Prognostic Value of Novel CARWL Score in Stage IIIC Non-Small-Cell Lung Cancer Patients Undergoing Concurrent Chemoradiotherapy by Erkan Topkan, Ahmet Kucuk, Duriye Ozturk, Emine Elif Ozkan, Ali Ayberk Besen, Berrin Pehlivan, Ugur Selek

“…The CARWL score’s significant impacts on PFS and OS outcomes were found to be independent of the other variables in the multivariate analysis (P<0.001, for each). Conclusions. Our findings indicate that the novel CARWL score, which accounts for pretreatment CAR and significant WL during the preceding 6 months, can reliably stratify newly diagnosed stage IIIC NSCLC patients into three groups with significantly different PFS and OS after definitive CCRT.…”
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Ficus deltoidea standardized methanolic extract improves kidney structure and function against streptozotocin-induced diabetic nephropathy in rats by Nurdiana Samsulrizal, Noor Syaffinaz Noor Mohamad Zin, Nur Syimal`ain Azmi, Mohd Daud Bakar, Hafandi Ahmad, Yong-Meng Goh

“…We noticed that biochemical and pathological changes corresponded to the infrared (IR) peaks at 1545 cm-1 and 1511 cm-1 (amide II), 1246 cm-1 (DNA/RNA phosphate backbones), and 1181 cm-1 (C–O vibrations). Multivariate analysis of IR spectra demonstrated that the diabetic rats treated with F. deltoidea extract had a similar clustering pattern to that of the normal animals. …”
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Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors by Hiroaki Ito, Haruhiro Inoue, Shomei Ryozawa, Haruo Ikeda, Noriko Odaka, Nikolas Eleftheriadis, Roberta Maselli, Norimasa Sando, Satoshi Kimura, Shin-ei Kudo

“…The procedure of EUS-guided FNA biopsy had no complications or recurrent disease. In a multivariate analysis, only EUS achieved a significantly superior rate of diagnosis (odds ratio, 11.884; 95% confidence interval, 1.204–289.230; P=0.034). …”
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Factors affecting attitudes towards caring for terminally ill patients among nursing students in Switzerland: a cross-sectional study by Jérôme Pasquier, Pauline Laporte, Typhaine Juvet, Jean-François Desbiens, Diane Tapp, Marc-Antoine Bornet

“…Better attitudes towards terminally ill patients were significantly associated with being aged 24–26 years (β=6.97, 95% CI 2.00 to 11.95, p=0.006), year of study (β=3.47, 95% CI 1.69 to 5.25, p&lt;0.001), professional encounters with terminally ill patients (β=3.59, 95% CI 2.23 to 4.95, p&lt;0.001) and self-perceived palliative care nursing competence (β=1.23, 95% CI 0.41 to 2.04; p=0.003). In the multivariate analysis, professionally encountering terminally ill patients remained significant (β=3.00; 95% CI 1.43 to 4.57; p&lt;0.001).Conclusions Nursing students’ attitudes towards caring for terminally ill patients were positive and improved as their year of study progressed. …”
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Shotgun metagenomics reveals the interplay between microbiome diversity and environmental gradients in the first marine protected area in the northern Arabian Gulf by Saja A. Fakhraldeen, Rakhesh Madhusoodhanan, Nazima Habibi, Sakinah Al-Haddad, Surendraraj Alagarsamy, Sabeena F. K. Habeebullah, Walid M. Al-Zakri, Fathima Thuslim, Loreta Fernandes, Faiza Al-Yamani, Turki Al-Said

“…Elevated inorganic phosphorus, nitrogen, and salinity were key factors driving this diversity. Multivariate analysis highlighted phosphate as a critical component affecting the MPA microbial community structure, particularly for the families Microbacteriaceae, Flavobacteriaceae, and Rhodobacteraceae.DiscussionThis study underscores the ecological importance of MPAs and highlights the impact of nutrient enrichment and other environmental stressors on microbial diversity, emphasizing the need to reduce nutrient influx to mitigate eutrophication and enhance marine ecosystem resilience in stressed environments.…”
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Tumor Size Is a Critical Factor in Adjuvant Chemotherapy for T3-4aN0M0 Gastric Cancer Patients after D2 Gastrectomy by Shi Chen, Li-Ying Ou-Yang, Run-Cong Nie, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, Ying-Bo Chen, Jun-Sheng Peng

“…For patients with tumors larger than 5 cm, univariate analysis revealed that tumor location (p=0.007), Borrmann type (p=0.039), postoperative chemotherapy (p=0.003), and pathological T stage (p<0.001) were significant prognostic factors. Multivariate analysis revealed that postoperative chemotherapy and pathological T stage were independent prognostic factors. …”
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The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma by Lianne M. Haveman, Andreas Ranft, Henk vd Berg, Anne Smets, Jarmila Kruseova, Ruth Ladenstein, Benedicte Brichard, Michael Paulussen, Thomas Kuehne, Heribert Juergens, Stephanie Klco‐Brosius, Uta Dirksen, Johannes H.M. Merks

“…No correlation was found between TVR and HisRes. Multivariate analysis showed that poor HisRes, pelvic location and late inadequate TVR were associated with poor outcome. …”
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Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators by Tong Lin, Shanshan Huang, Fen Zhou, Xingkai Shen, Haiyan Mao

“…Nonlinear relationships were assessed using restricted cubic spline (RCS) models.ResultsThe PRISm group had lower median vitamin D levels and distinct inflammatory and metabolic profiles compared to the non-PRISm group. Multivariate analysis confirmed an inverse association between vitamin D levels and PRISm (adjusted OR: 0.989, 95% CI: 0.984–0.994, p &lt; 0.001). …”
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A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma by Yingkun Xu, Xiunan Li, Yuqing Han, Zilong Wang, Chenglin Han, Ningke Ruan, Jianyi Li, Xiao Yu, Qinghua Xia, Guangzhen Wu

“…Finally, based on the model, we conducted correlation analysis of the clinicopathological characteristics, univariate analysis, and multivariate analysis. Results. We found that most of the genes related to the PPAR pathway had different degrees of expression differences in KIRC. …”
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Using CT imaging to identify sarcopenia as a risk factor for severe falls in older adults by Nadja Fries, Angeliki Kotti, Mischa Woisetschläger, Anna Spångeus

“…No correlation with other clinical risk assessment scores nor spine T-score was found. In the multivariate analysis, higher level of frailty, male sex as well as lower BMI, VAT and SAT remained as risk factors for low SMI ratio. …”
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Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients by Kota Hori, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Aomi Kuzuhara, Takenori Hamada, Kouki Yoneda, Kenichiro Maekawa

“…The median change in CRP was 2.1 mg/dL (interquartile range, 1.1–3.8). Multivariate analysis revealed that improvements in mGPS (β=0.125, p=0.012) and CRP levels (β=0.108, p=0.108) were independently and positively associated with FIM-motor at discharge. …”
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Ovarian Stimulation in Patient-oriented Strategies Encompassing Individualised Oocyte Number-4 Category; Antagonist versus Short-agonist Protocols by Tarek K. Al-Hussaini, Ahmed Aboelfadle Mohamed, Ayman Askar, Ahmed A. Abden, Yousra M. Othman, Reda S. Hussein

“…No significant impact for the protocol type on live birth rate was revealed after adjusting to cycle confounders in multivariate analysis (OR: 0.439, 95%CI 0.134-1.434, P = 0.173). …”
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Availability in ECMO Reduces the Failure to Rescue in Patients With Pulmonary Embolism After Major Surgery: A Nationwide Analysis of 2.4 Million Cases by Johannes Diers, MD, Nikolas Baumann, MD, Philip Baum, MD, Konstantin L. Uttinger, MD, Johanna C. Wagner, MD, Peter Kranke, MD, Patrick Meybohm, MD, Christoph-Thomas Germer, MD, Armin Wiegering, MD

“…The availability of and experience in ECMO therapy (defined as at least 20 ECMO applications per year; ECMO centers) are associated with a significantly reduced FtR in patients with PE after high-risk surgical procedures. In a multivariate analysis, the odds ratio (OR) for FtR after postoperative PE was significantly lower in ECMO centers (OR, 0.75 [0.70–0.81], P < 0.001). …”
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Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction by Jong-Sun Kim, Wan-Sik Lee, Cho-Yun Chung, Hyung-Chul Park, Dae-Seong Myung, Chan-Young Oak, Mi-Young Kim, Mi-Ok Jang, Seung-Ji Kang, Hee-Chang Jang, Sung-Bum Cho, Hyun-Soo Kim, Young-Eun Joo

“…The frequency of post-SEMS insertion fever, systemic inflammatory response syndrome (SIRS), and bacteremia was not significantly different between PA and non-PA groups. In multivariate analysis, the CRP level was risk factor related to post-SEMS insertion SIRS. …”
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Risk factors for moderate disturbance of consciousness in patients with unilateral chronic subdural hematoma by Adrian Liebert, Thomas Eibl, Thomas Bertsch, Hans-Herbert Steiner, Karl-Michael Schebesch, Leonard Ritter

“…History of ischemic stroke and intake of statins were more common in group 1 (p = 0.033, p = 0.04; resp.). In the multivariate analysis, midline shift (p = 0.033), occipital location (p = 0.005) and history of ischemic stroke (p = 0.046) remained significant. …”
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Attitude to RSV Vaccination Among a Cohort of Pregnant Women in Jordan: A Cross‐Sectional Survey Study by Malik Sallam, Tleen Kherfan, Amwaj Al‐Farajat, Leen Nemrawi, Nada Atawneh, Rand Fram, Ala'a B. Al‐Tammemi, Muna Barakat, Kamil Fram

“…Variables that were significantly associated with a higher RSV vaccine acceptance in multivariate analysis were: age < 30 years (adjusted odds ratio (aOR): 2.45, p = 0.010), undergraduates (aOR: 3.27, p = 0.026), being a healthcare worker (aOR: 4.50, p = 0.036), and the history of previous COVID‐19/influenza vaccine uptake (aOR: 2.47, p = 0.045). …”
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Relationship between serum ECP and TIgE levels and the risk of postoperative recurrence in patients with chronic rhinosinusitis with nasal polyps by Qing Zhang, Hui Li, Di Xie, SiJian Fan

“…Higher serum levels of TIgE and ECP (4.89 ± 0.79 &lt; 4.11 ± 0.72, P &lt; 0.001; 58.74 ± 8.27 &lt; 51.40 ± 8.04, P &lt; 0.001) were detected in the recurrence groups vs. the non-recurrence group. Multivariate analysis showed that serum ECP and TIgE were independent risk factors for recurrence of CRSwNP. …”
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Trends in the utilisation of maternal and child healthcare services from the public and private health sectors in India, 2005–2021: an analysis of cross-sectional survey data by Niranjan Saggurti, Rajib Acharya, Abhishek Kumar, Anchal Purbey, Arupendra Mozumdar, Punit Mishra

“…The results of the multivariate analysis showed that utilisation of ANC (67% from public vs 18% from private health facilities), institutional delivery (64% from public vs 25% from private health facilities) and PNC (73% from public vs 27% from private health facilities) was significantly higher (p&lt;0.001) in public than in private health facilities. …”
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Traditional Cardiovascular Risk Factors Associated with Diagonal Earlobe Crease (Frank Sign) in Mexican Adults: Aging, Obesity, Arterial Hypertension, and Being Male Are the Most I... by Rogelio Molina-Gallardo, Nomely S. Aurelien-Cabezas, Daniel Tiburcio-Jimenez, Jorge E. Plata-Florenzano, Jose Guzman-Esquivel, Iram P. Rodriguez-Sanchez, Margarita L. Martinez-Fierro, Roque Molina-Osorio, Adrian A. De-la-Madrid-Cernas, Jorge Armando Barriguete-Melendez, Ivan Delgado-Enciso

“…An unadjusted (univariate) analysis showed that being male, being older than 55 years, obesity, type 2 diabetes mellitus, arterial hypertension, smoking, and dyslipidemia, as well as having acute coronary syndrome, were associated with the presence of diagonal earlobe crease. The multivariate analysis showed that men (OR 1.6, 95% IC 1.1–2.4, P=0.007), being over 55 years old (OR 4.8, 95% IC 3.2–7.2, P<0.001), being obese (OR 2.1, 95% IC 1.4–3.1, P<0.001), having arterial hypertension (1.5, 95% IC 1.1–2.3, P=0.025), or suffering from acute coronary syndrome (OR 5.3, 95% IC 2.5–11.1, P<0.001), were independent factors associated with diagonal earlobe crease. …”
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Parasitological and clinical correlates of Plasmodium–Schistosoma mansoni co-infection and its determinants among Plasmodium-infected patients in the Wolaita Zone, South Ethiopia r... by Kemal Mohamed, Tariku Belay, Ahmed Zeynudin

“…Hemoglobin and hematocrit were significantly lower among co-infected individuals. On multivariate analysis, being male (AOR=3.03, CI: 1.56-5.91,p=0.001), being in the 6-15 years age group (AOR = 5.85, CI: 2.45–13.93,p=0.00), the presence of stream (AOR = 4.1, CI: 1.65–10.15,p=0.002), having a water body distance of less than 1,000 m (AOR=2.33, CI: 1.23–4.41,p=0.009), and presence of irrigation practice (AOR= 3.24, CI: 1.69–6.18,p=0.00) were found to be significant risk factors of co-infection.ConclusionMalaria attack and level of parasitemia were associated with the intensity of concurrent Schistosoma mansoni infection. …”
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