Huntington’s disease modeling on HEK293 cell line by D. V. Sharipova, T. B. Malankhanova, A. A. Malakhova

“…The mutant clones were obtained earlier using CRISPR/Cas9 genome editing technology. …”
Get full text

Development of the adaptive spring bread wheat cultivar ‘Omskaya Yubileynaya’ under the conditions of the Siberian region by N. A. Popolzukhina, P. V. Popolzukhin, A. A. Gaidar, Yu. Yu. Parshutkin, N. A. Yakunina

“…A decision was taken to apply multifold individual selection in accordance with the composition of agronomic traits in the mutant × cultivar hybrid population Lutescens 3 × [F5 B1 (Mutant 777 × G7251/03) × G7251/03] × Rosinka 3 (Mutant 112 × Irtyshanka 10) with backcrossing. …”
Get full text

Genetic polymorphism of hepatitis C virus and risk of hepatocellular carcinoma by S. N. Mammayev, A. M. Karimova

“…Frequency of mutant forms of 1b genotype is related to discovery of previously unknown protein of HCV — minicor-protein with absence of N-terminal of classical Cor-protein p21.Conclusion. …”
Get full text

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus. by Antonio Jordán-Pla, Yujie Zhang, José García-Martínez, Shiladitya Chattopadhyay, Anabel Forte, Mordechai Choder, Vicent Pelechano, José E Pérez-Ortín

“…Furthermore, a principal component analysis of the genomic datasets of this mutant and other Xrn1 mutants also shows that lack of a cytoplasmic 5'→3' exoribonuclease is the primary cause of the physiological defects seen in a xrn1Δ mutant, but also suggests that Xrn1 import into the nucleus is necessary for its full in vivo functions.…”
Get full text

The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C by Yekaterina Ye. Starostina, M. V. Sokolova, L. M. Samokhodskaya, T. П. Rozina, T. N. Krasnova, Ye. B. Yarovaya, N. A. Mukhin

“…CGV patients in comparison to those with ACG had 4G mutant allele are significantly more frequent (odds ratio (OR): 4G=2,008) as well as genotypes 5G4G+4G4G (OR: 5G4G+4G4G=4,950) of the gene PAI-675 5G/4G, and in comparison to patients without CG - CC mutant genotype of the gene ITGB3 1565 T/C (р =0,047). …”
Get full text

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi. by Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze, Yongliang Lou, Michael J Lynch, Brian R Crane, Mark H Kaplan, Chunhao Li, X Frank Yang

“…In the tick vector, the mcp5 mutants survived feeding but failed to transmit to mice. …”
Get full text

Development of source material for pea breeding through chemical mutagenesis and evaluation of its genetic diversity using SSR markers by K. P. Gainullina, B. R. Kuluev, F. A. Davletov

“…Experiments were carried out to obtain pea mutants using sodium azide at the concentrations of 1, 5 and 10 mM and the exposure time of 3 and 9 h. …”
Get full text

Effectiveness of the barley cultivar ‘Bios 1’ as source material for breeding by N. A. Zhilin, I. Yu. Zaytseva, I. N. Shchennikova, S. A. Emelev

“…In Vyatka State Agricultural Academy, 190 mutant forms of barley were produced using ‘Bios 1’ as the initial form. …”
Get full text

Defining candidate drug characteristics for Long-QT (LQT3) syndrome by Aslak Tveito, Glenn T. Lines, Pan Li, Andrew McCulloch

“…Our aim is to compute the rates specifying a drug in order to: (a) restore the steady-state open probability of the mutant channel to that of normal wild type channels; and (b) minimize the difference between whole cell currents in drugged mutant and wild type cells. …”
Get full text

Epitranscriptome profiles reveal participation of the RNA methyltransferase gene OsMTA1 in rice seed germination and salt stress response by Yingbo Li, Ming Yin, Juan Wang, Xiuqin Zhao, Jianlong Xu, Wensheng Wang, Binying Fu

“…Numerous genes involved in plant growth and stress response were hypomethylated in the osmta1-1 mutant during seed germination under salt stress. …”
Get full text

A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability by Xiujuan Yang, Zhongzhi Gan, Xiaoling Guo, Xiang Huang, Juan Liu, Yingchun Zheng, Xiaoqiang Zhou, Jingli Lian, Yue Liu, Tingting Yang, Chao Li, Fenying Chen, Fei He, Xiangmin Xu, Yasi Zhou, Qian Liu, Xingkun Yang, Fu Xiong

“…Additionally, protein stability was evaluated using I-Mutant, and 3D protein structures were modeled with I-TASSER. …”
Get full text

Rare <i>Wolbachia</i> genotypes in laboratory <i>Drosophila melanogaster</i> strains by A. S. Ryabinin, O. D. Shishkina, Yu. Yu. Ilinsky, R. A. Bykov

“…In the present study, we searched for the rare Wolbachia wMelCS and wMelCS2 genotypes, as well as for new genotypes in wild-type D. melanogaster strains and in several mutant laboratory strains. The symbiont was found in all populations, in 200 out of 385 wild-type strains and in 83 out of 170 mutant strains. …”
Get full text

Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear by Peipei Li, Zongzhuang Wen, Guangkai Zhang, Aizhen Zhang, Xiaolong Fu, Jiangang Gao

“…No difference in hearing between 2-month-old Myo3a mutant mice and wild-type mice was observed. The hearing threshold of the ≥6-month-old mutant mice was significantly elevated compared with that of the wild-type mice. …”
Get full text

GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD by Žuntar Irena, Petlevski Roberta, Dodig Slavica, Popović-Grle Sanja

“…In this study, the GSTP1 mutant genotype of exon 5 (GG), as well as GSTP1 mutant and heterozygous genotypes of exon 6 (TT and CT), were suggested to be genetic contributors to COPD susceptibility. …”
Get full text

PHYSICOCHEMICAL PROPERTIES OF CULMS IN RYE (SECALE CEREALE L.) WITH A BRITTLE STEM by A. A. Konovalov, I. K. Shundrina, E. V. Karpova, V. I. Mamatyuk

“…It was found that lateral load breaks stems of mutant plants by the brittle fracture mechanism, and normal plants, by ductile fracture. …”
Get full text

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease by Patricia Gómez-Suaga, Elena Fdez, Marian Blanca Ramírez, Sabine Hilfiker

“…Apart from cytotoxicity, changes in autophagy have been consistently reported in the context of G2019S mutant LRRK2. Here, we will discuss current knowledge about mechanism(s) by which mutant LRRK2 may regulate autophagy, which highlights additional putative therapeutic targets.…”
Get full text

Strain-limited biofilm regulation through the Brg1-Rme1 circuit in Candida albicans by Min-Ju Kim, Aaron P. Mitchell

“…In the reference strain SC5314, a brg1Δ/Δ mutant has reduced levels of biofilm/filament production; a brg1Δ/Δ rme1Δ/Δ double mutant has wild-type levels of biofilm/filament production. …”
Get full text

Biofilm-associated metabolism via ERG251 in Candida albicans. by Liping Xiong, Nivea Pereira De Sa, Robert Zarnowski, Manning Y Huang, Caroline Mota Fernandes, Frederick Lanni, David R Andes, Maurizio Del Poeta, Aaron P Mitchell

“…Overexpression of ERG25 in the erg251Δ/Δ mutant causes some increase in ergosterol levels. …”
Get full text

Elucidating the potential of EGFR mutated NSCLC and identifying its multitargeted inhibitors by Anakha D. Rajeeve, Ramasamy Yamuna, P. K. Krishnan Namboori

“…Molecular docking studies revealed that the ligands curcumin (-6.9 kcal/mol) and CB[2]UN (-8.1 kcal/mol) bound more strongly to the EGFR-mutant NSCLC proteins with 2ITX and 2ITV, respectively. …”
Get full text

Potency of agricultural wastes in mushroom (Pleurotus sajor-caju) biotechnology for feeding broiler chicks (Arbor acre) by Charles Oluwaseun Adetunji, Isaac Oluseun Adejumo

“…The effect of dietary mycomeat produced from ogi production wastes based on yellow maize using wild and mutant strains of Pleurotus sajor-caju was assessed based on chickens’ growth, haematology and histology. …”
Get full text