Toll-Like Receptor 4 in Bone Marrow-Derived Cells Contributes to the Progression of Diabetic Retinopathy by Hui Wang, Haojun Shi, Jing Zhang, Guoliang Wang, Jinxiang Zhang, Fagang Jiang, Qing Xiao

“…Grafting bone marrow-derived cells from TLR4 WT mice into TLR4 mutant mice increased the levels of TNF-α, IL-1β, and MIP-2 and increased the damage to the retina. …”
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The impact of the Hsp67Bc gene product on Drosophila melanogaster longevity, fecundity, and acute heat stress tolerance by D. Malkeyeva, S. A. Fedorova, E. Kiseleva

“…At the same time, the fecundity of the mutant females was lower by 6–13 % in all tested environments, except for permanent maintenance at 29 °C, where the mean numbers of eggs laid by the mutant and control f lies were equal. …”
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Exploration of different quantitative polymerase chain reaction-based genotyping methods to distinguish Apcmin/+ mice from wildtype mice. by Yuting Sun, Tingyu Zhou, Silin Ye, Effie Yin Tung Lau, Yao Zeng, Jessie Qiaoyi Liang

“…Dual-probe qPCR assays were developed to simultaneously detect mutant and wildtype alleles using differently labelled probes. …”
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The unique activity of the bone morphogenetic protein TGH4 affects the embryonic development of Trichinella spiralis and the establishment of vaccine protection by Wenjie Shi, Yi Liu, Yan Liu, Xue Bai, Yue Liang, Yaming Yang, Fangwei Wu, Mingyuan Liu, Ning Xu

“…Our findings demonstrate that the TGH4 mutant is an important vaccine candidate antigen that blocks embryonic development, kills larvae, and provides insight into parasite vaccine research.…”
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SSR loci potentially associated with high amylopectine content in maize kernel endosperm by S. I. Vakula, O. A. Orlovskaya, L. V. Khotyleva, A. V. Kilchevsky

“…Plant material used were 33 samples of corn kernels including mutant forms with a high content of amylose, amylopectin, short-chain starches, were kindly provided by VIR genetic collection (Russian Federation) and Maize Genetics Cooperation Stock Center (USA). …”
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Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. by Hildegard Nikki Hall, Hemant Bengani, Robert B Hufnagel, Giuseppe Damante, Morad Ansari, Joseph A Marsh, Graeme R Grimes, Alex von Kriegsheim, David Moore, Lisa McKie, Jamalia Rahmat, Catia Mio, Moira Blyth, Wee Teik Keng, Lily Islam, Meriel McEntargart, Marcel M Mannens, Veronica Van Heyningen, Joe Rainger, Brian P Brooks, David R FitzPatrick

“…Induced expression of GFP-tagged wildtype and mutant MAB21L1 in human cells caused only modest transcriptional changes. …”
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Somatic Mitochondrial DNA Point Mutations Used as Biomarkers to Demonstrate Genomic Heterogeneity in Primary Prostate Cancer by Christian Arstad, Kristin Taskén, Paulo Refinetti, Ulrika Axcrona, Karl-Erik Giercksky, Per Olaf Ekstrøm

“…The spots demonstrated a wide range of mutant fractions from 0 to 100% mutant copies. The mitochondrial DNA copy number in the samples was determined by real-time PCR. …”
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Cell–cell heterogeneity in phosphoenolpyruvate carboxylase biases early cell fate priming in Dictyostelium discoideum by Kenichi Abe, Hidenori Hashimura, Haruka Hiraoka, Shoko Fujishiro, Narufumi Kameya, Kazuteru Taoka, Satoshi Kuwana, Masashi Fukuzawa, Satoshi Sawai, Satoshi Sawai, Satoshi Sawai

“…Furthermore, the PEPC null mutant had high ATP levels and low mitochondrial membrane potential. …”
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The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii by Daniela Scribano, Martina Pasqua, Dolores Limongi, Lucia Nencioni, Anna Teresa Palamara, Cecilia Ambrosi

“…Methods An isogenic site-specific hslJ mutant of A. baumannii AB5075 was used to evaluate its sensitivity to H2O2, survival rate in human macrophages, biofilm, cell surface hydrophobicity, and motility. …”
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Improving Geldanamycin Production in <i>Streptomyces geldanamycininus</i> Through UV Mutagenesis of Protoplast by Yuan Yuan, Lu Yang, Zhikai Fang, Haimin Chen, Fei Sun, Hong Jiang, Jian Zhou

“…Multi-omic analysis revealed that the high-yielding geldanamycin in mutant strain 53 could upregulate <i>GdmG</i> and <i>GdmX</i> by 1.59 and 2.38 times in the ansamycin synthesis pathway, and downregulate <i>pks12</i>, <i>pikAI</i>, and <i>pikAII</i> by 0.25, 0.37, and 0.48 times in the fatty acid synthesis pathway, which was crucial for geldanamycin production. …”
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E46K α-Synuclein Mutation Fails to Promote Neurite Outgrowth by Not Inducing Cdc42EP2 Expression, Unlike Wild-Type or A53T α-Synuclein in SK-N-SH Cells by Hyunja Jung, Seonghan Kim

“…Methods: We transfected SK-N-SH cells with WT and mutant (A53T and E46K) α-syn to investigate the effects of their overexpression on neurite outgrowth. …”
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The Relevance of CD117-Immunocytochemistry Staining Patterns to Mutational Exon-11 in c-kit Detected by PCR from Fine-Needle Aspirated Canine Mast Cell Tumor Cells by A. Sailasuta, D. Ketpun, P. Piyaviriyakul, S. Theerawatanasirikul, P. Theewasutrakul, A. Rungsipipat

“…Only paranuclear pattern was significantly increased in the cells from high-grade MCT. Altogether, the ITD-mutant exon-11 was also detectable only in these cells. …”
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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…A sensitive and specific bioanalytical method was required to measure the exposure of a LAGA-mutated surrogate mouse IgG2a monoclonal antibody in mouse plasma, but the lack of highly specific reagents for the LAGA mutant hindered the development of a ligand-binding assay. …”
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Severe Drug-Induced Liver Injury from Combination Encorafenib/Binimetinib by Nicholas Gravbrot, Srinath Sundararajan

“…Encorafenib/binimetinib is a new combination BRAF/MEK inhibitor used in the treatment of advanced or metastatic BRAFV600-mutant melanoma. Though generally tolerated well, mild to moderate aminotransferase elevations are common. …”
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University of Florida Potato Variety Trials Spotlight: 'Atlantic' by Rodrick Z. Mwatuwa, Christian T. Christensen, Lincoln Zotarelli

“… This article introduces the potato variety, ‘Atlantic’, which was tested in trials at the University of Florida. ’Atlantic’ is a white-skinned, chipping potato commonly cultivated in Florida and resealed as a white mutant of the USDA breeding program. This 4-page fact sheet provides the general characteristics, season length and growth information, fertilization and planting instructions, as well as disease information for the potato variety, ‘Atlantic’. …”
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After-tourism revisited by Philippe Bourdeau

“…It was presented as a composite notion, intended to link together three mutant modalities of modern tourism, namely post-tourism(s), trans-tourism and hyper-tourism.This paper applies a reflexive approach to the genesis, developmental stages, reception and evolutions of this proposal. …”
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University of Florida Potato Variety Trials Spotlight: 'Atlantic' by Rodrick Z. Mwatuwa, Christian T. Christensen, Lincoln Zotarelli

“… This article introduces the potato variety, ‘Atlantic’, which was tested in trials at the University of Florida. ’Atlantic’ is a white-skinned, chipping potato commonly cultivated in Florida and resealed as a white mutant of the USDA breeding program. This 4-page fact sheet provides the general characteristics, season length and growth information, fertilization and planting instructions, as well as disease information for the potato variety, ‘Atlantic’. …”
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Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…The randomized FIRE‐4.5 (AIO KRK0116) trial compared first‐line therapy with FOLFOXIRI (folinic acid, fluorouracil, oxaliplatin, and irinotecan) plus either cetuximab or bevacizumab in B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) V600E‐mutant metastatic colorectal cancer (mCRC) patients. …”
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Magnetic resonance imaging-based deep learning for predicting subtypes of glioma by Zhen Yang, Zhen Yang, Peng Zhang, Yi Ding, Liyi Deng, Tong Zhang, Yong Liu

“…Patients were classified into IDH-wildtype (IDHwt) (490 cases), IDH-mutant/1p19q-noncodeleted (IDHmut-intact) (105 cases), and IDH-mutant/1p19q-codeleted (IDHmut-codel) (216 cases) based on their pathological findings, with the public database of patients were divided into training and validation sets, and patients from our hospital were used as an independent test set. …”
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A system of molecular markers to identify alleles of the Rht-B1 and Rht-D1 genes controlling reduced height in bread wheat by I. V. Porotnikov, O. P. Mitrofanova, O. Yu. Antonova

“…Mutant alleles of the Rht-B1 and Rht-D1 (Reduced height) genes are widely used in bread wheat breeding for the development of intensive-type cultivars. …”
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