Refining management strategies for Lennox–Gastaut syndrome: Updated algorithms and practical approaches by Stéphane Auvin, Alexis Arzimanoglou, Mercè Falip, Pasquale Striano, J. Helen Cross

“…Abstract Lennox–Gastaut syndrome (LGS) is a severe developmental and epileptic encephalopathy (DEE) characterized by multiple types of drug‐resistant seizures (which must include tonic seizures) with classical onset before 8 years (although some cases with later onset have also been described), abnormal electroencephalographic features, and cognitive and behavioral impairments. …”
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Severity of grinder injuries and related factors compared with other high-rotation cutting tool injuries: a multicenter retrospective study from 2011 to 2018 by Juni Song, Yang Bin Jeon, Jae Ho Jang, Jin Seong Cho, Jae Yeon Choi, Woo Sung Choi

“…The odds of a severe injury using a grinder were higher in arm injuries (OR, 1.60; 95% CI, 1.40–1.83) and multiple-part injuries (OR, 1.998; 95% CI, 1.639–2.437). …”
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Newborn morbidities and care procedures at the special newborn care units of Gandaki Province, Nepal: a retrospective study by Khim Bahadur Khadka, Nabina Koirala, Olena Ivanova, Ramchandra Bastola, Dela Singh, Kamala Rana Magar, Bidhya Banstola, Ramesh Prasad Adhikari, Vincentas Giedraitis, Deepak Paudel, Guenter Froeschl

“…Conclusions The study showed that newborns suffered from multiple health complications such as sepsis, hyperbilirubinemia, or asphyxia, and many newborns received essential medical services from hospitals. …”
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Geology of the Tabakoto gold deposit, Kédougou-Kéniéba Inlier, West African Craton, Mali by Diallo Mahamadou, Salvi Stefano, Baratoux Lenka, Béziat Didier, Vanderhaeghe Olivier, Labou Ibrahima, Baratoux David, Ly Saïdou

“…The Tabakoto deposit is characterized by multiple overlapping stages of magmatic dike intrusions and hydrothermal alteration during distinct regional-scale deformation events. …”
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Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation by Chuanren Zhuang, Ruomeng Hu, Ke Li, Zhengshuang Liu, Songjie Bai, Sheng Zhang, Xuehuan Wen

“…Subgroup analyses stratified patients by disease severity using SOFA scores (low ≤10, medium 11–15, high >15) and creatinine levels (low ≤3 mg/dL, medium 3–5 mg/dL, high >5 mg/dL). Multiple machine learning models were developed and evaluated to predict patient prognosis, with Shapley Additive exPlanations (SHAP) analysis identifying key prognostic factors.ResultsAfter propensity score matching, late CRRT initiation was associated with improved survival probability, but led to increased hospital and ICU stays. …”
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Understanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study by Katherine A. Kissel, MN, RN, Karla D. Krewulak, PhD, Thérèse G. Poulin, BSc, Ken Kuljit S. Parhar, MD, MSc, Daniel J. Niven, MD, PhD, Vanessa M. Doiron, MScHQ, RN, Kirsten M. Fiest, PhD

“…Quantitative questions (single/multiple choice, true/false, and Likert-based questions eliciting agreement with a statement) were analyzed using descriptive statistics. …”
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Nonlinear associations of the hs-CRP/HDL-C index with metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis in US adults: insights from NHANES 2017–2... by Bin Liang, Xue Qiu, Jiansheng Huang, Yequan Lu, Hairong Shen, Jianchao Ma, Yongyu Chen

“…The hs-CRP/HDL-C index was calculated by the quotient of hs-CRP and HDL-C. Multiple logistic regression models, Cochran-Armitage trend tests, smooth curve fitting, threshold effect analyses, and stratified analyses were used to evaluate whether the hs-CRP/HDL-C index associated with MASLD and advanced liver fibrosis. …”
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Effect of a Sodium and Calcium DL-β-Hydroxybutyrate Salt in Healthy Adults by Tobias Fischer, Ulrike Och, Ira Klawon, Tim Och, Marianne Grüneberg, Manfred Fobker, Ursula Bordewick-Dell, Thorsten Marquardt

“…The intake of ketone bodies is often discussed in relation to rare metabolic diseases, such as multiple acyl-CoA dehydrogenase deficiency (MADD), that have no alternatives for treatment. …”
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Relationship Between a Heavy Rainfall and Gravity Wave in Sichuan Basin by Xu Yizhou, Li Guoping, Zhang Xiaoyu, Xie Xin, Dong Yuanchang

“…Therefore, favorable water vapor conditions in the Basin combined with the specific circulation characteristics make the main precipitation of this process not occur in the slope and mountain area in the south of the Basin as the normal mountain rainstorm, but under the combined influence of gravity wave transmission to the north and multiple systems in the middle and low levels, the belt rainstorm occurs in the plain and hilly areas of the central Sichuan Basin.…”
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Identifying corridors for Asiatic black bear (Ursus thibetanus) in a part of Eastern Himalayas, India by Malyasri Bhattacharya, Debanjan Sarkar, Sneha Pandey, Indranil Mondal, Sambandam Sathyakumar, R. Suresh Kumar, Gautam Talukdar

“…Our analysis suggests that there are multiple options to maintain connectivity for black bears in Sikkim. …”
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Effects of acupuncture at the Taichong (LIV3) and Hegu (LI4) points on functional connectivity with the retrosplenial cortex in patients with Alzheimer’s disease by Junkai Wang, Xinyue Bai, Xiaojun Chen, Shui Liu, Mengmeng Sun, Kuncheng Li, Yunsong Zheng, Zhiqun Wang

“…Two sets of regions of interest (ROIs) in the RSC were selected to assess the sustained effect of acupuncture on FC with the RSC in AD patients and NCs.ResultsTwo sets of RSC ROI-based analyses demonstrated robust positive connectivity with the hippocampus (HPC). Furthermore, multiple brain regions, including the bilateral thalamus, bilateral posterior cingulate cortex (PCC), bilateral subcallosal cingulate gyrus (SCG), bilateral orbitofrontal cortex (OFC), and right precuneus, showed decreased FC with the RSC in the AD group and increased FC with the RSC in the NC group after acupuncture compared to that at baseline. …”
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Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis. by Yikun Yin, Jialin Wang, Qihan Lin, Yinghang Luo, Yongsheng Liu, Junzhi Sun

“…<h4>Methods</h4>Literature searches were conducted in multiple databases including China National Knowledge Infrastructure (CNKI), VIP, Wanfang, China Biology Medicine disc (CBM), PubMed, EBSCO (Medline, CINAHL, SPORTDiscus, and Rehabilitation & Sports Medicine Source), Embase, ScienceDirect, ProQuest, Cochrane Library, and Web of Science for randomized controlled trials assessing the effects of Proprioceptive Neuromuscular Facilitation interventions on patients with Chronic Ankle Instability. …”
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Shorter Digestion Times of Donor Islets Is Associated With Better Islet Graft Function After Islet Transplantation by Chia-Hao Wang, Christopher Orr, Jeannette Hacker-Stratton, Mohamed El-Shahawy, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…Although islet transplantation is effective in reducing severe hypoglycemia events and controlling blood glucose in patients with type 1 diabetes, maintaining islet graft function long-term is a significant challenge. Islets from multiple donors are often needed to achieve insulin independence, and even then, islet function can decline over time when metabolic demand exceeds islet mass/insulin secretory capacity. …”
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Secukinumab in the treatment of psoriatic arthritis: efficacy and safety results through 3 years from the year 1 extension of the randomised phase III FUTURE 1 trial by Philip J Mease, Arthur Kavanaugh, Andreas Reimold, Hasan Tahir, Jürgen Rech, Stephen Hall, Piet Geusens, Pascale Pellet, Evie Maria Delicha, Shephard Mpofu, Luminita Pricop

“…Overall, 76.8%/54.9% (secukinumab 150 mg) and 65.2%/39.0% (secukinumab 75 mg) of patients achieved an American College of Rheumatology (ACR) 20/50 response (multiple imputation data); ACR20 responses were sustained irrespective of previous anti-tumour necrosis factor exposure. …”
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A Critical Appraisal of System-Reported Organ Dose (OD) Versus Manually Calculated Mean Glandular Dose (MGD) in Dubai’s Mammography Services by Kaltham Abdulwahid Mohammad Noor, Norhashimah Mohd Norsuddin, Muhammad Khalis Abdul Karim, Iza Nurzawani Che Isa, Vaidehi Ulaganathan

“…<b>Background</b>: This study compares system-reported organ doses (ODs) to manually calculated mean glandular doses (MGDs) in mammography across multiple centers and manufacturers in Dubai. <b>Methods</b>: A retrospective study of 2754 anonymized mammograms from six clinics in Dubai were randomly retrieved from a central dose survey database. …”
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Les pratiques touristiques ciblées sur l’enfance : vers une nouvelle perspective ? by Fiorella Dallari, Alessia Mariotti

“…Les problématiques sont multiples, à commencer par la subdivision en classes d’âge établie en fonction des capacités cognitives, de perception et d’interprétation des mineurs, qui impose une distinction entre enfance et adolescence : la littérature scientifique disponible à ce sujet se base en effet sur des informations indirectes, qui renvoient à la famille responsable du mineur. …”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…ETS variant transcription factor 1 (ETV1) plays an important role in multiple malignancies. However, its function in ESCC progression and tumor microenvironment (TME) remains to be explored. …”
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Servicesheds connect people to the landscapes upon which they depend by Yiyi Zhang, Hugo Thierry, Lara Cornejo, Lael Parrott, Monique Poulin, Kate Sherren, Danika Van Proosdij, Brian Robinson

“…We demonstrate how serviceshed mapping, when integrating social and ecological information, can be useful in multiple decision contexts. Servicesheds can help planners and managers better design zoning restrictions, restoration activities to benefit communities, or subsidy programmes to replace the value of ES lost due to climate change or land use development. …”
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Sparse Convolution FPGA Accelerator Based on Multi-Bank Hash Selection by Jia Xu, Han Pu, Dong Wang

“…This design resolves address access conflicts when multiple computational units concurrently access a set of caches by utilizing a hash-based address indexing algorithm. …”
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Genome stability of the vaccine strain VAC∆6 by R. A. Maksyutov, S. N. Yakubitskiy, I. V. Kolosova, T. V. Tregubchak, A. N. Shvalov, E. V. Gavrilova, S. N. Shchelkunov

“…Both nucleotide substitutions are located in intergenic regions (positions 1431 and 189738 relative to LIVP), which indicates an extremely rare occurrence of off-target mutations when using transient dominant selection to obtain recombinant VAC variants with multiple insertions/deletions. To assess the genome stability of the resulting attenuated vaccine strain, 15 consecutive cycles of cultivation of the industrial VACΔ6 strain were performed in 4647 cells certified for vaccine production in accordance with the “Guidelines for Clinical Trials of Medicinal Products”. …”
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