Safety, Efficacy, and Predictive Factors of Conventional Epithelium-Off Corneal Crosslinking in the Treatment of Progressive Keratoconus by Rebecca Farhat, Mohamad Khaled Ghannam, Georges Azar, Joseph Nehme, Marwan Sahyoun, Najib Georges Hanna, Mariana Abi Karam, Charbel El Haber, Alexandre Schakal, Alexandre Jalkh, Ameed Samaha

“…Concerning the CDVA outcome, multivariate analysis showed that a better preoperative CDVA was associated with higher improvement in CDVA, and higher baseline K max and higher posterior mean K were associated with a worse outcome CDVA. …”
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LIPS and PaO2/FiO2 Combined Plasma Biomarkers Predict Onset of Acute Respiratory Distress Syndrome in Patients of High Risks in SICU: A Prospective Exploratory Study by Ziyuan Shen, Zhongnan Yin, Senhao Wei, Zhukai Cong, Feng Zhao, Hua Zhang, Xi Zhu

“…We included factors with p <0.2 in multivariate analysis and showed LIPS, PaO2/FiO2, IL-8, and receptor for advanced glycation end-products (RAGE) of the first day were independent risk factors for ARDS in SICU, a model combining them was good in predicting ARDS (C-index was 0.864 in total patients of high risks). …”
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Patterns of failure and prognosis in nasopharyngeal carcinoma according to Epstein-Barr virus DNA status by Lin-Feng Guo, Guan-Zhong Lu, Zhen-Zhen Lu, Yi-Feng Yu, San-Gang Wu

“…While the EBV-DNA positivity rate did not differ significantly between oligometastatic disease and polymetastatic disease (P = 0.493), the levels were significantly elevated in the polymetastatic disease group than the oligometastatic disease group (P < 0.001). Multivariate analysis showed that liver metastasis (P = 0.012) and EBV-DNA levels ≥ 3,525 copies/mL at progression (P = 0.009) independently correlated with poorer overall survival. …”
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Elevated Blood Urea Nitrogen-to-Serum Albumin Ratio as a Factor That Negatively Affects the Mortality of Patients with Hospital-Acquired Pneumonia by Ding-Yun Feng, Yu-Qi Zhou, Xiao-Ling Zou, Mi Zhou, Hai-Ling Yang, Xiao-Xia Chen, Tian-Tuo Zhang

“…In the second multivariate analysis, administration of proton-pump inhibitor, administration of antibiotics in the preceding 90 days, ICU admission, blood lymphocyte count less than 0.8 × 109/L, elevated BUN/ALB level, and presence of MDR pathogens were still associated with 30-day mortality. …”
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Radiomics-based biomarker for PD-1 status and prognosis analysis in patients with HCC by Gulizaina Hapaer, Feng Che, Qing Xu, Qian Li, Ailin Liang, Zhou Wang, Jituome Ziluo, Xin Zhang, Yi Wei, Yuan Yuan, Bin Song, Bin Song

“…Radiomics score was built for each patient and was integrated with independent clinic radiologic predictors into the radiomics model using multivariable logistic regression analysis.ResultsSeventeen radiomics features were finally selected to construct the radiomics score. In multivariate analysis, serum creatine and peritumoral enhancement were significant independent factors for PD-1 prediction. …”
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Fluid structure Interaction analysis for rupture risk assessment in patients with middle cerebral artery aneurysms by Jozsef Nagy, Wolfgang Fenz, Stefan Thumfart, Julia Maier, Zoltan Major, Harald Stefanits, Maria Gollwitzer, Johannes Oberndorfer, Nico Stroh, Michael Giretzlehner, Michael Sonnberger, Andreas Gruber, Philip-Rudolf Rauch, Matthias Gmeiner

“…In this study, we used advanced FSI techniques to investigate the rupture risk of middle cerebral artery bifurcation (MCA) aneurysms, analyzing a cohort of 125 patients treated for a MCA aneurysm at Kepler University Hospital, Linz, Austria. Multivariate analysis identified two significant rupture predictors: High Equivalent Stress Area (HESA; p = 0.049), which quantifies stress distribution relative to the aneurysm surface, and Gaussian curvature (GLN; p = 0.031), which captures geometric complexity. …”
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Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies by Ramin Assempoor, Mohammad Shahabaddin Daneshvar, Aryan Taghvaei, Alireza Sattari Abroy, Amir Azimi, John R. Nelson, Kaveh Hosseini

“…Cross-sectional studies, case-control studies, and prospective or retrospective cohort studies using multivariate analysis were included. Given that the true effect size may differ across studies, a random-effects model for all analyses was applied. …”
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Development and validation of a prediction model for acute kidney injury following cardiac valve surgery by Xiaotong Jia, Jun Ma, Zeyou Qi, Dongni Zhang, Junwei Gao

“…Relative to non-AKI patients, the AKI patients exhibited elevated postoperative complication incidences and worse outcome. Based on multivariate analysis, advanced age (OR: 1.855; p = 0.011), preoperative hypertension (OR: 1.91; p = 0.017), coronary heart disease (OR: 6.773; p &lt; 0.001), preoperative albumin (OR: 0.924; p = 0.015), D-Dimer (OR: 1.001; p = 0.038), plasma creatinine (OR: 1.025; p = 0.001), cardiopulmonary bypass (CPB) duration (OR: 1.011; p = 0.001), repeat CPB (OR: 6.195; p = 0.010), intraoperative red blood cell transfusion (OR: 2.560; p &lt; 0.001), urine volume (OR: 0.406 p &lt; 0.001) and vasoactive–inotropic score (OR: 1.135; p = 0.009) were independent risk factors for AKI. …”
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Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks by Atsuro Uchida, Masayuki Miwa, Hajime Shinoda, Takashi Koto, Norihiro Nagai, Hiroshi Mochimaru, Yohei Tomita, Mariko Sasaki, Kazushige Ikeda, Kazuo Tsubota, Yoko Ozawa

“…Among the 182 eligible infants (median GA, 29.1 weeks; median birth weight (BW), 1028 g), 84 (46%) developed any stage of ROP, of which 45 (25%) required laser treatment. Multivariate analysis using a stepwise method showed that GA (P=0.002; 95% confidence interval (CI), 0.508–0.858), BW (P<0.001; 95% CI, 0.994–0.998), and lower maternal age (P=0.032; 95% CI, 0.819–0.991) were the risk factors for ROP development and GA (P<0.001; 95% CI, 0.387–0.609) and lower maternal age (P=0.012; 95% CI, 0.795–0.973) were for laser treatment. …”
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Diversity of Picea omorika (Pančić) Purk. Populations Based on Morpho-anatomical Needle Traits and Bioclimatic Parameters by Biljana Nikolić, Nemanja Rajčević, Zorica Mitić, Sanja Jovanović, Nevena Čule, Katarina Mladenović, Marija Marković, Petar Marin

“…Both principal component analysis and discriminant analysis indicated population overlap, while cluster analysis identified three main groups. Multivariate analysis of bioclimatic data and a correlation study of morpho-anatomical traits were also performed. …”
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Reconstructive trends and complications following parotidectomy: incidence and predictors in 11,057 cases by Cory Donovan Bovenzi, Peter Ciolek, Meghan Crippen, Joseph M. Curry, Howard Krein, Ryan Heffelfinger

“…Univariate and multivariate analysis was utilized to determine associations between pre- and perioperative variables with patient outcomes. …”
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The Impact of EGDT on Sepsis Mortality in a Single Tertiary Care Center in Lebanon by Christopher El Khuri, Gilbert Abou Dagher, Ali Chami, Ralph Bou Chebl, Tarek Amoun, Rana Bachir, Batoul Jaafar, Nesrine Rizk

“…Data from the EHR were retrieved about patients’ demographics, medical comorbidities, and periresuscitation parameters. A multivariate analysis using logistic regression for the outcome in-hospital mortality after adjusting for protocol use and other confounders was done and AOR was obtained for the protocol use. 28-day mortality, ED, and hospital length of stay were compared between the two groups. …”
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Clinical Features of Impacted Common Bile Duct Stones at Duodenal Papilla by Jae Min Lee, Sang Hoon Lee, Ji Hyun Kim, Tae Suk Kim, Sung Hoon Chang, San Ha Kim, Jung Ho Lee, Chang Don Kang, Jin Myung Park

“…The success rates of selective biliary cannulation were comparable between the IPS and NIPS groups. Multivariate analysis showed that IPS was associated with pancreatitis (odds ratio [OR] 3.78, 95% confidence interval [CI]: 1.17–12.17, p=0.026), bile duct penetrating duodenal wall sign (BPDS, OR 12.09, 95% CI: 3.92–37.33, p<0.001), and the presence of pus (OR 27.05, 95% CI: 4.92–148.85, p<0.001). …”
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Usefulness of Discarded Vitreous Samples from Routine Vitrectomy by Natàlia Vilà, Pablo Zoroquiain, Vasco Bravo-Filho, Emilia Antecka, Helena Dietrich, John C. Chen, I. John Galic, Michael A. Kapusta, Miguel N. Burnier

“…The presence of inflammatory cells was the feature with the highest sensitivity for detecting diabetes mellitus (98%) and also the highest negative predictive value (89%). In the multivariate analysis, three variables emerged as independent significant predictors of diabetes in vitrectomy samples: hemorrhage, endothelial-lined vessels, and age (P<0.001, P<0.001, and P=0.019, resp.). …”
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Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients by Yushi Nagaki, MD, PhD, Satoru Motoyama, MD, PhD, Yusuke Sato, MD, PhD, Akiyuki Wakita, MD, PhD, Hiromu Fujita, MD, PhD, Kohei Kemuriyama, MD, Ryohei Sasamori, MD, Shu Nozaki, MD, Kyoko Nomura, MD, PhD, Yoshihiro Minamiya, MD, PhD

“…The 29 patients with hot tumors before NACRT had a significantly better 5-year disease-specific survival (DSS) rate than the remaining 70 patients with cold tumors (85% vs 64%; P = 0.036). In a multivariate analysis, tumor immunogenicity was a significant independent predictor of DSS. …”
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Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry by You-Jeong Ki, Kyung Woo Park, Jeehoon Kang, Chee-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim

“…The rate of definite or probable stent thrombosis (0.6% vs. 0.8% vs. 0.5%, P=0.549) was similar. In the multivariate analysis, chronic kidney disease was the strongest predictor of stent thrombosis (adjusted hazard ratio 3.178; 95% confidence interval 1.621–6.229; P<0.001). …”
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Low dose ATG-Fresenius for GVHD prophylaxis: a comparative study with ATG-Thymoglobulin by Itai Falicovich, Boaz Nachmias, Shlomo Elias, Eran Zimran, Adir Shaulov, Polina Stepensky, Batia Avni, Sigal Grisariu

“…Additionally, the ATG-F group had more myeloid leukemia and myelodysplastic syndrome patients, while the ATG-T group had more lymphoma patients.ResultsThe cumulative incidence of acute GVHD (aGVHD) grade II-IV and chronic GVHD (cGVHD) showed no significant differences. Multivariate analysis indicated that donor HLA mismatch influenced aGVHD risk significantly (p=0.005), and myeloablative conditioning increased cGVHD risk. …”
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Bladder mucosal smoothness predicts early recovery of urinary continence after laparoscopic radical prostatectomy by Le Yu, Ye Yan, Hongling Chu, Shaohui Deng, Jianfei Ye, Guoliang Wang, Yi Huang, Fan Zhang, Shudong Zhang

“…Results Age group, clinical T stage group, BMS grade group, PV group, IPPL group, and MUL group differed significantly between patients in the UI group and the UC group (all P values < 0.05). Multivariate analysis identified 3 MRI-related predictors selected for the prediction model: BMS grade (1 odds ratio [OR] 0.17, 95% CI 0.11–0.66; P value = 0.024) (2 + 3 OR 0.17, 95% CI 0.04–0.66; P value = 0.011), IPPL (> 5 mm OR 0.17, 95% CI 0.1–0.64; P = 0.004), and MUL (≥ 14 mm OR 6.41, 95% CI 2.72–15.09; P value < 0.001). …”
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p16 expression in patient with Loop Electrosurgical Excision Procedure (LEEP) by Putu Erika Paskarani, I Gede Sastra Winata, Elisa Laura Oktrinita Sitohang, Felyanto Felyanto, Sang Ayu Putu Yuliantini

“…In addition, 22.2% of the variation of p16 expression based on multivariate analysis demonstrating a significant correlation (p = 0.01). …”
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Risk Factors for an Iatrogenic Mallory-Weiss Tear Requiring Bleeding Control during a Screening Upper Endoscopy by Shin Na, Ji Yong Ahn, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Seungbong Han

“…Bleeding control due to severe bleeding was applied in 71 cases (13.0%), and rebleeding after initial bleeding control occurred in 1 case. Multivariate analysis showed that old age, a history of distal gastrectomy, and a less-experienced endoscopist (fewer than 2,237.5 endoscopic procedures at the time of the MWT) were associated with severe iatrogenic MWTs requiring an endoscopic procedure. …”
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