Clinical characteristics and outcomes of children with COVID-19 in pediatric intensive care units during the Omicron wave in Taiwan by Jeng-Hung Wu, Ching-Chia Wang, Frank Leigh Lu, Shu-Chien Huang, Ting-Yu Yen, Chun-Yi Lu, Luan-Yin Chang, En-Ting Wu

“…Patients admitted during the early stage had lower vaccination rates (7% vs. 50%), higher pediatric logistic organ dysfunction scores (2 vs. 0.1), and longer LOS in the PICU (6 vs. 2 days) than those admitted during the late stage. Multivariate analysis identified admission during the early stage as a risk factor for prolonged LOS (>7 days) in the PICU (odds ratio: 3.65, p = 0.047). …”
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Impact of invasive infections on clinical outcomes in acute pancreatitis: early predictive factors and implications for prophylactic anti-infective therapy by Fabienne Bender, Theresa König, Matthias Hecker, Moritz Fritzenwanker, Jacqueline Braun, Joern Pons-Kühnemann, Matthias Wolff, Andreas Hecker, Martin Reichert

“…Early predictors of pathogen detection were evaluated by multivariate analysis. Results 424 patients with acute pancreatitis were included. …”
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The association between Chlamydia pneumoniae infection and prognosis in lung cancer patients: a prospective study by Maolin Liu, Hailing Ye, Tao Lin, Zishan Chen, Xinying Xu, Jinman Zhuang, Yongsheng Yang, Xuezhen Chen, Chunting Chen, Mengxin Lin, Fei He

“…Serum IgA positivity indicated chronic infection and was associated with poor prognosis. Multivariate analysis confirmed that Cpn IgA(++) infection was an independent risk prognostic factor for operable lung cancer patients (with IgA(-) group as the control group, HR = 3.39, 95%CI: 1.41–8.17). …”
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Oral Plaque from Type 2 Diabetic Patients Reduces the Clonogenic Capacity of Dental Pulp-Derived Mesenchymal Stem Cells by Antonella Bordin, Francesca Pagano, Eleonora Scaccia, Matteo Saccucci, Iole Vozza, Noemi Incerti, Antonella Polimeni, Elena Cavarretta, Isotta Chimenti, Elena De Falco

“…Results have shown that the number of clones generated by DPSCs exposed to T2D oral plaque was significantly lower compared to controls (ctl). The multivariate analysis confirmed that the decreased clonogenesis was significantly correlated only with T2D diagnosis. …”
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End-tidal carbon dioxide-guided extracorporeal cardiopulmonary resuscitation improves neurological prognosis in patients: a single-center retrospective cohort study by Xiaozu Liao, Chen Gu, Zhou Cheng, Kepeng Liu, Qing Yin, Binfei Li

“…Approximately 37% of patients who received ECPR had good cerebral function at discharge, with a higher rate in the GDCPR group (52%) compared with the CCPR group (28%) (p = 0.047). Multivariate analysis showed that the Highest Interleukin-6 (H-IL6) levels after ECMO (Odds Ratio [OR = 1.001], 95% Confidence Interval [95% CI 1.000–1.003], p = 0.005) was a risk factor for neurological function at discharge. …”
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TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress by Veronica Tisato, Stefania Gallo, Elisabetta Melloni, Claudio Celeghini, Angelina Passaro, Giorgio Zauli, Paola Secchiero, Carlo Bergamini, Alessandro Trentini, Gloria Bonaccorsi, Giuseppe Valacchi, Giovanni Zuliani, Carlo Cervellati

“…We measured circulating TRAIL levels relative to praoxonas-1, lipoprotein phospholipase-A2, and ceruloplasmin levels in a cohort of healthy subjects (n=209). Results. Multivariate analysis revealed that ceruloplasmin levels were significantly inversely associated with TRAIL levels (r=−0.431, p<0.001). …”
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Characteristics and Outcomes of Elderly Patients Refused to ICU by María-Consuelo Pintado, Patricia Villa, Natalia González-García, Jimena Luján, Rocío Molina, María Trascasa, Esther López-Ramos, Cristina Martínez, José-Andrés Cambronero, Raúl de Pablo

“…High comorbidity, low functional status, unavailable ICU beds, and age were associated with refusal decision on multivariate analysis. Conclusions. Prior functional status and comorbidity, not only the age or severity of illness, can help us more to make the right decision of admitting or refusing to ICU patients older than 75 years.…”
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Risk factors for growth retardation in children with juvenile idiopathic arthritis: a case-control study by Ying Zhang, Liping Song, Weihu Ma, Ye Wang, Peipei Wang, Xiaolin Zhang, Zhe Zhang, Yuan Zhang, Qianhui Yu, Yang Yu, Lin Zhang

“…These factors were identified as independent risk factors for growth retardation in multivariate analysis. The area under the curve (AUC) values for these factors ranged from 0.651 to 0.676, indicating moderate predictive accuracy. …”
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Development and validation of nomograms for predicting pentafecta outcomes before and after robot-assisted radical prostatectomy: a retrospective study by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…The pentafecta outcome was achieved in 290 patients (16.6%). Multivariate analysis revealed that bilateral nerve sparing significantly increased the likelihood of achieving the pentafecta outcome (odds ratio 10.36, 95% CI: 5.75–18.66; p < 0.001). …”
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Prognostic Value of Novel CARWL Score in Stage IIIC Non-Small-Cell Lung Cancer Patients Undergoing Concurrent Chemoradiotherapy by Erkan Topkan, Ahmet Kucuk, Duriye Ozturk, Emine Elif Ozkan, Ali Ayberk Besen, Berrin Pehlivan, Ugur Selek

“…The CARWL score’s significant impacts on PFS and OS outcomes were found to be independent of the other variables in the multivariate analysis (P<0.001, for each). Conclusions. Our findings indicate that the novel CARWL score, which accounts for pretreatment CAR and significant WL during the preceding 6 months, can reliably stratify newly diagnosed stage IIIC NSCLC patients into three groups with significantly different PFS and OS after definitive CCRT.…”
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Ficus deltoidea standardized methanolic extract improves kidney structure and function against streptozotocin-induced diabetic nephropathy in rats by Nurdiana Samsulrizal, Noor Syaffinaz Noor Mohamad Zin, Nur Syimal`ain Azmi, Mohd Daud Bakar, Hafandi Ahmad, Yong-Meng Goh

“…We noticed that biochemical and pathological changes corresponded to the infrared (IR) peaks at 1545 cm-1 and 1511 cm-1 (amide II), 1246 cm-1 (DNA/RNA phosphate backbones), and 1181 cm-1 (C–O vibrations). Multivariate analysis of IR spectra demonstrated that the diabetic rats treated with F. deltoidea extract had a similar clustering pattern to that of the normal animals. …”
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Fine-Needle Aspiration Biopsy and Endoscopic Ultrasound for Pretreatment Pathological Diagnosis of Gastric Gastrointestinal Stromal Tumors by Hiroaki Ito, Haruhiro Inoue, Shomei Ryozawa, Haruo Ikeda, Noriko Odaka, Nikolas Eleftheriadis, Roberta Maselli, Norimasa Sando, Satoshi Kimura, Shin-ei Kudo

“…The procedure of EUS-guided FNA biopsy had no complications or recurrent disease. In a multivariate analysis, only EUS achieved a significantly superior rate of diagnosis (odds ratio, 11.884; 95% confidence interval, 1.204–289.230; P=0.034). …”
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Tumor Size Is a Critical Factor in Adjuvant Chemotherapy for T3-4aN0M0 Gastric Cancer Patients after D2 Gastrectomy by Shi Chen, Li-Ying Ou-Yang, Run-Cong Nie, Yuan-Fang Li, Jun Xiang, Zhi-Wei Zhou, Ying-Bo Chen, Jun-Sheng Peng

“…For patients with tumors larger than 5 cm, univariate analysis revealed that tumor location (p=0.007), Borrmann type (p=0.039), postoperative chemotherapy (p=0.003), and pathological T stage (p<0.001) were significant prognostic factors. Multivariate analysis revealed that postoperative chemotherapy and pathological T stage were independent prognostic factors. …”
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The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma by Lianne M. Haveman, Andreas Ranft, Henk vd Berg, Anne Smets, Jarmila Kruseova, Ruth Ladenstein, Benedicte Brichard, Michael Paulussen, Thomas Kuehne, Heribert Juergens, Stephanie Klco‐Brosius, Uta Dirksen, Johannes H.M. Merks

“…No correlation was found between TVR and HisRes. Multivariate analysis showed that poor HisRes, pelvic location and late inadequate TVR were associated with poor outcome. …”
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Association between vitamin D levels and preserved ratio impaired spirometry: an investigation of mediating roles of systemic inflammation and metabolic indicators by Tong Lin, Shanshan Huang, Fen Zhou, Xingkai Shen, Haiyan Mao

“…Nonlinear relationships were assessed using restricted cubic spline (RCS) models.ResultsThe PRISm group had lower median vitamin D levels and distinct inflammatory and metabolic profiles compared to the non-PRISm group. Multivariate analysis confirmed an inverse association between vitamin D levels and PRISm (adjusted OR: 0.989, 95% CI: 0.984–0.994, p &lt; 0.001). …”
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A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma by Yingkun Xu, Xiunan Li, Yuqing Han, Zilong Wang, Chenglin Han, Ningke Ruan, Jianyi Li, Xiao Yu, Qinghua Xia, Guangzhen Wu

“…Finally, based on the model, we conducted correlation analysis of the clinicopathological characteristics, univariate analysis, and multivariate analysis. Results. We found that most of the genes related to the PPAR pathway had different degrees of expression differences in KIRC. …”
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Using CT imaging to identify sarcopenia as a risk factor for severe falls in older adults by Nadja Fries, Angeliki Kotti, Mischa Woisetschläger, Anna Spångeus

“…No correlation with other clinical risk assessment scores nor spine T-score was found. In the multivariate analysis, higher level of frailty, male sex as well as lower BMI, VAT and SAT remained as risk factors for low SMI ratio. …”
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Ovarian Stimulation in Patient-oriented Strategies Encompassing Individualised Oocyte Number-4 Category; Antagonist versus Short-agonist Protocols by Tarek K. Al-Hussaini, Ahmed Aboelfadle Mohamed, Ayman Askar, Ahmed A. Abden, Yousra M. Othman, Reda S. Hussein

“…No significant impact for the protocol type on live birth rate was revealed after adjusting to cycle confounders in multivariate analysis (OR: 0.439, 95%CI 0.134-1.434, P = 0.173). …”
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Availability in ECMO Reduces the Failure to Rescue in Patients With Pulmonary Embolism After Major Surgery: A Nationwide Analysis of 2.4 Million Cases by Johannes Diers, MD, Nikolas Baumann, MD, Philip Baum, MD, Konstantin L. Uttinger, MD, Johanna C. Wagner, MD, Peter Kranke, MD, Patrick Meybohm, MD, Christoph-Thomas Germer, MD, Armin Wiegering, MD

“…The availability of and experience in ECMO therapy (defined as at least 20 ECMO applications per year; ECMO centers) are associated with a significantly reduced FtR in patients with PE after high-risk surgical procedures. In a multivariate analysis, the odds ratio (OR) for FtR after postoperative PE was significantly lower in ECMO centers (OR, 0.75 [0.70–0.81], P < 0.001). …”
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Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction by Jong-Sun Kim, Wan-Sik Lee, Cho-Yun Chung, Hyung-Chul Park, Dae-Seong Myung, Chan-Young Oak, Mi-Young Kim, Mi-Ok Jang, Seung-Ji Kang, Hee-Chang Jang, Sung-Bum Cho, Hyun-Soo Kim, Young-Eun Joo

“…The frequency of post-SEMS insertion fever, systemic inflammatory response syndrome (SIRS), and bacteremia was not significantly different between PA and non-PA groups. In multivariate analysis, the CRP level was risk factor related to post-SEMS insertion SIRS. …”
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