Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study by Jong Ho Kim, Sang Soo Kim, In Joo Kim, Bo Hyun Kim, Ja Young Park, Chang Won Lee, Ji Hye Suk, Sun Hae Shin, Sung Pyo Son, Min Chul Kim, Jun Hyeob Ahn, Kwang Jae Lee, Min Jung Kwon, Soon Hee Lee, Jeong Hyun Park

“…A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r=0.297, P<0.001) and eGFR (r=−0.220, P<0.001). A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r=0.150, P<0.001). …”
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Thyroid cancer survival and prognostic factors in Yantai, China (2012–2022): a population-based study by Haiyun Liu, Shuxia Zhang, Xiaohui Liu, Qianqian Wang, Hongjie Zhang, Weihong Cui

“…Disparities in the OS of thyroid cancer patients were found across different diagnosis periods, genders, age groups, places of residence, occupational classes, tumor sites and sizes, cervical lymph node metastasis statuses, TgAb levels, pathological types, clinical stages and treatment timings (all p < 0.05). Multivariate analysis showed that age group (≥ 65 years: HR = 1.727), tumor site (location in the isthmus: HR = 3.117), tumor size (> 3 cm: HR = 3.170), cervival lymph node metastasis (HR = 1.876), TgAb levels (115 − 500 IU/ml: HR = 7.103; > 500 IU/ml: HR = 13.554), pathological types (MTC: HR = 2.060; ATC: HR = 10.747), clinical stages (stage II: HR = 2.224; stage III: HR = 3.361; stage IV: HR = 3.494), treatment timing (> 3 months: HR = 2.594), diagnosis period (2017 − 2022: HR = 0.633) and gender (female: HR = 0.711) were found to be associated with the risk of death; after stratified adjustment, significant differences in prognostic factors were identified among thyroid cancer patients with varying pathological types. …”
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A Principal Component Analysis of Metabolome and Cognitive Decline Among Japanese Older Adults: Cross-sectional Analysis Using Tohoku Medical Megabank Cohort Study Data by Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N. Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, Atsushi Hozawa

“…The first 12 PC components (PC1–PC12) accounted for 71.7% of the total variance. Multivariate analysis showed that PC1, which mainly represented essential amino acids, was associated with lower odds of cognitive decline (OR 0.89; 95% CI, 0.80–0.98). …”
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Prevalence and Determinants of Peripheral Neuropathy among Type 2 Adult Diabetes Patients Attending Jimma University Medical Center, Southwest Ethiopia, 2019, an Institutional-Base... by Daba Abdissa, Nigusse Hamba, Kumsa Kene, Deriba Abera Bedane, Guluma Etana, Dassalegn Muleta, Asfaw Gerbi

“…A variable having a p value of < 0.25 in the bivariate model was subjected to multivariate analysis to avoid confounding variable’s effect. …”
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The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study by Min Ouyang, Hanquan Sun, Xiaoyu Liu, Haijun Wu, Feilong Deng, Erdong Shen, Guozheng Peng, Hanbing Wu, Yinshan Zhao, Hui Xiong, Bin Liu, Shasha He, Ying Hu, Ping Liu

“…Other factors analyzed did not show a statistically significant effect on PFS and OS. Multivariate analysis indicated that the distant organ metastasis and subsequent radiotherapy following this protocol were independent prognostic factors for PFS in patients with R/M HNSCC, and the latter was also an independent prognostic factor for OS in these patients. …”
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Incidence and predictors of seizure-related injuries among epileptic patients undergoing follow-up treatment at public hospitals in Central Ethiopia by Selamawit Wondale Begizew, Bethelhem Birhanu Muluneh, Taye Mezgebu Ashine, Asnakech Zekiwos Heliso, Getachew Ossabo Babore, Elias Ezo Ereta, Sentayehu Admasu Saliya, Awoke Girma Hailu, Elias Nigusu Abdisa

“…The incidence density rate of seizure-related injuries among epileptic patients was 11.97 per 100 person-months of observation (95% CI 10.61, 13.50). In multivariate analysis, epileptic patients who had generalized tonic–clonic seizures (adjusted hazard ratio 1.4, 95% CI 1.07–1.84), comorbidities (adjusted hazard ratio 1.3, 95% CI 1.11–1.71), were on polytherapy drug regimens (adjusted hazard ratio 1.80, 95% CI 0.30–2.49), and consumed alcoholic drinks (adjusted hazard ratio 1.5, 95% CI 1.21–1.89) were identified as independent predictors of seizure-related injuries. …”
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Outcomes of Idecabtagene Vicleucel Therapy in Patients with Relapsed/Refractory Multiple Myeloma: A Single-Institution Experience by Aaron Trando, Farid Ghamsari, Philip Yeung, Caitlin Costello, Ila Saunders, Ah-Reum Jeong

“…Univariate and multivariate analysis revealed no significant predictors of ORR, PFS, or OS. …”
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Incidence, prevalence, and predictors of osteoporotic fracture in adult lung transplant recipients by Elisabeth Ng, Shanal Kumar, Eldho Paul, Daniel Bennett, Luisa Rosi, Louise Fuller, Lauren Chiu, Shoshana Sztal-Mazer, Steven Ivulich, Greg Snell, Leon A. Bach, Kathryn L. Hackman

“…Antiresorptive therapy was received by 47% pre- and 89% post-LT. On multivariate analysis, risk factors for osteoporotic fracture were pre-LT osteoporotic fracture (hazard ratio (HR) 2.32 (95% confidence interval (CI) 1.09-4.96)), female sex (HR 2.08 (95% CI 1.09-3.94)), glucocorticoid use pre-LT (HR 2.08 (95% CI 1.09-3.99)), and time (months) to first ZA infusion post-LT (HR 1.04 (95% CI 1.01-1.06)). …”
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Evolution of Treatment Outcomes and Prognostic Factors in Esophageal Cancer Surgery: A Retrospective Analysis of 1500 Consecutive Esophagostomies by Yasue Kimura, MD, PhD, Eiji Oki, MD, PhD, Tomonori Nakanoko, MD, PhD, Qingjiang Hu, MD, PhD, Keita Natsugoe, MD, Sho Nanbara, MD, PhD, Ryota Nakanishi, MD, PhD, Yuichiro Nakashima, MD, PhD, Mitsuhiko Ota, MD, PhD, Tomoharu Yoshizumi, MD, PhD

“…The prognosis improved over time. Multivariate analysis revealed that depth of invasion, lymph node metastasis, the extent of lymph node resection, curative resection, pulmonary complications, and anastomotic leakage were significant independent prognostic factors. …”
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Liver Transplantation without Perioperative Transfusions Single-Center Experience Showing Better Early Outcome and Shorter Hospital Stay by Nicolás Goldaracena, Patricio Méndez, Emilio Quiñonez, Gustavo Devetach, Lucio Koo, Carlos Jeanes, Margarita Anders, Federico Orozco, Pablo D. Comignani, Ricardo C. Mastai, Lucas McCormack

“…While median MELD was significantly higher in Yes-Transfusion (11 versus 21; P=0.0001) group, platelet count, prothrombin time, and hemoglobin were significantly lower. On multivariate analysis, the unique independent risk factor associated with P-RBC transfusions was preoperative hemoglobin (P<0.001). …”
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Knowledge of prevention and treatment of infectious diarrhea among parents of children under five with diarrhea in Anhui province: an outpatient-clinic-based questionnaire survey by Yuanfang SUN, Yongkang XIAO, Lei GONG, Hongyuan WEI, Wanwan MA, Shuo FENG, Qiang ZHANG, Linlin LI, Qile WU, Jiabing WU

“…A self-developed questionnaire was used in the survey, which included the parental demographic information, general awareness of infectious diarrhea, and knowledge of infectious diarrhea prevention (10 questions with one point for each correct answer and a total score of 8 was defined as knowledge of the disease prevention) and treatment. A multivariate analysis of factors influencing parental knowledge of diarrhea prevention was performed using binary logistic regression, adjusting for potential confounders. …”
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Minimal disease activity and associated factors in patients with psoriatic arthritis: cross-sectional study from a single center by Murat Bektas, Berk Çelik, Burak İnce, Yasemin Yalçınkaya, Bahar Artım Esen, Ahmet Gül, Murat İnanç

“…In univariate analysis, MDA was associated with higher patient age, longer psoriasis duration, late-onset PsA, and continued use of first TNFi. In multivariate analysis, higher patient age, late-onset PsA, and higher continuation rate of first TNFi were associated with MDA. …”
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Distinct Impacts of Clinicopathological and Mutational Profiles on Long-Term Survival and Recurrence in Medullary Thyroid Carcinoma by Moon Young Oh, Kyong Yeun Jung, Hoonsung Choi, Young Jun Chai, Sun Wook Cho, Su-jin Kim, Kyu Eun Lee, Eun-Jae Chung, Do Joon Park, Young Joo Park, Han-Kwang Yang

“…The 2010–2020 group exhibited greater extents of surgical and lymph node dissection (P=0.003) and smaller tumors (P=0.003). Multivariate analysis identified extrathyroidal extension as the strongest prognostic factor for both RFS and DSS. …”
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Prevalence of and factors associated with long COVID among diverse healthcare workers in the UK: a cross-sectional analysis of a nationwide study (UK-REACH) by Kamlesh Khunti, Katherine Woolf, Luke Bryant, Manish Pareek, Carolyn Tarrant, Christopher A Martin, Amani Al-Oraibi, Laura B Nellums

“…We adjusted for demographic information, health status and existing long-term conditions in our multivariate analysis.Results In our analysis of 11 513 HCWs, we found that 2331 (20.25%) reported COVID-19, of whom 525 (22.52%) experienced long COVID. …”
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Prevalence, Patterns and Factors Associated with Dyslipidemia Among Adult Hypertensive Patients by Muktar Hassan Mohamud, Awil Abdulkadir Abdi, Abishir Mohamud Hirsi, Ibrahim Ahmed Nur, Alina Peris

“…High LDL levels were observed in 24.4% (105), high TC in 22.5% (97), high TG in 20.0% (86), and low HDL in 20.0% (86 patients). Multivariate analysis revealed that patients with elevated blood pressure, stage 1 hypertension, and stage 2 hypertension had 1.350 (aOR = 1.350, CI = 1.194-1.525, P < 0.001), 1.290 (aOR = 1.290, CI = 1.123-1.482, P < 0.001), and 1.302 (aOR = 1.302, CI = 1.077-1.576, P = 0.007) times higher odds of having dyslipidemia, respectively. …”
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Prevalence of Diabetes and Associated Risk Factors among a Group of Prisoners in the Yaoundé Central Prison by Sylvain Raoul Simeni Njonnou, Jérôme Boombhi, Martine Claude Etoa Etoga, Aimée Tiodoung Timnou, Ahmadou Musa Jingi, Kevin Nkem Efon, Esther Astrid Mbono Samba Eloumba, Marie-Josiane Ntsama Essomba, Odette Kengni Kebiwo, Alice Ninon Tsitsol Meke, Stéphane Talbit Ndjonya, Mesmin Dehayem Yefou, Eugène Sobngwi

“…Hypertension (p=0.005), obesity (p=0.0006), smoking (p=0.04), sedentary lifestyle (p=0.04), major crime (p=0.007), and minor crime (p=0.003) were associated with diabetes in univariate analysis. In multivariate analysis, only obesity and sedentary lifestyle were associated with diabetes. …”
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A Randomized Trial of Ionic Silver Dressing to Reduce Surgical Site Infection After Gastrointestinal Surgery by Chihiro Kosugi, MD, Keiji Koda, MD, Hiroaki Shimizu, MD, Masato Yamazaki, MD, Kiyohiko Shuto, MD, Mikito Mori, MD, Akihiro Usui, MD, Hiroyuki Nojima, MD, Satoshi Endo, MD, Hiroo Yanagibashi, MD, Hidehito Arimitsu, MD, Toru Tochigi, MD, Tetsutaro Sazuka, MD, Mihono Hirota, MD, Hideyuki Kuboki, MD

“…There was no significant difference in superficial SSI rates between the groups in patients undergoing upper gastrointestinal surgery; however, the rate was significantly lower in the study group in patients undergoing lower gastrointestinal surgery (P = 0.042). Multivariate analysis identified Aquacel Ag Hydrofiber dressings as an independent factor for reducing superficial SSIs (odds ratio, 0.602; 95% confidence interval, 0.367–0.986; P = 0.044). …”
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An analysis of extraskeletal osteosarcoma based on the literature by De-Hui Wang, Jun-Liang Zhang, Xiao-Wen Fan, Hui-Qun Du, Zi-Fan Gao, Dong-Dong Ling, Ying Cui, Meng-Han Chang, Xing Zhou

“…There was no significant difference in 5-year OS between osteosarcoma-type and soft tissue-type regimens (P = 0.273). Multivariate analysis of 431 patients showed that postoperative recurrence and metastasis were significant prognostic factors for survival, and CT was not a significant prognostic factor, though CT decreased the incidence of local recurrence in ≤ 45-year age group (P = 0.047). …”
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Impact of Helicobacter pylori infection on neoadjuvant chemotherapy in locally advanced gastric cancer: a retrospective analysis by Bin Zhong, Zhizhong Xiong, Jiabo Zheng, Saddam Ahmed Mohamed, Jiachen Sun, Dayin Huang, Zijian Deng, Jianping Guo, Junsheng Peng, Huashe Wang, Lei Lian

“…Further analysis revealed that H. pylori infection was significantly associated with the major pathological response (P = 0.009). Multivariate analysis showed that factors related to major pathological response included; age ≤ 50 (OR: 0.423, 95% CI: 0.194–0.925), H. pylori infection (OR: 0.396, 95% CI: 0.183–0.854), pathological stage T 3/4 (OR: 0.524, 95% CI: 0.288–0.954), and CA12-5 > 35 U/mL (OR: 0.345, 95% CI: 0.132–0.904). …”
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Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender by Nicoletta Luciano, Elisa Barone, Enrico Brunetta, Alessio D’Isanto, Maria De Santis, Angela Ceribelli, Marta Caprioli, Giacomo M. Guidelli, Daniela Renna, Carlo Selmi

“…D2T-RA cases suffered with higher frequency of obesity (33% vs. 19% in non-D2T, p = 0.021) and fibromyalgia (25% vs. 10% in non-D2T, p < 0.0001). The multivariate analysis confirmed the correlations of D2T-RA with disease duration (Odds ratio -OR- 1.06, 95% confidence interval -CI—1.03–1.09; p < 0.0001), baseline erosions (OR 2.73, 95% CI 1.28–5.82; p = 0.009), obesity (OR 2.22, 95% CI 1.10–4.50; p = 0.026) and fibromyalgia (OR 3.91, 95% CI 1.76–8.70; p = 0.001), independent of age and gender. …”
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