Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma by Eun Seop Seo, Eun Seop Seo, In Hwa Jeong, In Hwa Jeong, Hee Young Ju, Ju Kyung Hyun, Ji Won Lee, Keon Hee Yoo, Won Young Heo, Ki Woong Sung, Hee Won Cho, Eun-Suk Kang

“…When combined, the PIRCHE-I and PIRCHE-II scores demonstrated an even stronger association with improved OS (HR 0.35, 95% CI 0.15-0.82, P = 0.016). Multivariable analysis confirmed that a higher combined PIRCHE-I and PIRCHE-II score was independently associated with improved OS (combined PIRCHE score HR 0.22, 95% CI 0.06-0.79, P = 0.021), and a higher PIRCHE-II score was significantly associated with reduced progression (HR 0.42, 95% CI 0.25-0.70, P < 0.001).ConclusionIn conclusion, higher PIRCHE-I and PIRCHE-II scores are linked to better survival outcomes and reduced complications in pediatric haplo-SCT neuroblastoma patients. …”
Get full text

Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…After a median follow-up time of 29.7 months, patients with higher burden of skin, endocrine and musculoskeletal irAEs (the latter two’s effect was confirmed at multivariable analysis) had longer overall survival (OS), as opposed to gastrointestinal, pneumonitis, neurological, liver, renal and other irAEs, which showed an harmful effect. …”
Get full text

Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context by Charlotte Ocana de Sentuary, Clara Testard, Marion Lagrée, Maxime Leroy, Lisa Gasnier, Alicia Enes-Dias, Constance Leruste, Diariatou Diallo, Michael Génin, Thameur Rakza, François Dubos

“…The nirsevimab acceptance rate [95% confidence interval] was 91.6% [89.1%–94.2%]. In a multivariable analysis, the mother's age, lower parity and having a partner in work were significantly associated with nirsevimab acceptance. …”
Get full text

Traumatic dental injuries in the first year of life and related risk factors in three regions of Brazil: a multicenter birth cohort study by Carlos Alberto Feldens, Bruno Antonio Sehn Konzen, Elisa Maria Rosa de Barros Coelho, Alessandra Castro Alves, Eliane Gerson Feldens, Márcia Regina Vítolo, Paulo Floriani Kramer

“…Results The incidence of TDI in the first year of life (range: 12 to 16 months) was 18.1% (95% CI: 13.6–22.6%). The multivariable analysis revealed a significantly greater risk of TDI in children from non-nuclear families (RR = 1.83; 95% CI: 1.11-3.00) as well as those whose mothers had a higher level of schooling (RR = 2.42; 95% CI: 1.04–5.63) and when tooth eruption began up to six months of age (RR = 2.30; 95% CI: 1.34–3.95). …”
Get full text

Urinary incontinence (UI) in older women in low- and middle-income countries: a rapid review and case study from Burkina Faso by Arthi Kozhumam, Mamadou Bountogo, Dina Goodman Palmer, Carolyn Grieg, Carolyn Grieg, Carolyn Grieg, Maxime Inghels, Maxime Inghels, Sandra Agyapong-Badu, Sandra Agyapong-Badu, Cristina Osborne, Guy Harling, Guy Harling, Guy Harling, Guy Harling, Till Bärnighausen, Till Bärnighausen, Till Bärnighausen, David Rapp, David Rapp, Molly Beestrum, Justine Davies, Justine Davies, Justine Davies, Lisa R. Hirschhorn

“…Of those with UI, 88.5% experienced leakage daily, and 50% reported moderate or greater interference with daily life, yet most (88.5%) had not spoken to a healthcare provider. Multivariable analysis revealed that UI was more common among women who were not currently married and decreased with higher education levels. …”
Get full text

Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study by Jasmine De Troy, Sarah-Maria Fendt, Sigrid Hatse, Patrick Neven, Ann Smeets, Annouschka Laenen, Hans Wildiers

“…Results: In total, 1113 patients were included, 10% of them developed distant metastasis over a median follow-up period of 7 years. In multivariable analysis adjusting for age, stage, and subtype, transferrin saturation and serum iron were significantly associated with an increased risk of breast cancer metastasis. …”
Get full text

Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients by Silvia De Rosa, Nicolò Sella, Giacomo Bellani, Giuseppe Foti, Andrea Cortegiani, Giulia Lorenzoni, Dario Gregori, Annalisa Boscolo, Lucia Cattin, Muhammed Elhadi, Giorgio Fullin, Eugenio Garofalo, Leonardo Gottin, Alberto Grassetto, Salvatore Maurizio Maggiore, Elena Momesso, Mario Peta, Daniele Poole, Roberto Rona, Ivo Tiberio, Andrea Zanoletti, Emanuele Rezoagli, Paolo Navalesi, for the SIAARTI Study Group

“…The length of the first cycle of prone position showed an inverse relationship with ICU mortality [OR (95% CI) 0.82 (0.73, 0.91)]. At the multivariable analysis, the duration of the first cycle of prone position, Delta-PP and Delta-PostPP for PaO2/FiO2, and Delta-PostPP for ventilatory ratio were independently associated with ICU mortality. …”
Get full text

Postoperative blood glucose increase can predict all-cause mortality within 3 months after successful interventional recanalization in patients with acute large vessel occlusion ce... by Wensheng Zhang, Yajie Liu, Hongxing Zhou, Jie Li, Weifang Xing, Kaifeng Li, Yudi Li, Xiongjun He, Li Ling, Jinzhao He

“…After adjusting for potential covariates, multivariable analysis showed a significant correlation between BGI and 3-month postoperative mortality rate (adjusted HR: 5.694, 95%CI: 2.379–13.626, P<0.001). …”
Get full text

Can aortic valve calcium score predict a need for permanent pacemaker implantation after transcatheter aortic valve implantation? by Helene Eltchaninoff, Eric Durand, Christophe Tron, Charles Fauvel, Thomas Barbe, Thibaut Hemery, Guillaume Le Pessec, Najime Bouhzam, Nicolas Bettinger, Julie Burdeau, Jade Makke, Quentin Laissac, Jean-Nicolas Dacher

“…AVCS score was significantly higher in patients requiring PPM (3788 (2487–5218) vs 3050 (2043–4367) AU, p&lt;0.001). Using multivariable analysis, preprocedural right bundle branch block (RBBB) (OR 6.61, 95% CI 3.82 to 11.5, p&lt;0.001), first atrioventricular block (OR 1.71, 95% CI 1.03 to 2.83, p=0.037), self-expanding valve (OR 3.25, 95% CI 1.17 to 9.09, p=0.025) and AVCS&gt;4510 AU (OR 1.83, 95% CI 1.04 to 3.20, p=0.035) were independently associated with PPM. …”
Get full text

Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…NLR, PLR, MLR, and PNI from the training dataset were utilized for Lasso calculation. Multivariable analysis indicated that age, pathological grade, chemotherapy status, Ki-67 expression, and the Lasso score were independent predictors of OS and were then included in the nomogram. …”
Get full text

Integration and acceptability of cervical cancer screening as part of postnatal care among women attending postnatal clinics in the Accra Metropolis, Greater Accra Region, Ghana. by Lawrence Oppong Buadi, Raphael Odame, Ali Samba, Mumuni Kareem, Angela Amoanimaa Boateng, Claudette Ahliba Diogo, Rebecca Tricia Morrision, George Kumi Kwakye, Cecilia Smith-Togobo

“…In the univariable analysis, participants' educational level (p = 0.006); occupation (p < 0.001), and contraceptive use (p = 0.019) were significantly associated with the acceptability of the Pap test procedure. The multivariable analysis revealed that educational level (aOR = 3.27; 95% CI = 1.05-10.21; p = 0.041) and occupation (aOR = 6.49; 95% CI = 1.67-25.29; p = 0.007) were significantly associated with the acceptability of the Pap test procedure and showed higher odds of acceptability. …”
Get full text

Near-infrared spectroscopy combined with vascular occlusion test to predict acute kidney injury in patients undergoing cardiac surgery: a prospective observational study by Ling Peng, Yeying Zheng, Fei Guo, Mengdan Su, Wei Wei

“…Results In our patient population (n = 87), 13.79% (12/87) patients developed AKI after surgery. Multivariable analysis revealed that CPB time and post-CPB desaturation speed (D-speed) were independently associated with AKI. …”
Get full text

Surgery lengthens survival for collecting duct carcinoma: analysis of hospital-based cancer registry data in Japan by Shuya Kandori, Shuhei Suzuki, Kosuke Kojo, Bunpei Isoda, Takazo Tanaka, Satoshi Nitta, Masanobu Shiga, Yoshiyuki Nagumo, Atsushi Ikeda, Takashi Kawahara, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Ayako Okuyama, Hiroyuki Nishiyama

“…The median OS of patients who undertook chemotherapy alone was significantly shorter than patients who undertook surgery alone for advanced disease (4 months [95% CI: 4-NA] vs. 15 months [95% CI: 13–68]; p < 0.001) and surgery-only patients had a similar median OS as surgery-plus-chemotherapy patients (19 months [95% CI: 13-NA]; p < 0.001). Moreover, a multivariable analysis for the OS in advanced disease revealed that surgery-plus-chemotherapy patients had significantly more favorable prognoses (HR 0.21, 95% CI: 0.07–0.57). …”
Get full text

Diabetic ketoacidosis treatment outcomes and its associated factors among adult patients with diabetes mellitus admitted to public hospitals in Nekemte Town, Ethiopia: a cross-sect... by Daniel Mitiku Yigazu, Matiyos Lema, Firomsa Bekele, Dawit Tesfaye Daka, Dagim Samuel, Nigatu Addisu

“…A P-value &lt; 0.05 was considered significant in the multivariable analysis.ResultComplete data was available for 201 patients admitted with DKA. …”
Get full text

Delirium at the intensive care unit and long-term survival: a retrospective study by Ignazio De Trizio, Maria Angeliki Komninou, Jutta Ernst, Reto Schüpbach, Jan Bartussek, Giovanna Brandi

“…Overall, patients in the group D had a significantly lower probability of survival than patients in the group ND (p < 0.0001, ARD = 11.8%). In the multivariable analysis, ICU-delirium was confirmed as independently associated with long-term survival. …”
Get full text

Non-cancerous CT findings as predictors of survival outcome in advanced non-small cell lung cancer patients treated with first-generation EGFR-TKIs. by Pakorn Prakaikietikul, Pattraporn Tajarenmuang, Phumiphat Losuriya, Natee Ina, Thanika Ketpueak, Thanat Kanthawang

“…MPA size, MPA size > 29 mm, and total adiposity ≤85 cm2 remained significant in multivariable analysis, adjusted by BMI [HR 1.14 (1.07-1.21), p < 0.001; 3.10 (1.81-5.28), p < 0.001; 3.91 (1.63-9.40), p = 0.002]. …”
Get full text

Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database by Aleksandar Radunović, Carol Coupland, Julia Hippisley-Cox, Christopher J McDermott, Tom A Ranger, Judith Burchardt, Xue W Mei

“…The nested case–control data set comprised of 6437 cases of MND diagnosed between January 1998 and December 2019, matched by year of birth, gender, general practice and calendar year to 62 003 controls.Main outcome measures Clinically recognised symptoms and signs of MND prior to diagnosis and symptoms and factors which are relevant in primary care setting.Results This study identified 17 signs and symptoms that were independently associated with MND diagnosis in a multivariable analysis. Of these, seven were new to the Red Flag tool: ataxia, dysphasia, weight loss, wheeze, hoarseness of voice, urinary incontinence and constipation. …”
Get full text

Combining systemic inflammation biomarkers with traditional prognostic factors to predict surgical site infections in elderly hip fracture patients: a risk factor analysis and dyna... by Yuhui Guo, Chengsi Li, Haichuan Guo, Peiyuan Wang, Xuebin Zhang

“…Results A total of 1430 patients were included in model development, with 41 cases (2.87%) of superficial SSI and 6 cases (0.42%) of deep SSI. Multivariable analysis identified traditional prognostic factors older age (OR = 1.08, 95% CI 1.04–1.12), ASA class III-IV (OR = 2.46, 95% CI 1.32–4.56), surgical delay ≥ 6 days (OR = 3.59, 95% CI 1.36–9.47), surgical duration > 180 min (OR = 2.72, 95% CI 1.17–6.35), and systemic inflammation biomarkers Platelet-to-lymphocyte ratio (PAR) ≥ 6.6 (OR = 2.25, 95% CI 1.17–4.33) and Systemic Immune-Inflammation Index (SII) ≥ 541.1 (OR = 2.24, 95% CI 1.14–4.40) as independent predictors of SSI. …”
Get full text

Adult dietary patterns and their association with iodine nutrition levels and thyroid function: a cross-sectional study by Gulinaizeer Abuduwaili, Jia Huang, Yan Ma, Hongguang Sun

“…The results of the multivariable analysis showed that PCA1, Q1, Q2 and Q3 were associated with an increased risk of iodine deficiency compared with Q4 ((OR): 260·41 (95 % CI: 20·16, 663·70)), 59·89 (5·64, 335·81), and 2·01 (0·15, 26·16), respectively). …”
Get full text

Practice of balanced scorecard implementation and its contributing factors among public primary hospital professionals in Central Gondar zone, Northwest Ethiopia by Seid Yeshaw, Seid Yeshaw, Geta Asrade, Asebe Hagos, Muluken Genetu Chanie, Nigusu Worku

“…The strength of associations was measured using the adjusted odds ratio (AOR) at 95% CI and a p-value of less than 0.05 in the multivariable analysis to declare significant factors. Thematic analysis was applied for the qualitative data using open code 4.03 version software.ResultsThe implementation practice of BSC was found at 48.5% (95% CI: 43.6, 53.4%) with a response rate of 95.28%. …”
Get full text