Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins by Hu Wei, Jiang Wen-Bing

“…Pitavastatin was found to ameliorate the cardiac dysfunction in mice with dilated cardiomyopathy by reversing the changes in the ratios of phosphorylated PLB to total PLB, SERCA-2a and RyR2 via reducing the plasma AngII concentration and the expressions of myocardium angiotensin II type 1 receptor (AT1R) and protein kinase C (PKC)b2. …”
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IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway. by Ruisong Ma, Xiaochun Hu, Wenwen Fu, Xiaorong Hu

“…The level of IL-34 peaked at 4 h after MI/R in the ischemic myocardium. Next, ischemia for 30min and reperfusion for 4h (I/R) model was used. 24 rats were randomly divided into I/R group (n = 8), IL-34+IR group (n = 8) and IL-34+ab12+IR group (n = 8). …”
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Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress by Tingting Fang, Congcong Ma, Bingyun Yang, Meiyu Zhao, Luning Sun, Ningning Zheng

“…This study explores the protective effect of FG-4592 on the diabetic myocardium and further investigates the specific mechanisms responsible for this action. …”
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The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma by Teruhito Takakuwa, Ippei Otomaru, Taku Araki, Akiko Miura, Yotaro Fujitani, Yasuhide Mochizuki, Yoshimi Miyagi, Hideto Senzaki, Ryosuke Yamamura

“…There was no obvious thrombus in the coronary artery of the heart, and no infarction or amyloid deposition was observed in the myocardium. Pathological findings of hypersensitivity myocarditis, a drug-induced cardiomyopathy, appeared to agree with this case except for absence of an eosinophilic infiltration of the myocardium. …”
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Premature Ventricular Complex Causing Ice-Pick Headache by Selcuk Ozturk, Ertan Yetkin

“…Premature ventricular contractions are early depolarization of the ventricular myocardium and in the absence of a structural heart disease, it is considered to be a benign disease. …”
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Ultrasound-Targeted Microbubble Destruction Improves the Migration and Homing of Mesenchymal Stem Cells after Myocardial Infarction by Upregulating SDF-1/CXCR4: A Pilot Study by Lu Li, Shengzheng Wu, Zheng Liu, Zhongxiong Zhuo, Kaibin Tan, Hongmei Xia, Lisha Zhuo, Xiaojun Deng, Yunhua Gao, Yali Xu

“…Ultrasound-targeted microbubble destruction (UTMD) has proven to be promising to improve the homing of MSCs to the ischemic myocardium, but the concrete mechanism remains unclear. …”
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Effect of Thrombolysis on Circulating Microparticles in Patients with ST-Segment Elevation Myocardial Infarction by Zhe Li, Wei Zhang, Qun-Rang Wang, Yu-juan Yang, Xin-Hong Liu, Gong Cheng, Feng-Jun Chang

“…Compared with those in the control group, MPs in both CCS and STEMI patients before thrombolysis inhibited the expression of eNOS (both immunohistochemistry and western blot analysis of phosphorylation at Ser1177), NO production in the isolated myocardium and vasodilation in vitro and stimulated the expression of iNOS (immunohistochemistry and western blot analysis of phosphorylation at Thr495), and the generation of O2•– in the isolated myocardium. …”
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PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism by Mao T, Wang Y

“…The excessive accumulation of lipid metabolic intermediates within the myocardium can lead to increased production of reactive oxygen species (ROS) and promote apoptosis. …”
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Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism by Ying-hao Pei, Jiao Chen, Liang Xie, Xiao-min Cai, Run-Hua Yang, Xing Wang, Jian-bin Gong

“…A subsequent mechanistic study revealed that the cardioprotective effects of HT during the process of I/R of the myocardium were dependent on the activation of the Akt/GSK3β pathway. …”
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Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery by Izabela Wojtkowska, Tomasz A. Bonda, Jadwiga Wolszakiewicz, Jerzy Osak, Andrzej Tysarowski, Katarzyna Seliga, Janusz A. Siedlecki, Maria M. Winnicka, Ryszard Piotrowicz, Janina Stępińska

“…We evaluated the relationship between expression of PPARγ in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. …”
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The use of veno-arterial extra corporeal membrane oxygenation for hemodynamics support during high-risk percutaneous coronary intervention by Wael Samy, Helmy Elghawaby, Akram Abdelbary, Hany Zakaria Mohamed, Alia Hassan Abdel Fattah

“…Patients and methods A prospective interventional study performed on patients with viable ischemic myocardium who refused CABG, syntax score>22, excluding scarred myocardium. …”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…HF is an established frequent complication of myocardial infarction (MI), and numerous influences including persistent myocardial ischemia, shocked myocardium, ventricular remodeling, infarct size, and mechanical impairments, as well as hibernating myocardium trigger the development of left ventricular systolic dysfunction following MI. …”
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Black Chokeberry (<i>Aronia melanocarpa</i>) Juice Supplementation Affects Age-Related Myocardial Remodeling in Rats by Elena Daskalova, Mina Pencheva, Slavi Delchev, Lyudmila Vladimirova-Kitova, Spas Kitov, Stoyan Markov, David Baruh, Petko Denev

“…The mean number of CD34+ cells in the myocardium increased by 18.6% in the AMJ group, as compared to CO (<i>p</i> < 0.05). …”
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Acroparesthesia in a Female: Diagnostic Dilemma by Fnu Kelash, Lara Kujtan, Padmaja V. Mallidi

“…The disease affects nearly all major organ systems, with the primary sites damaged by Gb3 including renal glomeruli, myocardium, neurons of the dorsal ganglion and autonomic nervous system, and vascular endothelial and smooth muscle. …”
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Cardiac Tuberculoma Presenting as Sudden Cardiac Death in an Immunocompetent Young Man: A Case Report and Literature Review by Alemayehu Shiferaw Lema

“…Although rare, most cases of tuberculosis involving the myocardium and endocardium present as sudden cardiac death in asymptomatic cases. …”
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Myocardial Gene Expression of T-bet, GATA-3, Ror-γt, FoxP3, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed TH1-Type Response by Luciana Gabriel Nogueira, Ronaldo Honorato Barros Santos, Alfredo Inácio Fiorelli, Eliane Conti Mairena, Luiz Alberto Benvenuti, Edimar Alcides Bocchi, Noedir Antonio Stolf, Jorge Kalil, Edecio Cunha-Neto

“…Conversely, cytokines expressed by TH2 cells (IL-4, IL-5, and IL-13) or associated with Treg (TGF-β and IL-10) were not upregulated in CCC myocardium. Expression of TH1-related genes such as T-bet, IFN-γ, and IL-18 correlated with ventricular dilation, FoxP3, and CTLA-4. …”
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Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells by Jan Trieschmann, Moritz Haustein, Annette Köster, Jürgen Hescheler, Konrad Brockmeier, Gerardus Bennink, Tobias Hannes

“…Contractile force was differently regulated by β-adrenergic stimulation in hiPS-CBs and the native myocardium. If used for cardiotoxicity screening, caution is warranted as hiPS-CBs might be less sensitive to pharmacologic targets compared to the native myocardium of neonates and infants.…”
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Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation by Yiyan Liu

“…Another potential problem of which we may be aware but has not been previously discussed is significant SUV overestimation of lesions in the direct neighborhood of large hot sources, namely, areas with high FDG uptake or activity such as a tumor, myocardium, urinary bladder, kidney, or gastrointestinal tract. …”
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Advances in Imaging Studies for Assessing Epicardial Adipose Tissue by Yu ZHANG, Xiangling LIN, Pei NIE

“…Epicardial adipose tissue (EAT) is situated adjacent to the myocardium and coronary arteries and closely associated with the occurrence and progression of various cardiovascular diseases, including coronary artery disease (CAD), atrial fibrillation (AFib), and heart failure (HF). …”
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Severe Hyponatremia-Induced Stress Cardiomyopathy: A Case Report and Review of Literature by Irushna Perera, Sanjeewa Rajapakse, Shamila T. De Silva

“…Takotsubo or stress cardiomyopathy is a non ischemic disease affecting the myocardium, which presents with typical features of myocardial ischemia. …”
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