OsWRKY26 negatively regulates bacterial blight resistance by suppressing OsXa39 expression by Win Tun, Kieu Thi Xuan Vo, Behnam Derakhshani, Jinmi Yoon, Lae-Hyeon Cho, Kay Tha Ye Soe Win, Sang-Won Lee, Ki-Hong Jung, Jong-Seong Jeon, Gynheung An

“…Transcriptomic analysis of mutant and WT plants revealed that several pathogen resistance genes were upregulated in mutants. …”
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Biophysical modeling and experimental analysis of the dynamics of C. elegans body-wall muscle cells. by Xuexing Du, Jennifer Crodelle, Victor James Barranca, Songting Li, Yunzhu Shi, Shangbang Gao, Douglas Zhou

“…Specifically, by conducting voltage clamp and mutant experiments, we identify key ion channels, particularly the L-type voltage-gated calcium channel (EGL-19) and potassium channels (SHK-1, SLO-2), which are crucial for generating action potentials. …”
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Dynamics of Positive Frequency Dependent Selection Triggers Selection for Silence by I. Hashem, V. De Buck, J. Van Impe

“…The model results show that the longer the silence interval of the new mutant before its expression, the better its chances of getting fixed in the population. …”
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Rational Design for Improving the Thermostability of Saccharomyces cerevisiae Nicotinamide Riboside Kinase 1 by WANG Yao, SHEN Taisong, LI Sichen, SHI Hongling, YAO Lunguang, TANG Cunduo

“…Out of these, three superior mutants were selected for a second round of combined mutagenesis. …”
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Normalization of Deviant Behavior in Muc2+/+ Mice through Dietary Incorporation of Bacillus subtilis Spores by Maryana Morozova, Alexander Alekseev, Arsalan Saeidi, Ekaterina Litvinova

“…In contrast to Muc2-/-, the wild type mice (Muc2+/+) have normal gut barrier function, but the intestinal microbiota and behavior are similar to their mutant siblings Muc2-/- mice. Similar to the mutant sibling, Muc2+/+mice exhibit greater locomotor activity in the open field and light-dark tests, as well as decreased anxiety in the open field test, light-dark test, and marble burying tests. …”
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DELLA MUTATIONS IN PLANTS WITH SPECIAL EMPHASIS ON WHEAT by G. A. Chebotar, S. V. Chebotar, Yu. M. Sivolap

“…It is shown that the mutant Rht-D1b allele is the commonest dwarfing allele among those tested in Ukrainian wheat cultivars (68 %), but its distribution over Ukraine is not random.…”
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Study of morphology with assessment of expression of proliferation marker Ki67 antigen and P53 protein in lesions of gall bladder by Ojasvi Ramesh, Mamta Gupta, Sanjay Kaushik, Seema Acharya, Brijesh Thakur, Aparna Bhardwaj

“…In the group of 20 gall bladder carcinoma cases, 65% were p53 mutant and the remaining 35% cases had a p53 wild-type immunophenotype. 55% cases showed high expression for ki67 labeling. …”
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Genotoxicity of Copper and Nickel Nanoparticles in Somatic Cells of Drosophila melanogaster by Erico R. Carmona, Alba García-Rodríguez, Ricard Marcos

“…However, when Ni-NPs and Ni-MPs were evaluated, a significant increase of small single spots and total mutant spots was observed only for Ni-NPs (P<0.05) at the highest dose assessed. …”
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Accurate assembly of full-length consensus for viral quasispecies by Jia Tian, Ziyu Gao, Minghao Li, Ergude Bao, Jin Zhao

“…Abstract Background Viruses can inhabit their hosts in the form of an ensemble of various mutant strains. Reconstructing a robust consensus representation for these diverse mutant strains is essential for recognizing the genetic variations among strains and delving into aspects like virulence, pathogenesis, and selecting therapies. …”
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Drosophila Torsin Protein Regulates Motor Control and Stress Sensitivity and Forms a Complex with Fragile-X Mental Retardation Protein by Phuong Nguyen, Jong Bok Seo, Hyo-Min Ahn, Young Ho Koh

“…Altered expression of ADH has also been reported in Drosophila Fragile-X mental retardation protein (DFMRP) mutant flies. Interestingly, expression of DFMRP was altered in DTor mutant flies, and DTor and DFMRP were present in the same protein complexes. …”
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Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants by Rodrigo Ribeiro, Rayanne Melo, Pedro Tortamano Neto, André Vajgel, Paulo Roberto Eleutério Souza, Renata Cimões

“…The implant success rate in this population was 34.4%. The mutant allele (G) in RANKL had an incidence of 52.3% and mutant allele (A) in IL-10 was observed in 37.8%. …”
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Developmental defects in ectodermal appendages caused by missense mutation in edaradd gene in the nfr mangrove killifish kryptolebias marmoratus by Hussein A. Saud, Paul A. O’Neill, Brian C. Ring, Tetsuhiro Kudoh

“…From an ENU-mutated mangrove killifish line R228, we have isolated a novel mutant line, no-fin-ray/nfr in which homozygous mutant of adult fish fin ray development is largely reduced. …”
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Exploring the potential role of EPSPS mutations for enhanced glyphosate resistance in Nicotiana tabacum by Bingjie Li, Bingjie Li, Chen Chen, Chen Chen, Mengmeng Cui, Yuhe Sun, Jing Lv, Changbo Dai

“…In this study, we engineered two mutant variants of the tobacco EPSPS gene through amino acid substitution (TIPS-NtEPSPS and P180S-NtEPSPS). …”
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Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations by Ekaterina Bezpalaya, Svetlana Kurilova, Nataliya Vorobyeva, Elena Rodina

“…Based on the comparison of the wild-type and mutant PPases dynamics, we suggest the possible molecular mechanisms of the functional incompetence of hPPA2 caused by mutations. …”
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Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. by Larissa B Patterson, David M Parichy

“…Yet, we found that rescue of melanophores and xanthophores was insufficient for the recovery of stripes in the bnc2 mutant. We therefore asked whether bnc2-dependent iridophores might contribute to stripe and interstripe patterning as well. …”
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SCO6564, a novel 3-ketoacyl acyl carrier protein synthase III, contributes in fatty acid synthesis in Streptomyces coelicolor. by Jian-Rong Ma, Jia-Ying Lin, Yuan-Yin Zhang, Yun Chen, Wen-Bing Zhang, Xian-Pu Ni, Yong-Hong Yu

“…The expression of fabH2 restored the growth of Ralstonia solanacearum fabH mutant and made the mutant produce small amounts of branched-chain fatty acids. …”
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Nephrogenic Syndrome of Inappropriate Antidiuresis by D. Morin, J. Tenenbaum, B. Ranchin, T. Durroux

“…Mutations in the vasopressin V2 receptor gene are responsible for two human tubular disorders: X-linked congenital nephrogenic diabetes insipidus, due to a loss of function of the mutant V2 receptor, and the nephrogenic syndrome of inappropriate antidiuresis, due to a constitutive activation of the mutant V2 receptor. …”
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Allelic variants for Waxy genes in common wheat lines bred at the Lukyanenko National Grain Center by E. R. Davoyan, L. A. Bespalova, R. O. Davoyan, E. V. Agaeva, G. I. Bukreeva, Yu. S. Zubanova, D. S. Mikov, D. M. Boldakov

“…Lukyanenko, by crossing mutant forms carrying inactive (null) alleles of genes Wx-A1, Wx-B1, and Wx-D1 with bread wheat cultivars. …”
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Development of new powdery mildew resistant lines in garden pea (Pisum sativum L.) using induced mutagenesis and validation of resistance for the er1 and er2 gene through molecular... by Akhilesh Sharma, Devinder Kumar Banyal, Vinod Janardan Dhole, Bansuli, Ranbir Singh Rana, Rajesh Kumar, Prabhat Kumar, Nimit Kumar, Srishti, Arshia Prashar, Vivek Singh, Anoushka Sharma

“…SSR markers “PSMPSAD60 d” and “PSMPA5 c” linked to the er-1 gene indicated the presence of the “er1” gene in the mutant L-0.3-139 while the er-2 gene-linked SCAR marker “ScX171400” and SSR marker “AD141” indicated the probability of the “er-2” gene in mutant L-40-1014. …”
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Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells by Rati Lama, Joseph M. Fose, Diana Martín, Inés G. Muñoz, Eunice S. Wang, Pamela J. Sung, Sherry R. Chemler, Xinjiang Wang

“…However, these inhibitors are not designed to work for p53-null/mutant cancer cells. Owing to the importance of the E3 ligase of MDM2 in its p53-independent oncogenic activity, inhibitors targeting the E3 ligase activity of MDM2-MDM4 are desirable for p53-mutant cancer cells. …”
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