Synergistic effects of mutation and glycosylation on disease progression by Shodai Suzuki, Motoyuki Itoh, Motoyuki Itoh, Motoyuki Itoh

“…We highlight the synergistic contributions of missense amino acids in the mutant proteins and alterations in their glycosylation states to their molecular pathogenesis.…”
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Genetic Factors in Animal Models of Intestinal Inflammation by R Balfour Sartor

“…The dominant role of genetic background in induction of intestinal inflammation is further documented by spontaneous colitis which develops in spontaneously mutant mice, cotton-top tamarins, human leukocyte antigen-B27/ β2 microglobulin transgenic rats and mice with targeted deletions of certain immunoregulatory cytokine and T lymphocyte genes. …”
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University of Florida Potato Variety Trials Spotlight: Atlantic by Mario H. M. L. Andrade, Rodrick Z. Mwatuwa, Christian T. Christensen, Lincoln Zotarelli

“…The cultivar was released as a white mutant of the USDA breeding program. It was selected from a cross of Wauseon and Lenape (UDSA seedling B5141-6). …”
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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…An attenuated genotype I ASFV was constructed by replacing the wild-type EP402R gene for a mutant form expressing CD2v bearing a single amino acid substitution, which abrogated the binding to erythrocytes. …”
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Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…Surface expression assays demonstrated an elevated surface/total ratio of the mutant GluN2C, correlating with the increased NMDAR current. …”
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Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequences by Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao

“…Therefore, the remodeled PRRSV TRS mutant generated in this study can serve as a recombination-resistant platform for the rational design of safe PRRS vaccines in the future.…”
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Peningkatan akumulasi tiamin pada kultur Escherichia coli melalui peningkatan oksigenasi dan penghilangan rpoS by Nuraliah Rusman, Prayoga Suryadarma, Nisa Rachmania Mubarik

“…The investigation was conducted by comparing the cultivation of  Escherichia coli BW25113 (parent strain) and BW25113-∆rpoS (rpoS mutant) cultures under aerobic conditions at different shaking rotation rates of 150 and 200 rpm. …”
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RhoA Regulation of Cardiomyocyte Differentiation by Mari Kaarbø, Denis I. Crane, Wayne G. Murrell

“…Overexpression of a dominant negative mutant of mouse RhoA (mRhoAN19) blocked this cardiomyocyte differentiation of P19CL6 cells and led to the accumulation of the cardiac transcription factors SRF and GATA4 and the early cardiac marker cardiac α-actin. …”
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Intratumor heterogeneity in KRAS signaling shapes treatment resistance by Oleksi Petrenko, Varvara Kirillov, Stephen D'Amico, Nancy C. Reich

“…Selective targeting of mutant KRAS suppresses the growth of tumor cells with high RAS/mitogen-activated protein kinase (MAPK) activity while sparing pre-existing subsets with low RAS signaling activity, necessitating alternative treatments. …”
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Streptokinase is dispensable in Streptococcus dysgalactiae subspecies equisimilis infections of human dendritic cells by Katharina E. Folz, Nikolai Siemens

“…MoDCs were infected with SDSE strain S118 and its isogenic mutant lacking streptokinase. All infections were performed with and without human serum to compare direct Ska-mediated as well as plasmin activity-related effects. …”
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Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels by Tuba Günebak Şahin, Berkan Sayal, Erdal Coşgun, Tanju Besler, Sinan Beksaç

“…RESULTS: Both folic acid and vitamin B12 are significantly important and effective factors in homocysteine metabolism in MTHFR mutant subjects. CONCLUSION: Folic acid is a much more important mass measure for controlling elevation of plasma homocysteine concentration. …”
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Genetic bases of compact forms among cucurbit crops by A. V. Inozemtseva, A. G. Elatskova, E. K. Khlestkina, N. A. Shvachko

“…The review includes examples of mutant compact phenotypes and their associated genes in representatives of the Cucurbitaceae family, such as Cucurbita maxima Duch., Cucurbita pepo L., Cucurbita moschata Duch., Citrullus lanatus (Thunb.) …”
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Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas by Michaela Aubele, Martin Werner, Heinz Höfler

“…Using immuno‐histochemistry overexpression of the c‐erbB‐2 oncogene was found in ductal carcinoma in situ(DCIS), but not in atypical intraductal hyperplasia (AIDH) and intraductal hyperplasia (IDH). An expression of mutant p53 tumor suppressor gene as well as expression of cyclin D1 was identified in DCIS. …”
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Maffesoli e a "investigação do sentido" - das identidades às identificações by Eduardo Portanova Barros

“…If we were able to have a delineated profile, a safe profession, a life project before, that no longer happens. Now, profiles are mutant, professions (almost) do not exist, projects are occasional and the future, uncertain. …”
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Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster by Herbert Izo, Ninsiima, Emmanuel Tiyo, Ayikobua, Josephine, Kasolo, Keneth Iceland, Kasozi, Ejike, Daniel Eze

“…Background: The Phosphatase and tensin-induced putative kinase 1 (PINK1B9) mutant for Drosophila melanogaster is a key tool that has been used in assessing the pathology of Parkinsonism and its possible remedy. …”
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CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Victoria Jennings, Kevin Harrington, Hardev Pandha, Alan Melcher, Adel Samson, Fiona Errington-Mais, Victoria Roulstone, Eva Crespo-Rodriguez, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Martin McLaughlin, Malin Pedersen, Richard Vile, Joan Kyula, Jehanne Hassan, Lizzie Appleton, Charleen ML Chan Wah Hak, Gabby Baker, Edward Armstrong, Matthew Chiu, Masahiro Ono

“…Background Combination herpes simplex virus (HSV) oncolytic virotherapy and BRAF inhibitors (BRAFi) represent promising immunogenic treatments for BRAF mutant melanoma, but an improved understanding of the immunobiology of combinations is needed to improve on the benefit of immune checkpoint inhibitors (ICI).Methods Using a BRAFV600E-driven murine melanoma model, we tested the immunogenicity of HSV/BRAFi in immunocompetent C57BL mice. …”
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Comparative genomics analysis of the reason for 12C6+ heavy-ion irradiation in improving Fe3O4 nanoparticle yield of Acidithiobacillus ferrooxidans by Jiani Yang, Shuang Zhang, Lirong Geng, Dan Zhao, Siyu Xing, Xinyue Ji, Lei Yan

“…Herein, we employed a 12C6+ heavy-ion beam to induce mutagenesis of A. ferrooxidans BYM and successfully screened a mutant BYMT-200 with a 1.36 mg/L Fe3O4 nanoparticle yield, which could stably inherit over many generations based on assessing cell magnetism and Fe3O4 nanoparticle synthesis. …”
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Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity by Yaqin Yuan, Wenqing Ning, Junjie Chen, Jiquan Li, Tianqi Xue, Cuihong An, Lingling Mao, Guangzhi Zhang, Shizhong Zhou, Jiabo Ding, Xiaowen Yang, Jianqiang Ye

“…Here, this study identified the deletion of serine/threonine protein kinase (STPK) gene in B. melitensis as an efficient trigger for rifampicin resistance using bioinformatics predictions, a transposon mutant library, and gene mutation strains. Notably, the absence of the STPK could increase the expression of ribosomal proteins and genes involved in sulfur metabolism and reduced glutathione, and decrease NADPH oxidase activity and NADP+/NADPH ratio, which is associated with the antioxidant capacity of B. melitensis. …”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…MutCMs were generated from 10 donors using GNAQ Q209L -carried lentivirus with high mutant copies (up to 98.8% of total GNAQ copies being mutant). …”
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Spatial stochastic models of cancer: Fitness, migration, invasion by Natalia L. Komarova

“…We show that migration has a directpositive impact on the ability of a single mutant cell to invade apre-existing colony. Thus, a decrease in the reproductive potentialcan be compensated by an increase in cell migration. …”
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