, Tianjin, 300222, People’s Republic of China; 3Department of Psychiatry, Tianjin Fourth Center Hospital, Nankai University Affiliated Tianjin Fourth Center Hospital, Tianjin, 300140, People’s Republic of China; 4Department of Psychiatry, Shandong Mental Health Center, Jinan, 250014, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chuanjun Zhuo, Tianjin Anding Hospital, Nankai University Affiliated Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Anding Hospital, Tianjin Medical University Affiliated Tianjin Mental Health Center, Tianjin, 300222, People’s Republic of China, Tel/Fax +86-22-24394542, Email chuanjunzhuotjmh@163.comBackground: Distinguishing bipolar depression (BD) from unipolar depression (UD) remains a major clinical challenge, especially in drug-naïve patients. The present study aimed to investigate whether demographic, clinical, and biochemical parameters can help differentiate drug-naïve BD from UD.Methods: Drug-naïve patients with UD and BD were recruited from Shandong Mental Health Center. …”
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Haggard’s Questioning of the Heroic by John Coates

“…Rider Haggard is sometimes thought of as a writer who offered thrilling incidents, racial stereotypes and imperialist propaganda, or as a naïve myth-maker, unlocking his subconscious and reaching out to ours. …”
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