Therapeutic Implications of PPARγ in Cardiovascular Diseases by Hiroshi Hasegawa, Hiroyuki Takano, Issei Komuro

“…In addition, activation of PPARγ is implicated in the regulation of endothelial function, proliferation and migration of vascular smooth muscle cells, and activation of macrophages. Many studies suggest that PPARγ ligands not only ameliorate insulin sensitivity, but also have pleiotropic effects on the pathophysiology of atherosclerosis, cardiac hypertrophy, ischemic heart, and myocarditis.…”
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Promotion of nitric oxide production: mechanisms, strategies, and possibilities by Marcos Gonzalez, Sarah Clayton, Eric Wauson, Daniel Christian, Quang-Kim Tran

“…Endothelium-derived NO activates soluble guanylate cyclase (sGC) in vascular smooth muscle cells (VSMCs), elevating cyclic GMP (cGMP), causing vasodilation. …”
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New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis by Jochen Neuhaus, Thilo Schwalenberg, Lars-Christian Horn, Henry Alexander, Jens-Uwe Stolzenburg

“…Analysis of molecular alterations of receptor expression in detrusor smooth muscle cells and urothelial integrity is necessary to develop patient-tailored therapeutical concepts. …”
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Case Report: Unveiling the unexpected: a rare case of adult-type rhabdomyoma in a 9-year-old boy by Li Wang, Shan Li, Lingling Sun

“…Postoperative histological examination revealed adult rhabdomyoma, characterized by specific immunohistochemical and histologic traits including cytoplasmic positivity for muscle-specific Actin (MSA), Desmin, Myogenin, and MYOD1, large polygonal skeletal muscle cells and frequent extensive vacuolization. This report highlights the unusual age of presentation for this variant and underscores the need for heightened clinical awareness to ensure accurate diagnosis and effective management of such rare occurrences.…”
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Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle by H. Stigter, T. Krap, W. L. J. M. Duijst

“…<b>Conclusions:</b> We hypothesize two pathways, depending on the level of energy in the muscle cell, that could be responsible for post-mortem muscle excitability by mechanical stimulation.…”
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Clinicopathological analysis of sclerosing angiomatoid nodular transformation in the spleen by Shufei Wei, Yongliang Han, Yingyong Hou, Liangliang Wang

“…The hemangiomatous nodules were positive for CD31 and CD34, while the vascular wall smooth muscle cells and fibrocytes around the nodules were positive for SMA. …”
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Roles of Cells from the Arterial Vessel Wall in Atherosclerosis by Di Wang, Zhiyan Wang, Lili Zhang, Yi Wang

“…The migration and proliferation of smooth muscle cells also play a pivotal role in the progression of atherosclerosis. …”
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The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis by Mohsin H. K. Roshan, Amos Tambo, Nikolai P. Pace

“…Furthermore, TLR9 also stimulates interferon-α (INF-α) secretion and increases cytotoxic activity of CD4+ T-cells towards coronary artery tunica media smooth muscle cells. This review outlines the pathophysiological role of TLR2, TLR4, and TLR9 in atherosclerosis, focusing on evidence from animal models of the disease.…”
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Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis by Henning Neubauer, Clemens Wirth, Katharina Ruf, Helge Hebestreit, Meinrad Beer

“…Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular Ca2+ release dynamics in CFTR-deficient animal models. …”
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Impaired Muscle Regeneration in Ob/ob and Db/db Mice by Mai-Huong Nguyen, Ming Cheng, Timothy J. Koh

“…Impaired regeneration in ob/ob and db/db mice could be due partly to the lack of leptin signaling, since leptin is expressed both in damaged muscle and in cultured muscle cells. In summary, impaired muscle regeneration in ob/ob and db/db mice was associated with reduced macrophage accumulation, angiogenesis, and myoblast activity, and could have implications for insulin sensitivity in the skeletal muscle of obese and type 2 diabetic patients.…”
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LOX-1, OxLDL, and Atherosclerosis by Angela Pirillo, Giuseppe Danilo Norata, Alberico Luigi Catapano

“…Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effects of OxLDL. …”
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Cell-specific functions of androgen receptor in skeletal muscles by Hiroshi Sakai, Yuuki Imai

“…We focus on three specific cell populations expressing AR within skeletal muscles: skeletal muscle cells, responsible for muscle contraction; satellite cells, which are essential stem cells contributing to the growth and regeneration of skeletal muscles; and mesenchymal progenitors, situated in interstitial areas and playing a crucial role in muscle homeostasis. …”
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Human epicardial organoids from pluripotent stem cells resemble fetal stage with potential cardiomyocyte- transdifferentiation by Fanwen Wang, Xinle Zou, Huilin Zheng, Tianci Kong, Duanqing Pei

“…After 8-days treatment of TGF-beta following by bFGF, cells enter into epithelium-mesenchymal transition and give rise to smooth muscle cells. Epicardium could also integrate and invade into mouse heart with SNAI1 expression, and give birth to numerous cardiomyocyte-like cells. …”
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Identification of cardiac premature senescence markers through GEO database interaction approach by Tiwuk Susantiningsih, Ani Retno Prijanti, Novi Silvia Hardiany, Fadilah

“… Background: Cardiomyocytes are cardiac muscle cells where premature senescence can occur. The availability of in silico research regarding premature senescence in cardiomyocytes is still limited. …”
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Role of Fractalkine/CX3CL1 and Its Receptor in the Pathogenesis of Inflammatory and Malignant Diseases with Emphasis on B Cell Malignancies by Elisa Ferretti, Vito Pistoia, Anna Corcione

“…The biological activities of CX3CL1 are mediated by CX3CR1, that is expressed on different cell types such as NK cells, CD14+ monocytes, cytotoxic effector T cells, B cells, neurons, microglia, smooth muscle cells, and tumor cells. The CX3CL1/CX3CR1 axis is involved in the pathogenesis of several inflammatory cancer including various B cell malignancies. …”
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Epidemiological Research Advances in Vascular Calcification in Diabetes by Haipeng Yao, Zhen Sun, Guangyao Zang, Lili Zhang, Lina Hou, Chen Shao, Zhongqun Wang

“…Vascular calcification is the transformation of arterial wall mesenchymal cells, particularly smooth muscle cells (SMCs), into osteoblast phenotypes by various pathological factors. …”
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Associations of NF-kappaB and Bax with Apoptosis in Varicose Veins of Women of Different Age Groups by Helle Evi Simovart, Andres Arend, Jüri Lieberg, Marina Aunapuu

“…The study aimed at detecting apoptotic endothelial cells (ECs) and smooth muscle cells (SMCs) together with determining expression of NF-kappaB (p105/p50) and Bax in varicose vein walls. …”
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Prostacyclin Synthase: Upregulation during Renal Development and in Glomerular Disease as well as Its Constitutive Expression in Cultured Human Mesangial Cells by Thomas Klein, Günther Klaus, Martin Kömhoff

“…In the normal adult kidney, PGIS-immunoreactive protein and mRNA appear to localize to mesangial fields and endothelial and smooth muscle cells of arteries and peritubular capillaries. …”
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Vascular Remodeling in Experimental Hypertension by Norma R. Risler, Montserrat C. Cruzado, Roberto M. Miatello

“…The vascular wall is an active, flexible, and integrated organ made up of cellular (endothelial cells, smooth muscle cells, adventitia cells, and fibroblasts) and noncellular (extracellular matrix) components, which in a dynamic way change shape or number, or reorganize in response to physiological and pathological stimuli, maintaining the integrity of the vessel wall in physiological conditions or participating in the vascular changes in cardiovascular diseases such as hypertension. …”
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Leiomyoma of the Cheek by Ricardo Roberto de Souza Fonseca, Mário Augusto Ramos Junior, Douglas Baruchi, Tabata Resque Beckmann Carvalho, Andresa Borges Soares, Silvio Augusto Fernandes de Menezes, João de Jesus Viana Pinheiro, Jorge Nazareno Ferreira Fadul

“…Leiomyomas are rare benign tumors that grow in the tunica media of smooth muscle cells. Leiomyomas occur most frequently in the uterus or gastrointestinal tract and only very rarely in the area of the cheek. …”
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