Temporal trends, associated risk factors and longitudinal cardiovascular outcomes of body roundness among middle-aged and older Chinese adults: from the China Health and Retirement... by Ying-Yuan Gan, Yun-Dan Luo, Lu Zhai, Rong-Rui Huo, Xia Dai, Qian Liao

“…BRI continued to rise slowly across survey cycles but was higher in women, older adults, and urban residents. Multivariable analysis identified age, alcohol consumption, elevated blood pressure, and diabetes as positive predictors of BRI, while male sex, rural residence, and smoking were negatively associated. …”
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The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis by Zuo-hu Niu, Li Lin, Hong-ye Peng, Xin-zhuo Zheng, Mi-yuan Wang, Feng-xia Sun, Chun-jun Xu

“…We extracted and synthesized hazard ratios (HRs) and 95% confidence intervals (CIs) using STATA/SE 12.0, stratifying HRs based on univariable and multivariable analysis. Due to substantial heterogeneity, we applied a random-effect model for all pooled analyses. …”
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Factors influencing the kinetics of MSU crystal depletion measured with dual-energy CT in patients with gout by Tristan Pascart, Victor Laurent, Charlotte Jauffret, Aurore Pacaud, Vincent Ducoulombier, Julie Legrand, Stéphane Verdun, Laurène Norberciak, Jean-François Budzik

“…The median decrease from baseline MSU crystal volume was greater in patients reaching the <5.0 mg/dL SU target than in those reaching ≥5.0 SU <6.0 mg/dL: −85% (95% CI: −94% to −72%) versus −40% (−57% to −22%; p<0.05) at 12 months. In multivariable analysis, time (in days) with a multilevel coefficient of −0.06 (95% CI: −0.08 to −0.03, p<0.001), hypertension (coefficient: 41.87, 95% CI: 16.38 to 67.18, p<0.01) and SU level <5.0 mg/dL (coefficient: −39.46, 95% CI: −70.93 to −8.34, p=0.02) were the only variables significantly associated with MSU crystal volume change.Conclusion In patients with DECT-measured MSU crystal deposition, reaching the <5.0 mg/dL SU target provides more extensive and rapid crystal dissolution than reaching the <6.0 mg/dL SU target.…”
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Clinical outcomes of early remdesivir administration in hospitalized patients at high risk for severe COVID-19 during the Omicron wave by Yeon Ju La, Won Sup Oh, Changhyup Kim, Myoung-nam Lim, Yong Duk Jeon

“…The primary outcome was all-cause mortality within 28 days and the secondary outcome was the need for oxygen supplementation within 28 days. Multivariable analysis was conducted to assess risk factors for all-cause mortality and the need for oxygen supplementation. …”
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Infarct Growth in Patients with Emergent Large Vessel Occlusion Stroke Transferred for Endovascular Thrombectomy by Xiangjun Xu, Yujuan Zhu, Yapeng Guo, Hao Wang, Junfeng Xu, Ke Yang, Liang Ge, Yi Sun, Xianhui Ding, Qian Yang, Chuyuan Ni, Xianjun Huang

“…Overall, fast infarct growth was independently associated with worse 90-day outcome (absolute rate of ASPECTS decay: OR = 3.395; 95% CI 1.844–6.250; P < 0.001; relative ASPECTS deterioration ratio: OR = 3.754; 95% CI 2.050–6.873; P < 0.001). In multivariable analysis, fast infarct growth was independently associated with high admission NIHSS, proximal occlusions, and poor collateral status, while intravenous thrombolysis before transfer was negative with fast inter-hospital infarct growth. …”
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Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study by Jindi Zhang, Pei Wang, Jie Liu

“…Results: Univariate analysis showed that the PE group had significantly higher levels of TG, Cr, UA, and urea than the control group [3.56 (3.01–4.38) mmol/L vs. 2.98 (2.50–3.42) mmol/L, 54.00 (47.00–62.00) μmol/L vs. 46.00 (42.00–51.00) μmol/L, 367.00 (305.50–425.00) μmol/L vs. 278.00 (244.00–306.00) μmol/L, 3.50 (2.75–4.40) mmol/L vs. 2.90 (2.60–3.55) mmol/L respectively]. Multivariable analysis showed that the serum TG [adjusted odds ratio (AOR) = 1.827 (95% confidence interval (95% CI) = 1.277–2.615)], Cr [AOR = 1.066 (95% CI = 1.028–1.106)] and UA [AOR = 1.016 (95% CI = 1.011–1.022)] were risk factors for PE (p < 0.001). …”
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Excessive occupational sitting increases risk of cardiovascular events among working individuals with type 1 diabetes in the prospective Finnish Diabetic Nephropathy Study by Matias Seppälä, Heidi Lukander, Johan Wadén, Marika I. Eriksson, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn, FinnDiane Study Group

“…Furthermore, in a stratified multivariable analysis among current smokers, excessive occupational sitting increased the risk of all-cause mortality (2.06 [1.02‒4.20]). …”
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Attitudes of radiologists and interns toward the adoption of GPT-like technologies: a National Survey Study in China by Tianyi Xia, Shijun Zhang, Ben Zhao, Ying Lei, Zebin Xiao, Bingwei Chen, Junhao Zha, Yaoyao Yu, Zhijun Wu, Chunqiang Lu, Tianyu Tang, Yang Song, Yuancheng Wang, Shenghong Ju

“…Based on the acceptance level of GPT-like technologies, the respondents were 3 (0.2%), 29 (2.2%), 352 (27.3%), 677 (52.5%), and 228 (17.7%) from low to high acceptance degrees. Multivariable analysis revealed significant associations between positive attitudes towards GPT-like technologies and their acceptance: writing papers and language polishing (odds ratio [OR] = 1.99; p < 0.001), influence of colleagues using such technologies (OR = 1.77; p = 0.007), government regulation introduction (OR = 2.25; p < 0.001), and enhancement of decision support capabilities (OR = 2.67; p < 0.001). …”
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Coronary plaque characteristics quantified by artificial intelligence-enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population by Guadalupe Flores Tomasino, Caroline Park, Kajetan Grodecki, Jolien Geers, Donghee Han, Andrew Lin, Keiichiro Kuronuma, Nipun Manral, Emily Xing, Heidi Gransar, Sebastien Cadet, Alan Rozanski, Piotr J. Slomka, Michelle Williams, Daniel S. Berman, Damini Dey

“…Men presented higher volumes of all plaque components compared to women (P<0.05). In multivariable analysis adjusted for cardiovascular risk factors, only African American patients were associated with lower total plaque (β=-89.2, P=0.036), calcified (β=-26.1, P=0.015), and non-calcified plaque volumes (β=-62.7, P=0.022). …”
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Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective lon... by Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

“…C2D1 LIPI, but not C1D1, remained significantly associated to rapid PD in multivariable analysis. Conclusions LIPI may improve patient selection for ICI and guide treatment adjustments according to on-treatment dynamics in a pancancer context.…”
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Early COVID-19 and protection from Omicron in a highly vaccinated population in Ontario, Canada: a matched prospective cohort study by Altynay Shigayeva, Christopher Kandel, Lubna Farooqi, Zoe Zhong, Anne-Claude Gingras, Brenda L. Coleman, Lois Gilbert, Wayne L. Gold, Maria Major, Tony Mazzulli, Samira Mubareka, Jelena Vojicic, Jingyan Yang, Pingping Zhang, Catherine Martin, Moe H. Kyaw, John M. McLaughlin, Allison McGeer

“…Of 624 EI, 175 (28%) had one SARS-CoV-2 re-infection and 8 (1.3%) had two, compared to 84 (48%) non-EI participants with one, 5 (2.9%) with two and 1 (0.6%) with 3 infections (P < 0.0001). In multivariable analysis of risk factors for Omicron infection, the overall hazard ratio (HR, 95%CI) associated with EI was 0.56 (0.43–0.74); HRs for BA.1/2, BA.4/5 and mixed BA.5/BQ.1/XBB periods were 0.66 (0.45–0.97), 0.44 (0.28–0.68) and 0.71 (0.32–1.56). …”
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The Novel Histological Prostatic Inflammation Score Helps Defining the Association Between Stromal and Glandular Inflammation with the Risk of Prostate Cancer at Prostate Biopsy by Ugo Giovanni Falagario, Francesca Sanguedolce, Angelo Cormio, Antonella Ninivaggi, Marco Finati, Francesco Guzzi, Gian Maria Busetto, Carlo Bettocchi, Daniele Castellani, Giuseppe Carrieri, Luigi Cormio

“…Notably, almost one-quarter of patients had heterogeneous Irani features. Multivariable analysis pointed out a significant association between PIS and the risk of being diagnosed with PCa and csPCa; the higher the PIS, the lower the likelihood of such diagnoses. …”
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Medication adherence and blood pressure control in treated hypertensive patients: first follow-up findings from the PREDIcT-HTN study in Northern Bangladesh by Ahmed Hossain, Gias Uddin Ahsan, Mohammad Zakir Hossain, Mohammad Anwar Hossain, Probal Sutradhar, Sarowar-E. Alam, Zeeba Zahra Sultana, Heba Hijazi, Syed Azizur Rahman, Mohamad Alameddine

“…Certain patient subgroups had higher rates of poor adherence: females (17.1%) compared to males (12.2%), rural residents (22.4%) compared to city-dwellers (12.2%), and newly diagnosed patients (17.2%) compared to those diagnosed 2–5 years earlier (12.6%). Multivariable analysis found a strong association between medication adherence and BP control. …”
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Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma &le;3 cm in Potentially Transplantable Patients: A Over 1... by Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

“…Cumulative survival rates without RBM at 3, 5, 8, 10, and 13 years were 77.3%, 65.9%, 56.5%, 51.0%, and 37.6%, respectively. Multivariable analysis identified older age, C-reactive protein(CRP)≥ 1.81 mg/L, and platelet(PLT)≤ 80× 109/L as independent risk factors for TRBM. …”
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Low ITN utilization among households in SWEPR Ethiopia: challenge for malaria elimination, a mixed design approach by Wondwossen Niguse, Bezuayehu Alemayehu, Tadesse Gebremedhin, Mathewos Alemu, Girma Mamo, Ephrem Negeri, Ibrahim Temam, Haile Zewdie, Tamirat Bogale, Erkyihun pawulos, Endale Sahlie

“…A binary Logistic Regression model was fitted to identify the associated factors. In the multivariable analysis, an adjusted odds ratio (AOR) with a corresponding 95% confidence interval (CI) was used to measure the strength of the association and the statistically significant association was declared at a P-value less than 5%. …”
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Determinants of Dietary Diversity Practice among Pregnant Women in the Gurage Zone, Southern Ethiopia, 2021: Community-Based Cross-Sectional Study by Tolesa Gemeda Gudeta, Ayana Benti Terefe, Girma Teferi Mengistu, Seboka Abebe Sori

“…The overall prevalence of the adequate dietary diversity practice was found to be 42.1% with 95% CI (48.4–46.1%) and the mean dietary diversity score was 5.30 ± 1.49 standard deviation (SD). Multivariable analysis revealed that primary school level [AOR = 6.471 (2.905, 12.415)], secondary school level (9–12) [AOR = 7.169 (4.001, 12.846)], college and above level [AOR = 32.27 (15.044, 69.221)], women with higher empowerment [AOR = 3.497 (2.301, 5.315)], women with a favorable attitude toward dietary diversity [AOR = 1.665 (1.095, 2.529)], women from wealthier households [AOR = 2.025 (1.252, 3.278)], and having well-secured food status [AOR = 3.216 (1.003, 10.308)] were variables that influence dietary diversity practice. …”
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Financial crisis and its association with parental stress and children’s mental health in Lebanon by Ramona Nasr, Samantha Abi Saab, Nada Nasr, Chadia Haddad, Eman Swaidan, Sara Abou Ibrahim, Joanne Karam

“…Negative correlations were observed between the IFDFW scale and both PSS (r=-0.200, p < 0.001) and PSC scores (r=-0.086, p = 0.038), indicating lower stress and symptoms with improved financial well-being. Multivariable analysis showed that higher PSC scores, age, complementary education, and Lebanese nationality were associated with increased parental stress, while unemployment, lower age, and higher IFDFW were associated with reduced stress. …”
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Significance of Heparin-Binding Protein and D-dimers in the Early Diagnosis of Spontaneous Bacterial Peritonitis by Tomasz Mikuła, Mariusz Sapuła, Joanna Jabłońska, Joanna Kozłowska, Wojciech Stańczak, Dagny Krankowska, Alicja Wiercińska-Drapało

“…A very weak, but statistically significant, correlation of HBP, WBC, and D-dimer levels with the peritoneal fluid polymorphonuclear (PMN) count was observed in the simple regression model, but multivariable analysis using the multiple regression model showed that only D-dimers correlated with peritoneal fluid PMNs independently from other inflammation biomarkers. …”
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Norepinephrine use in cardiogenic shock patients is associated with increased 30 day mortality by Xin Lu, Xue Wang, Yanxia Gao, Joseph Harold Walline, Shiyuan Yu, Zengzheng Ge, Mubing Qin, Huadong Zhu, Yi Li

“…Thirty day mortality for patients treated with norepinephrine was significantly higher than for those in the non‐norepinephrine group (41% vs. 30%, OR 1.61, 95% CI 1.09–2.39, P = 0.017; HR 1.50, 95% CI 1.09–2.06, P = 0.013). In the multivariable analysis, there was no significant difference between norepinephrine therapy and long‐term (90 day, 180 day, or 1 year) mortality (90 day (OR 1.19, 95% CI 0.82–1.74, P = 0.363), 180 day (OR 1.17, 95% CI 0.80–1.70, P = 0.418), 1 year (OR 1.14, 95% CI 0.79–1.66, P = 0.477). …”
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Associations of dose to the urethra and long-term patient-reported outcomes after radiotherapy with EBRT and HDR brachytherapy boost for prostate cancer by Lars Haack, David Krug, Justus Domschikowski, Olaf Wittenstein, Severin Rodler, Philipp Nuhn, Christof van der Horst, Claudia Schmalz, Christian Schulz, Oliver Blanck, Frank-André Siebert, Alexander Fabian

“…Per predefined multivariable analysis, DU0.1cc and urinary incontinence remained significantly associated (B = −0.005; CI = −0.008 − -0.002; p = 0.003). …”
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