Noninvasive imaging biomarker reveals invisible microscopic variation in acute ischaemic stroke (≤ 24 h): a multicentre retrospective study by Kui Sun, Rongchao Shi, Xinxin Yu, Ying Wang, Wei Zhang, Xiaoxia Yang, Mei Zhang, Jian Wang, Shu Jiang, Haiou Li, Bing Kang, Tong Li, Shuying Zhao, Yu Ai, Jianfeng Qiu, Haiyan Wang, Ximing Wang

“…Through a series of procedures: head alignment, co-registration of NCCT and DWI, the volume of interest delineation and feature extraction. Multiple ML models (random forest, RF; support vector machine, SVM; logistic regression, LR; multilayer perceptron, MLP) were used to discriminate microscopic AIS and non-AIS. …”
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Pharmacological action of Angelica sinensis polysaccharides: a review by Chunzhen Ren, Chunzhen Ren, Chunzhen Ren, Yali Luo, Xiaojuan Li, Like Ma, Chunling Wang, Chunling Wang, Chunling Wang, Xiaodong Zhi, Xiaodong Zhi, Xinke Zhao, Xinke Zhao, Xinke Zhao, Yingdong Li, Yingdong Li, Yingdong Li

“…The search keywords for such work included “Angelica sinensis” or “Angelica sinensis polysaccharides,” and “pharmacological effects,” “extraction” and “structure.” Multiple studies have shown that ASP has important pharmacological effects, such as antitumor, anemia-improving, anti-inflammatory, antioxidative, immunomodulatory, hepatoprotective, antifibrotic, hypoglycemic, antiradiation, and antiviral effects, the mechanisms of which appear to involve the regulation of inflammation, oxidative stress, and profibrotic signaling pathways. …”
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Optimizing Neurobehavioral Assessment for Patients with Disorders of Consciousness: Proposal of a Comprehensive Pre-Assessment Checklist for Clinicians by Kristen Keech, Caroline Schnakers, Brooke Murtaugh, Katherine O’Brien, Beth Slomine, Marie-Michèle Briand, Rita Formisano, Aurore Thibaut, Anna Estraneo, Enrique Noé, Olivia Gosseries, Liliana da Conceição Teixeira

“…There are numerous challenges to valid and reliable neurobehavioral assessment and classification of DoC due to multiple environmental and patient-related biases including behavioral fluctuation and confounding or co-occurring medical conditions. …”
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Evaluation of nitrous oxide reduction in solid carbon source-driven counter-diffusional biofilm denitrification system by Yingrui Liu, Feng Chen, Yanying He, Yufen Wang, Tingting Zhu, Yindong Tong, Yingxin Zhao, Bing-Jie Ni, Yiwen Liu

“…This suggested that when treating wastewater containing multiple NOx, the PCL-driven biofilm denitrification system can not only relatively improve the total nitrogen removal efficiency, but also relatively alleviate N2O emissions. …”
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FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models by Timothy Weeden, Tyler Picariello, Brendan Quinn, Sean Spring, Pei-Yi Shen, Qifeng Qiu, Benjamin F. Vieira, Lydia Schlaefke, Ryan J. Russo, Ya-An Chang, Jin Cui, Monica Yao, Aiyun Wen, Nelson Hsia, Tama Evron, Katy Ovington, Pei-Ni Tsai, Nicholas Yoder, Bo Lan, Reshmii Venkatesan, John Hall, Cody A. Desjardins, Mo Qatanani, Scott Hilderbrand, John Najim, Zhenzhi Tang, Matthew K. Tanner, Romesh Subramanian, Charles A. Thornton, Oxana Ibraghimov-Beskrovnaya, Stefano Zanotti

“…Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by expanded CUG triplets in the DMPK RNA, which sequester splicing proteins in the nucleus, lead to spliceopathy, and drive disease progression. Methods Multiple surrogate conjugates were generated to characterize the FORCE platform. …”
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Proteomic, metabolomic and lipidomic profiles in community acquired pneumonia for differentiating viral and bacterial infections by Samuel Rischke, Robert Gurke, Ann-Sophie Zielbauer, Nicole Ziegler, Lisa Hahnefeld, Michaela Köhm, Aimo Kannt, Maria JGT Vehreschild, Gerd Geisslinger, Gernot Rohde, Carla Bellinghausen, Frank Behrens, CAPNETZ Study group

“…Lipid and metabolite analyses were LC-MS-based, while proteomic analyses were performed using multiple panels of the Olink platform. Statistical methods, machine learning and pathway analyses were conducted investigating differences between the infection types. …”
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Integrating green manure and fertilizer reduction strategies to enhance soil carbon sequestration and crop yield: evidence from a two-season pot experiment by Jun Zhang, Jun Zhang, Jun Zhang, Wei He, Wei He, Wei He, Zheng Wei, Zheng Wei, Yifei Chen, Yifei Chen, Weichun Gao, Weichun Gao

“…This study addresses this gap by investigating the effects of reducing nitrogen and phosphorus fertilizers (N-P) by up to 24% in conjunction with multiple cropping of soybean green manure on soil fertility, organic carbon fractions, and wheat yield. …”
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Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes by Ana Cecilia Fernández-Gaxiola, Roxana Valdés-Ramos, Kimberly Fulda, Ana Laura Guadarrama López, Beatriz E. Martínez-Carrillo, Susan F. Franks, Shane Fernando

“…Total cholesterol and HDL were higher among Mexican-Americans (p<0.001). In conclusion, multiple risk factors were present in the sample. We found differences by gender and between high and low risk for T2DM adolescents in all liver enzymes in both sites.…”
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Lateralized differences in power spectra across different frequency bands during NREM sleep in patients with primary insomnia by Jiao Huang, Jiao Huang, Jing Ye, Mingjie Gao, Wentao Gao, Weijia Chen, Yifeng Zhu, Yongbo Wang, Daijin Huang, Yunhui Lv, Hong Shi

“…ObjectiveTo compare the electroencephalogram power spectrum of patients with primary insomnia and good sleep controls in multiple brain areas and different frequency bands during non-rapid eye movement sleep.Methods48 primary insomnias and 30 age-and gender-matched good sleep controls were recorded overnight with polysomnography. …”
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…The promoter region of these genes was found to contain multiple cis-acting elements related to hormone responses, defence, and stress, indicating that they may respond to a variety of developmental and environmental stimuli. …”
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Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry by Masafumi Kurajoh, Shinya Fukumoto, Takayo Murase, Takashi Nakamura, Takuma Ishihara, Hirofumi Go, Kouji Yamamoto, Shinya Nakatani, Akihiro Tsuda, Tomoaki Morioka, Katsuhito Mori, Yasuo Imanishi, Masaaki Inaba, Masanori Emoto

“…The mean values for VFA, log HOMA-IR, and log plasma XOR activity were 76.8 ± 45.8 cm2, 0.14 ± 0.30, and 1.50 ± 0.44 pmol/h/mL, respectively. Multiple regression analysis showed that HOMA-IR was significantly (p=0.020) associated with plasma XOR activity independent of other factors, including VFA and adiponectin level, as well as age, sex, alcohol drinking habit, smoking habit, alanine transaminase, HbA1c, and eGFR. …”
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Mild ultrasound-assisted alkali de-esterification modified pectins: Characterization and structure–activity relationships in immunomodulatory effects by Huan Guo, Dong Li, Baohe Miao, Kanglin Feng, Guijing Chen, Renyou Gan, Zhiliang Kang, Hong Gao

“…Metabolomics analysis revealed that AP-E3 effectively restored metabolic homeostasis by activating multiple signaling pathways associated with signal transduction, immune regulation, and metabolism. …”
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Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans by Benjamin R Kop, Yazan Shamli Oghli, Talyta C Grippe, Tulika Nandi, Judith Lefkes, Sjoerd W Meijer, Soha Farboud, Marwan Engels, Michelle Hamani, Melissa Null, Angela Radetz, Umair Hassan, Ghazaleh Darmani, Andrey Chetverikov, Hanneke EM den Ouden, Til Ole Bergmann, Robert Chen, Lennart Verhagen

“…TUS is already well-established in animal models, providing foundations to now optimize neuromodulatory efficacy for human applications. Across multiple studies, one promising protocol, pulsed at 1000 Hz, has consistently resulted in motor cortical inhibition in humans (Fomenko et al., 2020). …”
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Childhood BMI trajectories and sociodemographic factors in an Italian pediatric population by Erich Batzella, Joaquin Gutierrez de Rubalcava Doblas, Gloria Porcu, Silvia Bressan, Elisa Barbieri, Carlo Giaquinto, Anna Cantarutti, Cristina Canova

“…Yet, more research relying on multiple time-point BMI measurements is warranted to gain further insight into obesity’s temporal trends. …”
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Experimental analysis of micro-cavity influence on the effective solar absorptance of white sand curtain on porous obstructions of particle heating receivers by Rageh Saeed, Shaker Alaqel, Eldwin Djajadiwinata, Nader S. Saleh, Abdulelah Alswaiyd, Hany Al-Ansary, Syed Noman Danish, Abdelrahman El-Leathy, Zeyad Al-Suhaibani, Sheldon Jeter, Redhwan Almuzaiqer, Zeyad Almutairi

“…Within this curtain, micro-cavities are generated, which dramatically reduce radiation loss to the sky by facilitating multiple reflections, effectively trapping intercepted rays, and thereby maximizing solar absorptance. …”
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The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors by Renhao Li, Jing-Chu Hu, Li Rong, Yige He, Xiaolei Wang, Xuansheng Lin, Wenjun Li, Yangfan Wu, Chaiyaporn Kuwentrai, Canhui Su, Thomas Yau, Ivan Fan-Ngai Hung, Xiang Gao, Jian-Dong Huang

“…Abstract We investigated a novel cancer immunotherapy strategy that effectively suppresses tumor growth in multiple solid tumor models and significantly extends the lifespan of tumor-bearing mice by introducing pathogen antigens into tumors via mRNA-lipid nanoparticles. …”
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Severe pneumonia caused by Nocardia otitidiscaviarum in a patient with bronchiectasis and IgA nephropathy: a case report by Yi Lin, Zhao-Zhao Jiang, Xiao-Qian Chi, Jian-Sheng Chen, Chao Wen, Chao Zhang, Ying-Ying Wang, Guang-Liang Xie

“…The laboratory examination and pulmonary computer tomography results indicated pulmonary infection, but the blood and multiple sputum cultures failed to identify the pathogen. …”
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The Sunburst Arc with JWST. III. An Abundance of Direct Chemical Abundances by Brian Welch, T. Emil Rivera-Thorsen, Jane R. Rigby, Taylor A. Hutchison, Grace M. Olivier, Danielle A. Berg, Keren Sharon, Håkon Dahle, M. Riley Owens, Matthew B. Bayliss, Gourav Khullar, John Chisholm, Matthew Hayes, Keunho J. Kim

“…We detect the temperature-sensitive auroral lines [S ii ] λλ 4070, 4076, [O iii ] λ 4363, [S iii ] λ 6314, [O ii ] λλ 7320, 7330, and [Ne iii ] λ 3343 in a stacked spectrum of five multiple images of the Lyman-continuum emitter (LCE), from which we directly measure the electron temperature in the low-, intermediate-, and high-ionization zones. …”
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Genetic characteristics and pathogenesis of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus isolated from poultry in South Korea, 2022–2023 by Ra Mi Cha, Min-Ji Park, Yoon-Gi Baek, Yu-Na Lee, Yunyueng Jang, Yong-Myung Kang, Gyeong-Beom Heo, Se-Hee An, Kwang-Nyeong Lee, Jae-Kyeom Kim, Hye-Ryoung Kim, Youn-Jeong Lee, Eun-Kyoung Lee

“…During the 2022–2023 winter season in South Korea, a novel clade 2.3.4.4b H5N1 HPAIV was first detected in wild birds, which then subsequently caused multiple outbreaks in poultry farms and wild birds. …”
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Antibody Responses to mRNA COVID-19 Vaccine Among Healthcare Workers in Outpatient Clinics in Japan by Teruhime Otoguro, Keita Wagatsuma, Toshiharu Hino, The Society of Ambulatory and General Pediatrics of Japan, Yusuke Ichikawa, Tri Bayu Purnama, Yuyang Sun, Jiaming Li, Irina Chon, Hisami Watanabe, Reiko Saito

“…Background: This study aimed to assess the antibody response to SARS-CoV-2 vaccines among healthcare workers (HCWs) from multiple outpatient clinics in Japan, examining the effects of baseline characteristics (e.g., sex, age, underlying condition, smoking history, occupation) and prior infections. …”
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