Dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients with chronic coronary artery disease (CAD) - current state of knowledge and perspective... by Hubert Bochenek, Anna Bielicka, Michał Bzoma, Julia Gugulska, Irmina Czerepak, Marcin Kapij, Karolina Niewczas, Adrianna Brzozowska

“… Introduction and purpose: aa Chronic coronary artery disease (CAD) is a prevalent condition affecting millions of people worldwide, significantly reducing quality of life and increasing the risk of myocardial infarction (MI). Percutaneous coronary intervention (PCI), often combined with stent implantation, is a cornerstone of CAD treatment. …”
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The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion by Qian Chen, Elizabeth Eun Jung Kim, Katrina Elio, Christopher Zambrano, Samuel Krass, Jane Chun-wen Teng, Helen Kay, Kerry-Anne Perkins, Sailesh Pershad, Sloane McGraw, Jeffrey Emrich, Jovan S. Adams, Lindon H. Young

“…The effects of BH4 and BH2 on oxidative stress and postreperfused cardiac functions were examined in ex vivo myocardial and in vivo femoral I (20 min)/R (45 min) models. …”
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Clinical and anamnestic characteristics of patients with clinical manifestations of peripheral artery disease as a function of Т(–786)С polymorphism of the endothelial NO-synthase... by V.I. Tseluyko, L.M. Yakovleva, O.D. Yarova

“…The patients with C/C genotype had more severe course of the coronary artery disease (CAD): myocardial infarction in ІІІ group was 31.7 % (13) (vs 3.0 % (1) in І group, р = 0.005 and 7.7 % (2) in ІІ group, р = 0.045); the stable angina of ІІІ functional class was detected significantly more often in ІІІ group (29.3 % (12) vs 3 % (1), p = 0.008). …”
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A novel data augmentation tool for enhancing machine learning classification: A new application of the higher order dynamic mode decomposition for improved cardiac disease identifi... by Nourelhouda Groun, María Villalba-Orero, Lucía Casado-Martín, Enrique Lara-Pezzi, Eusebio Valero, Jesús Garicano-Mena, Soledad Le Clainche

“…The HODMD algorithm is used first as feature extraction technique for the echocardiography datasets, taken from both healthy mice and mice afflicted by different cardiac diseases (Diabetic Cardiomyopathy, Obesity, TAC Hypertrophy and Myocardial Infarction). A total number of 130 echocardiography datasets are used in this work. …”
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Effect of ticagrelor combined with metoprolol extended-release tablets on cardiac function and clinical prognosis in elderly patients with acute coronary syndrome after percutaneou... by Lili Wang, Linlin Gao, Qin Chen, Li Chen, Hui Xu, Ling Sun, Youbin Hu

“…Additionally, it effectively increases myocardial injury markers and reduces serum inflammatory factor levels.…”
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Preoperative D-dimer level predicts adverse events after coronary endarterectomy combined with coronary artery bypass grafting: a retrospective cohort study by Lianxin Chen, Xieraili Tiemuerniyazi, Ziang Yang, Liaoming He, Yifeng Nan, Yangwu Song, Wei Zhao, Wei Feng

“…The occurrence of perioperative myocardial infarction was also much higher in high DD group (3.1% vs. 11.2%, P = 0.013). …”
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Systematic Review and Meta-Analysis of Risk Factors Associated with Postoperative Stress Hyperglycemia in Patients without Diabetes Following Cardiac Surgery by Mengli Zhang, Ziyi Zhang, Ningning Zhu, Lulu Wang, Hui Huang, Yike Wang, Fang Xue

“…The results of the meta-analysis indicated that statistically significant risk factors included age >65 years [odds ratios (OR) (95% CI ) = 3.47 (2.61–4.32)], female gender [OR (95%) = 1.54 (1.34–1.76)], combined heart valve and coronary artery bypass surgery [OR (95%) = 1.82 (1.23–2.70)], ejection fraction <40% [OR (95%) = 1.38 (1.17–1.63)], history of heart surgery [OR (95%) = 1.30 (1.06–1.59)], myocardial infarction [OR (95%) = 1.17 (1.05–1.31)], hyperlipidemia [OR (95%) = 0.76 (0.67–0.86)], hypertension [OR (95%) = 1.12 (1.03–1.22)], anticoagulant medication [OR (95%) = 0.77 (0.65–0.90)], cardiopulmonary bypass time >2 hours [OR (95%) = 20.26 (17.03–23.48)] and history of cardiopulmonary bypass [OR (95%) = 1.24 (1.09–1.41)]. …”
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Impact of Arterial Remodeling of Intermediate Coronary Lesions on Long-Term Clinical Outcomes in Patients with Stable Coronary Artery Disease: An Intravascular Ultrasound Study by Liang Geng, Peizhao Du, Yuan Yuan, Liming Gao, Yunkai Wang, Jiming Li, Qi Zhang

“…The primary endpoint was the composite vessel-oriented clinical events, defined as the composition of target vessel-related cardiac death, target vessel-related myocardial infarction, and target vessel revascularization. …”
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Reattempt Percutaneous Coronary Intervention of Chronic Total Occlusions after Prior Failures: A Single-Center Analysis of Strategies and Outcomes by Mingqiang Fu, Shufu Chang, Lei Ge, Dong Huang, Kang Yao, Feng Zhang, Qing Qin, Jianying Ma, Juying Qian, Junbo Ge

“…Of the patients, 47.1% had a prior myocardial infarction and 70.4% underwent stent implantation previously, while the in-stent occlusion rate was 6.6%. …”
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Safety and efficacy of dual versus triple antithrombotic therapy (DAT vs TAT) in patients with atrial fibrillation following a PCI: a systematic review and network meta-analysis by Abdulaali R Almutairi, Renad M Altoukhi, Reema A Alshouimi, Shahad M Al Rammah, Mohammed Y Alzahrani, Abdulmajeed M Alshehri, Osamah M Alfayez, Majed S Al Yami, Omar A Almohammed

“…We aimed to compare the efficacy and safety of DAT regimens using a network meta-analysis (NMA) approach.Design A systematic review and NMA of randomised clinical trials.Methods We conducted a systematic literature review to identify relevant randomised clinical trials and performed a Bayesian NMA for International Society on Thrombosis and Haemostasis (ISTH) major or clinically relevant non-major (CRNM) bleeding, all-cause mortality, stroke, myocardial infarction (MI) and stent thrombosis outcomes. …”
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Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

“…Echocardiographic evidence of dilated cardiomyopathy of all chambers, a reduced 24% ejection fraction at absent acute myocardial infarction. Primary haemochromatosis was suspected upon high ferritin, transferrin iron saturation and multiple organ dysfunction. …”
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Epidemiological characteristics of stroke incidence from 2017 to 2022 in Songjiang District, Shanghai by SU Xuyan, WANG Yuzhuo, WU Yiling, HE Jingyi, YANG Peng, LANG Dongchen, JIANG Yonggen, ZHAO Genming, ZHENG Yang

“…ObjectiveTo investigate the prevalence of stroke in Songjiang District from 2017 to 2022, to analyze the epidemiological characteristics of stroke incidence, so as to provide a scientific basis for the formulation of stroke prevention and control policies.MethodsData of new stroke incidence from 2017 to 2022 in Songjiang District were obtained from the Shanghai Stroke and Acute Myocardial Infarction Registration and Reporting Information System. …”
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Association of β-Blocker Therapy at Discharge with Clinical Outcomes after Acute Coronary Syndrome in Patients without Heart Failure by Yan Chen, Xiao-fang Tang, Run-lin Gao, Yue-jin Yang, Bo Xu, Jin-qing Yuan

“…During a 2-year follow-up, no significant association was observed of β-blocker use with all-cause mortality (with β-blockers 47/5,043 (0.9%) vs. without β-blocker use 8/588 (1.4%); hazard ratio (HR) 0.762, 95% confidence interval 0.36 to 1.64; P=0.485), cardiac death, myocardial infarction (MI), or major adverse cardiovascular and cerebrovascular events. …”
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Elevated resting heart rate in adolescent men and risk of heart failure and cardiomyopathy by Martin Lindgren, Josefina Robertson, Martin Adiels, Maria Schaufelberger, Maria Åberg, Kjell Torén, Margda Waern, N. David Åberg, Annika Rosengren

“…These findings indicate a causal pathway between elevated RHR and myocardial dysfunction that warrants further investigation.…”
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Stemness Maintenance Properties in Human Oral Stem Cells after Long-Term Passage by Francesca Diomede, Thangavelu Soundara Rajan, Valentina Gatta, Marco D’Aurora, Ilaria Merciaro, Marco Marchisio, Aurelio Muttini, Sergio Caputi, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani

“…Neural crest-derived mesenchymal stem cells (MSCs) from human oral tissues possess immunomodulatory and regenerative properties and are emerging as a potential therapeutic tool to treat diverse diseases, such as multiple sclerosis, myocardial infarction, and connective tissue damages. …”
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Efficacy and Safety of Dual Antiplatelet Therapy in Patients Undergoing Coronary Stent Implantation: A Systematic Review and Network Meta-Analysis by Yi Xu, Yimin Shen, Delong Chen, Pengfei Zhao, Jun Jiang

“…Primary endpoints were all-cause mortality, cardiac death, myocardial infarction (MI), major bleeding, any bleeding, definite or probable stent thrombosis (ST), and net adverse clinical events (NACE). …”
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The Optimal Intervention Time of Bone Marrow Mesenchymal Stem Cells in Ameliorating Cardiac Fibrosis Induced by Viral Myocarditis: A Randomized Controlled Trial in Mice by Tingting Wu, Yuan Xie, Jing Huang, Ping Li, Xuliang Wang, Yaoyao Yan, Tianhe Xia, Lei Li, Feng Zhu, Hao Li, Rongzhou Wu

“…Bone marrow-derived mesenchymal stem cells (BMSCs) have recently been introduced to treat cardiovascular diseases, such as myocardial infarction and dilated cardiomyopathy. Nevertheless, there are few researches focused on the application of BMSCs in treating viral myocarditis, not to mention its optimal intervention timer potential mechanisms. …”
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Assessment of Birth Preparedness and Complication Readiness among Pregnant Women: A Cross-sectional Study by T Elamathi, K Ananthi, Rimi Singh

“…It has less affinity and strength of depressant effects on myocardial and Central Nervous System (CNS) vital centers in pharmacodynamic studies, along with a superior pharmacokinetic profile. …”
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Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study by Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Cristian Papara, Katja Bieber, David A. De Luca, Jan Philipp Klein, Marlene A. Ludwig, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Artem Vorobyev, Astrid Dempfle, Ralf J. Ludwig

“…Using propensity score matching (PSM) to control for age, sex, ethnicity, and other CID risk factors, we contrasted the risk of developing any or any of the 38 CIDs in 881,192 EHRs from individuals with nicotine dependence to PSM-matched unexposed counterparts.ResultsThe analytical pipeline was validated by demonstrating an increased risk of individuals exposed to nicotine dependence for subsequent diagnosis of myocardial infarction, malignant neoplasm of the lung, and chronic obstructive pulmonary disease. …”
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Bioinformatics combining machine learning and single-cell sequencing analysis to identify common mechanisms and biomarkers of rheumatoid arthritis and ischemic heart failure by Ziyi Sun, Jianguo Lin, Xiaoning Sun, Zhangjun Yun, Xiaoxiao Zhang, Siyu Xu, Jinlong Duan, Kuiwu Yao

“…One hundred and seventy-seven common differentially expressed genes (CDEGs) were identified, with enrichment analysis highlighting pathways related to sarcomere organization, ventricular myocardial tissue morphogenesis, chondrocyte differentiation, prolactin signaling, hematopoietic cell lineage, and protein methyltransferases. …”
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