The prevalence and 6-year incidence of myopic tessellation in a Chinese rural adult population: the Handan Eye Study by Caixia Lin, Jian Wu, Kai Cao, Bingsong Wang, Yuxin Fang, Ohno-Matsui Kyoko, Yunyun Sun, Jie Hao, Lixia Ma, Ye Zhang, Qing Zhang, Ningli Wang, the Handan Eye Study Group

“…The progression rate of fundus tessellation in those with fundus tessellation at baseline was 1.5% (95% CI: 0.82%, 2.38%). By multivariable analysis, subjects being older (OR: 1.079, P < 0.001) and havingβ-parapapillary atrophy at baseline (OR: 2.657, P = 0.002) were associated with a higher risk of incidence of fundus tessellation. …”
Get full text

Metabolic Syndrome and Its Components Predict the Risk of Type 2 Diabetes Mellitus in the Mainland Chinese: A 3-Year Cohort Study by Kun Wang, Qun-Fang Yang, Xing-Lin Chen, Yu-Wei Liu, Sheng-Shuai Shan, Hua-Bo Zheng, Xiao-Fang Zhao, Chang-Zhong Chen, Cheng-Yun Liu

“…MetS and its components were assessed by multivariable analysis using Cox regression. Prediction models were developed. …”
Get full text

Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatmentResearch in context by Haritha Desu, Renaud Balthazard, Audrey Daigneault, Sandra Da Cal, Wendy Klément, Jennifer Yu, Marie-Laure Clénet, Clara Margarido, Annie Levert, Canisius Fantodji, Olivier Tastet, Jean-Marc Girard, Pierre Duquette, Alexandre Prat, Gabrielle Macaron, Marie-Claude Rousseau, Nathalie Arbour, Catherine Larochelle

“…IL-4 and β-NGF levels were lower in untreated PwMS compared to controls, while EGF and bFGF levels were influenced by age and markedly elevated in PwMS in multivariable analysis. Samples from treated PwMS, but not untreated PwMS, showed lower levels of BDNF and TNF than controls. …”
Get full text

Impact of Sjögren’s disease on quality of sexual life using the Qualisex score by Eric Hachulla, Xavier Mariette, Jacques-Eric Gottenberg, Philippe Dieude, Aleth Perdriger, Emanuelle Dernis, Marion Couderc, Raphaele Seror, Gaetane Nocturne, Rakiba Belkhir, Valérie Devauchelle-Pensec, Veronique Le Guern, Alexandra Kachaner, Sophie Berville

“…Interestingly, EULAR Sjögren’s disease Disease Activity Index (ESSDAI) score did not differ significantly (4 (1–10) vs 2.5 (1.8–4), p=0.35). In a multivariable analysis, the Qualisex score remained strongly associated with a higher HADS depression score and, to a lesser extent, with a higher ESSPRI. …”
Get full text

Sorafenib as Adjuvant Therapy Post–Liver Transplant: A Single-center Experience by Hala Hassanain, MD, Ashton A. Connor, MD, PhD, Elizabeth W. Brombosz, PhD, Khush Patel, MD, MS, Ahmed Elaileh, MD, Tamneet Basra, MD, Sudha Kodali, MD, MSPH, David W. Victor, III, MD, Caroline J. Simon, MD, Yee Lee Cheah, MD, Mark J. Hobeika, MD, Constance M. Mobley, MD, PhD, Ashish Saharia, MD, Sadhna Dhingra, MD, Mary Schwartz, MD, Anaum Maqsood, MD, Kirk Heyne, MD, Ahmed O. Kaseb, MD, Jean-Nicolas Vauthey, MD, A. Osama Gaber, MD, Maen Abdelrahim, MD, PhD, R. Mark Ghobrial, MD, PhD

“…OS was similar among the 3 groups (P = 0.2), and adjuvant sorafenib was not associated with OS in multivariable analysis (hazard ratio, 1.31; 95% confidence interval, 0.45-3.78; P = 0.62). …”
Get full text

Characteristics of nursing homes and early preventive measures associated with risk of infection from COVID-19 in Lazio region, Italy: a retrospective case–control study by Leonardo Palombi, Alessio Abbondanzieri, Stefano Orlando, Tuba Mazhari, Gennaro Cerone, Fausto Ciccacci, Giuseppe Liotta, Sandro Mancinelli, Maria Cristina Marazzi

“…In binary logistic regression models, facilities with more than 15 beds were five times more likely to experience an outbreak than facilities with less than 15 beds OR=5.60 (CI 1.61 to 25.12; p value 0.002); admitting new residents to facilities was associated with a substantially higher risk of an outbreak: 6.46 (CI 1.58 to 27.58, p value 0.004). In a multivariable analysis, facility size was the only variable that was significantly associated with a COVID-19 outbreak OR= 5.37 (CI 1.58 to 22.8; p value 0.012) for larger facilities (&gt;15 beds) versus smaller (&lt;15 beds). …”
Get full text

Comparison of Performance on the Clock Drawing Test Using Three Different Scales in Dialysis Patients by Taim Abdullah Muayqil, Ahmad Raed Tarakji, Abdullah Mohammad Khattab, Nasser Talal Balbaid, Ahmad Mohedeen Al-Dawalibi, Sami Ahmed Alqarni, Reema Ali Hazazi, Mohammed H. Alanazy

“…However, only age and years of education were significant in the multivariable analysis. In factor analysis, two shared factors appeared between the three scales: hand and number placement and the clock face. …”
Get full text

Surgical Outcomes and Sociodemographic Disparities Across All Races: An ACS-NSQIP and NHIS Multi-Institutional Analysis of Over 7.5 Million Patients by Dany Y. Matar, BA, Samuel Knoedler, Anthony Y. Matar, BS, Sarah Friedrich, PhD, Harriet Kiwanuka, MD, Ryoko Hamaguchi, MD, Carla M. Hamwi, BS, Gabriel Hundeshagen, MD, MMS, Valentin Haug, MD, Ulrich Kneser, MD, PhD, Keisha Ray, PhD, Dennis P. Orgill, MD, PhD, Adriana C. Panayi, MD, PhD

“…In a registry-based cohort study using the 2008 to 2020 American College of Surgeons National Surgical Quality Improvement Program, we evaluated 24 postoperative outcomes through multivariable analysis, incorporating 28 preoperative risk factors. …”
Get full text

Thromboelastometry-Based Profiling of Haemostatic Alterations in Neonatal Sepsis by Causative Pathogens by Rozeta Sokou, Eleni A. Gounari, Konstantina A. Tsante, Aikaterini Konstantinidi, Maria Lampridou, Martha Theodoraki, Anastasios G. Kriebardis, Sotirios P. Fortis, Nicoletta Iacovidou, Andreas G. Tsantes

“…This is reflected in the higher ROTEM values such as A10, α-angle, and MCF in the EXTEM and INTEM assays. Multivariant analysis showed that Gram-positive infections were linked to increased clot thickness at 10 min (coefficient: 8.9, CI: 2.8–15.0, <i>p</i> = 0.004), higher maximum clot stability (coefficient: 10.4, CI: 4.3–16.6, <i>p</i> = 0.001), and a bigger α-angle (coefficient: 8.0, CI: 2.7–13.2, <i>p</i> = 0.003). …”
Get full text

Direct Oral Anticoagulants Versus Vitamin K Antagonists After Mitral Valve Transcatheter Edge‐to‐Edge Repair in Patients With Atrial Fibrillation: A Single‐Center Observational Stu... by Jan‐Hendrik Schipper, Anne‐Sophie Sommer, Richard Julius Nies, Clemens Metze, Max Maria Meertens, Jonas Wörmann, Sebastian Dittrich, Jan‐Hendrik van den Bruck, Arian Sultan, Jakob Lüker, Daniel Steven, Christopher Hohmann, Roman Pfister, Stephan Baldus, Ingo Eitel, Christian Frerker, Tobias Schmidt

“…However, the overall mortality rate was higher in the VKA group (HR, 2.56 [95% CI, 1.54–4.26]; P=0.002). In the multivariable analysis, oral anticoagulation with a VKA was an independent predictor for death (adjusted HR, 2.23 [95% CI, 1.08–5.06]; P=0.03). …”
Get full text

Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult by Kangyu Huang, Min Dai, Qiuli Li, Nannan Liu, Dainan Lin, Qiang Wang, Xuan Zhou, Zhixiang Wang, Ya Gao, Hua Jin, Xiaoli Liu, Qifa Liu, Hongsheng Zhou

“…Furthermore, multivariable analysis revealed that T-ALL mixed infection was more likely related to chemotherapy response (OR, 0.025; 95% CI 0.127-0.64; P=0.012) and identified myeloid percentage as a predictor associated with ETP-ALL mixed infection (OR, 0.915; 95% CI 0.843-0.993; P=0.033), with ROC-defined cut-off value of 2.24% in ETP cohorts. …”
Get full text

Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma by Eun Seop Seo, Eun Seop Seo, In Hwa Jeong, In Hwa Jeong, Hee Young Ju, Ju Kyung Hyun, Ji Won Lee, Keon Hee Yoo, Won Young Heo, Ki Woong Sung, Hee Won Cho, Eun-Suk Kang

“…When combined, the PIRCHE-I and PIRCHE-II scores demonstrated an even stronger association with improved OS (HR 0.35, 95% CI 0.15-0.82, P = 0.016). Multivariable analysis confirmed that a higher combined PIRCHE-I and PIRCHE-II score was independently associated with improved OS (combined PIRCHE score HR 0.22, 95% CI 0.06-0.79, P = 0.021), and a higher PIRCHE-II score was significantly associated with reduced progression (HR 0.42, 95% CI 0.25-0.70, P &lt; 0.001).ConclusionIn conclusion, higher PIRCHE-I and PIRCHE-II scores are linked to better survival outcomes and reduced complications in pediatric haplo-SCT neuroblastoma patients. …”
Get full text

Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…After a median follow-up time of 29.7 months, patients with higher burden of skin, endocrine and musculoskeletal irAEs (the latter two’s effect was confirmed at multivariable analysis) had longer overall survival (OS), as opposed to gastrointestinal, pneumonitis, neurological, liver, renal and other irAEs, which showed an harmful effect. …”
Get full text

Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context by Charlotte Ocana de Sentuary, Clara Testard, Marion Lagrée, Maxime Leroy, Lisa Gasnier, Alicia Enes-Dias, Constance Leruste, Diariatou Diallo, Michael Génin, Thameur Rakza, François Dubos

“…The nirsevimab acceptance rate [95% confidence interval] was 91.6% [89.1%–94.2%]. In a multivariable analysis, the mother's age, lower parity and having a partner in work were significantly associated with nirsevimab acceptance. …”
Get full text

Traumatic dental injuries in the first year of life and related risk factors in three regions of Brazil: a multicenter birth cohort study by Carlos Alberto Feldens, Bruno Antonio Sehn Konzen, Elisa Maria Rosa de Barros Coelho, Alessandra Castro Alves, Eliane Gerson Feldens, Márcia Regina Vítolo, Paulo Floriani Kramer

“…Results The incidence of TDI in the first year of life (range: 12 to 16 months) was 18.1% (95% CI: 13.6–22.6%). The multivariable analysis revealed a significantly greater risk of TDI in children from non-nuclear families (RR = 1.83; 95% CI: 1.11-3.00) as well as those whose mothers had a higher level of schooling (RR = 2.42; 95% CI: 1.04–5.63) and when tooth eruption began up to six months of age (RR = 2.30; 95% CI: 1.34–3.95). …”
Get full text

Plasma Iron Levels at Early Breast Cancer Diagnosis Are Associated With Development of Secondary Metastases: A Single-Center Retrospective Cohort Study by Jasmine De Troy, Sarah-Maria Fendt, Sigrid Hatse, Patrick Neven, Ann Smeets, Annouschka Laenen, Hans Wildiers

“…Results: In total, 1113 patients were included, 10% of them developed distant metastasis over a median follow-up period of 7 years. In multivariable analysis adjusting for age, stage, and subtype, transferrin saturation and serum iron were significantly associated with an increased risk of breast cancer metastasis. …”
Get full text

Oxygenation improvement and duration of prone positioning are associated with ICU mortality in mechanically ventilated COVID-19 patients by Silvia De Rosa, Nicolò Sella, Giacomo Bellani, Giuseppe Foti, Andrea Cortegiani, Giulia Lorenzoni, Dario Gregori, Annalisa Boscolo, Lucia Cattin, Muhammed Elhadi, Giorgio Fullin, Eugenio Garofalo, Leonardo Gottin, Alberto Grassetto, Salvatore Maurizio Maggiore, Elena Momesso, Mario Peta, Daniele Poole, Roberto Rona, Ivo Tiberio, Andrea Zanoletti, Emanuele Rezoagli, Paolo Navalesi, for the SIAARTI Study Group

“…The length of the first cycle of prone position showed an inverse relationship with ICU mortality [OR (95% CI) 0.82 (0.73, 0.91)]. At the multivariable analysis, the duration of the first cycle of prone position, Delta-PP and Delta-PostPP for PaO2/FiO2, and Delta-PostPP for ventilatory ratio were independently associated with ICU mortality. …”
Get full text

Postoperative blood glucose increase can predict all-cause mortality within 3 months after successful interventional recanalization in patients with acute large vessel occlusion ce... by Wensheng Zhang, Yajie Liu, Hongxing Zhou, Jie Li, Weifang Xing, Kaifeng Li, Yudi Li, Xiongjun He, Li Ling, Jinzhao He

“…After adjusting for potential covariates, multivariable analysis showed a significant correlation between BGI and 3-month postoperative mortality rate (adjusted HR: 5.694, 95%CI: 2.379–13.626, P<0.001). …”
Get full text

Development and approval of a Lasso score based on nutritional and inflammatory parameters to predict prognosis in patients with glioma by Huixian Li, Hui Hong, Jinling Zhang

“…NLR, PLR, MLR, and PNI from the training dataset were utilized for Lasso calculation. Multivariable analysis indicated that age, pathological grade, chemotherapy status, Ki-67 expression, and the Lasso score were independent predictors of OS and were then included in the nomogram. …”
Get full text

Surgery lengthens survival for collecting duct carcinoma: analysis of hospital-based cancer registry data in Japan by Shuya Kandori, Shuhei Suzuki, Kosuke Kojo, Bunpei Isoda, Takazo Tanaka, Satoshi Nitta, Masanobu Shiga, Yoshiyuki Nagumo, Atsushi Ikeda, Takashi Kawahara, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Ayako Okuyama, Hiroyuki Nishiyama

“…The median OS of patients who undertook chemotherapy alone was significantly shorter than patients who undertook surgery alone for advanced disease (4 months [95% CI: 4-NA] vs. 15 months [95% CI: 13–68]; p < 0.001) and surgery-only patients had a similar median OS as surgery-plus-chemotherapy patients (19 months [95% CI: 13-NA]; p < 0.001). Moreover, a multivariable analysis for the OS in advanced disease revealed that surgery-plus-chemotherapy patients had significantly more favorable prognoses (HR 0.21, 95% CI: 0.07–0.57). …”
Get full text