Severe Drug-Induced Liver Injury from Combination Encorafenib/Binimetinib by Nicholas Gravbrot, Srinath Sundararajan

“…Encorafenib/binimetinib is a new combination BRAF/MEK inhibitor used in the treatment of advanced or metastatic BRAFV600-mutant melanoma. Though generally tolerated well, mild to moderate aminotransferase elevations are common. …”
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University of Florida Potato Variety Trials Spotlight: 'Atlantic' by Rodrick Z. Mwatuwa, Christian T. Christensen, Lincoln Zotarelli

“… This article introduces the potato variety, ‘Atlantic’, which was tested in trials at the University of Florida. ’Atlantic’ is a white-skinned, chipping potato commonly cultivated in Florida and resealed as a white mutant of the USDA breeding program. This 4-page fact sheet provides the general characteristics, season length and growth information, fertilization and planting instructions, as well as disease information for the potato variety, ‘Atlantic’. …”
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After-tourism revisited by Philippe Bourdeau

“…It was presented as a composite notion, intended to link together three mutant modalities of modern tourism, namely post-tourism(s), trans-tourism and hyper-tourism.This paper applies a reflexive approach to the genesis, developmental stages, reception and evolutions of this proposal. …”
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University of Florida Potato Variety Trials Spotlight: 'Atlantic' by Rodrick Z. Mwatuwa, Christian T. Christensen, Lincoln Zotarelli

“… This article introduces the potato variety, ‘Atlantic’, which was tested in trials at the University of Florida. ’Atlantic’ is a white-skinned, chipping potato commonly cultivated in Florida and resealed as a white mutant of the USDA breeding program. This 4-page fact sheet provides the general characteristics, season length and growth information, fertilization and planting instructions, as well as disease information for the potato variety, ‘Atlantic’. …”
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Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…The randomized FIRE‐4.5 (AIO KRK0116) trial compared first‐line therapy with FOLFOXIRI (folinic acid, fluorouracil, oxaliplatin, and irinotecan) plus either cetuximab or bevacizumab in B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) V600E‐mutant metastatic colorectal cancer (mCRC) patients. …”
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Enhancing the Ability of Escherichia coli to Synthesise L-Isoleucine Using λ-Red Recombinant Technology Combined with Complex Mutagenesis by Jipeng WANG, Tengteng ZHU, Lu LIU, Cheng MA, Xiaobo WEI, Huiyan LIU, Haitian FANG

“…Firstly, taking E. coli NXA as the original strain, λ-Red homologous recombination was used to knock out the coding gene brnQ of branched chain amino acid transport protein to obtain mutant strain E. coli NXA1. Secondly, E. coli NXA1 was subjected to multiple rounds of complex mutagenesis with atmospheric room temperature plasma (ARTP), ultraviolet (UV), and nitrosoguanidine (NTG), which was screened to obtain the mutant strain E. coli NXA2 with α-AB being structural analogue. …”
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Subtilisin-like protease 4 regulates cold tolerance through cell wall modification in rice by Jingyan Liu, Fei He, Zhicai Chen, Meng Liu, Yingni Xiao, Ying Wang, YuMeng Cai, Jin Du, Weiwei Jin, Xuejun Liu

“…In this study, we observed that a loss-of-function SUB4 mutant exhibited enhanced cold tolerance at the seedling stage. …”
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Magnetic resonance imaging-based deep learning for predicting subtypes of glioma by Zhen Yang, Zhen Yang, Peng Zhang, Yi Ding, Liyi Deng, Tong Zhang, Yong Liu

“…Patients were classified into IDH-wildtype (IDHwt) (490 cases), IDH-mutant/1p19q-noncodeleted (IDHmut-intact) (105 cases), and IDH-mutant/1p19q-codeleted (IDHmut-codel) (216 cases) based on their pathological findings, with the public database of patients were divided into training and validation sets, and patients from our hospital were used as an independent test set. …”
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A system of molecular markers to identify alleles of the Rht-B1 and Rht-D1 genes controlling reduced height in bread wheat by I. V. Porotnikov, O. P. Mitrofanova, O. Yu. Antonova

“…Mutant alleles of the Rht-B1 and Rht-D1 (Reduced height) genes are widely used in bread wheat breeding for the development of intensive-type cultivars. …”
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Isolation of PCSK9-specific nanobodies from synthetic libraries using a combined protein selection strategy by Apisitt Thaiprayoon, Yodpong Chantarasorn, Worrapoj Oonanant, Anongnard Kasorn, Phoomintara Longsompurana, Satita Tapaneeyakorn, Pinpunya Riangrungroj, Fabien Loison, Andrew C. Kruse, Matthew P. DeLisa, Dujduan Waraho-Zhmayev

“…This combined process enabled isolation of three unique Nb clones (NbT15, NbT21, and NbT22) that all bound specifically to a target antigen, namely proprotein convertase subtilisin/kexin type 9 (PCSK9) as well as a gain-of-function PCSK9 mutant (D374Y). All three clones bound to PCSK9 and blocked the interaction between the low-density lipoprotein receptor (LDLR) and either wild-type PCSK9 or the D374Y mutant. …”
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Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families in Aspergillus niger highlighting the versatility of the fu... by Katharina J. Ost, Mark Arentshorst, Bruno M. Moerschbacher, Mareike E. Dirks-Hofmeister, Arthur F.J. Ram

“…The 12-fold deletion mutant was viable and did not exhibit growth defects under non-stressing growth conditions. …”
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Receptor-like Kinase GOM1 Regulates Glume-Opening in Rice by Xinhui Zhao, Mengyi Wei, Qianying Tang, Lei Tang, Jun Fu, Kai Wang, Yanbiao Zhou, Yuanzhu Yang

“…In this study, we report the isolation and functional characterization of a glum-opening mutant after anthesis, named <i>gom1</i>. <i>gom1</i> exhibits dysfunctional lodicules that lead to open glumes following anthesis. …”
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Effect of RAS mutations and related immune characteristics on the prognosis of patients with MSI-H/dMMR colorectal cancer by Yupeng Jiang, Yuyao Liu, Hong Huang, Tiantian Zhao, Zengyi Zhao, Yawen Gao

“…Results RAS-mutant MSI-H colorectal patients were more likely to have: (1) higher platelet values; (2) shorter disease-free survival (DFS); (3) lower infiltrated numbers of CD11c+ dendritic cells, CD4+ T lymphocytes, and CD8+ T lymphocytes, and higher infiltrated numbers of Foxp3+ Treg cells. …”
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<i>Weizmannia coagulans</i> BC99 Attenuates Oxidative Stress Induced by Acute Alcoholic Liver Injury via Nrf2/SKN-1 Pathway and Liver Metabolism Regulation by Ying Wu, Cheng Li, Yinyin Gao, Jie Zhang, Yao Dong, Lina Zhao, Yuwan Li, Shaobin Gu

“…The protective effects of BC99 were markedly diminished in the <i>skn-1</i> mutant (GR2245) and <i>daf-16</i> mutant (CF1038), further confirming the pivotal roles of SKN-1 and DAF-16 pathways in BC99-mediated antioxidant protection. …”
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A Systematic Review of the Prevalence and Diagnostic Workup of PIK3CA Mutations in HR+/HER2– Metastatic Breast Cancer by Elizabeth J. Anderson, Lea E. Mollon, Joni L. Dean, Terri L. Warholak, Ayal Aizer, Emma A. Platt, Derek H. Tang, Lisa E. Davis

“…Given the clinical benefit of the PI3Ki alpelisib in patients with PIK3CA mutant HR+/HER2– mBC, determination of tumor PIK3CA mutation status is of importance in managing patients with HR+/HER2– mBC. …”
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Polymorphism of renin — angiotensin system genes in progression of liver fibrosis in patients with chronic hepatitis C by O. V. Taratina, T. N. Krasnova, L. M. Samokhodskaya, T. N. Lopatkina, V. A. Tkachuk, N. A. Mukhin

“…No significant differences between groups in distribution of alternative alleles and genotypes of ATR1 gene on A1166C locus have been revealed.Conclusion. Carriage of mutant alleles of angiotensinogen gene on any of loci (G-6A or M235T) is the factor predicting more rapid progression of disease. …”
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p18 encoded by FgGMTV1 is responsible for asymptomatic infection in Fusarium graminearum by Lihang Zhang, Pengfei Li, Yanfei Wang, Shuangchao Wang, Lihua Guo

“…Furthermore, the p18 null mutant virus converts F. graminearum from virulent to hypovirulent strains on wheat leaves after horizontal transmission. …”
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Co-occurrence of direct and indirect extracellular electron transfer mechanisms during electroactive respiration in a dissimilatory sulfate reducing bacterium by Liyuan Hou, Rebecca Cortez, Michael Hagerman, Zhiqiang Hu, Erica L.-W. Majumder

“…The mutant with a deficiency in biofilm formation, however, did not eliminate current production indicating the existence of indirect extracellular electron transfer. …”
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Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations by Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb

“…However, a detailed analysis of basal/constitutive activity also revealed a gain-of-function phenotype for mutant M345R. For a more comprehensive investigation of heterotrimeric G-protein complex signaling, we investigated the impact of WT mutants in combination with (i) a specifically suggested assay, and (ii) the most abundantly expressed heterotrimeric G-protein complex combinations in WT receptor-enriched regions. …”
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The regulatory effects of (p)ppGpp and indole on cAMP synthesis in <i>Escherichia coli</i> cells by N. M. Kashevarova, E. A. Khaova, A. G. Tkachenko

“…At the same time, the (p)ppGpp0 mutant showed a decrease in maximum cAMP levels compared to the (p)ppGpp+ parent, which was the most pronounced in the medium with 22.2 mM glucose. …”
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