Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation: insights from a multicenter GETH-TC study to optimize outcomes and care by María Queralt Salas, María Teresa Solano, Mónica Baile González, Marina Acera Gómez, Laura Fox, María del Mar Pérez Artigas, Ana Santamaría, María del Carmen Quintela González, Andrés Sánchez Salinas, Joaquina M. Salmerón Camacho, Verónica Illana Álvaro, Zahra Abdallahi-Lefdil, Javier Cornago Navascues, Laura Pardo, Sara Fernández-Luis, Leddy Patricia Vega Suárez, Sara Villar, Patricia Beorlegui-Murillo, Albert Esquirol, Isabel Izquierdo García, Sonia Rodríguez González, Alberto Mussetti, Esperanza Lavilla, Javier Lopez-Marín, Silvia Filaferro, Ángel Cedillo, Leyre Bento, Leyre Bento, Anna Sureda, Anna Sureda

“…In contrast, pre-habilitated patients (n=62) showed improvements, with fit patients increasing from 24.2% to 46.8%, and frail patients decreasing from 9.7% to 3.2%. Multivariate analysis confirmed lower OS (HR 2.52, P=0.002) and higher NRM (HR 2.69, P=0.013) in frail patients at HCT admission compared to fit ones, with a trend towards lower OS in pre-frail patients (HR 1.54, P=0.097).ConclusionThis study highlights the feasibility of incorporating the HCT Frailty Scale into clinical practice, confirms its negative impact of frailty on transplant outcomes, and suggests that frailty is dynamic and potentially reversible through pre-transplant interventions.…”
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Comparison of outcome and toxicity of postoperative intensity‐modulated radiation therapy with two‐dimensional radiotherapy in patients with soft tissue sarcoma of extremities and... by Jianyang Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Ning Li, Hui Fang, Hua Ren, Yuan Tang, Yu Tang, Bo Chen, Ningning Lu, Shunan Qi, Shulian Wang, Yexiong Li

“…Compared to 2D‐RT group, the IMRT group had higher 5‐year local recurrence‐free survival (LRFS) (91.1% vs 80.8%; P = 0.029), distant metastasis‐free survival (DMFS) (80.0% vs 69.7%; P = 0.048), disease‐free survival (DFS) (75.2% vs 59.2%; P = 0.021), and overall survival (OS) (90.2% vs 81.0%; P = 0.029). Multivariate analysis showed IMRT was an independent favorable factor for LRFS, DMFS, DFS, and OS. …”
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Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…The median OS was 20.4 months vs 12.9 months for patients with MRD below or above 10–3, respectively (P = .006). In a multivariate analysis, only MRD >10–3 was associated with a poorer OS (hazard ratio, 2.6; 95% confidence interval, 1.2-5.5; P = .013). …”
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Gut dysbiosis is associated with difficult-to-treat rheumatoid arthritis by Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Arkaitz Mucientes, Arkaitz Mucientes, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Rocío Redondo-Rodriguez, Rocío Redondo-Rodriguez, Laura Cano-García, Laura Cano-García, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…We recorded data on clinical findings, inflammation, and cytokines. A Cox multivariate analysis was performed to identify factors related to D2T RA.ResultsThe study population comprised 39 patients: 13 (33%) with D2T RA and 26 (66%) with E2T RA. …”
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Assessment of myocardial deformation by CMR tissue tracking reveals left ventricular subclinical myocardial dysfunction in patients with gynecologic cancer undergoing chemotherapy by Kai Tao, Kai Tao, Lu Ye, Yan-Jia-Ni Xu, Yan-Jia-Ni Xu, Meng-Xi Yang, Ru-Tie Yin, Qing-Li Li, Xiao-Juan Lin, Ke-Min Li, Liang Song, Yu Ma, Lan Zhong, Ying Hu, Hua-Yan Xu, Dan-Qing Wang, Ying-Kun Guo

“…GRS (39.71 ± 8.09% vs. median 30.56% [IQR 26.52 to 38.15%]; p = 0.001), GCS (-23.45 ± 2.09% vs. median -19.71% [IQR -21.71 to -19.10%]; p < 0.001) and GLS (-16.17 ± 2.42% vs. median -12.12% [IQR -14.10 to -8.53%]; p< 0.001) further decreased as the number of chemotherapy cycles increased during follow-up (all p < 0.05). Multivariate analysis showed that GCS was independently associated with the number of chemotherapy regimens (Standard regression coefficient [β] = 0.397, p < 0.001).ConclusionsMyocardial deformation is more sensitive than LVEF in detecting subclinical left ventricular dysfunction in patients with gynecologic cancer undergoing chemotherapy. …”
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Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms by Dennyson Leandro M. Fonseca, Maj Jäpel, Michael Adu Gyamfi, Igor Salerno Filgueiras, Gabriela Crispim Baiochi, Yuri Ostrinski, Gilad Halpert, Yael Bublil Lavi, Elroy Vojdani, Thayna Silva-Sousa, Júlia Nakanishi Usuda, Juan Carlo Santos e Silva, Paula P. Freire, Adriel Leal Nóbile, Anny Silva Adri, Pedro Marçal Barcelos, Yohan Lucas Gonçalves Corrêa, Fernando Yuri Nery do Vale, Letícia Oliveira Lopes, Solveig Lea Schmidt, Xiaoqing Wang, Carl Vahldieck, Benedikt Fels, Lena F. Schimke, Gustavo Cabral-Miranda, Mario Hiroyuki Hirata, Taj Ali AKhan, Yen-Rei A. Yu, Rodrigo JS Dalmolin, Howard Amital, Aristo Vojdani, Haroldo Dutra Dias, Helder Nakaya, Hans D. Ochs, Jonathan I. Silverberg, Jason Zimmerman, Israel Zyskind, Avi Z. Rosenberg, Kai Schulze-Forster, Harald Heidecke, Rusan Catar, Guido Moll, Alexander Hackel, Kristina Kusche-Vihrog, Yehuda Shoenfeld, Gabriela Riemekasten, Reza Akbarzadeh, Alexandre H. C. Marques, Otavio Cabral-Marques

“…Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms. …”
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Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group by Aysegul Oruc, Abdullah Sumnu, Aydın Turkmen, Taner Basturk, Egemen Cebeci, Kenan Turgutalp, Hakkı Cetinkaya, Müge Uzerk Kibar, Nurhan Seyahi, Erhan Tatar, Metin Ergul, Ülver Derici, Mehmet Deniz Aylı, Musa Pınar, Betül Bakar, Rümeyza Kazancıoglu, Abdülmecit Yıldız, Ahmet Burak Dirim, Zülfükar Yılmaz, Kültigin Turkmen, Onur Tunca, Mehmet Koc, Sim Kutlay, Hasan Micozkadıoglu, Alper Azak, Burcu Boztepe, Sedat Ustundag, Seda Şafak Ozturk, Abdulkadir Unsal, Serhat Karadag, Gülizar Sahin, Ezgi Coşgun Yenigun, Necmi Eren, Mustafa Gullulu, Meltem Gursu, Savaş Ozturk

“…The remission rate was significantly higher among patients with segmental sclerosis compared to those without (60.4% vs. 49%, p = 0.047). In the multivariate analysis, MEST-C S1 (HR 1.43, 95% CI 1.08–1.89, p = 0.013), MEST-C T1 (HR 0.68, 95% CI 0.51–0.91, p = 0.008) and combined IST (HR 0.66, 95% CI 0.49–0.91, p = 0.009) were found to be significant regarding remission.Conclusion CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. …”
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Analysis of quality of life and influence factors in patients with lung cancer undergoing radiotherapy or chemotherapy under the normalization of epidemic prevention (疫情常态化防控期间肺癌放化... by WU Suya (吴苏娅), WAN Jing (万晶), ZHANG Liuliu (张柳柳), WANG Min (王敏), LIU Dan (刘丹), ZHU Ping (邾萍)

“…Results The total quality of life in 134 patients with lung cancer was (72. 33±11. 13); Univariate analysis showed that treatment delay (t=5. 355, P<0. 001), traffic difficulty (t=2. 746, P=0. 007), adequate life security (t=3. 702, P<0. 001), clinical stage (F=50. 084, P<0. 001) and fatigue (F =2. 956, P=0. 035) were important factors affecting quality of life．Pearson correlation analysis showed that epidemic knowledge score (r=0. 179, P=0. 038) was positively correlated with quality of life, anxiety (r=-0. 551, P<0. 001) and depression (r=-0. 456, P<0. 001) were negatively correlated with quality of life. Multivariate analysis showed that clinical stage (t=-4. 880, P<0. 001), treatment delay (t =3. 158, P=0. 002), epidemic knowledge score (t =2. 019, P=0. 046) and anxiety (t =-3. 160, P=0. 002) were independent influence factors. …”
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Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study by Jung Hee Kim, Sung-Eun Kim, Do Seon Song, Hee Yeon Kim, Eileen L. Yoon, Ji Won Park, Tae Hyung Kim, Young-Kul Jung, Ki Tae Suk, Hyung Joon Yim, Jung Hyun Kwon, Sung Won Lee, Seong Hee Kang, Moon Young Kim, Soung Won Jeong, Jae-Young Jang, Jeong Ju Yoo, Sang Gyune Kim, Young-Joo Jin, Gab Jin Cheon, Byung Seok Kim, Yeon Seok Seo, Hyoungsu Kim, Dong Hyun Sinn, Woo Jin Chung, Hwi Young Kim, Han Ah Lee, Seung Woo Nam, In Hee Kim, Ji Hoon Kim, Hee Bok Chae, Joo Hyun Sohn, Ju Yeon Cho, Yoon Jun Kim, Jin Mo Yang, Jung Gil Park, Won Kim, Hyun Chin Cho, Dong Joon Kim

“…The difference in aetiology was a significant factor for 28-day adverse outcomes in multivariate analysis even in a high MELD score (≥15), which indicated poor baseline liver function and prognosis (p < 0.001).Conclusion The aetiology of CLD constitutes a pivotal determinant influencing both short- and long-term adverse outcomes of AD in CLD, even among individuals presenting with elevated MELD scores. …”
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Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study by Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Fabio Angeli, Carlo Maria Barbagallo, Bruno Berardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Lanfranco D’Elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Egidio Imbalzano, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Claudio Borghi, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

“…TG/HDL-C ratio showed a positive association with increasing of SUA/GFR ratio, even in non-diabetic patients. Multivariate analysis showed that the TG/HDL-C ratio increases the mortality risk even after adjustment for potential confounding factors. …”
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Comparison of autologous hematopoietic cell transplantation, matched sibling donor hematopoietic cell transplantation, and chemotherapy in patients with favorable- and intermediate... by Mingyang Wang, Shulian Chen, Qiuqiu Zhang, Linyu Yuan, Xue Wang, Junshi Zhang, Xiaoyu Zhang, Yigeng Cao, Dongmei Li, Xinxiao Lu, Meijiao Wang, Xiaosi Jiang, Rongli Zhang, Xin Chen, Qiaoling Ma, Jialin Wei, Donglin Yang, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Weihua Zhai, Xingli Zhao, Erlie Jiang

“…Notably, both auto-HSCT and MSD-HSCT demonstrated significantly improved DFS compared to chemotherapy in patients with favorable-risk AML. Multivariate analysis further revealed that chemotherapy was significantly associated with inferior DFS compared to auto-HSCT (HR=2.82; 95% CI, 1.26–6.32, p=0.012), while DFS was similar between the MSD-HSCT and auto-HSCT groups (HR=0.80; 95% CI, 0.31–2.09, p=0.645).DiscussionThe findings suggested the advantages of both MSD-HSCT and auto-HSCT over chemotherapy as post-remission therapy for AML patients with favorable and intermediate risk. …”
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Long-term outcomes after AKI in hospitalized patients with COVID-19 by Bernardo Marques da Silva, Joana Gameiro, Joana Lei Teixeira, Cláudia Costa, Carolina Branco, João Oliveira, João Bernardo, Filipe Marques, José Agapito Fonseca, José António Lopes

“…The incidence of MAKE was 60.9% (n = 249), and MARCE was 62.6% (n = 256). On a multivariate analysis, older age (adjusted HR 1.02 (95% CI: 1.01–1.04), p = 0.008), cardiovascular disease (adjusted HR 2.22 (95% CI: 1.24–3.95), p = 0.007), chronic kidney disease (adjusted HR 5.15 (95% CI: 2.22–11.93), p < 0.001), and AKI (adjusted HR 1.76 (95% CI: 1.12–2.78), p = 0.015) were independent predictors of MAKE. …”
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Clinical and genetic drivers of oligo-metastatic disease in colon cancer by Alessandro Ottaiano, Mariachiara Santorsola, Roberto Sirica, Annabella Di Mauro, Antonella Di Carlo, Monica Ianniello, Francesco Sabbatino, Rosa Castiello, Francesca Del Peschio, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Nicola Martucci, Edoardo Mercadante, Valentina Borzillo, Rossella Di Franco, Francesco Izzo, Vincenza Granata, Carmine Picone, Antonella Petrillo, Massimiliano Berretta, Salvatore Stilo, Luca Tarotto, Anna Chiara Carratù, Gerardo Ferrara, Madhura Tathode, Alessia Maria Cossu, Marco Bocchetti, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese

“…OMD was more prevalent in males (P = 0.0299) and with single organ involvement (P = 0.0226). Multivariate analysis adjusted for age (>70 vs. <70 years), gender (male vs. female), tumor side (right vs. left), metastatic involvement (more than one site vs. one site), response to first-line therapy (disease control vs. no disease control), and RAS/BRAF variants (wild-type vs. mutated) identified OMD vs. …”
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Intravenous versus subcutaneous tocilizumab in Takayasu arteritis: multicentre retrospective study by Patrice Cacoub, Arsène Mekinian, David Saadoun, Pavel I Novikov, Savino Sciascia, Corrado Campochiaro, Olivier Fain, Ilya Smitienko, Nicolas Schleinitz, Patrick Jégo, Francesco Muratore, Carlo Salvarani, Elena Galli, Sabine Berthier, Marc Lambert, François Maurier, Isabelle Kone-Paut, Sergey Moiseev, Masataka Kuwana, Alexandre Belot, Martin Michaud, Francis Gaches, Achille Aouba, Xavier Puechal, Karim Sacre, Tiphaine Goulenok, Alessandro Tomelleri, Thomas Sené, Elena Marina Baldissera, Luigi Boiardi, Abid Awisat, Ygal Benhamou, Vahan Mukuchyan, Mathieu Vautier, Azeddine Dellal, Lucie Biard, Julie Seguier, José Hernández-Rodríguez, Olivier Espitia, Sebastien Humbert, Guillaume Denis, Nolan Hassold, Dagna Lorenzo, Helene Munoz Pons, Jean Baptiste Gaultier, Le Mouel Edwige, Antoinette Perlat, Bertrand Lioger, Jonathan Broner, Virginie Dufrost, Faten Frikha, Alexandra Audemard-Verger, Pascal Woaye-Hune, Pierre Zeminsky, Moya Alvarado, Matheus Vieira, Alberto Lo Gullo

“…The factors associated with complete response to tocilizumab at 6 months in multivariate analysis, only age &lt;30 years (OR 2.85, 95% CI 1.14 to 7.12; p=0.027) and time between TAK diagnosis and tocilizumab initiation (OR 1.18, 95% CI 1.02 to 1.36; p=0.034). …”
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Long-Term Mortality following Acute Noninvasive Ventilation for Obesity-Related Respiratory Failure: A Retrospective Single-Centre Study by Aditya Krishnan, Paul Ellis, Pearlene Antoine-Pitterson, Amy Oakes, Bethany Jones, Alice Turner, Rahul Mukherjee

“…Adults with hypercapnic ORRF requiring acute NIV were included. pH data were grouped by threshold (pH≤ and >7.25) and correlated with time from presentation to death; multivariable analysis was performed using Cox proportional hazards. …”
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Copper and iron as unique trace elements linked to fibromyalgia risk by Wenxing Zeng, Minhua Hu, Luyao Ma, Feng Huang, Ziwei Jiang

“…These associations remained significant in the multivariable analysis, highlighting the independent effects of Cu and Fe. …”
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Maternal Satisfaction and Associated Factors with Postcesarean Section Pain Management: A Cross-Sectional Study by Biruk Adie Admass, Fikadu Tadesse Diress, Demeke Yilkal Fentie, Nigussie Simeneh Endalew

“…Variables with a p value of <0.2 in the bivariable analysis were included in the multivariable analysis. In the multivariable analysis, variables with a p value of <0.05 were considered statistically significant. …”
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Incidence and determinants of mortality among patients with colorectal cancer in oncology centers of Amhara region, Ethiopia, 2024: multicenter retrospective follow up study by Getachew Tesfaw Walle, Tegene Atamenta Kitaw, Seteamlak Adane

“…The overall mortality rate was 2.9 per 100 person-months. Multivariable analysis identified presenting symptoms, low baseline hemoglobin levels, poor performance status, late-stage cancer, and tumor location as significant predictors of mortality. …”
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Evaluation of Long-Term Lymphedema Rate in Patients With Subclinical Lymphedema Diagnosed in the Preoperative Period via Bioimpedance by Zeynep Erdoğan İyigün, Tolga Ozmen, Serkan İlgün, Cansu Nakipoğlu, Enver Özkurt, Filiz Çelebi, Çağlar Ünal, Alper Öztürk, Gül Alço, Çetin Ordu, Gürsel Soybir

“…At the end of the follow-up period, lymphedema persisted in 11 patients (27.5%) and resolved in 29 patients (72.5%). In multivariable analysis, the positive lymph node count was identified as an independent variable in these patients. …”
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Neutrophil to Lymphocyte Ratio as a Predictor of Adverse Outcome in Patients with Decompensated Liver Cirrhosis by Valeriy D. Lunkov, Marina V. Maevskaya, Ekaterina K. Tsvetaeva, Ana G. Mendez, Maria S. Zharkova, Petr E. Tkachenko, Vladimir T. Ivashkin

“…Correlation analysis, univariate and multivariable analysis were provided to find factors statistically significantly associated with lethal outcome and SIRS. …”
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