Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion. by Carla Duncan, Frances B Jamieson, JoLynn Troudt, Linda Izzo, Helle Bielefeldt-Ohmann, Angelo Izzo, Carolina Mehaffy

“…We also demonstrated lesser virulence of the natural mutant in the guinea pig animal model. Overall, our findings suggest that the ON-A natural mutant is less fit to cause disease, but nevertheless has the potential to cause extended transmission in at-risk populations.…”
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Geometric Simulation Approach for Grading and Assessing the Thermostability of CALBs by B. Senthilkumar, D. Meshachpaul, R. Rajasekaran

“…In this work, the stability of native (4K6G) and mutant (4K5Q) CALB was studied through various structural parameters using conformational sampling approach. …”
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Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. by June Yao, Tu Cam Le, Claudine H Kos, Joel M Henderson, Phillip G Allen, Bradley M Denker, Martin R Pollak

“…Localization of mutant alpha-actinin-4 in transfected and injected cells, as well as in situ glomeruli, showed aggregates of the mutant protein. …”
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Enhancement of Streptomyces aureoverticillatus HN6 through mutagenesis for improved biocontrol of banana wilt disease: an WGS approach by Xiangnan Yan, Shakil Ahmad, Nazia Manzar, Yunfei Zhang, Coline C. Jaworski, Abhijeet Shankar Kashyap, Lanying Wang, Yanping Luo

“…Moreover, the fermentation broth of the mutant strain E95 substantially improved the bacterial inhibitory activity. …”
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Effects of Colchicine and ⁶⁰Co-γ Radiation Treatments on the Leaf Size and Fruit Quality of Kiwifruit ‘Donghong’ by Limei Wang, Qing Liu, Xishi Li, Guanglian Liao, Xiaobiao Xu

“…PCA results showed that the 25d mutant had the best comprehensive traits. And, except for the 0.4c mutant, all other mutant materials exhibited significant genetic changes at the DNA level.…”
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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis by Alexis T. Clark, Lillian Russo-Savage, Luke A. Ashton, Niki Haghshenas, Nicolas A. Amselle, Ira G. Schulman

“…Strikingly LXRα mutant mice have decreased liver triglycerides but increased liver cholesterol. …”
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A Constitutively Mannose-Sensitive Agglutinating Salmonella enterica subsp. enterica Serovar Typhimurium Strain, Carrying a Transposon in the Fimbrial Usher Gene stbC, Exhibits Mul... by Kuan-Hsun Wu, Ke-Chuan Wang, Lin-Wen Lee, Yi-Ning Huang, Kuang-Sheng Yeh

“…Flagella were observed in the stbC mutant and this phenotype was correlated with the motile phenotype. …”
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The IclR-family transcriptional regulator XyrR controls flotation, motility, antibiotic production and virulence in Serratia sp. ATCC 39006 by Carlo Miguel Castro Sandoval, Carlo Miguel Castro Sandoval, George P. C. Salmond

“…The iclR mutant showed diminished production of carbapenem, prodigiosin, GVs and cellulase. …”
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The Mla pathway promotes Vibrio cholerae re-expansion from stationary phase by Deborah R. Leitner, Franz G. Zingl, Alexander A. Morano, Hailong Zhang, Matthew K. Waldor

“…The mutant defect in transitioning out of stationary phase into active growth (culturability) was also observed in monocultures at 48 h. …”
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Biallelic mutations in CDC20 cause female infertility due to oocyte maturation abnormality by Guangzhong Jiao, Jinhao Xing, Zhaoli Du, Hongchu Bao, Xiaoyan Liu

“…Based on the three-dimensional (3D) structures of the CDC20 protein used to assess the effect of the mutant, the mutant causes a change in hydrogen bond in the protein structure, which may affect the stability of the mutant protein. …”
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Genetic profile of domestic cat (<i>Felis catus</i> L.) population of Aoshima Island (Japan) by S. K. Kholin

“…The population lacks the mutant alleles d (Dilution locus), W and wg (White), tab (Tabby), TiA (Ticked) present in other populations of Japan. …”
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Involvement of a 1-Cys peroxiredoxin in bacterial virulence. by Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Suelen Silvana dos Santos, Luis Eduardo Soares Netto, Sandro Rogério de Almeida, Regina Lúcia Baldini

“…Infection of macrophages with the lsfA mutant strains resulted in higher levels of the cytokine TNF-α production due to the activation of the NF-kB and MAPK pathways, that are partially inhibited by the wild-type P. aeruginosa strain. …”
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Clinical and molecular analysis of JCPyV and BKPyV infection and associated risk of urothelial carcinoma development in the upper tract by Chun-Nun Chao, Chi-Feng Hung, Wei‑Hong Lai, Chun-Liang Tung, Wan-Yun Yeh, Kai-Wu Yang, Meilin Wang, Ya-Yan Lai, Pei-Lain Chen, Cheng-Huang Shen

“…The OR of UTUC was higher by 10.34-fold in patients with mutant p53 and by 10.37-fold in those with simultaneous LT and mutant p53 expression. …”
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Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus by Manisha Vaish, Vineet K. Singh

“…The SaNOS mutant also showed reduced survival after phagocytosis by PMN cells with respect to wild-type S. aureus.…”
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Effect of Methylation on Storage Properties of Lacticaseibacillus paracasei as Analyzed by Untargeted Metabolomics by YOU Mingkun, ZHANG Wenyi

“…In order to better utilize the strain, this study focused on the effect of methylation on the storage properties of two starter cultures of L. paracasei Zhang and its DNA methylation mutant (ΔpglX) at 30 ℃. The results showed that after 90 d of storage, the viable number of the mutant significantly increased compared with the wild type (P < 0.01). …”
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Iron triggers TvPI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Tric... by Kuan-Yi Wu, Yen-Ju Chen, Shu-Fan Lin, Hong-Ming Hsu

“…In dominant-active HA-TvArf220 Q71L mutant, TvPI4P5K plasma membrane trafficking, PIP2 production, and intracellular calcium levels were increased, while these processes were inhibited in dominant-negative T31N mutant or those by Brefeldin A (BFA) treatment. …”
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The small GTPases FoRab5, FoRab7, and FoRab8 regulate vesicle transport to modulate vegetative development and pathogenicity in Fusarium oxysporum f. sp. conglutinans by Xiangyu Tan, Lin Chen, Ying Chen, Yuxin Li, Lihan Lu, Erfeng Li

“…Compared to the wild type, the growth rate of the mutant ΔFoRab8 strain decreased, the sporulation decreased, and the sensitivity of the mutant to osmotic stress and endoplasmic reticulum pressure increased. …”
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Huntington’s disease modeling on HEK293 cell line by D. V. Sharipova, T. B. Malankhanova, A. A. Malakhova

“…The mutant clones were obtained earlier using CRISPR/Cas9 genome editing technology. …”
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Development of the adaptive spring bread wheat cultivar ‘Omskaya Yubileynaya’ under the conditions of the Siberian region by N. A. Popolzukhina, P. V. Popolzukhin, A. A. Gaidar, Yu. Yu. Parshutkin, N. A. Yakunina

“…A decision was taken to apply multifold individual selection in accordance with the composition of agronomic traits in the mutant × cultivar hybrid population Lutescens 3 × [F5 B1 (Mutant 777 × G7251/03) × G7251/03] × Rosinka 3 (Mutant 112 × Irtyshanka 10) with backcrossing. …”
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Genetic polymorphism of hepatitis C virus and risk of hepatocellular carcinoma by S. N. Mammayev, A. M. Karimova

“…Frequency of mutant forms of 1b genotype is related to discovery of previously unknown protein of HCV — minicor-protein with absence of N-terminal of classical Cor-protein p21.Conclusion. …”
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