Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy by Danielle Sidsworth, Noah Tregobov, Noah Tregobov, Colin Jamieson, Jennifer Reutens-Hernandez, Joshua Yoon, Geoffrey W. Payne, Geoffrey W. Payne, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers

“…Early theories of AD sought to identify a single unifying explanation underlying AD pathogenesis; however, evolving evidence suggests it is a multifactorial, systemic disease, involving multiple systems. Of note, vascular dysfunction, encompassing both cerebral and peripheral circulation, has been implicated in AD pathogenesis. …”
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Piloting an external quality assurance program (QAP) for COVID-19 antigen rapid diagnostic tests (Ag-RDTs): findings and lessons learned from Cambodia by Vonthanak Saphonn, John Kaldor, Deborah Williamson, Sothavireak Bory, Philip Cunningham, Jessica Markby, Kennarey Seang, Jacqueline Prestedge, Chan Leakhena Phoeung, Marilyn Ninan, Kanika Heng, Andrew Valley

“…Rapid antigen diagnostic tests (Ag-RDTs) that quickly and accurately identify SARS-CoV-2 are an essential part of the COVID-19 response, but multiple factors can affect the validity of Ag-RDTs results. …”
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Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction by Irene López-Ferreruela, Sara Malo, Blanca Obón-Azuara, María José Rabanaque, Adriana Gamba, Sara Castel-Feced, Isabel Aguilar-Palacio

“…It is crucial to analyse them from an intersectional perspective, considering the influence of multiple axes of inequality on health, in order to develop gender-sensitive strategies with a multidisciplinary approach.…”
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Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…Our search encompassed multiple databases including PubMed, EMBASE, the Web of Science Core Collection, the Cochrane Library, China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, the Wanfang database, and the China Biology Medicine Database to cover studies from database inception until 20 March 2024., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?…”
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Physical symptoms distress and demoralization among haemodialysis patients; the mediating effect of spirituality and self-compassion. A cross-sectional questionnaire survey by Chia-Hui Lin, Yi-Chien Chiang, Wen-Yi Li, Tsung-Lan Chu, Ya-Chu Hsiao

“…Relationships and mediators were examined with Pearson's correlations and multiple linear regression analysis, respectively. …”
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Ocular Signs and Ocular Comorbidities in Monoclonal Gammopathy: Analysis of 80 Subjects by Kitti Kormányos, Klaudia Kovács, Orsolya Németh, Gábor Tóth, Gábor László Sándor, Anita Csorba, Cecília Nóra Czakó, Achim Langenbucher, Zoltán Zsolt Nagy, Gergely Varga, László Gopcsa, Gábor Mikala, Nóra Szentmáry

“…The hematological diagnosis was MGUS in 9 (11.25%), multiple myeloma in 61 (76.25%), smoldering myeloma in 6 (7.50%), and amyloidosis or Waldenström macroglobulinemia in 2 cases (2.50%–2.50%). …”
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Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population by Qing Chen, Yanan Hou, Yifan Zhou, Jianfeng Luo, KaiweiSa Abuduxukuer, Chuchu Wang, Jialong Dong, Yiting Wang, Wenming Shi, Fei Shi, Qing Peng

“…Only WWI was significantly related to the prevalence of VI after adjustment for multiple confounders in both cross-sectional and longitudinal analyses (all p values <0.05). …”
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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation by Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

“…However, utilising tailored biomimetic three-dimensional (3D) topological porous structures combined with multiple bio-effect neurotrophic factors to create environments similar to neural tissues, regulate local immune responses, and develop a supportive microenvironment to promote peripheral nerve regeneration and repair poses significant challenges. …”
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Construction of an anaplastic thyroid cancer stratification signature to guide immune therapy selection and validation of the pivotal gene HLF through in vitro experiments by Li Pengping, Yin Kexin, Xie Yuwei, Sun Ke, Li Rongguo, Wang Zhenyu, Jin Haigang, Wang Shaowen, Huang Yuqing

“…Our study aims to identify ATC patients who might bene t from immunotherapy.MethodsOur study uses multiple algorithms by R4.2.0, and gene expression and clinical data are collected from TCGA, GEO and local cohort. …”
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Learning from wildfires: A scalable framework to evaluate treatment effects on burn severity by Caden P. Chamberlain, Garrett W. Meigs, Derek J. Churchill, Jonathan T. Kane, Astrid Sanna, James S. Begley, Susan J. Prichard, Maureen C. Kennedy, Craig Bienz, Ryan D. Haugo, Annie C. Smith, Van R. Kane, C. Alina Cansler

“…Our framework offers a robust approach for evaluating treatment effects on burn severity at the scale of individual fires, which can be scaled up to assess treatment effectiveness across multiple fires. As climate change brings increased uncertainty to dry forest ecosystems of western North America, our framework can support more strategic management actions to reduce wildfire risk and foster resilience.…”
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A suite of wildlife crossing structures facilitates mammal movement across tropical forest fragments in a city by Li Si Tay, Ruisheng Choo, Max D. Y. Khoo, Eunice Kong, Yi Xiang Chan, Wivian H. Y. Neo, Sebastian Ow, Yuet Hsin Toh, Han Ling, Malcolm C. K. Soh, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er

“…Although many species used multiple crossing types, most species had a preferred crossing method. …”
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Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy by Yue Wang, Kevin Chang, Aslan Mansurov, Jun Ishihara, Seounghun Kang, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Brendan T K Berg, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Melody A Swartz, Jeffrey A Hubbell

“…This resulted in remarkable synergistic efficacy in multiple solid tumor models treated with the dual cytokine combination. …”
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Association between Chronic Pain and Diabetes/Prediabetes: A Population-Based Cross-Sectional Survey in Saudi Arabia by Khaled K. Aldossari, Mamdouh M. Shubair, Jamaan Al-Zahrani, Abdulrahman A. Alduraywish, Khalid AlAhmary, Salwa Bahkali, Sara M. Aloudah, Sami Almustanyir, Laila Al-Rizqi, Sally A. El-Zahaby, Paivi Toivola, Ashraf El-Metwally

“…Compared to prediabetic and nondiabetic individuals, diabetic subjects had a higher prevalence of lower limb pain (11.1%), back pain (8.9%), abdominal pain (6.7%), and neck pain (4.4%) (X2 = 27.792, P=0.015). In a multiple logistic regression model, after adjusting for age, gender, education level, cholesterol, and smoking status, diabetic/prediabetic patients had a significantly higher prevalence of chronic pain ((OR) = 1.931 (95% CI = 1.536–2.362), P=0.037). …”
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Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas by Elise A. Chong, Elicia Penuel, Ellen B. Napier, Rachel K. Lundberg, Lihua E. Budde, Mazyar Shadman, Matthew J. Matasar, Nancy L. Bartlett, Ian W. Flinn, Francesc Bosch, Keith Fay, Andre Goy, Anita Kumar, Loretta J. Nastoupil, Michael C. Wei, Mei Wu, Shen Yin, Joseph A. Fraietta, Emeline R. Chong, Stephen J. Schuster

“…The median time from CAR-T to mosunetuzumab was significantly longer for responding than for nonresponding patients (P = .006, unadjusted for multiple comparisons). Most patients (20/30) did not receive intervening therapy between CAR-T administration and mosunetuzumab. …”
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Effect of crystalline lens decentration and tilt on visual performance in eyes implanted with bifocal or extended depth of focus intraocular lenses by Yu Zhang, Jiaqing Zhang, Chen Liang, Yifan Xu, Jiaying Wu, Junming Wu, Yifan Zhang, Aixia Jin, Xuhua Tan, Lixia Luo

“…Results Eighty‑seven patients with ZMB00 IOL and 76 patients with ZXR00 IOL were included. Multiple 6-mm internal aberrations showed a nonlinear increase with greater crystalline lens decentration. …”
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Designing an online intervention for adults with addictive eating: a qualitative integrated knowledge translation approach by Phillipa Hay, Amanda L Baker, Clare Collins, Tracy Burrows, Mark Leary, Kirrilly Pursey, Antonio Verdejo-García, Janelle Skinner, Megan C Whatnall

“…This process resulted in the identification of eight barriers and three facilitators to providing and receiving treatment for FA, eight components needed or missing from current treatments, telehealth as a feasible delivery platform, and refinement of key elements to ensure the intervention met the needs of both health professionals and possible patients.Conclusion Using an IKT approach allowed for a range of viewpoints and enabled multiple professions and disciplines to engage in a semiformalised way to bring expertise to formulate a possible intervention for FA. …”
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Investigation and analysis of clinical medical undergraduate learning behaviors under different teaching models by Yang-Zheng Lan, Yang-Zheng Lan, Wen-Ting Lin, Zheng Wu, Zheng Wu, Wen-Jia Chen, Wen-Jia Chen, Dan Guo, Shu-Hui Liu, Shu-Hui Liu, Jing Liu, Jing Liu

“…The survey explored multiple dimensions of learning behaviors, including classroom engagement, study time, and overall motivation. …”
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Constraints on triggered seismicity and its control on permeability evolution by Derek Elsworth, Ziyan Li, Pengliang Yu, Mengke An, Fengshou Zhang, Rui Huang, Zihan Sun, Guanglei Cui, Tianyu Chen, Quan Gan, Yixin Zhao, Jishan Liu, Shimin Liu

“…Machine learning deciphers the principal features of MEQs and the resulting permeability evolution that best track permeability changes – with transfer learning methods allowing robust predictions across multiple eological settings. Changes in permeability at reactivated fractures in both shear and extensional modes suggest that permeability change (Δk) scales with the seismic moment (M) of individual MEQs as Δk∝M. …”
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Predictors and Outcomes of Hematoma Expansion and Neurological Decline in Intracerebral Hemorrhage: A Multisite Mobile Stroke Unit Study by Asish K. Gulati, Tianwen Ma, Isaiah Rolle, Ryan Peterson, Bianca Pirlog, Justine Chen, Megan Heckathorn, Jonathan Ratcliff, Nicolas Bianchi, Carol Fleming, Michael Frankel, James Grotta, Ritvij Bowry, Stephanie Parker, William Hicks, Digvijaya Navalkele

“…Predictive factors were analyzed using multiple logistic regression models. Results Of the 55 patients who met the inclusion criteria, 27% experienced HE within the first 4 hours from last known well with the majority of HE occurring within the first 60 to120 minutes. …”
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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities by Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu

“…Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. …”
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