Safety of tenecteplase vs. alteplase in telestroke: a large multistate experience (STAT) by Morgan Figurelle, Sandro Corti, Oleg Collins, Lan Gao, Amanda Avila, Kristie Delfino, Laurie Mayer, Theresa Sevilis

“…Recently, hospital systems have switched to the IVT tenecteplase (TNK) instead of the FDA-approved alteplase (tPA) for treatment. Multiple studies and meta-analyses evaluating the efficacy and safety of TNK demonstrate similar or superior outcomes when compared to tPA. …”
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Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging by Seul Ki Kim, Sang-Back Kim, Seul Bi Lee, Kang sub Kim, So-Ri Son, En Jin Choi, Byung Chul Park, Eunyoung Hong, You Ah Kim, Byoung Seok Moon, Sullim Lee

“…These findings underscore the potential therapeutic applications of Nypa fruticans (NF) in mitigating oxidative stress, inflammation, skin barrier dysfunction, dehydration, and microbial imbalances. By targeting multiple pathways implicated in skin aging, NF represents a promising comprehensive approach for preserving skin health and addressing age-related dermatological conditions. …”
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Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation by Joohyun Kim, MD, PhD, Michael T. Zimmermann, PhD, Angela J. Mathison, PhD, Gwen Lomberk, PhD, Raul Urrutia, MD, Johnny C. Hong, MD

“…Therefore, we sought to characterize transcriptomic profiles of IRI during multiple phases in human OLT. Methods:. We conducted clinical data analyses, histologic evaluation, and RNA sequencing of 17 consecutive human primary OLT. …”
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Klasifikasi Alzheimer Berdasarkan Data Citra MRI Otak Menggunakan Fcm Dan Anfis by Nilna Almumtazah, Muhammad Sahrul Kiromi, Nurissaidah Ulinnuha

“…The best average sensitivity value was reached during the k-fold 5 trial with the type of membership function trapezoidal, 50 epoch, and 90° angle, with a sensitivity of 90.27%, according to the results of multiple tests that have been run. While k-fold 10 was found to have the same angle and kind of membership function at the time of the epoch 150 trial, a value of 89.94% was attained. …”
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Abnormalities in Blood Parameters in Athletes Taking Anabolic Androgenic Steroidal Agents; an Observational Clinical Study by Mubarak GS, Bamagous GA, Alsanosi SM, Alhindi YZ, Alqashqari HS, Albar HT, Siddiqi AM, Ayoub N, Falemban AH

“…Ghaida Siraj Mubarak,1 Ghazi A Bamagous,2 Safaa M Alsanosi,2 Yosra Z Alhindi,2 Hamsah S Alqashqari,3 Halah Tariq Albar,4 Ahmed M Siddiqi,5 Nahla Ayoub,2 Alaa H Falemban2 1Pharmacy Department, Hera’ General Hospital, Ministry of Health, Makkah, Saudi Arabia; 2Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al Qura University, Makkah, Saudi Arabia; 3Department of Community Medicine and Pilgrims Health Care, Faculty of Medicine, Umm Al Qura University, Makkah, Saudi Arabia; 4Department of Physiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 5Department of Internal Medicine, National Guard Hospital, Jeddah, Saudi ArabiaCorrespondence: Alaa H Falemban, Email ahfalemban@uqu.edu.saBackground: Many studies indicate that high and multiple doses of anabolic-androgenic steroids (AAS) for athletic enhancement can result in serious and irreversible adverse effects. …”
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Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis by Zhe Chen, Mingyang Tang, Nan Wang, Jiangjiang Liu, Xiaoyan Tan, Haitao Ma, Jing Luo, Kai Xie

“…Additionally, we conducted a comprehensive evaluation of therapeutic value, pathogenic mechanisms, and safety through phenome-wide association study (PheWAS), mediation analysis, transcriptomic analyses, shared causal variant exploration, DNA methylation MR, and protein interactions. Results Multiple MR results revealed that BRSK2 has a significant pathogenic impact on IPF at both transcriptional and translational levels, with a lung tissue-specific association (OR = 1.596; CI, 1.300–1.961; Pval = 8.290 × 10 − 6). …”
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Predictive value of dendritic cell-related genes for prognosis and immunotherapy response in lung adenocarcinoma by Zihao Sun, Mengfei Hu, Xiaoning Huang, Minghan Song, Xiujing Chen, Jiaxin Bei, Yiguang Lin, Size Chen

“…Performance of the prognostic model, DCRGS, for the prognostic evaluation, was assessed using a multiple time-dependent receiver operating characteristic (ROC) curve, the R package, “timeROC”, and validated using GEO datasets. …”
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Detection of Antimicrobial Resistance Genes Associated with Carbapenem Resistance from the Whole-Genome Sequence of Acinetobacter baumannii Isolates from Malaysia by Mohan Rao, Fairuz A. Rashid, Surianti Shukor, Rohaidah Hashim, Norazah Ahmad

“…All 13 CrAb isolates harbored multiple β-lactamase genes. blaOXA-23 (n = 13) and blaOXA-66 (n = 11) were the dominant carbapenemase gene families found in these isolates. …”
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Factores asociados al bloqueo de rama derecha en adultos mayores by María José Rentería Cabrejos, Cinthia Karina Picón-Reátegui, Annel Rojas Alvarado, Sandy P. Bulnes Alvarez, César Johan Pereira Victorio, Mario Valladares Garrido

“…El 41 % tuvo diagnóstico de bloqueo de rama derecha. En la regresión múltiple; el sexo femenino (RP=1,53, IC 95 %: 1,21 - 1,95), antecedente de hipertensión (RP=1,55; IC 95 %: 1,21 - 2,00) y diabetes mellitus (RP=1,49, IC 95 %: 1,12 - 2,00) se asociaron de forma positiva a presentar bloqueo de rama derecha. …”
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Sex-biased prevalence in infections with heterosexual, direct, and vector-mediated transmission: a theoretical analysis by Andrea Pugliese, Abba B. Gumel, Fabio A. Milner, Jorge X. Velasco-Hernandez

“…It is interesting to note that transient patterns can differ from final attack ratios, as new cases will tend to occur more often in the more susceptible sex, while later depletion of susceptibles may bias the ratio in the opposite direction.The analysis of these simple models, despite their lack of realism, can help in providing insight into, and assessment of, the potential role of gender-specific transmission in infections with multiple modes of transmission, such as Zika virus (ZIKV), by gauging what can be expected to be seen from epidemiological reports of new cases, disease incidence and seroprevalence surveys.…”
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Improving the physiological status of broiler chickens using rosemary leaf meal and sodium bentonite as ammonia gas control agents by Mercy Chisara Ogwuegbu, Fredrick Ugochukwu Udeh, Josephine Chinenye Ugwuozor, Precious Ezinne Okoye, Joy Chimela Kalu, Emmanuel Chinonso Arum, Doctor Mziwenkosi Nhlanhla Mthiyane

“…Data were analyzed using two-way ANOVA, and significant differences were determined using Duncan's New Multiple Range Test. A Student's t-test was used for comparisons between two treatment groups. …”
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Evaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants by Pooja Budhiraja, Jesse D. Schold, Jesse D. Schold, Rocio Lopez, Rocio Lopez, Susana Arrigain, Susana Arrigain, Bruce Kaplan, Bruce Kaplan

“…BackgroundThis study assesses the impact of human leukocyte antigen (HLA)-DR mismatch and donor-estimated glomerular filtration rate (eGFR) on outcomes of living donor kidney transplantation (LDKT), which are especially relevant to the availability of multiple donors and paired kidney exchanges.MethodsUsing data from the Scientific Registry of Transplant Recipients (SRTR), we retrospectively analyzed graft survival in adult LDKT recipients transplanted between January 2013 and September 2022. …”
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Cancer vaccines compensate for the insufficient induction of protective tumor-specific immunity of CD3 bispecific antibody therapy by Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Jim Middelburg, Kristel Kemper, Janine Schuurman, Gaby Schaap, Katy Lloyd, Vitalijs Ovcinnikovs

“…Induction of long-lasting tumor-specific immunity might therefore improve therapeutic efficacy, but has not been studied in detail yet for CD3 bsAbs. Here, we examined multiple combination strategies aiming to improve survival rates in solid tumors and, simultaneously, install endogenous immunity capable of protection to tumor rechallenge.Methods Two syngeneic mouse tumor models were employed: The immunologically “cold” B16F10 melanoma and the immunologically “hot” MC38.TRP1 colon carcinoma model. …”
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The Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-Urban Dairy Cattle Farms in Kathmandu, Nepal by Erda E. Rame Hau, Minu Sharma, Bal K. Sharma Khanal, Peter D. Sly, Deirdre Mikkelsen, Nicholas Clark, Ricardo J. Soares Magalhães

“…Moreover, samples from farms with a higher number of calves and milking cows were more likely to contain single and multiple residues exceeding the MRL, while milk from farms with higher numbers of dry cows and farmers reported by a visiting chemist were less likely to have multidrug residues exceeding the MRL. …”
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Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer by Zhe Chen, Gaoming Wang, Nan Wang, Jiangjiang Liu, Yu Yao, Haitao Ma, Haitao Ma, Jing Luo, Kai Xie

“…Patients with SPLC who received combined chemoradiotherapy for FPLC exhibited significantly reduced survival times (OS: HR=1.157, P=0.030; CSS: HR=1.198, P=0.018), a finding confirmed across multiple models. For SPLC patients with prior FPLC chemoradiotherapy, subsequent SPLC radiotherapy significantly improved prognosis. …”
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High clinical burden of classical homocystinuria in the United States: a retrospective analysis by Mahim Jain, Mehul Shah, Kamlesh M. Thakker, Andrew Rava, Agnes Pelts Block, Colette Ndiba-Markey, Lionel Pinto

“…Among the 601 patients with a tHcy level, almost one-half (n = 297, 49.4%) had at least one thrombotic/thromboembolic, skeletal, ocular, or neurological event and 14.1% (n = 85) had multiple events. Thrombotic/thromboembolic events (n = 186, 30.9%) were the most common type of events, followed by skeletal (n = 100, 16.6%), ocular (n = 63, 10.5%), and neurological events (n = 50, 8.3%). …”
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Determination of Vibration Properties and Reliable Frequency Estimation for Synchronous Vibrations Through Improved Blade Tip Timing Techniques Without a Once-per-Revolution Sensor by Marios Sasakaros, Luca Mann, Markus Schafferus, Manfred Wirsum

“…This approach enables the blind analysis of BTT measurements and can identify multiple vibration frequencies. The proposed method expands the capabilities of BTT through a reliable assessment of vibration frequencies from under-sampled BTT signals. …”
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OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer by Qihui Sun, Xiaoqi Zhu, Qi Zou, Yang Chen, Tingting Wen, Tingting Jiang, Xiaojia Li, Fang Wei, Keping Xie, Jia Liu

“…Results Our risk prediction model, developed using machine learning algorithms, demonstrated high predictive accuracy across multiple datasets. Notably, the “rf” algorithm model showed an AUC of 1 in the training set and AUCs of 0.887 and 0.977 in two validation datasets. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…In this study, we explored the role of aging-related genes (ARGs) in UC pathogenesis and diagnosis prediction.Methods: Gene expression data were obtained from four independent datasets (GSE75214, GSE87466, GSE94648, and GSE169568) in the GEO database, and ARGs were derived from multiple public databases. After identifying UC-related ARGs, consistent clustering was performed to screen aging-related molecular subtypes, followed by the exploration of differences in the immune microenvironment and pathways between distinct subtypes. …”
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Depression among people living in rural and urban areas of Thailand: A cross-sectional study. by Wiriya Mahikul, Wisut Lamlertthon, Kanchana Ngaosuwan, Pawaree Nonthasaen, Napat Srisermphoak, Wares Chancharoen, Saimai Chatree, Arpaporn Arnamwong, Pisinee Narayam, Chatchamon Wandeecharassri, Pakin Wongpanawiroj

“…We found a higher prevalence of depression in the urban (31.8%) than the rural (4.5%) setting. In multiple logistic regression analysis, urban residence was significantly associated with higher rates of depression compared with rural residence (adjusted odds ratio [AOR] 9.43, 95% confidence interval [CI] 5.08-17.52). …”
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