Astaxanthin mitigates doxorubicin-induced cardiotoxicity via inhibiting ferroptosis and autophagy: a study based on bioinformatic analysis and in vivo/vitro experiments by Bowen Yin, Jingyi Ren, Xuanyi Liu, Yadong Zhang, Jinshi Zuo, Rui Wen, Huanting Pei, Miaomiao Lu, Siqi Zhu, Zhenao Zhang, Ziyi Wang, Yanyi Zhai, Yuxia Ma

“…The experimental results show that ASX significantly mitigates DOX-induced myocardial tissue damage, inflammatory response, oxidative stress, and damage to H9C2 cells. …”
Get full text

Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels by Cheng Luo, Cheng Luo, Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang, Fan Yang

“…The effectiveness and robustness of the gene-derived diagnostic tool were validated using two independent IHD cohorts.Subsequently, we validated the signature genes using a rat post-myocardial infarction heart failure model.ResultsWe conducted an analysis on high-quality snRNA-seq data obtained from 3 IHD and 4 cardiac sarcoidosis heart samples, resulting in the identification of 16 FB clusters. …”
Get full text

High-quality targeted temperature management combined with decompressive craniectomy in patients with poor-grade aneurysmal subarachnoid hemorrhage: a secondary analysis of a multi... by Yang Liu, Bingsha Han, Yanru Li, Zhiqiang Ren, Yong Chen, Ming Zhang, Jiao Li, Jv Wang, Fan Yang, Mengyuan Xu, Jiaqi Zhang, Pengzhao Zhang, Tiancai Wang, Jinying Tian, Guang Feng

“…Safety outcomes comprised the incidence of pneumonia, myocardial infarction, stress hyperglycemia, thrombocytopenia, acute liver injury, hypokalemia, hypoproteinemia, and death at 90 days.ResultsOf the 141 patients enrolled in the High-Quality TTM for PaSAH study, 43 (25 in the TTM-DC group and 18 in the DC-alone group) were eligible for this secondary analysis. …”
Get full text

Gambaran Profil Lipid pada Pasien Sindrom Koroner Akut di Rumah Sakit Khusus Jantung Sumatera Barat Tahun 2011-2012 by Fitri Zahara, Masrul Syafri, Eti Yerizel

“…<br />Keywords:acute myocardial infarction, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride</p>…”
Get full text

Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis by Xiao Li, Yubo Guo, Kaini Shen, Sisi Huang, Yajuan Gao, Lu Lin, Jian Wang, Jian Cao, Xinxin Cao, Zhengyu Jin, Zhuoli Zhang, Akos Varga-Szemes, U. Joseph Schoepf, Jian Li, Yining Wang

“…Conclusion: This study highlights that T2 is a valuable independent predictor of mortality in an AL amyloidosis population, additive to common CMR risk factors. Moreover, myocardial edema assessment identified patients in need of adjunctive therapies, which is of particular prognostic significance in patients with deep therapeutic response.…”
Get full text

Dietary sodium-to-potassium ratio as a risk factor for stroke, cardiovascular disease and all-cause mortality in Japan: the NIPPON DATA80 cohort study by Hirofumi Ohnishi, Yoshitaka Murakami, Katsuyuki Miura, Koji Tamakoshi, Hirotsugu Ueshima, Akira Okayama, Tomonori Okamura, Takayoshi Ohkubo, Toshiyuki Ojima, Yoshihiro Miyamoto, Maryam Zaid, Aya Kadota, Akira Fujiyoshi, Yosikazu Nakamura, Naoyuki Takashima, Atsushi Hozawa, Shigeyuki Saitoh, Yutaka Kiyohara, Fumiyoshi Kasagi, Nagako Okuda, Takehito Hayakawa, Hiroshi Akasaka, Yusuke Arai, Katsushi Yoshita, Kiyomi Sakata, Nobuo Nishi, Toru Izumi, Yasuhiro Matsumura, Hideaki Nakagawa, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Kazunori Kodama

“…Men and women aged 30–79 years without hypertensive treatment, history of stroke or acute myocardial infarction (n=8283) were divided into quintiles according to dietary Na–K ratio assessed by a 3-day weighing dietary record at baseline. …”
Get full text

MSCs Contribute to the Conversion of Ly6Chigh Monocytes into Ly6Clow Subsets under AMI by Wenbin Lu, Genshan Ma, Zulong Sheng, Qingjie Wang, Lijuan Chen, Junhua Qi, Ronghui Shi, Jingjing Ji, Zhenjun Ji, Qiming Dai

“…Ly6Chigh monocytes are inflammatory cells that accumulate in an infarcted myocardium, and Ly6Clow monocytes are believed to be reparative and curb myocardial remodeling. NR4A1 is a novel target for modulating the inflammatory phenotype of monocytes during atherogenesis. …”
Get full text

Future atherosclerotic cardiovascular disease in systemic lupus erythematosus based on CSTAR (XXVIII): the effect of different antiphospholipid antibodies isotypes by Can Huang, Yufang Ding, Zhen Chen, Lijun Wu, Wei Wei, Cheng Zhao, Min Yang, Shudian Lin, Qian Wang, Xinping Tian, Jiuliang Zhao, Mengtao Li, Xiaofeng Zeng

“…Future ASCVD events were defined as new-onset myocardial infarction, stroke, artery revascularization, or cardiovascular death. …”
Get full text

Utility of Noninvasive Testing Before Invasive Coronary Angiography in the Assessment for Revascularization by Simon Parlow, MD, Richard G. Jung, MD, PhD, Pietro Di Santo, MD, Joanne Joseph, MD, Stephanie Skanes, MD, Omar Abdel-Razek, MD, Graeme Prosperi-Porta, MSc, MD, Pouya Motazedian, MD, Michael Froeschl, MSc, MD, Marino Labinaz, MD, Rebecca Mathew, MD, F. Daniel Ramirez, MSc, MD, Trevor Simard, MD, PhD, Benjamin Hibbert, MD, PhD

“…Objective: To examine the role of noninvasive testing (NIT) before invasive coronary angiography (ICA) by evaluating the association between a positive myocardial perfusion imaging (MPI) or computed tomography angiography (CTA) result and the decision to perform coronary revascularization. …”
Get full text

Differential Prognosis of True Bifurcation Lesions According to Left Main Versus Non–Left Main Location and Treatment Strategy by Ki Hong Choi, Chang‐Wook Nam, Francesco Bruno, Yun‐Kyeong Cho, Leonardo De Luca, Jeehoon Kang, Alessio Mattesini, Young Bin Song, Alessandra Truffa, Hyo‐Soo Kim, Wojciech Wańha, Woo Jung Chun, Sebastiano Gili, Gerard Helft, Seung Hwan Han, Bernardo Cortese, Cheol Hyun Lee, Javier Escaned, Hyuck‐Jun Yoon, Alaide Chieffo, Joo‐Yong Hahn, Guglielmo Gallone, Seung‐Hyuk Choi, Gaetano De Ferrari, Bon‐Kwon Koo, Giorgio Quadri, Seung‐Ho Hur, Fabrizio D'Ascenzo, Hyeon‐Cheol Gwon, Ovidio de Filippo

“…The primary end point was major adverse cardiac events (MACEs; composite of all‐cause death, myocardial infarction, target lesion revascularization, and stent thrombosis) at 800 days. …”
Get full text

Percutaneous coronary intervention vs. medical therapy in patients on dialysis with coronary artery disease in China by Enmin Xie, Yaxin Wu, Zixiang Ye, Yong He, Hesong Zeng, Jianfang Luo, Mulei Chen, Wenyue Pang, Yanmin Xu, Chuanyu Gao, Xiaogang Guo, Lin Cai, Qingwei Ji, Yining Yang, Di Wu, Yiqiang Yuan, Jing Wan, Yuliang Ma, Jun Zhang, Zhimin Du, Qing Yang, Jinsong Cheng, Chunhua Ding, Xiang Ma, Chunlin Yin, Zeyuan Fan, Qiang Tang, Yue Li, Lihua Sun, Chengzhi Lu, Jufang Chi, Zhuhua Yao, Yanxiang Gao, Changan Yu, Jingyi Ren, Jingang Zheng, Rongman Jia

“…The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Secondary outcomes included all-cause death, the individual components of MACE, and Bleeding Academic Research Consortium criteria types 2, 3, or 5 bleeding. …”
Get full text

Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio by Daixin Ding, PhD, Jinlong Zhang, MD, PhD, Peng Wu, PhD, Zhiqing Wang, MD, PhD, Huiping Shi, MSc, Wei Yu, PhD, Xinyang Hu, MD, PhD, Jeehoon Kang, MD, Joo-Yong Hahn, MD, Chang-Wook Nam, MD, Joon-Hyung Doh, MD, Bong-Ki Lee, MD, Weon Kim, MD, Jinyu Huang, MD, Fan Jiang, MD, Hao Zhou, MD, Peng Chen, MD, Lijiang Tang, MD, Wenbing Jiang, MD, Xiaomin Chen, MD, Wenming He, MD, Sung Gyun Ahn, MD, Myeong-Ho Yoon, MD, Ung Kim, MD, You-Jeong Ki, MD, Eun-Seok Shin, MD, Seung-Jea Tahk, MD, Jun Pu, MD, William Wijns, MD, PhD, Jian’an Wang, MD, PhD, Bon-Kwon Koo, MD, PhD, Shengxian Tu, PhD

“…The primary endpoint was 2-year target vessel failure, including cardiac death, target vessel myocardial infarction, and target vessel revascularization. …”
Get full text

Left ventricular global longitudinal strain is associated with filling pressure and cardiac output in an outpatient setting: Insights from CardioMEMS™ by Francisco Barbas de Albuquerque, Rita Teixeira, Tiago Pereira-da-Silva, Vera Ferreira, António Valentim Gonçalves, Rita Ilhão Moreira, Ana Teresa Timóteo, Ana Galrinho, Luísa Branco, Pedro Rio, João Alves, Sofia Barquinha, Duarte Cacela, Rui Cruz Ferreira

“…Introduction and objectives: Left ventricular global longitudinal strain (LVGLS) is an indicator of myocardial function in patients with heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). …”
Get full text

Análisis de los datos del Registro Español de Cirugía Cardiaca (RECC) 2021-2023 by Lourdes Montero-Cruces, Manuel Carnero-Alcázar, Rafael Rodríguez-Lecoq, José C. Sureda-Barbosa, Jorge Rodríguez-Roda-Stuart, Fabrizio Sbraga, Juan J. Legarra-Calderón, Juan M. Gracia-Baena, Alejandro Adsuar-Gómez, Félix Gómez-Blasco, José F. Valderrama-Marcos, Nuria Arce-Ramos, Carlos E. Martín-López, Stefano Urso, José A. Hernández-Campos, Nora García-Borges, Álvaro Pedraz-Prieto, Marta Matamala-Adell, Jorge Rivas Oyarzabal, Diego Macías-Rubio, Enrique Pérez-de la Sota, Alejandro Crespo-de Hubsch, Pilar Gascón-García-Verdugo, José López-Menéndez

“…A total of 10,852 interventions have been included in the RECC, of which 9,236 were major cardiac surgeries. 53.4% (n = 4,935) of major procedures were valve surgeries, 25.2% (n = 2,324) myocardial revascularization surgeries and 15.0% (n = 1,387) aorta procedures. …”
Get full text

Clinical features and long-term outcomes in patients under 35 years with coronary artery disease: Nested case–control study by Pablo Juan-Salvadores, Dahyr Olivas-Medina, Luis Mariano de la Torre Fonseca, Cesar Veiga, Silvia Campanioni, Francisco Caamaño Isorna, Andrés Iñiguez Romo, Víctor Alfonso Jiménez Díaz

“…Conclusion: Patients aged ≤35 exhibited a poor long-term prognosis, with a high risk of new revascularization and acute myocardial infarction during the follow-up period. Focusing on preventive measures can have a significant impact on overall prognosis. …”
Get full text

Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…Interpretation: Subphenotypes with the highest concentration of biomarkers of endothelial dysfunction and inflammation (inflammatory) or myocardial injury/fibrosis (cardiopathic) were associated with mortality independently from the SCAI shock stages. …”
Get full text

Therapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content by Danielle J. Beetler, Danielle J. Beetler, Danielle J. Beetler, Presley Giresi, Damian N. Di Florio, Damian N. Di Florio, Damian N. Di Florio, Jessica J. Fliess, Elizabeth J. McCabe, Molly M. Watkins, Molly M. Watkins, Molly M. Watkins, Vivian Xu, Matthew E. Auda, Katelyn A. Bruno, Katelyn A. Bruno, Emily R. Whelan, Emily R. Whelan, Emily R. Whelan, Stephen P. C. Kocsis, Brandy H. Edenfield, Sierra A. Walker, Sierra A. Walker, Sierra A. Walker, Logan P. Macomb, Kevin C. Keegan, Angita Jain, Angita Jain, Angita Jain, Andrea C. Morales-Lara, Isha Chekuri, Anneliese R. Hill, Houssam Farres, Joy Wolfram, Joy Wolfram, Atta Behfar, Atta Behfar, Paul G. Stalboerger, Andre Terzic, Andre Terzic, Leslie T. Cooper, DeLisa Fairweather, DeLisa Fairweather, DeLisa Fairweather

“…Because of the protective effect of estrogen against myocardial inflammation, we hypothesized that pmPEV would be more effective than PEV at inhibiting myocarditis. …”
Get full text

Risk factors affecting progression and course of primary open-angle glaucoma in patients with different disease stages (multicenter study) by N.E. Fomin, P.Ch. Zavadskiy, A.V. Kuroyedov, A.V. Seleznev, Z.M. Nagornova, D.A. Baryshnikova, R.V. Avdeev, A.M. Getmanova, I.A. Glushnev, A.A. Gusarevich, D.A. Dorofeev, S.V. Kosmynina, O.S. Myakonkaya, N.A. Rebenok, Yu.I. Razhko, I.I. Semenova, T.V. Chernyakova

“…Moreover, PEX, PDS, DED, CHD, prior myocardial infarction, and disability resulting from a general illness are additional factors determining POAG resistance to treatment.…”
Get full text

卒中恢复期患者心肺适能评估及中高强度有氧训练的可行性、安全性及有效性研究 Feasibility, Safety, and Efficacy of Cardiopulmonary Fitness Assessment and Moderate to High Intensity Aerobic Training for Patients Recovering... by 谢丽娜1，朱杰2，李琴英3，刘承弘3，邓盼墨3，贾杰2，3，4 (XIE Li’na1, ZHU Jie2, LI Qinying3, LIU Chenghong3, DEN Panmo3, JIA Jie2,3,4 )

“…Among them, 13 cases (19.12%) did not complete the cardiopulmonary exercise testing, 5 cases (7.35%) experienced adverse reactions such as lower extremity pain, myocardial ischemia, hypertension, and arrhythmia during the evaluation, and 6 cases (8.82%) refused the follow-up trial. …”
Get full text

Traumatic Cardiac Injury: Ventricular Perforation Caught on CT by Behrad Golshani, Paul Dong, Scott Evans

“…Myocardial rupture is a rare imaging diagnosis given its clinical severity and high mortality. …”
Get full text