Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma by Yuji Uehara, MD, Hiroki Izumi, MD, PhD, Tetsuro Taki, MD, PhD, Tetsuya Sakai, MD, PhD, Hibiki Udagawa, MD, PhD, Eri Sugiyama, MD, PhD, Shigeki Umemura, MD, PhD, Yoshitaka Zenke, MD, PhD, Shingo Matsumoto, MD, PhD, Kiyotaka Yoh, MD, PhD, Shoko Kubota, MD, PhD, Keiju Aokage, MD, PhD, Naoya Sakamoto, MD, PhD, Shingo Sakashita, MD, PhD, Motohiro Kojima, MD, PhD, Michiko Nagamine, MD, PhD, Yukio Hosomi, MD, PhD, Masahiro Tsuboi, MD, PhD, Koichi Goto, MD, PhD, Genichiro Ishii, MD, PhD

“…Similarly, high-podoplanin (n = 31) versus low-podoplanin (n = 62) expression in CAFs was not associated with worse disease-free survival after surgery (p = 0.65), but was significantly associated with worse PFS and showed a trend towards worse overall survival following osimertinib treatment (p < 0.001, p = 0.11). In the multivariable analysis, solid predominant histology and high-podoplanin expression in CAFs were independently associated with worse PFS. …”
Get full text

High prevalence of fecal carriage of extended-spectrum beta-lactamase producing Enterobacterales among patients with urinary tract infections in rural Tanzania by Magreth Erick Macha, Magreth Erick Macha, Magreth Erick Macha, Weihong Qi, Salome N. Seiffert, Anja Bösch, Philipp Kohler, Honorathy Msami Urassa, Sabine Haller, Erin West, Maja Weisser Rohacek, Maja Weisser Rohacek, Maja Weisser Rohacek, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury

“…Positive samples underwent further analysis in Switzerland using MALDI-ToF, Vitek MS, and whole-genome sequencing. Multivariable analysis assessed predictors associated with ESBL-PE carriage for risk factors with p &lt; 0.05.ResultsWe enrolled 326 UTI patients (median age: 35.5 years, range: 25–52) and 189 (58.0%) were females. …”
Get full text

Doctor, what is my risk of bleeding after cardiac surgery while on combined anticoagulant with antiplatelet therapy? A validated nomogram for risk assessment by Haolong Han, Haolong Han, Hang Xu, Hang Xu, Jifan Zhang, Weihui Zhang, Yi Yang, Xia Wang, Li Wang, Dongjin Wang, Weihong Ge

“…Predictive factors were identified using univariate logistic regression, LASSO regression and multivariable analysis. Various models were developed, validated and evaluated by using methods including ROC curves, calibration curves, the Hosmer-Lemeshow test, net reclassification improvement (NRI), integrated discrimination improvement (IDI) index, decision curve analysis (DCA) and clinical impact curves (CIC).ResultsMod2 showed the best performance (AUC of validation set = 0.863) which consists of 8 independent predictive factors (gender, age &gt; 65 years, diabetes, anemia, atrial fibrillation, cardiopulmonary bypass time, intraoperative bleeding and postoperative drainage), with a significantly higher AUC compared to Mod1 (only preoperative factors) and Mod3 (the HAS-BLED scoring model). …”
Get full text

Correlation between Obesity and Left Atrial Enlargement in Patients Using Cardiac Magnetic Resonance by Solos Jaturapisanukul, Yodying Kaolawanich, Methat Meechuen, Thananya Boonyasirinant

“…Univariable analysis indicated that the factors affecting LA volume included BMI (r = 0.3, p < 0.001), LV mass index (r = 0.3, p = 0.001), waist circumference (r = 0.3, p < 0.001), male sex (p = 0.01), and hypertension (p = 0.01). In stepwise multivariable analysis, BMI (p < 0.001), LV mass index (p = 0.02), and male sex (p = 0.03) were independently associated with LA volume. …”
Get full text

The prevalence and 6-year incidence of myopic tessellation in a Chinese rural adult population: the Handan Eye Study by Caixia Lin, Jian Wu, Kai Cao, Bingsong Wang, Yuxin Fang, Ohno-Matsui Kyoko, Yunyun Sun, Jie Hao, Lixia Ma, Ye Zhang, Qing Zhang, Ningli Wang, the Handan Eye Study Group

“…The progression rate of fundus tessellation in those with fundus tessellation at baseline was 1.5% (95% CI: 0.82%, 2.38%). By multivariable analysis, subjects being older (OR: 1.079, P < 0.001) and havingβ-parapapillary atrophy at baseline (OR: 2.657, P = 0.002) were associated with a higher risk of incidence of fundus tessellation. …”
Get full text

Metabolic Syndrome and Its Components Predict the Risk of Type 2 Diabetes Mellitus in the Mainland Chinese: A 3-Year Cohort Study by Kun Wang, Qun-Fang Yang, Xing-Lin Chen, Yu-Wei Liu, Sheng-Shuai Shan, Hua-Bo Zheng, Xiao-Fang Zhao, Chang-Zhong Chen, Cheng-Yun Liu

“…MetS and its components were assessed by multivariable analysis using Cox regression. Prediction models were developed. …”
Get full text

Time to progression predicts outcome of patients with multiple myeloma that can be influenced by autologous hematopoietic stem cell transplantation by Yanhua Yue, Yingjie Miao, Yifang Zhou, Yangling Shen, Luo Lu, Fei Wang, Yang Cao, Bai He, Weiying Gu

“…For patients who experienced progression within 12 or 24 months after remission, undergoing autologous hematopoietic stem cell transplantation (ASCT) after progression conferred a median OS and OS-2 advantage over receiving post-progression chemotherapy. Multivariable analysis confirmed that TTP was an independent predictor for OS in patients with MM.Conclusion Patients with MM who experience earlier disease progression within 12 months after remission have a worse prognosis, and post-progression ASCT can improve their survival outcomes.…”
Get full text

Assessing microvascular dysfunction and predicting long-term prognosis in patients with cardiac amyloidosis by cardiovascular magnetic resonance quantitative stress perfusion by Leting Tang, Wenjin Zhao, Kang Li, Lin Tian, Xiaoyue Zhou, Hu Guo, Mu Zeng

“…The MPR of the transmural LGE group was significantly lower than that of the no LGE and subendocardial LGE groups (P < 0.001). In multivariable analysis, ECV, MPR, and LGE were independently predictive. …”
Get full text

Perceived risk for screen-detectable cancers among american indian adults in the zuni pueblo, USA: Insights and implications for intervention programs by Deborah Kanda, Kate Cartwright, V. Shane Pankratz, Judith Sheche, Mikaela Kosich, Nicholas Edwardson, Samantha Leekity, Shiraz I. Mishra

“…From bivariate analysis, factors associated with high perceived cancer risk included: positive family cancer history (odds ratio [OR] = 1.95; 95 % confidence interval [CI]: 1.23–3.11), higher knowledge of cancer risk factors (OR = 1.45; CI: 1.09–1.93), higher education (OR = 1.46; CI: 1.16–1.84), and higher body mass index (OR = 1.44; CI: 1.07–1.94). In multivariable analysis, family cancer history (OR = 1.81; CI: 1.10–2.99), knowledge of risk factors (OR = 1.38; CI: 1.03–1.86), and education (OR = 1.81; CI: 1.10–2.96) remained statistically significant. …”
Get full text

Assessment of the efficacy of palliative sedation in advanced cancer patients by evaluating discomfort levels: a prospective, international, multicenter observational study by Maaike Rijpstra, Kris Vissers, Alazne Belar, Michael Van der Elst, Séverine Marie Surges, Claudio Adile, Rocío Rojí, Yasmine Grassi, Ewald Bronkhorst, Sebastiano Mercadante, Lukas Radbruch, Johan Menten, Carlos Centeno, Evelien Kuip, Jeroen Hasselaar

“…The mean discomfort score before start was 9.4 points (95% CI 8.3–10.5), which showed a significant decrease of 6.0 points (95% CI 4.8–7.1) after start of sedation for the total sedation period. In the multivariable analysis, no significant factors influencing baseline discomfort levels were identified. …”
Get full text

Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatmentResearch in context by Haritha Desu, Renaud Balthazard, Audrey Daigneault, Sandra Da Cal, Wendy Klément, Jennifer Yu, Marie-Laure Clénet, Clara Margarido, Annie Levert, Canisius Fantodji, Olivier Tastet, Jean-Marc Girard, Pierre Duquette, Alexandre Prat, Gabrielle Macaron, Marie-Claude Rousseau, Nathalie Arbour, Catherine Larochelle

“…IL-4 and β-NGF levels were lower in untreated PwMS compared to controls, while EGF and bFGF levels were influenced by age and markedly elevated in PwMS in multivariable analysis. Samples from treated PwMS, but not untreated PwMS, showed lower levels of BDNF and TNF than controls. …”
Get full text

Factors Determining Rehabilitation Needs After Intradural Spinal Tumor Surgery: A Prospective Study by Stanisław Krajewski, Jacek Furtak, Monika Zawadka-Kunikowska, Michał Kachelski, Jakub Soboń, Marek Harat

“…In the ID-EM group, age, thoracic level, subtotal resection (STR), repeat surgery, and functional scale scores predicted the need for rehabilitation. In multivariable analysis, MMS (odds ratio (OR) 8.7; 95% confidence interval (CI): 2.37–32.44) and STR (OR 13.00; 95%CI: 1.56–107.87) remained independent predictors of rehabilitation need (area under curve, 92%). …”
Get full text

The Predictive Role of Lactate in the Emergency Department in Patients with Severe Dyspnea by Maciej Niczewski, Szymon Gawęda, Paulina Kluszczyk, Mikołaj Rycerski, Daria Syguła, Anna Danel, Szymon Szmigiel, Konrad Mendrala, Aleksandra Oraczewska, Czarosław Kijonka, Monika Nowicka, Michał Wita, Tomasz Cyzowski, Grzegorz Brożek, Maciej Dyrbuś, Szymon Skoczyński

“…Patients who died were more frequently initially assigned to the red triage risk group, more burdened with comorbidities, and the median SpO2 on admission was significantly lower than in patients who survived the follow-up period. In the multivariable analysis, lactate was the strongest independent predictor of death, with 1 mmol/L increasing all-cause mortality by 58% in ABG (95% CI: 1.01–2.47), by 80% in VBG (95% CI: 1.13–2.88), and by 68% in the mixed blood gas analysis (95% CI: 1.22–2.31), what remained significant in VBG and mixed group after correction for base excess. …”
Get full text

Effect of schistosomiasis and soil-transmitted helminth infections on physical fitness of school children in Côte d'Ivoire. by Ivan Müller, Jean T Coulibaly, Thomas Fürst, Stefanie Knopp, Jan Hattendorf, Stefanie J Krauth, Katarina Stete, Aurélie A Righetti, Dominik Glinz, Adrien K Yao, Uwe Pühse, Eliézer K N'goran, Jürg Utzinger

“…No statistically significant difference was detected between any groups. Multivariable analysis revealed that VO(2) max was influenced by sex (reference: female, coef. = 4.02, p<0.001) and age (years, coef. = -1.23, p<0.001), but not by helminth infection and intensity, Plasmodium spp. infection, and environmental parameters.…”
Get full text

Poor COVID-19 Preventive Practice among Healthcare Workers in Northwest Ethiopia, 2020 by Belayneh Ayanaw Kassie, Aynishet Adane, Eskeziaw Abebe Kassahun, Amare Simegn Ayele, Aysheshim Kassahun Belew

“…Adjusted odds ratio (AOR) with 95% confidence interval was used to determine independent predictors of COVID-19 preventive practice. In multivariable analysis, a variable with a P value of less than 0.05 was considered as statically significant. …”
Get full text

Cultural and urban city living expectations of knee motion in a Southeast Asian city: implications on total knee arthroplasty outcomes by Yong Yao Tan, Ke Xin Magneline Ang, Ching Yi Aliza Wong, Kinjal Vidyut Mehta, Sir Young James Loh

“…Variables with p-values &lt;0.3 in univariate analysis were included in the multivariable analysis.ResultsFifty participants (32 men, 18 women) were enrolled in the study. …”
Get full text

Determinants of Preterm Birth among Women Who Gave Birth in Amhara Region Referral Hospitals, Northern Ethiopia, 2018: Institutional Based Case Control Study by Abebayehu Melesew Mekuriyaw, Muhabaw Shumye Mihret, Ayenew Engida Yismaw

“…The result of multivariable analysis show that mothers with no formal education (AOR = 2.24; 95% CI: 1.28, 3.91), history of abortion (AOR = 2.92; 95% CI: 1.3, 6.4), multiple gestation (AOR = 4.1; 95% CI: 1.7, 9.8), hemoglobin level <11 gm/dl (AOR = 2.75; 95% CI: 1.11, 7.31), premature rupture of membrane (AOR = 6.4; 95% CI: 3.23, 12.7) and pregnancy induced hypertension (AOR = 4.74; 95% CI: 2.49, 9.0) had statistically significant association with experiencing preterm birth. …”
Get full text

Survival Status and Predictors of Mortality among Newborns Admitted with Neonatal Sepsis at Public Hospitals in Ethiopia by Samuel Dessu, Aklilu Habte, Tamirat Melis, Mesfin Gebremedhin

“…Variables which had p value < 0.05 in multivariable analysis using the cox proportional hazard model were declared as statistically significant predictors of mortality. …”
Get full text

Goiter and Its Associated Factors among Adolescent High School Girls at Tach Armachiho District, Northwest Ethiopia: An Institution-Based Cross-Sectional Study by Belaynew Mesfin, Bisrat Misganaw, Melkamu Tamir Hunegnaw, Esmael Ali Muhammad

“…Those variables having p value of less than 0.05 in the multivariable analysis were considered as significant factors for goiter. …”
Get full text

Efficacy of ceftazidime-avibactam with or without polymyxin for carbapenem-resistant Klebsiella pneumoniae infections after initial treatment with polymyxin by Jingli Lu, Yani Ma, Zhe Cao, Baoling Zhu, Luna Fan, Haiyang Meng

“…Therapeutic response was observed in 81 (76.4%) patients, with microbiological eradication achieved in 77.1% (74/96) of cases. Multivariable analysis identified that the length of intensive care unit stays, the sequential organ failure assessment (SOFA) score at CAZ-AVI withdrawal, and regimens containing polymyxin B were independently associated with in-hospital mortality, whereas the duration of CAZ-AVI treatment was independently associated with survival. …”
Get full text