Prehospital scale to differentiate intracerebral hemorrhage from large-vessel occlusion patients: a prospective cohort study by A. Freixa-Cruz, G. Jimenez-Jimenez, G. Mauri-Capdevila, Y. Gallego-Sánchez, A. García-Díaz, R. Mitjana-Penella, M. Paul-Arias, C. Pereira-Priego, E. Ruiz-Fernández, S. Salvany-Montserrat, A. Sancho-Saldaña, E. San-Pedro-Murillo, E. Saureu, D. Vázquez-Justes, Francisco Purroy

“…Out of 989 stroke code patients, we included 190 (66.7%) LVO cases and 95 (33.3) ICH cases. In the multivariate analysis, headache (odds ratio [OR] 3.56; 1.50–8.43), GCS < 8 (OR 8.19; 3.17–21.13), SBP > 160mmHg (OR 6.43; 3.37–12.26) and male sex (OR 2.07; 1.13–3.80) were associated with ICH, while previous hypercholesterolemia (OR 0.35; 0.19–0.65) with LVO. …”
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Biochemical recurrence prediction after robot-assited radical prostatectomy (BCR-PRARP) by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…Univariate analysis demonstrated significant associations between BCR and PSA, clinical T stage, biopsy Gleason score, D'Amico risk classification, pathologic T stage, pathologic Gleason score, extraprostatic extension, seminal vesicle invasion, and positive surgical margins. Multivariate analysis identified high PSA ≥20 ng/mL (HR: 1.93; p = 0.034), pathologic T stage 3–4 (HR: 1.89; p < 0.001), pathologic Gleason score 8–10 (HR: 5.43; p < 0.001), extraprostatic extension (HR: 1.41; p < 0.001), seminal vesicle involvement (HR: 1.92; p = 0.018), and positive surgical margin (HR: 2.73; p < 0.001) as independent predictors of BCR. …”
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Antibiotic resistance genotype, phenotype, and clinical outcomes in patients with Gram-negative infections at Rabin Medical Center in Israel by Rachelle E. Koch, Jackson Barth, Andrew E. Clark, Dhara Desai, Jiwoong Kim, Christine A. Pybus, Xiaowei Zhan, Leonard Leibovici, Dafna Yahav, David E. Greenberg

“…Sequencing revealed possible patient-to-patient transmission events. blaCTX-M-15 was associated with multidrug-resistance in E. coli (OR = 3.888, P = 0.023) on multivariate analysis. Increased blaOXA-72 copy number was associated with carbapenem-resistance in A. baumannii (P = 0.003) and meropenem minimum inhibitory concentration (P = 0.005), yet carbapenem-resistant isolates retained sensitivity to cefiderocol and sulbactam–durlobactam. …”
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Influence of Organ‐Specific Extranodal Involvement on Survival Outcomes in Stage IV Diffuse Large B‐Cell Lymphoma by Tong‐Yoon Kim, Tae‐Jung Kim, Eun Ji Han, Gi June Min, Sung‐Soo Park, Silvia Park, Jae‐Ho Yoon, Sung‐Eun Lee, Byung‐Sik Cho, Ki‐Seong Eom, Yoo‐Jin Kim, Hee‐Je Kim, Seok Lee, Chang‐Ki Min, Jong‐Wook Lee, Youngwoo Jeon, Seok‐Goo Cho

“…Results Univariate analysis revealed a significant decrease in survival rates in patients with a Deauville score of 3 and those with extranodal DLBCL affecting the spleen, bone marrow, nasosinus, and liver. In multivariate analysis, only nasosinusal involvement remained a significant predictor of reduced OS. …”
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Impacts of genomic alterations on the efficacy of HER2-targeted antibody–drug conjugates in patients with metastatic breast cancer by Riqing Huang, Anqi Hu, Qixiang Rong, Ditian Shu, Meiting Chen, Wei Yang, Yue Zhang, Qiufan Zheng, Xin An, Cong Xue, Haifeng Li, Yanxia Shi

“…Additionally, ERBB2/CDK12 co-amplification exhibited a superior median PFS in all patients (19.33 months vs. 5.43 months; HR = 0.13; 95% CI 0.04–0.45; p < 0.001) and in HER2-positive patients (19.33 months vs. 6.87 months; HR = 0.18; 95% CI 0.05–0.72; p = 0.007). Multivariate analysis indicated that amplification in cell cycle-related genes was an independent predictor of inferior PFS (HR = 4.46; 95% CI 1.08–18.40; p = 0.039), while the presence of ERBB2/CDK12 co-amplification was independently correlated with superior PFS (HR = 0.16; 95% CI 0.04–0.65; p = 0.010). …”
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Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study by Linru Fu, Xinyan Liu, Zhao Tian, Zhe Du, Xinyi Wang, Xiuqi Wang, Xiaodong Li, Tao Xu, Zhijing Sun

“…Univariate analysis revealed that gravidity, previous EP, gestational age, pretreatment β-human chorionic gonadotropin (β-hCG) level, number of MTX treatments, and presence of a visible yolk sac in ultrasound were significant predictors (all P < 0.05). Multivariate analysis confirmed that higher gravidity (odds ratio (OR) = 1.2487, 95% confidence interval (CI): 1.0103 – 1.5433, P = 0.040) and elevated pretreatment β-hCG levels (OR = 1.0006, 95% CI: 1.0004 – 1.0008, P < 0.001) were independent risk factors. …”
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Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response by Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti

“…We studied the associations between immunophenotype and depressive symptoms, social and working functioning, and subjective quality of life during the acute phase and after three months of treatment. Multivariate analysis showed that CD4+ terminally differentiated effector memory (TEMRA) were associated with more depressive symptoms with a particular emphasis on anhedonic features and worse social and working functioning and quality of life. …”
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Multispecies pasture diet and cow breed affect the functional lipid profile of milk across lactation in a spring-calving dairy system by Renata Kostovska, Gaetan Drouin, Joaquín J. Salas, Mónica Venegas-Calerón, Brendan Horan, John T. Tobin, Tom F. O'Callaghan, Sean A. Hogan, Alan L. Kelly, Laura G. Gómez-Mascaraque

“…Changes in total fatty acid (FA) and triglyceride carbon number profiles were determined by GC with a flame ionization detector, and those in polar lipids (PL) content by HPLC–evaporative light scattering–MS. Based on multivariate analysis, both diet (34.0% contribution) and breed (19.1% contribution) influenced milk FA on a yearly basis; however, in early lactation there were no differences in FA profile between the groups. …”
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Risk of angioedema and thrombolytic therapy among stroke patients: An analysis of data from the FDA Adverse Event Reporting System database by Hunong Xiang, Yu Ma, Xiaochao Luo, Jian Guo, Minghong Yao, Yanmei Liu, Ke Deng, Xin Sun, Ling Li

“…The adapted Bradford Hill criteria suggested a probable causal relationship between alteplase and angioedema, whereas there was insufficient evidence of a probable causal relationship with tenecteplase. Multivariate analysis revealed that ACE-inhibitors use (aROR 9.73 [95 ​% CI, 7.29–12.98]), female sex (aROR 1.38 [95 ​% CI, 1.13–1.67]) and hypertension (aROR 2.11 [95 ​% CI, 1.52–2.92]) were significant risk factors for angioedema among alteplase-treated stroke patients. …”
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A multicenter retrospective study of early cardiac toxicity in operable breast cancer patients receiving concurrent dual or mono anti-HER2 therapy with postoperative radiation ther... by Jing Yang, Meng-Yun Zhou, Bo Yu, Qing Lin, Yuan Yao, Hua-Ling Wu, Qi-Wei Zhu, Ming Ye, Hua-Ying Xie, Jian-Wei Wu, Gang Cai, Rong Cai, Wei-Xiang Qi, Jia-Yi Chen, Lu Cao

“…The median follow-up was 11 months. Multivariate analysis showed that left-sided breast cancer (HR 2.38; 95%CI 1.65–3.44, p < 0.001) and IMN RT (HR 1.47; 95 % CI 1.01–2.15, P-value = 0.047) are independent risk factors for ECG abnormalities. …”
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Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients by Toshiaki Takahashi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Sho Takeda, Hibiki Umeda, Kazuya Moriwake, Masashi Kayano, Yuya Sakurai, Shunsuke Nakamura, Masafumi Takahashi, Kaori Nitta, Kazuhiro Yoshida, Yuki Matsumi, Hiroyuki Michiue, Hideki Yamamoto, Hiroyuki Kishimoto, Fuminori Teraishi, Ryohei Shoji, Nobuhiko Kanaya, Hajime Kashima, Yoshihiko Kakiuchi, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara

“…Moreover, high ADAR1 expression was associated with longer PFS (p = 0.0151). In multivariate analysis, low ADAR1 (HR = 3.43, p = 0.01) and absence of bevacizumab (HR = 4.25, p = 0.01) were identified as factors shortening PFS. …”
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Association Between Gastrointestinal-Related Quality of Life and Frailty Using Baseline Data of the Prospective Cohort Study (JUSTICE-TOKYO Study) by Daisuke Asaoka, Osamu Nomura, Koji Sugano, Kei Matsuno, Hiroyuki Inoshita, Nobuto Shibata, Hideki Sugiyama, Noemi Endo, Yoshiyuki Iwase, Miyuki Tajima, Naoko Sakuma, Megumi Inoue, Mariko Nagata, Taeko Mizutani, Mizuki Ishii, Sachi Iida, Yoshiko Miura, Yuji Nishizaki, Naotake Yanagisawa, Tsutomu Takeda, Akihito Nagahara, Katsumi Miyauchi

“…<b>Results:</b> Of the 1039 eligible subjects (male: <i>n</i> = 460 [44.3%]; mean age: 78.2 ± 6.1 years), 172 (16.6%) had frailty (male: <i>n</i> = 77 [44.8%]; mean age: 80.9 ± 6.2 years). The multivariate analysis revealed that age (odds ratio [OR]: 1.070, <i>p</i> < 0.001), QOL (OR: 0.982, <i>p</i> = 0.009), a history of falls (OR: 1.702, <i>p</i> = 0.029), sarcopenia (OR: 4.708, <i>p</i> < 0.001), steroid use (OR: 3.741, <i>p</i> = 0.001), analgesic drug use (OR: 2.056, <i>p</i> = 0.014), Mini Mental State Examination (OR: 0.915, <i>p</i> = 0.011), Geriatric Depression Scale 15 (OR: 1.101, <i>p</i> = 0.008), fullness-related QOL score (OR: 1.119, <i>p</i> = 0.010), chronic obstructive pulmonary disease assessment test (OR: 1.048, <i>p</i> = 0.007), and 10-item Eating Assessment Tool (OR: 1.071, <i>p</i> = 0.009) were related to frailty. …”
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Impact of Immune Checkpoint Inhibitors and Local Radical Treatment on Survival Outcomes in Synchronous Oligometastatic NSCLC by Mandy Jongbloed, MD, Valentina Bartolomeo, MD, Martina Bortolot, MD, Shahan Darwesh, MD, Jarno W.J. Huijs, MD, Safiye Dursun, MD, Juliette Degens, MD, PhD, Ben E.E.M. van den Borne, MD, PhD, Maggy Youssef-El Soud, MD, PhD, Marcel Westenend, MD, PhD, Cordula Pitz, MD, PhD, Dirk K.M. De Ruysscher, MD, PhD, Lizza E.L. Hendriks, MD, PhD

“…The median OS was significantly longer in the chemotherapy-ICI compared with the chemotherapy-only group (33.6 versus 15.9 mo, hazard ratio [HR] = 0.5, 95% confidence interval [CI]: 0.4–0.7, p < 0.001), in the subgroups who were candidate for LRT (36.1 versus 17.2 mo, HR = 0.5, 95% CI: 0.4–0.7, p < 0.001) and those proceeding to LRT (not reached versus 23.1 mo, HR = 0.4, 95% CI: 0.2–0.7, p < 0.001). In multivariate analysis, an ICI-based strategy was associated with improved survival in the total group (HR = 0.6, 95% CI: 0.4–0.9, p < 0.001), in those with intention of LRT (HR = 0.6, 95% CI: 0.4–0.9, p = 0.02) and those who proceeded to LRT (HR = 0.3, 95% CI: 0.1–0.6, p = 0.002). …”
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Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression by Tingting Xu, Jianmin Huang, Jiajing Lin, Yuanyuan Liu, Yi Wang, Wenkang Shen, Jianjie He, Shuyun Chen, Xi Zhu, Yuqin Que, Mengting Hu, Yu Chen, Liming Cheng, Honghao He, Xin Liu, Si Liu

“…Methods The IgG N-glycome in GC was characterized using a custom high-throughput orthogonal mass spectrometry approach. Multivariate analysis was employed to identify and assess glycomic alterations. …”
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Temporal trends in guideline-recommended medical therapy after an acute heart failure decompensation event: an observational analysis from Generator Heart Failure DataMart by Antonio Gasbarrini, Giuseppe Patti, Filippo Crea, Giovanni Scambia, Domenico D'Amario, Vincenzo Valentini, Gianluigi Savarese, Alfredo Cesario, Jacopo Lenkowicz, Stefano Patarnello, Renzo Laborante, Agni Delvinioti, Andrada Mihaela Tudor, Chiara Iacomini, Antonio Iaconelli, Donato Antonio Paglianiti, Mattia Galli, Daniele Rodolico, Attilio Restivo, Giuseppe Ciliberti, Gaetano Rizzo, Emiliano Bianchini, Matteo Busti, Luca Sensini

“…Over time, an increase in the prescription rate occurred only for SGLT2 inhibitors (3% vs 10% vs 32%, p&lt;0.001), whereas the rate of the composite of all-cause death and rehospitalisation for urgent causes at 30 days remained stable (9.9% vs 10.3% vs 8.4%; p=ns). In multivariate analysis, the use of ACEi/ARB/ARNi was associated with a lower risk of 30-day all-cause death and urgent rehospitalisation (adjusted OR 0.38; 95% CI 0.24 to 0.59; p&lt;0.01). …”
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Combined Age with Mean Decrease Rates of Total Bilirubin and MELD Score as a Novel and Simple Clinical Predictor on 90-Day Transplant-Free Mortality in Adult Patients with Acute Li... by Di Jin, Kai Kang, Bing-zhu Yan, Jian-nan Zhang, Jun-bo Zheng, Zhi-hui Wang, Di Wu, Yu-jia Tang, Xin-tong Wang, Qi-qi Lai, Yang Cao, Hong-liang Wang, Yang Gao

“…Univariate analysis showed a significant difference in age, mean decrease rates of total bilirubin and MELD score mean increase rate of prothrombin activity, decrease rates of total bilirubin and MELD score, and increase rate of prothrombin activity after the first PE between the death group and survival group. Multivariate analysis showed that age and mean decrease rates of total bilirubin and MELD score were closely associated with 90-day transplant-free mortality in adult patients with ALF undergoing PE. …”
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Twenty years’ experience of midgut malrotation and volvulus in a tertiary center in northern Taiwan: A retrospective study by Wen-Yu Tseng, Ming-Wei Lai, Jin-Yao Lai, Chien-Chang Chen, Hsun-Chin Chao, Jeng-Chang Chen, Shih-Yen Chen, Yung-Ching Ming, Hung-Yu Yeh, Hung-Hsiang Lai, Sze-Ya Ting, Pai-Jui Yeh

“…The INR, hemoglobin, HCO3, base excess, and aspartate transaminase values showed significant variation between the two groups. Multivariate analysis identified that lower hemoglobin (OR 0.677, p = 0.043) and higher AST (OR 1.036, p = 0.044) were independent predictors of adverse outcomes. …”
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The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease by Jiaxin Zhou, Jing Shi, Jinjing Liu, Luxi Sun, Lu Li, Chaoran Li, Xiuhua Wu, Yining Wang, Xinping Tian, Xiaofeng Zeng, Yi Liu, Wenjie Zheng, Yan Zhao

“…For the other 97 aortic and/or peripheral artery aneurysms in 59 patients, the most commonly affected vessels were abdominal aorta (27/97, 27.8%), coronary artery (10/97, 10.3%), and superficial femoral artery (8/97, 8.2%). Multivariate analysis revealed pathergy reaction (OR=3.78 (1.70-8.41)), arterial stenosis or occlusion (OR=44.12 (11.56-168.35)), and arterial thrombosis (OR=9.27 (2.33-36.93)) as independent predictors of aneurysmal lesions in BD. …”
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Tandem Versus Single Autologous Stem Cell Transplantation for High‐Risk Multiple Myeloma in the Era of Novel Agents: A Real‐World Study of China by Xuelin Dou, Juan Ren, Jiangtao Li, Xiaodan Liu, Li Bao, Yuan Chen, Peng Zhao, Yuping Zhong, Nan Peng, Lei Wen, Leqing Cao, Yang Liu, Daoxing Deng, Fengrong Wang, Liru Wang, Hui Liu, Xiaojun Huang, Xiaodong Mo, Jin Lu

“…The tandem ASCT cohort showed a trend of better 3‐year probability of PFS (58.1% vs. 64.7%, p = 0.064) compared with the single ASCT cohort. In multivariate analysis, ultra high‐risk and achieving<VGPR response after ASCT1 were associated with an inferior PFS. …”
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Screening 215 Lentil Genotypes under Salinity Stress During the Seedling Stage in Greenhouse Conditions by Ahmad Nezami, jafar Nabati, Mohammad Kafi, Elahe Boroumand Rezazadeh

“…The performed grouping was validated through a multivariate analysis of variance and discriminant function analysis. …”
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