Prognostic correlation analysis of multiple myeloma based on HALP score of peripheral blood before chemotherapy by CHEN Min, AN Liying, LIN Xiaojing, ZHAO Pan, ZOU Xingli, WEI Jin, NI Xun

“…The results of univariate and multivariate analysis using the Cox regression model showed that a HALP score <29.15 was an independent risk factor for progression-free survival (PFS) and overall survival (OS) (P<0.05). …”
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Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma by Min He, Eduard van Wijk, Ruud Berger, Mei Wang, Katrin Strassburg, Johannes C. Schoeman, Rob J. Vreeken, Herman van Wietmarschen, Amy C. Harms, Masaki Kobayashi, Thomas Hankemeier, Jan van der Greef

“…The results in univariate Student’s t-test revealed 10 significantly up- or downregulated oxylipins in CIA mice, which were supplemented by another 6 additional oxylipins, contributing to group clustering upon multivariate analysis. The dysregulation of these oxylipins revealed the presence of ROS-generated oxylipins and an increase of inflammation in CIA mice. …”
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Factor Analysis Influencing Postoperative Hospital Stay and Medical Costs for Patients with Definite, Suspected, or Unmatched Diagnosis of Acute Cholecystitis according to the Toky... by Aoi Hayasaki, Koji Takahashi, Takehiro Fujii, Koji Kumamoto, Koji Fujii, Eiichi Matsumoto, Shigeki Miyahara, Tsukasa Kusuta, Yoshinori Azumi, Shuji Isaji

“…Performance status (PS), white blood cell count, and severity grade were identified as preoperative factors influencing PHS by multivariate analysis, and significant independent preoperative factors influencing MC were age, PS, preoperative biliary drainage, hospital stay before surgery, albumin, and severity grade. …”
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Assessment of adequacy and determinants of HIV related knowledge among senior school students in public schools in Abakaliki Southeast Nigeria by Maria-Lauretta Chito Orji, Ngozi Appolonia Ifebunandu, Chinwe Ifeoma Joe-Akunne, Mmeremikwu Appolus Chidiebere, Stella Echefu, Justus Ndulue Eze

“…Adequacy of HIV-related knowledge was denoted by a mean score of 6 and above. A multivariate analysis using a logistic regression model was used to determine the factors that predicted the adequacy of knowledge of HIV among students. …”
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Factors and Their Correlation with Injury Severity of Elderly Pedestrian Traffic Accidents by Tae gyu Hyun, Seok-Ran Yeom, Sung-Wook Park, Deasup Lee, Hyung bin Kim, Il Jae Wang, Byung Gwan Bae, Min keun Song, Youngmo Cho

“…Most accidents occurred in the afternoon and on general roads. In the multivariate analysis, the odds ratio (OR) of injury severity for male pedestrians was 1.165 (95% confidence interval: 1.034–1.313, p=0.012). …”
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Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease by Tristan Gabriel-Segard, Margherita Boltri, Mathilde Barrau, Catherine Massoubre, Stéphane Paul, Xavier Roblin

“…Avolition associates and correlates with the experience of fatigue (r = 0.49) in multivariate analysis. <b>Conclusions:</b> To tackle the question of fatigue in IBD, research should consider investigating the biological mechanisms implicating intestinal physiopathology of IBD in the impairment of brain structure involved in motivation. …”
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Acute Kidney Injury Complicating Critical Forms of COVID-19: risk Factors and Prognostic Impact [version 3; peer review: 2 approved] by Ghadhoune Hatem, Yosra Yahia, Olfa Hammami, Hend Allouche, Insaf Trabelsi, Jihene Guissouma, Hana Ben Ali

“…In fact, age > 53 years (p: 0.018), septic shock complicating hospital acquired infection (p: 0.003) and mechanical ventilation (p<0.001) were the three prognostic factors in multivariate analysis. Conclusions The incidence of AKI was high in this study and associated to an increased mortality. …”
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Clinical treatment score Post-5 Years (CTS5) predicts the benefit of postmastectomy radiotherapy in patients with T1-2N1 luminal breast cancer by Ke Liu, Guan-Qiao Li, Si-Qi Li, Xue-Qin Chen, San-Gang Wu

“…Patients with younger age, T2 stage, higher tumor grade, a higher number of positive lymph nodes, infiltrating lobular carcinoma subtype, and receipt of chemotherapy were associated with the receipt of PMRT (all P < 0.05). The multivariate analysis showed that the receipt of PMRT was the independent prognostic factor associated with better BCSS (P = 0.005) and OS (P < 0.001). …”
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Hemodynamic and Lesion Characteristics Associated with Discordance between the Instantaneous Wave-Free Ratio and Fractional Flow Reserve by Hiroyuki Arashi, Natsuko Satomi, Issei Ishida, Kanintorn Soontorndhada, Suguru Ebihara, Kazuki Tanaka, Hisao Otsuki, Masashi Nakao, Kentaro Jujo, Junichi Yamaguchi, Nobuhisa Hagiwara

“…These trends were not seen between the FFR ≤0.8 group and FFR >0.8 group. A multivariate analysis showed that independent predictors of iFR ≤0.89 and FFR >0.8 discordance were female sex and higher rate-pressure product. iFR >0.89 and FFR ≤0.8 discordance was rare in hemodialysis patients. …”
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Clinical characteristics and outcomes of children with COVID-19 in pediatric intensive care units during the Omicron wave in Taiwan by Jeng-Hung Wu, Ching-Chia Wang, Frank Leigh Lu, Shu-Chien Huang, Ting-Yu Yen, Chun-Yi Lu, Luan-Yin Chang, En-Ting Wu

“…Patients admitted during the early stage had lower vaccination rates (7% vs. 50%), higher pediatric logistic organ dysfunction scores (2 vs. 0.1), and longer LOS in the PICU (6 vs. 2 days) than those admitted during the late stage. Multivariate analysis identified admission during the early stage as a risk factor for prolonged LOS (>7 days) in the PICU (odds ratio: 3.65, p = 0.047). …”
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Impact of invasive infections on clinical outcomes in acute pancreatitis: early predictive factors and implications for prophylactic anti-infective therapy by Fabienne Bender, Theresa König, Matthias Hecker, Moritz Fritzenwanker, Jacqueline Braun, Joern Pons-Kühnemann, Matthias Wolff, Andreas Hecker, Martin Reichert

“…Early predictors of pathogen detection were evaluated by multivariate analysis. Results 424 patients with acute pancreatitis were included. …”
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The association between Chlamydia pneumoniae infection and prognosis in lung cancer patients: a prospective study by Maolin Liu, Hailing Ye, Tao Lin, Zishan Chen, Xinying Xu, Jinman Zhuang, Yongsheng Yang, Xuezhen Chen, Chunting Chen, Mengxin Lin, Fei He

“…Serum IgA positivity indicated chronic infection and was associated with poor prognosis. Multivariate analysis confirmed that Cpn IgA(++) infection was an independent risk prognostic factor for operable lung cancer patients (with IgA(-) group as the control group, HR = 3.39, 95%CI: 1.41–8.17). …”
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Oral Plaque from Type 2 Diabetic Patients Reduces the Clonogenic Capacity of Dental Pulp-Derived Mesenchymal Stem Cells by Antonella Bordin, Francesca Pagano, Eleonora Scaccia, Matteo Saccucci, Iole Vozza, Noemi Incerti, Antonella Polimeni, Elena Cavarretta, Isotta Chimenti, Elena De Falco

“…Results have shown that the number of clones generated by DPSCs exposed to T2D oral plaque was significantly lower compared to controls (ctl). The multivariate analysis confirmed that the decreased clonogenesis was significantly correlated only with T2D diagnosis. …”
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End-tidal carbon dioxide-guided extracorporeal cardiopulmonary resuscitation improves neurological prognosis in patients: a single-center retrospective cohort study by Xiaozu Liao, Chen Gu, Zhou Cheng, Kepeng Liu, Qing Yin, Binfei Li

“…Approximately 37% of patients who received ECPR had good cerebral function at discharge, with a higher rate in the GDCPR group (52%) compared with the CCPR group (28%) (p = 0.047). Multivariate analysis showed that the Highest Interleukin-6 (H-IL6) levels after ECMO (Odds Ratio [OR = 1.001], 95% Confidence Interval [95% CI 1.000–1.003], p = 0.005) was a risk factor for neurological function at discharge. …”
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TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress by Veronica Tisato, Stefania Gallo, Elisabetta Melloni, Claudio Celeghini, Angelina Passaro, Giorgio Zauli, Paola Secchiero, Carlo Bergamini, Alessandro Trentini, Gloria Bonaccorsi, Giuseppe Valacchi, Giovanni Zuliani, Carlo Cervellati

“…We measured circulating TRAIL levels relative to praoxonas-1, lipoprotein phospholipase-A2, and ceruloplasmin levels in a cohort of healthy subjects (n=209). Results. Multivariate analysis revealed that ceruloplasmin levels were significantly inversely associated with TRAIL levels (r=−0.431, p<0.001). …”
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Characteristics and Outcomes of Elderly Patients Refused to ICU by María-Consuelo Pintado, Patricia Villa, Natalia González-García, Jimena Luján, Rocío Molina, María Trascasa, Esther López-Ramos, Cristina Martínez, José-Andrés Cambronero, Raúl de Pablo

“…High comorbidity, low functional status, unavailable ICU beds, and age were associated with refusal decision on multivariate analysis. Conclusions. Prior functional status and comorbidity, not only the age or severity of illness, can help us more to make the right decision of admitting or refusing to ICU patients older than 75 years.…”
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Risk factors for growth retardation in children with juvenile idiopathic arthritis: a case-control study by Ying Zhang, Liping Song, Weihu Ma, Ye Wang, Peipei Wang, Xiaolin Zhang, Zhe Zhang, Yuan Zhang, Qianhui Yu, Yang Yu, Lin Zhang

“…These factors were identified as independent risk factors for growth retardation in multivariate analysis. The area under the curve (AUC) values for these factors ranged from 0.651 to 0.676, indicating moderate predictive accuracy. …”
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Factors involved in maintaining Karnofsky Performance Status (≥ 50%) in glioblastoma, IDH-wildtype patients treated with temozolomide and radiotherapy by Shigeo Ohba, Takao Teranishi, Kazuyasu Matsumura, Masanobu Kumon, Daijiro Kojima, Eiji Fujiwara, Kazutaka Nakao, Kiyonori Kuwahara, Kazuhiro Murayama, Eriel Sandika Pareira, Seiji Yamada, Masahiro Joko, Shunsuke Nakae, Jun Muto, Yuya Nishiyama, Kazuhide Adachi, Hikaru Sasaki, Masato Abe, Mitsuhiro Hasegawa, Yuichi Hirose

“…In univariate analysis, preoperative KPS (≥ 80%), KPS at the start of RT (≥ 80%), residual tumor size (< 2 cm3), methylated MGMT promotor, and implantation of BCNU wafer were associated with survival with KPS ≥ 50%. In multivariate analysis, KPS at the start of RT (≥ 80%), methylated MGMT promotor, and residual tumor size (< 2 cm3) were significantly associated with increased survival with KPS ≥ 50%. …”
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Radiotherapy Combined with Immunotherapy and Chemotherapy Improves Prognosis and Demonstrates Synergistic Effects in Extensive-stage Small Cell Lung Cancer by Huaijun JI, Meiling SUN, Jingyi LI, Ge YU, Yongbing CHEN

“…Similarly, the RT+CT group demonstrated superior mOS (18.5 vs 12.3 mon, P<0.001) and mPFS (7.1 vs 6.2 mon, P=0.006) compared to the CT group. Multivariate analysis identified RT, IT, and Eastern Cooperative Oncology Group performance status (ECOG PS) as independent prognostic factors for mOS (P<0.05), while gender and ECOG PS were independent predictors for mPFS (P<0.05). …”
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Development and validation of nomograms for predicting pentafecta outcomes before and after robot-assisted radical prostatectomy: a retrospective study by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…The pentafecta outcome was achieved in 290 patients (16.6%). Multivariate analysis revealed that bilateral nerve sparing significantly increased the likelihood of achieving the pentafecta outcome (odds ratio 10.36, 95% CI: 5.75–18.66; p < 0.001). …”
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