Hei-Gu-Teng Zhuifenghuoluo Granule Modulates IL-12 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis by Kang Zheng, Zexu Chen, Wen Sun, Bin Liu, Danping Fan, Qingqing Guo, Hui Luo, Jiawen Shen, Li Li, Xiaojuan He, Shuang Kou, Xiaoya Li, Guoming Pang, Hongchuan Zhao, Cheng Lu

“…Rheumatoid arthritis (RA) is a type of chronic systemic inflammatory disease; it has a very complicated pathogenesis, and multiple pathological changes are implicated. Traditional Chinese medicine (TCM) like Tripterygium wilfordii Hook. …”
Get full text

Polysomnographic titration of non-invasive ventilation in motor neurone disease (3TLA): study protocol for a randomised controlled trial by David J. Berlowitz, Dominic Rowe, Mark E. Howard, Amanda Piper, Marnie Graco, Sabine Braat, Bhajan Singh, Tanara Viera Souza, Natasha Lannin, Alistair McLean, Abbey Sawyer, Kate A. Carey, Yasmin Ahamed, on behalf of the 3TLA Trial Group

“…However, for this clinical practice model to result in sustained benefits, evidence of effectiveness across multiple sites, as well as culture and practice change, must occur. …”
Get full text

Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia by Fouzul Kansul, Deborah Vela, MD, Judit Csore, MD, Bright Benfor, MD, Sasha Suarez, MD, Anahita Dua, MD, MBA, MSC, Trisha L. Roy, MD, PhD

“…Results: Male and female patients were remarkably similar across multiple plaque characteristics, including degree of stenosis, calcification severity and localization, and atherosclerotic patterns. …”
Get full text

Exploring the metabolic dynamics, storage stability, and functional potential of Lacticaseibacillus rhamnosus Probio-M9-fermented milk by Xiaoye Liu, Kaiyang Liu, Jie Yang, Hui Qiao, Lai-Yu Kwok, Wenyi Zhang

“…Metabolite profiles were generated using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight MS with multiple segment extraction. A total of 34 representative differential metabolites were identified, primarily comprising peptides and saccharides, followed by acids, amino acids, alcohols, aldehydes, ketones, and intermediate metabolites. …”
Get full text

3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification by Fan Chen, An-Feng Luo, Kai-Xin Pan, Hao Gu, Chang-Fan Zhou, Wei Zeng, Song Liu, Adrian Molenaar, Hong-Yan Ren, Li-Jun Huo, Yan-Zhen Bi

“…SMART-seq2 transcriptome sequencing further confirmed that PNMC treatment disrupted global gene expression in 2-cell embryos, with differentially expressed genes enriched in multiple signaling pathways, including those related to autophagy, apoptosis, fertilization, embryonic development, transcription, and mRNA processing. …”
Get full text

The Clinical Features, Risk Factors, and Outcome of Aneurysmal Lesions in Behcet’s Disease by Jiaxin Zhou, Jing Shi, Jinjing Liu, Luxi Sun, Lu Li, Chaoran Li, Xiuhua Wu, Yining Wang, Xinping Tian, Xiaofeng Zeng, Yi Liu, Wenjie Zheng, Yan Zhao

“…Thirty-three patients (47.8%) had multiple aneurysmal lesions. Ten patients developed 20 pulmonary artery aneurysms alone. …”
Get full text

Lost and found: dynamics of relationship and employment status over time in people with affective and psychotic spectrum disorders by Fanny Senner, Lisa Kerkhoff, Kristina Adorjan, Michael Lauseker, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Bernhardt T. Baune, Udo Dannlowski, Nina Dalkner, Detlef E. Dietrich, Andreas J. Fallgatter, Christian Figge, Carsten Konrad, Fabian U. Lang, Jens Reimer, Eva Z. Reinighaus, Max Schmauß, Andrea Schmitt, Simon Senner, Carsten Spitzer, Jörg Zimmermann, Alkomiet Hasan, Peter Falkai, Thomas G. Schulze, Urs Heilbronner, Sophie-Kathrin Greiner

“…Multistate models (Markov) were used to analyse transitions in employment and relationship status, focusing on transition intensities. Analyses contained multiple multistate models adjusted for age, gender, job or partner, diagnostic group and Global Assessment of Functioning (GAF) in different combinations to analyse the impact of the covariates on the hazard ratio of changing employment or relationship status. …”
Get full text

Peripapillary atrophy area predicts the decrease of macular choroidal thickness in young adults during myopia progression by Xun Xu, Jianfeng Zhu, Ying Fan, Luyao Ye, Ya Shi, Menghan Li, Qiuying Chen, Guangyi Hu, Jiamin Xie, Jiangnan He

“…The macular ChT, PPA area and axial length (AL) were measured at baseline and follow-up visits. Multiple regression analysis was performed to identify factors associated with ChT changes. …”
Get full text

The perceived workload of first-line healthcare professionals during neonatal resuscitation by Hai-Bo Huang, Kui Sang, Ming Zhou, Lin Yi, Jiang-Qin Liu, Chuan-Zhong Yang, Brenda H.Y. Law, Georg M. Schmölzer, Po-Yin Cheung

“…Demographics of participants and deliveries were also collected for statistical analyses using univariate comparison and multiple linear regression. Results: From 410 valid surveys (187 (46%) MDs; 223 (54%) nurses/midwives), significant differences were noted between MDs and nurses/midwives including working years and dimensional and overall NASA-TLX scores. …”
Get full text

Decrease in platelet count in patients with AKI and its association with major adverse kidney events by Ramón Medina-González, Jose J. Zaragoza, Eduardo M. Hernández-Barajas, Juarez Correa-de Leon, Rolando Claure-Del Granado, Armando Vazquez-Rangel, Liliana M. Pineda-Segura, Martha K. Franco-Garcia, Gael Chávez-Alonso, Juan A. Gómez-Fregoso, Francisco G. Rodríguez-García, Guillermo Navarro-Blackaller, Luz Alcantar-Vallin, Alejandro Martínez Gallardo-González, Gabriela J. Abundis-Mora, Guillermo García-García, Jonathan S. Chávez-Iñiguez

“…Those who underwent hemodialysis (HD) had lower platelet counts. After multiple adjustments, a platelet reduction >21% was associated with MAKE10 (OR 4.2, CI 2.1-8.5) but not with MAKE30-90. …”
Get full text

Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriersResearch in context by Pedro A.F. Galante, Gabriela D.A. Guardia, Janina Pisani, Renata L. Sandoval, Mateus C. Barros-Filho, Ana Carolina Leite Vieira Costa Gifoni, Diogo F.C. Patrão, Patricia Ashton-Prolla, Vitor Fiorin de Vasconcellos, Claire Freycon, Arnold Levine, Pierre Hainaut, Maria Isabel Achatz

“…Interpretation: This study shows that R337H is associated with a lifetime risk of multiple LFS-spectrum cancers but with incomplete penetrance, particularly in males. …”
Get full text

The structural characteristics of dietary fibers from Tremella fuciformis and their hypolipidemic effects in mice by Shanshan Zhang, Xinle Xu, Xu Cao, Tingting Liu

“…In this study, Tremella fuciformis residues as raw material, dietary fibers from tremella were prepared by multiple enzymes. The structure of dietary fibers from tremella was studied by Fourier transform infrared (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). …”
Get full text

Genome-wide association analysis of key genes for feed efficiency in Qingyuan Partridge chickens by Fei Ye, Hongwei Jie, Jiankang Gan, Kunyu Liu, Zhengfen Zhang, Hai Xiang, Wei Liu, Qiong Yin, Siyu Chen, Hui Yu, Hua Li

“…GWAS results revealed 28 significant SNPs associated with body weight, feed intake, metabolic weight, weight gain, feed conversion ratio, and residual feed intake. The multiple genes are significantly enriched in the aromatic compound biosynthetic process, heterocycle biosynthetic process, and nucleobase-containing compound biosynthetic process. …”
Get full text

Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. by Andrés F. Zea-Vera, Carlos Andrés Rodríguez, Sebastián Giraldo, Mario Alejandro Chacón, Luis Fernando Guerrero, Ricardo Mosquera, Raúl Andrés Vallejo, Fabio Samir Vargas, María Andrea García, María A. Rengifo, Anilza Bonelo, Maximiliano Parra

“…Non-cystic fibrosis bronchiectasis is a complex medical condition with multiple etiologies, characterized by chronic productive cough and radiologic evidence of airway lumen dilation and wall thickening. …”
Get full text

Assemblies design and modeling analysis of a new fine mesh neutronics/thermal-hydraulics coupling benchmark for plate-type PWR core by Zhigang Li, Wei Lu, Shanfang Huang, Xiafeng Zhou, Yingwei Wu, Bangyang Xia, Junji Chen, Tao He, Guodong Liu, Yangyu Zhong, Zhiying Yue

“…In order to support the verification of neutronics/thermal-hydraulics coupling calculation method or simulation codes at the fine mesh for plate-type pressurized water reactor (PWR) with high parameters (which the ratio of power to mass flow rate is greater than 235 kW/kg, the core outlet enthalpy exceeds 1500 kJ/kg), a set of coupling calculation of plate-type PWR based on high parameters (COPHP) is design by Nuclear Power Institute of China (NPIC). Multiple industry research teams, including Tsinghua University, Xi'an Jiaotong University, and Huazhong University of Science and Technology, participated in the production of COPHP benchmark. …”
Get full text

Tracking Immunity: An Increased Number of COVID-19 Boosters Increases the Longevity of Anti-RBD and Anti-RBD-Neutralizing Antibodies by Ching-Wen Hou, Stacy Williams, Veronica Boyle, Alexa Roeder, Bradley Bobbett, Izamar Garcia, Giavanna Caruth, Mitch Magee, Yunro Chung, Douglas F. Lake, Joshua LaBaer, Vel Murugan

“…Background/Objectives: Since the World Health Organization declared COVID-19 a pandemic in March 2020, the virus has caused multiple waves of infection globally. Arizona State University (ASU), the largest four-year university in the United States, offers a uniquely diverse setting for assessing immunity within a large community. …”
Get full text

RETRACTED ARTICLE: A prospective diagnostic model for breast cancer utilizing machine learning to examine the molecular immune infiltrate in HSPB6 by Lizhe Wang, Yu Wang, Yueyang Li, Li Zhou, Sihan Liu, Yongyi Cao, Yuzhi Li, Shenting Liu, Jiahui Du, Jin Wang, Ting Zhu

“…Results The study identified multiple genes that displayed differential expression in breast cancer, notably FHL1 and HSPB6. …”
Get full text

Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study by Chao Bai, Chao Bai, Wenwen Yang, Guangwei Qi, Liuyu Yang, Qingrui Wu, Jieguang Peng, Ning Wang, Tao Liu

“…ObjectiveDiabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. While multiple studies have indicated changes in the expression of specific matrix metalloproteinases (MMPs) in patients with DN, and basic research has reported the impact of MMPs on DN, there is a lack of systematic research and the causal relationship remains unclear. …”
Get full text

Managerial thinking in neonatal care: a qualitative study of place of care decision-making for preterm babies born at 27–31 weeks gestation in England by Neena Modi, Elizabeth S Draper, Miaoqing Yang, Sarah E Seaton, Kelvin Dawson, Vasiliki Bountziouka, Oliver Rivero-Arias, Thillagavathie Pillay, Natalie Armstrong, Alexis Paton, Elaine Boyle, Victor L Banda, Caroline Cupit, Bradley Manktelow, Abdul Qader T Ismail

“…Two were neonatal intensive care units and four were local neonatal units.Participants Clinical staff (n=15) working in neonatal units, and people present in neonatal units during periods of observation.Results In the context of real-world neonatal practice, with multiple (and rapidly-evolving) uncertainties relating to mothers, babies and unit/network capacity, ‘best place of care’ protocols were only one element of much more complex decision-making processes. …”
Get full text

Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs by Lin Wang, Jiaxi Wang, Chao Lin, Furong Wang, Xiangping Li, Wanhui Liu

“…The elution procedure was as follows: 20%B (0–0.1 min), 80%B (0.1–0.3 min), 80%B (0.3–2.0 min), and 20%B (2.1–3.0 min). A multiple reaction monitor (MRM) was used under positive ionization mode with electrospray ion source to detect pioglitazone (357.1 ⟶ 134.1), omarigliptin (399.2 ⟶ 153.0), and sitagliptin (408.2 ⟶ 235.0). …”
Get full text