Potassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells by Paola Sabbatini, Sabrina Cipriani, Andrea Biagini, Luana Sallicandro, Cataldo Arcuri, Rita Romani, Paolo Prontera, Alessandra Mirarchi, Rosaria Gentile, Diletta Del Bianco, Elko Gliozheni, Sandro Gerli, Irene Giardina, Maurizio Arduini, Alessandro Favilli, Antonio Malvasi, Andrea Tinelli, Bernard Fioretti

“…These cells are highly appealing due to their numerous potential applications in the field of regenerative medicine for tissues and organs as well as for treating conditions such as traumatic or ischemic injuries to the nervous system, myocardial infarction, or cancer. AF-SCs, when subcultured in the presence of basic Fibroblast Growth Factor (bFGF), have been shown to survive and migrate when transplanted into the striatum of the rat brain, exhibiting behavior characteristics of neuronal/glial progenitor cells. …”
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Multiparametric cardiovascular magnetic resonance is associated with outcomes in pediatric heart transplant recipients by Andrew A. Lawson, Kae Watanabe, Lindsay Griffin, Christina Laternser, Michael Markl, Cynthia K. Rigsby, Joshua D. Robinson, Nazia Husain

“…ABSTRACT: Background: Multiparametric cardiovascular magnetic resonance (CMR) has an emerging role in non-invasive surveillance of pediatric heart transplant recipients (PHTR). Higher myocardial T2, higher extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) have been associated with adverse clinical outcomes in adult heart transplant recipients. …”
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Percutaneous Coronary Intervention Complexity and Risk of Adverse Events in relation to High Bleeding Risk among Patients Receiving Drug-Eluting Stents: Insights from a Large Singl... by Hao-Yu Wang, Yang Wang, Dong Yin, Run-Lin Gao, Yue-Jin Yang, Bo Xu, Ke-Fei Dou

“…The primary ischemic endpoint was major adverse cardiovascular events (MACE) (composite of cardiac death, myocardial infarction, definite/probable stent thrombosis, and target lesion revascularization), and primary bleeding endpoint was Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 bleeding. …”
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Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness by Stepanka Pruhova, Petra Dusatkova, Pavel J. Kraml, Michal Kulich, Zdena Prochazkova, Jan Broz, Jaroslav Zikmund, Ondrej Cinek, Michal Andel, Oluf Pedersen, Torben Hansen, Jan Lebl

“…No difference was detected for other characteristics, with the exception of fasting blood glucose (GCK-MODY 7.6 mmol/L ± 1.2 (136.4 mg/dL); controls 5.3 mmol/L ± 0.3 (95.4 mg/dL); P<0.0001) and glycated hemoglobin HbA1c (GCK-MODY 6.9% ± 1.0%, 52 mmol/mol ± 10; controls 5.7% ± 0.4%, 39 mmol/mol ± 3; P<0.0001). The frequency of myocardial infarction and ischemic stroke did not differ between groups. …”
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The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy by Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò

“…Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis. All these features make VWF an attractive therapeutic target in thromboinflammation. …”
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Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study by Xiaopeng Guo, Jian Cao, Peijun Liu, Yihan Cao, Xiao Li, Lu Gao, Zihao Wang, Ligang Fang, Zhengyu Jin, Yining Wang, Bing Xing

“…We aimed to evaluate the frequencies of left ventricular hypertrophy (LVH), interventricular septum hypertrophy (IVSH), LV systolic dysfunction (LVSD), right ventricular systolic dysfunction (RVSD), and myocardial fibrosis (MCF) and detailed quantitative parameters in acromegaly patients using CMR and analyze their correlations with clinical features. …”
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Differential Diagnosis, Clinical Characteristics, and Interventions of Braid-Like Coronary Artery: Case Series Analysis Based on Optical Coherence Tomography by Wen-Xiu Leng, Huan-Huan Wang, Hai Ming Liu, Ying Song, Lian-Jun Xu, Jing-Jing Xu, Xue-Yan Zhao, Xiao-Yan Tan, Rong Li, Zhan Gao, Li-Jian Gao, Jue Chen, Jin-Qing Yuan, Yue-Jin Yang, Ji-Lin Chen

“…Four patients were diagnosed with an old myocardial infarction and the other 3 with unstable angina. …”
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Predictors of Unfavorable Outcomes in Patients with Atrial Fibrillation and Concomitant Heart Failure with Different Ejection Fractions: RIF-CHF Register One-Year Follow-Up by Igor Zhirov, Natalia Safronova, Yulia Osmolovskaya, Alina Alshevskaya, Andrey Moskalev, Sergey Tereshchenko

“…AF + HFpEF patients were significantly older than patients in two other groups (40.6% of patients were older than ≥75 years vs. 24.8%, respectively, p<0.001) and had the lowest rate of prior myocardial infarctions (25.3% vs. 46.1%, p<0.001) and the lowest adherence to rational therapy of HF (27.4% vs. 47.1%, p<0.001). …”
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Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study by Frans H Rutten, Hester M den Ruijter, Sander van Doorn, Dorien L Zwart, Loes T C M Wouters, Anna S M Dobbe, Laurens van der Hem, D Carmen Erkelens

“…Calls were selected based on International Classification of Primary Care codes and keywords, that is, chest pain, heart complaints, heart, myocardial infarction, heart attack, heart infarction or common abbreviations of these keywords. …”
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Risk of acute coronary syndrome and relationship with the use of khat and tobacco products in the Jazan region, Saudi Arabia: A prospective case-control study by Rashad Alsanosy, Mohamed Salih Mahfouz, Abdulelah Mohammed Arishi, Siddig Ibrahim Abdelwahab, Manal Taha, Osama Albasheer, Hasan Mohammed Daghriri, Khalid Ahmed Majrashi, Abdullah Farasani, Ahmed A. A. Altraifi, Isameldin E. Medani, Nasser Hakami

“…In the final model, tobacco use was more likely to be reported among cases with myocardial infarction (MI) (AOR=4.58; 95% CI: 1.01–4.73, p<0.05) as was khat chewing (AOR=3.4; 95% CI: 1.55–7.46, p<0.05), after controlling for other traditional risk factors. …”
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Integrating the GRACE Score with the Ceramide Risk Score Enhances the Predictive Accuracy of Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome Undergoing Percut... by Xiaofei Wang, Chengzhe Liu, Fu Yu, Zizhuo Zhang, Jiale Wang, Xiaoyu Shi, Tianyou Xu, Qiang Deng, Liping Zhou, Wanyue Sang, Hong Jiang, Lilei Yu

“…MACE was defined as the recurrence of non-fatal acute myocardial infarction, repeat coronary revascularization procedures (PCI or coronary artery bypass grafting, CABG), or death excluding the initial event qualifying the patient for the study. …”
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The prevalence of thromboembolic events among COVID-19 patients admitted to a single centre intensive care unit (ICU): an epidemiological study from a Malaysian population by Nur Farhani Mansor, Izzati Abdul Halim Zaki, Lee Chew Kiok, Eng Kar Seng, Tharmini Ravi, Mohan Pathmanathan, Khang Wen Goh, Long Chiau Ming, Pakhrur Razi, Hanis Hanum Zulkifly

“…TE event is a combination of venous [(deep vein thrombosis (DVT), pulmonary embolism (PE)] and arterial (myocardial infarction (MI), stroke) thromboembolism.Results Mean (SD) age 56.6 (13.7), 63.5% were male, 61.6% Malays, median (IQR) 7 (3–14) days of ICU stay, 64.2%, 53.2% and 20.9% had underlying hypertension, diabetes and obesity respectively. …”
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Efficacy of Intramuscular versus Intravenous Dexmedetomidine on Attenuation of Haemodynamic Responses to Laryngoscopy and Endotracheal Intubation: A Randomised Clinical Trial by Anupama Kumari, Paras Anand, Jigisha Mehta, Sara Mary Thomas

“…Introduction: Laryngoscopy and endotracheal intubation during anaesthesia administration provokes physiological stress responses like tachycardia, hypertension and can also lead to potential adverse events such as bronchospasm, myocardial ischaemia, arrythmias, cerebrovascular accidents etc. …”
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Cardioprotective effects of the electrolyte solution sterofundin and the possible underlying mechanisms by Min Chen, Min Chen, Yingying Xiao, Jijian Zheng, Peibin Zhao, Lin Cheng, Chuan Jiang, Sixie Zheng, Zheng Wang, Sijuan Sun, Lincai Ye, Lincai Ye, Guozhen Chen, Hao Zhang, Yanhui Huang

“…It provides powerful correction of acid-base imbalances, ion fluctuations, and impaired energy metabolism, which are the three most important characteristics after myocardial infarction (MI). However, whether and how SF protects the heart from post-MI damage are largely unknown.Methods and ResultsPretreating mice with SF before MI surgery reduced the number of reactive oxygen species (ROS)-positive and TUNEL-positive cells. …”
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Placement of an elastic, biohybrid patch in a model of right heart failure with pulmonary artery banding by Yasunari Hayashi, Yasunari Hayashi, Seungil Kim, Seungil Kim, Seungil Kim, Taro Fujii, Taro Fujii, Drake Dalton Pedersen, Drake Dalton Pedersen, Takahiro Ozeki, Takahiro Ozeki, Hongbin Jiang, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, Antonio D’Amore, William R. Wagner, William R. Wagner, William R. Wagner

“…In addition, von Willebrand factor expression was significantly greater in the patch group (p = 0.007).ConclusionsThe placement of a degradable, biohybrid patch onto the RV in a right ventricular failure model with fixed afterload improved myocardial output, moderated pressure stress, and was associated with reduced right ventricular fibrosis.…”
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Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders by Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz

“…In the hearts of obese mice, senolytic combination abolished myocardial maladaptation, reducing the senescence-associated secretory phenotype (SASP) and DNA damage, repressing cardiac hypertrophy, and improving diastolic dysfunction. …”
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Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional studyResearch in context by Antero Ylänen, Juhani Isojärvi, Antti Virtanen, Helena Leijon, Tiina Vesterinen, Aapo L. Aro, Heini Huhtala, Eeva Kokko, Ilkka Pörsti, Marianna Viukari, Pasi I. Nevalainen, Niina Matikainen

“…Of these, the most prevalent findings [25 (6.2%)] were aldosterone-producing adenomas (APA) or nodules (APN), which were associated with myocardial infarction and atherosclerosis at autopsy. …”
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Infection‐Related Hospitalization and Incident Heart Failure: The Atherosclerosis Risk in Communities Study by Rebecca L. Molinsky, Amil Shah, Melana Yuzefpolskaya, Bing Yu, Jeffrey R. Misialek, Bruno Bohn, David Vock, Richard MacLehose, Barry A. Borlaug, Paolo C. Colombo, Chiadi E. Ndumele, Junichi Ishigami, Kunihiro Matsushita, Pamela L. Lutsey, Ryan T. Demmer

“…Background The immune response to infections may become dysregulated and promote myocardial damage contributing to heart failure (HF). …”
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Can a mechanical circulatory support comprehensive approach to cardiogenic shock at referral centers reduce 30-day mortality? by Marina Pieri, Marina Pieri, Mario Iannaccone, Francesco Burzotta, Francesco Burzotta, Giulia Botti, Giulia Botti, Cristina Aurigemma, Carlo Trani, Carlo Trani, Silvia Ajello, Savino Altizio, Tommaso Sanna, Tommaso Sanna, Enrico Romagnoli, Lazzaro Paraggio, Luigi Cappannoli, Anna Mara Scandroglio, Alaide Chieffo, Alaide Chieffo

“…Consecutive CS patients supported by pVAD Impella (Abiomed, Danvers, MA) at two national referral centers were included. 170 patients were included: age was 65 ± 13 years, and 75.9% were male and acute myocardial infarction was the prevalent cause of shock (71.1%). …”
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Intravascular Imaging-Guided Percutaneous Coronary Intervention in Patients With End-Stage Renal Disease on Maintenance Dialysis by Chia-Pin Lin, MD, Fu-Chih Hsiao, MD, Ying-Chang Tung, MD, Tzyy-Jer Hsu, MD, Shing-Hsien Chou, MD, Yu-Sheng Lin, MD, Shao-Wei Chen, MD, PhD, Pao-Hsien Chu, MD

“…The primary outcome was composite cardiovascular outcomes, including coronary revascularization, cardiovascular death, and acute myocardial infarction. Results: In 2021, IVI was used to guide PCIs in 27% (15,613 of 57,845) of general and 27.5% (1,754 of 6,387) of ESRD patients. …”
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