Adjuvant chemotherapy followed by concurrent chemoradiation is associated with improved survival for resected stage I‐II pancreatic cancer by Sung Jun Ma, Gregory M. Hermann, Kavitha M. Prezzano, Lucas M. Serra, Austin J. Iovoli, Anurag K. Singh

“…Results Among 5667 patients, median follow‐up was 34.7, 45.2, and 39.7 months for the C, CRT, and C + CRT cohorts, respectively. By multivariable analysis for all patients, C and CRT had worse OS compared to C + CRT. …”
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Goiter and Its Associated Factors among Adolescent High School Girls at Tach Armachiho District, Northwest Ethiopia: An Institution-Based Cross-Sectional Study by Belaynew Mesfin, Bisrat Misganaw, Melkamu Tamir Hunegnaw, Esmael Ali Muhammad

“…Those variables having p value of less than 0.05 in the multivariable analysis were considered as significant factors for goiter. …”
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High Seroprevalence of Autoantibodies Typical of Autoimmune Liver Disease in Eastern Ethiopia: Is Chewing of Khat (Catha edulis) a Triggering Factor? by Stian Magnus Staurung Orlien, Tekabe Abdosh Ahmed, Nejib Yusuf Ismael, Nega Berhe, Trine Lauritzen, Svein Gunnar Gundersen, Asgeir Johannessen

“…ANA was excluded from multivariable analysis since there was no seropositive in the reference group. …”
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Clinical Utility of a Structured Program to Reduce the Risk of Health-Related Quality of Life Impairment after Discharge from Intensive Care Unit: A Real-World Experience by Angelica Venni, Francesca Ioia, Silvia Laviola, Francesca Frigieri, Alessandra Pieri, Simona Marilli, Daniela Balzi, Piercarlo Ballo, Stefano Gori, Diletta Guarducci

“…Similar good results were found by the questionnaire of memories. In multivariable analysis, no variable was found to predict the risk of PICS in our population. …”
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Blood Pressure Control among Hypertensive Diabetic Patients on Follow-Up at Chronic Clinic of Nekemte Referral Hospital in West Ethiopia by Mohammed Gebre Dedefo, Dureti Bayisa Gemechu, Ginenus Fekadu, Tesfa Tekle Dibessa

“…Blood pressure and blood glucose were controlled in 104 (55.9%) and 106 (57.0%) study participants, respectively. In the multivariable analysis, age ≥60 years (AOR = 4.537, 95% CI = 1.142–18.024, p=0.032), duration with hypertension ≥5 years (AOR = 3.534, 95% CI = 1.062–11.760, p=0.040), cigarette smoking (AOR = 7.697, 95% CI = 2.356–25.146, p=0.001), nonadherence (AOR = 6.584, 95% CI = 2.337–18.553, p<0.001), and uncontrolled glycaemia (AOR = 21.630, 95% CI = 8.057–58.070, p<0.001) were independent predictors of uncontrolled blood pressure. …”
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Correlation between Obesity and Left Atrial Enlargement in Patients Using Cardiac Magnetic Resonance by Solos Jaturapisanukul, Yodying Kaolawanich, Methat Meechuen, Thananya Boonyasirinant

“…Univariable analysis indicated that the factors affecting LA volume included BMI (r = 0.3, p < 0.001), LV mass index (r = 0.3, p = 0.001), waist circumference (r = 0.3, p < 0.001), male sex (p = 0.01), and hypertension (p = 0.01). In stepwise multivariable analysis, BMI (p < 0.001), LV mass index (p = 0.02), and male sex (p = 0.03) were independently associated with LA volume. …”
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Incidence of Hyperlipidemia among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007–2021 by Jun Li, Selom Agbobli-Nuwoaty, Frank J. Palella, Richard M. Novak, Ellen Tedaldi, Cynthia Mayer, Jonathan D. Mahnken, Qingjiang Hou, Kimberly Carlson, Angela M. Thompson-Paul, Marcus D. Durham, Kate Buchacz

“…During a median follow-up of 1.4 years, hyperlipidemia rates were 12.8, 22.3, 22.7, 17.4, and 12.6 per 100 person years for RAL-, DTG-, INSTI-others-, non-INSTI-PI-, and non-INSTI-non-PI-based ART, respectively. In multivariable analysis, compared with the RAL group, hyperlipidemia rates were higher in INSTI-others (RR = 2.25; 95% confidence interval (CI): 1.29–3.93) and non-INSTI-PI groups (RR = 1.89; CI: 1.12–3.19) but not statistically higher for the DTG (RR = 1.73; CI: 0.95–3.17) and non-INSTI-non-PI groups (RR = 1.55; CI: 0.92–2.62). …”
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Exploring health related quality of life for women with breast cancer in Ireland and Québec, Canada throughout the COVID-19 pandemic by Charlotte Myers, Kathleen Bennett, Caitriona Cahir, Josée Savard, Sophie Lauzier

“…COVID-19 stressor impact was computed post-pandemic, and change in HR-QoL during and post-pandemic was compared between Ireland and Québec using independent t-tests. Multivariable analysis of covariance (ANCOVA) was used to evaluate the association between COVID-19 stressor impact and changes in HR-QoL, and compare it between Ireland and Québec. 405 participants were included from both settings (Ireland n = 267; Québec n = 138). …”
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Psychological distress and associated factors among healthcare professionals in Ethiopia during the COVID-19 pandemic: a cross-sectional study by Berhanie Getnet, Dessie Abebaw Angaw, Zewudu Andualem, Habtamu Kerebih, Asmamaw Atnafu, Bizuneh Tesfaye, Demeke Demilew

“…The prevalence of depression, anxiety and stress during the COVID-19 pandemic among healthcare workers was 167 (42.7%), 201 (51.4%) and 242 (61.9%), respectively. In multivariable analysis, respondents found in the ages between 35 and 44; unmarried marital status; educational status with specialty, subspecialty and PhD holders; anaesthesia professionals; and healthcare professionals with known medical illness were significantly associated with depression. …”
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Evaluating the utility of the HAS‐BLED bleeding‐estimator tool for transurethral resection of prostate by Lu Yu Kuo, Zhong Li Titus Lim, Caitlin Letch, Joshua Silverman, Jason Jae Yeun Kim, Scott McClintock

“…Further weight‐adjusted multivariable analysis and ROC curve was performed to evaluate the predictive value of HAS‐BLED score. …”
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Association between triglyceride/high density lipoprotein ratio and incidence risk of Parkinson’s disease: a population-based cohort study by Yoonkyung Chang, Ju-young Park, Tae-Jin Song

“…In contrast, the lowest (T1) and highest tertiles (T3) were not associated with the incidence risk of PD in the DM cohort (HR: 1.128, 95% CI 0.909–1.348) in fully adjusted multivariable analysis. Our study provides information that TG/HDL ratio may be positively associated with PD incidence risk in a non-DM population in longitudinal setting of the general population.…”
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Nutritional Status and Educational Performance of School-Aged Children in Lalibela Town Primary Schools, Northern Ethiopia by Muluken Ayalew, Alemayehu Bayray, Abate Bekele, Simegnew Handebo

“…In this study, 14.7% of the study participants had low academic achievement in the semester. The multivariable analysis showed that rural residence (POR=0.39; 95% CI: (0.21, 0.75)), not studying regularly (POR=0.49; 95% CI: (0.29, 0.82)), severe underweight (POR=0.25; 95% CI: (0.09, 0.71)), and severe stunting (POR=0.03; 95% CI: (0.01, 0.37)) were associated with decreased odds of high average semester score achievement of school-aged children. …”
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Unintended Pregnancy and Associated Factors among Pregnant Women Attending Antenatal Care at Bako Tibe District Public Health Facility, Oromia Region, Ethiopia by Habtamu Bekele, Merga Dheressa, Bezatu Mengistie, Yitagesu Sintayehu, Gelana Fekadu

“…The variables, which were significant at P≤0.2 in the bivariate logistic regression, were included in the multivariable analysis. The direction and strength of statistical association were measured by an odds ratio with 95% CI. …”
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Prevalence of neonatal sepsis and associated factors among neonates admitted in the neonatal intensive care unit at Lira Regional Referral Hospital, Northern Uganda. by Brendah Katugume, JohnBaptist Muzungu, Nelson Okello, Eustes Kigongo, Deborah Andrinar Namutebi

“…Logistic regression analysis was used to show associations and the statistical significance was declared at a P value of 0.05 after multivariable analysis.<h4>Results</h4>Among a total of 194 neonates whose charts were reviewed, 80 neonates had neonatal sepsis, giving a proportion of 0.412 and then prevalence of 41.2%. …”
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Factors Determining Rehabilitation Needs After Intradural Spinal Tumor Surgery: A Prospective Study by Stanisław Krajewski, Jacek Furtak, Monika Zawadka-Kunikowska, Michał Kachelski, Jakub Soboń, Marek Harat

“…In the ID-EM group, age, thoracic level, subtotal resection (STR), repeat surgery, and functional scale scores predicted the need for rehabilitation. In multivariable analysis, MMS (odds ratio (OR) 8.7; 95% confidence interval (CI): 2.37–32.44) and STR (OR 13.00; 95%CI: 1.56–107.87) remained independent predictors of rehabilitation need (area under curve, 92%). …”
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Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study by Daniela Iacono, Serena Fasano, Ilenia Pantano, Virginia D’Abrosca, Piero Ruscitti, Domenico Paolo Emanuele Margiotta, Luca Navarini, Nicola Maruotti, Rosa Daniela Grembiale, Francesco Paolo Cantatore, Antonella Afeltra, Roberto Giacomelli, Gabriele Valentini

“…The CV event-free rate was longer in ASA-treated patients than in non-ASA-treated patients (log-rank test 12.8; p=0.0003). At multivariable analysis, arterial hypertension (HR 9.3) and hypercholesterolemia (HR 2.8) resulted to be positive predictors and ASA (HR 0.09) and hydroxychloroquine (HCQ) (HR 0.22) to be negative predictors. …”
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Clinical and microbiological analysis of risk factors for breakthrough bloodstream infection during Tigecycline Therapy by Sol Jin, So Yun Lim, Yun Woo Lee, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Eun Hee Song, Yong Pil Chong

“…Intraabdominal (33.9%), catheter-related (30.4%), and hepatobiliary (19.1%) infections were the main sources of breakthrough BSI. In multivariable analysis, independent risk factors for breakthrough BSI during tigecycline therapy were liver cirrhosis (adjusted odds ratio [aOR], 3.09), indwelling catheter (aOR, 3.42), previous Candida colonization (aOR, 14.95), and previous multi-drug resistant bacteria colonization (aOR, 10.30). …”
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Ursodeoxycholic acid relieves clinical severity of COVID-19 in patients with chronic liver diseases by Tiantian Hu, Tiantian Hu, Jie Tong, Yunhui Yang, Changrong Yuan, Jiming Zhang, Jiming Zhang, Jiming Zhang, Jinyu Wang, Jinyu Wang

“…After performing a 1:1 age-and sex-matching, the analysis proceeded with 309 patients from each group for further evaluation.ResultsIn the UDCA-treated cohort, the incidence of asymptomatic SARS-CoV-2 infections was significantly higher, with 30.1% of patients affected, compared to 6.47% in the non-UDCA group (p &lt; 0.0001). Multivariable analysis identified UDCA as a protective factor against symptomatic infections, yielding an odds ratio (OR) of 4.77 (95% CI: 2.70–8.44, p &lt; 0.001). …”
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Local Recurrence of Rectal Cancer After Transanal Total Mesorectal Excision and Risk Factors: A Nationwide Multicenter Cohort Study in Japan by Takeru Matsuda, MD, PhD, Ichiro Takemasa, MD, PhD, Hideki Endo, MD, MPH, Shinichiro Mori, MD, PhD, Suguru Hasegawa, MD, PhD, Koya Hida, MD, PhD, Takuya Tokunaga, MD, PhD, Keitaro Tanaka, MD, PhD, Toshiki Mukai, MD, PhD, Jun Watanabe, MD, PhD, Junichiro Kawamura, MD, PhD, Kei Kimura, MD, PhD, Yoshihiro Kakeji, MD, PhD, Masahiko Watanabe, MD, PhD, Seiichiro Yamamoto, MD, PhD, Takeshi Naitoh, MD, PhD, Ta-Ta-Mi study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery

“…Tumor height from the anal verge, pathological T4 disease, pathological stage III/IV, positive perineural invasion, and R1 resection were significant risk factors for LR in multivariable analysis. Conclusions:. In this selected cohort in which intersphincteric resection or abdominoperineal resection was performed in more than half of cases, oncological outcomes were acceptable during a median follow-up of more than 3 years.…”
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Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma by Yuji Uehara, MD, Hiroki Izumi, MD, PhD, Tetsuro Taki, MD, PhD, Tetsuya Sakai, MD, PhD, Hibiki Udagawa, MD, PhD, Eri Sugiyama, MD, PhD, Shigeki Umemura, MD, PhD, Yoshitaka Zenke, MD, PhD, Shingo Matsumoto, MD, PhD, Kiyotaka Yoh, MD, PhD, Shoko Kubota, MD, PhD, Keiju Aokage, MD, PhD, Naoya Sakamoto, MD, PhD, Shingo Sakashita, MD, PhD, Motohiro Kojima, MD, PhD, Michiko Nagamine, MD, PhD, Yukio Hosomi, MD, PhD, Masahiro Tsuboi, MD, PhD, Koichi Goto, MD, PhD, Genichiro Ishii, MD, PhD

“…Similarly, high-podoplanin (n = 31) versus low-podoplanin (n = 62) expression in CAFs was not associated with worse disease-free survival after surgery (p = 0.65), but was significantly associated with worse PFS and showed a trend towards worse overall survival following osimertinib treatment (p < 0.001, p = 0.11). In the multivariable analysis, solid predominant histology and high-podoplanin expression in CAFs were independently associated with worse PFS. …”
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