Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus. by Antonio Jordán-Pla, Yujie Zhang, José García-Martínez, Shiladitya Chattopadhyay, Anabel Forte, Mordechai Choder, Vicent Pelechano, José E Pérez-Ortín

“…Furthermore, a principal component analysis of the genomic datasets of this mutant and other Xrn1 mutants also shows that lack of a cytoplasmic 5'→3' exoribonuclease is the primary cause of the physiological defects seen in a xrn1Δ mutant, but also suggests that Xrn1 import into the nucleus is necessary for its full in vivo functions.…”
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The clinical role of blood coagulation and platelet receptors gene allelic variants in development of cryoglobulinemic vasculitis at chronic hepatitis C by Yekaterina Ye. Starostina, M. V. Sokolova, L. M. Samokhodskaya, T. П. Rozina, T. N. Krasnova, Ye. B. Yarovaya, N. A. Mukhin

“…CGV patients in comparison to those with ACG had 4G mutant allele are significantly more frequent (odds ratio (OR): 4G=2,008) as well as genotypes 5G4G+4G4G (OR: 5G4G+4G4G=4,950) of the gene PAI-675 5G/4G, and in comparison to patients without CG - CC mutant genotype of the gene ITGB3 1565 T/C (р =0,047). …”
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MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi. by Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze, Yongliang Lou, Michael J Lynch, Brian R Crane, Mark H Kaplan, Chunhao Li, X Frank Yang

“…In the tick vector, the mcp5 mutants survived feeding but failed to transmit to mice. …”
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Development of source material for pea breeding through chemical mutagenesis and evaluation of its genetic diversity using SSR markers by K. P. Gainullina, B. R. Kuluev, F. A. Davletov

“…Experiments were carried out to obtain pea mutants using sodium azide at the concentrations of 1, 5 and 10 mM and the exposure time of 3 and 9 h. …”
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Effectiveness of the barley cultivar ‘Bios 1’ as source material for breeding by N. A. Zhilin, I. Yu. Zaytseva, I. N. Shchennikova, S. A. Emelev

“…In Vyatka State Agricultural Academy, 190 mutant forms of barley were produced using ‘Bios 1’ as the initial form. …”
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Defining candidate drug characteristics for Long-QT (LQT3) syndrome by Aslak Tveito, Glenn T. Lines, Pan Li, Andrew McCulloch

“…Our aim is to compute the rates specifying a drug in order to: (a) restore the steady-state open probability of the mutant channel to that of normal wild type channels; and (b) minimize the difference between whole cell currents in drugged mutant and wild type cells. …”
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Epitranscriptome profiles reveal participation of the RNA methyltransferase gene OsMTA1 in rice seed germination and salt stress response by Yingbo Li, Ming Yin, Juan Wang, Xiuqin Zhao, Jianlong Xu, Wensheng Wang, Binying Fu

“…Numerous genes involved in plant growth and stress response were hypomethylated in the osmta1-1 mutant during seed germination under salt stress. …”
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A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability by Xiujuan Yang, Zhongzhi Gan, Xiaoling Guo, Xiang Huang, Juan Liu, Yingchun Zheng, Xiaoqiang Zhou, Jingli Lian, Yue Liu, Tingting Yang, Chao Li, Fenying Chen, Fei He, Xiangmin Xu, Yasi Zhou, Qian Liu, Xingkun Yang, Fu Xiong

“…Additionally, protein stability was evaluated using I-Mutant, and 3D protein structures were modeled with I-TASSER. …”
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Rare <i>Wolbachia</i> genotypes in laboratory <i>Drosophila melanogaster</i> strains by A. S. Ryabinin, O. D. Shishkina, Yu. Yu. Ilinsky, R. A. Bykov

“…In the present study, we searched for the rare Wolbachia wMelCS and wMelCS2 genotypes, as well as for new genotypes in wild-type D. melanogaster strains and in several mutant laboratory strains. The symbiont was found in all populations, in 200 out of 385 wild-type strains and in 83 out of 170 mutant strains. …”
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Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates by Léna Mazza, Léna Mazza, Alexandre Bory, Alexandre Bory, Alexandre Luscher, Alexandre Luscher, Joachim Kloehn, Jean-Luc Wolfender, Jean-Luc Wolfender, Christian van Delden, Christian van Delden, Thilo Köhler, Thilo Köhler

“…We constructed a PA14 mutant, genetically deleted in the major multidrug efflux pumps MexAB-OprM, MexCD-OprJ, MexXY-OprM, and MexEF-OprN and expressed in this mutant each efflux pump individually from an inducible promoter. …”
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Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear by Peipei Li, Zongzhuang Wen, Guangkai Zhang, Aizhen Zhang, Xiaolong Fu, Jiangang Gao

“…No difference in hearing between 2-month-old Myo3a mutant mice and wild-type mice was observed. The hearing threshold of the ≥6-month-old mutant mice was significantly elevated compared with that of the wild-type mice. …”
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ABIOTIC STRESS RESPONSE-ASSOCIATED PROTEINS IN A SALT TOLERANT STRAIN OF THE CYANOBACTERIUM FREMYELLA DIPLOSIPHON: A POTENTIAL BIOFUEL AGENT by Behnam TABATABAI, Viji SITTHER

“…Results of our study indicate that TRAP transporter solute receptor likely assists in enhancing halotolerance of the mutant, while elongation factor Tu is up-regulated in response to heat shock. …”
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GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD by Žuntar Irena, Petlevski Roberta, Dodig Slavica, Popović-Grle Sanja

“…In this study, the GSTP1 mutant genotype of exon 5 (GG), as well as GSTP1 mutant and heterozygous genotypes of exon 6 (TT and CT), were suggested to be genetic contributors to COPD susceptibility. …”
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Mobilisations collectives et femmes immigrées en France by Sylvie Thiéblemont-Dollet

“…On the other hand, this article brings out the specifications of their words according to where and when they were delivered, and catches their way of getting organized and their mobilizing capacities.This analysis may be read too as a suggestion that these women constitute an emergent and mutant social body. Emergent, because it is relatively recent, considering its visibility in the public sphere; and mutant, too, because it involves women who take part in a change currently intervening in French society, and who give of themselves a new image: not the image of feminists in the classical sense of the term with the connotations it carries, but one, rather, that fits in the perspective of gender behaviour, like coeducation and modalities of interaction between women and men. …”
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PHYSICOCHEMICAL PROPERTIES OF CULMS IN RYE (SECALE CEREALE L.) WITH A BRITTLE STEM by A. A. Konovalov, I. K. Shundrina, E. V. Karpova, V. I. Mamatyuk

“…It was found that lateral load breaks stems of mutant plants by the brittle fracture mechanism, and normal plants, by ductile fracture. …”
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A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease by Patricia Gómez-Suaga, Elena Fdez, Marian Blanca Ramírez, Sabine Hilfiker

“…Apart from cytotoxicity, changes in autophagy have been consistently reported in the context of G2019S mutant LRRK2. Here, we will discuss current knowledge about mechanism(s) by which mutant LRRK2 may regulate autophagy, which highlights additional putative therapeutic targets.…”
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Strain-limited biofilm regulation through the Brg1-Rme1 circuit in Candida albicans by Min-Ju Kim, Aaron P. Mitchell

“…In the reference strain SC5314, a brg1Δ/Δ mutant has reduced levels of biofilm/filament production; a brg1Δ/Δ rme1Δ/Δ double mutant has wild-type levels of biofilm/filament production. …”
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The triterpenoid curcumene mediates the relative hydrophilicity of Bacillus subtilis spores by Stefany Castaldi, Giuliana Donadio, Ivana Staiano, Ezio Ricca, Rachele Isticato

“…This study reports that a mutant strain lacking the spsA-L operon, encoding 11 enzymes involved in the synthesis of spore surface polysaccharides, produced spores exposing on their surface hydrophobic molecules that were responsible for the drastic reduction of hydrophilicity of the mutant spores. …”
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Biofilm-associated metabolism via ERG251 in Candida albicans. by Liping Xiong, Nivea Pereira De Sa, Robert Zarnowski, Manning Y Huang, Caroline Mota Fernandes, Frederick Lanni, David R Andes, Maurizio Del Poeta, Aaron P Mitchell

“…Overexpression of ERG25 in the erg251Δ/Δ mutant causes some increase in ergosterol levels. …”
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Elucidating the potential of EGFR mutated NSCLC and identifying its multitargeted inhibitors by Anakha D. Rajeeve, Ramasamy Yamuna, P. K. Krishnan Namboori

“…Molecular docking studies revealed that the ligands curcumin (-6.9 kcal/mol) and CB[2]UN (-8.1 kcal/mol) bound more strongly to the EGFR-mutant NSCLC proteins with 2ITX and 2ITV, respectively. …”
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